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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen <i>Pseudomonas aeruginosa</i>
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
– Biochemistry
(2017)
56,
5539
(DOI: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
– Angewandte Chemie
(2017)
129,
13046
(DOI: 10.1002/ange.201705611)
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes
YR Baker, JT Hodgkinson, BI Florea, E Alza, WRJD Galloway, L Grimm, SM Geddis, HS Overkleeft, M Welch, DR Spring
– Chemical Science
(2017)
8,
7403
(DOI: 10.1039/c7sc01270e)
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
– Angew Chem Int Ed Engl
(2017)
56,
12866
(DOI: 10.1002/anie.201705611)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
– Chemical communications (Cambridge, England)
(2017)
53,
9372
(DOI: 10.1039/c7cc05379g)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
– Bioorganic &amp; Medicinal Chemistry
(2017)
25,
3471
(DOI: 10.1016/j.bmc.2017.04.037)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring
– Tetrahedron
(2017)
72,
3567
(DOI: 10.1016/j.tet.2015.10.061)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes.
A Guarnieri-Ibáñez, F Medina, C Besnard, SL Kidd, DR Spring, J Lacour
– Chemical science
(2017)
8,
5713
(DOI: 10.1039/c7sc00964j)
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1–42)
TH Sum, TJ Sum, S Collins, WRJD Galloway, DG Twigg, F Hollfelder, DR Spring
– Organic and Biomolecular Chemistry
(2017)
15,
4554
(DOI: 10.1039/c7ob00804j)
Protein modification
TT-L Kwan, O Boutureira, EC Frye, SJ Walsh, MK Gupta, S Wallace, Y Wu, F Zhang, HF Sore, WRJD Galloway, JW Chin, M Welch, GJL Bernardes, DR Spring
– Chem Sci
(2017)
8,
3871
(DOI: 10.1039/c6sc05313k)
Stereocontrolled semi-syntheses of deguelin and tephrosin
DA Russell, JJ Freudenreich, JJ Ciardiello, HF Sore, DR Spring
– Organic & biomolecular chemistry
(2017)
15,
1593
(DOI: 10.1039/c6ob02659a)
(Z)-Selective Takai olefination of salicylaldehydes
SM Geddis, CE Hagerman, WRJD Galloway, HF Sore, JM Goodman, DR Spring
– Beilstein J Org Chem
(2017)
13,
323
(DOI: 10.3762/bjoc.13.35)
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, M Hyvönen, C Verma, DR Spring, LS Itzhaki
– Journal of the American Chemical Society
(2017)
139,
2245
(DOI: 10.1021/jacs.6b10234)
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
– Angewandte Chemie
(2017)
129,
539
(DOI: 10.1002/ange.201609427)
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
– Angewandte Chemie International Edition
(2017)
56,
524
(DOI: 10.1002/anie.201609427)
A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine
JJ Ciardiello, HL Stewart, HF Sore, WRJD Galloway, DR Spring
– Bioorganic & medicinal chemistry
(2017)
25,
2825
(DOI: 10.1016/j.bmc.2017.02.060)
Glyoxylate shunt as an antibacterial drug target
S Bartlett, A McVey, A Crousilles, M Welch, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
253,
Strain-promoted double-click functionalised stapled peptides for inhibiting protein-protein interactions
K Sharma, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
254,
Identification and development of small molecule inhibitors of the aggregation of amyloid β
S Collins, F Gielen, L van Vliet, G Kaminski, F Hollfelder, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
253,
Divergent Synthesis of Quinolone Natural Products from $\textit{Pseudonocardia}$ sp. CL38489
SM Geddis, L Carro Santos, JT Hodgkinson, DR Spring
– European Journal of Organic Chemistry
(2016)
2016,
5799
(DOI: 10.1002/ejoc.201601195)

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