Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Synthesis of diverse semi-saturated bicyclic heteroaromatics
H Stewart, T Moss, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Site-selective generation of stable antibody-drug conjugates via cysteine bridging of native antibodies
S Walsh, S Omarjee, M Hyvonen, J Carroll, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Using peptidomimetics and constrained peptides as valuable tools for inhibiting protein-protein interactions
NS Robertson, DR Spring
Molecules (Basel, Switzerland)
(2018)
23
(doi: 10.3390/molecules23040959)
Diversity-oriented synthesis for the generation of N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters
S Kidd, N Mateu-Sanchis, A Madin, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Second-generation CK2α inhibitors targeting the αd pocket
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring
Chem Sci
(2018)
9
(doi: 10.1039/c7sc05122k)
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring
Chemical science
(2018)
9
(doi: 10.1039/c8sc00284c)
Adventures in Drugging Undruggable Targets
D Spring
JOURNAL OF PEPTIDE SCIENCE
(2018)
24
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
Journal of Natural Products
(2017)
80
(doi: 10.1021/acs.jnatprod.7b00527)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201705611)
Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes.
YR Baker, JT Hodgkinson, BI Florea, E Alza, WRJD Galloway, L Grimm, SM Geddis, HS Overkleeft, M Welch, DR Spring
Chemical Science
(2017)
8
(doi: 10.1039/c7sc01270e)
Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angew Chem Int Ed Engl
(2017)
56
(doi: 10.1002/anie.201705611)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase–TPX2 protein–protein interaction
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
Chemical Communications
(2017)
53
(doi: 10.1039/c7cc05379g)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066.
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
Bioorganic and Medicinal Chemistry
(2017)
25
(doi: 10.1016/j.bmc.2017.04.037)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring
Tetrahedron
(2017)
72
(doi: 10.1016/j.tet.2015.10.061)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes.
A Guarnieri-Ibáñez, F Medina, C Besnard, SL Kidd, DR Spring, J Lacour
Chemical Science
(2017)
8
(doi: 10.1039/c7sc00964j)
Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42)
TH Sum, TJ Sum, S Collins, WRJD Galloway, DG Twigg, F Hollfelder, DR Spring
Organic & Biomolecular Chemistry
(2017)
15
(doi: 10.1039/c7ob00804j)
Protein modification
TT-L Kwan, O Boutureira, EC Frye, SJ Walsh, MK Gupta, S Wallace, Y Wu, F Zhang, HF Sore, WRJD Galloway, JW Chin, M Welch, GJL Bernardes, DR Spring
Chem Sci
(2017)
8
(doi: 10.1039/c6sc05313k)
Stereocontrolled semi-syntheses of deguelin and tephrosin.
DA Russell, JJ Freudenreich, JJ Ciardiello, HF Sore, DR Spring
Organic & Biomolecular Chemistry
(2017)
15
(doi: 10.1039/c6ob02659a)
(Z)-Selective Takai olefination of salicylaldehydes
SM Geddis, CE Hagerman, WRJD Galloway, HF Sore, JM Goodman, DR Spring
Beilstein Journal of Organic Chemistry
(2017)
13
(doi: 10.3762/bjoc.13.35)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge