Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Bioinspired Total Synthesis of Bussealin E.
DG Twigg, L Baldassarre, EC Frye, WRJD Galloway, DR Spring
Organic Letters
(2018)
20
(doi: 10.1021/acs.orglett.8b00340)
Loving the poison: the methylcitrate cycle and bacterial pathogenesis.
SK Dolan, A Wijaya, SM Geddis, DR Spring, R Silva-Rocha, M Welch
Microbiology (Reading)
(2018)
164
(doi: 10.1099/mic.0.000604)
Second-generation CK2α inhibitors targeting the αD pocket.
J Iegre, P Brear, C De Fusco, M Yoshida, SL Mitchell, M Rossmann, L Carro, HF Sore, M Hyvönen, DR Spring
Chemical science
(2018)
9
(doi: 10.1039/c7sc05122k)
Stapled peptides as a new technology to investigate protein-protein interactions in human platelets.
J Iegre, NS Ahmed, JS Gaynord, Y Wu, KM Herlihy, YS Tan, ME Lopes-Pires, R Jha, YH Lau, HF Sore, C Verma, DH O' Donovan, N Pugh, DR Spring
Chemical Science
(2018)
9
(doi: 10.1039/x0xx00000x)
Diversity-oriented synthesis for the generation of N-substituted quaternary carbon containing small molecules from α,α-disubstituted propargyl amino esters
S Kidd, N Mateu-Sanchis, A Madin, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Adventures in Drugging Undruggable Targets
D Spring
JOURNAL OF PEPTIDE SCIENCE
(2018)
24
The Application of Diversity-oriented Synthesis in Chemical Biology
N Mateu, SL Kidd, TJ Osberger, HL Stewart, S Bartlett, WRJD Galloway, AJP North, HF Sore, DR Spring
(2018)
10
Highly Reactive Bis-Cyclooctyne-Modified Diarylethene for SPAAC-mediated Cross-Linking
AV Strizhak, K Sharma, O Babii, S Afonin, AS Ulrich, IV Komarov, DR Spring
Organic and Biomolecular Chemistry
(2018)
16
(doi: 10.1039/C8OB02428F)
Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein-Protein Interactions
NS Robertson, DR Spring
Molecules
(2018)
23
(doi: 10.3390/molecules23040959)
Synthesis of diverse semi-saturated bicyclic heteroaromatics
H Stewart, T Moss, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Site-selective generation of stable antibody-drug conjugates via cysteine bridging of native antibodies
S Walsh, S Omarjee, M Hyvonen, J Carroll, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
256
Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
DA Russell, WJS Fong, DG Twigg, HF Sore, DR Spring
Journal of Natural Products
(2017)
80
(doi: 10.1021/acs.jnatprod.7b00527)
Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa.
AC McVey, P Medarametla, X Chee, S Bartlett, A Poso, DR Spring, T Rahman, M Welch
Biochemistry
(2017)
56
(doi: 10.1021/acs.biochem.7b00852)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201705611)
Identification of new quorum sensing autoinducer binding partners in
YR Baker, JT Hodgkinson, BI Florea, E Alza, WRJD Galloway, L Grimm, SM Geddis, HS Overkleeft, M Welch, DR Spring
Chemical science
(2017)
8
(doi: 10.1039/c7sc01270e)
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design
Y Wu, F Villa, J Maman, YH Lau, L Dobnikar, AC Simon, K Labib, DR Spring, L Pellegrini
Angewandte Chemie International Edition
(2017)
56
(doi: 10.1002/anie.201705611)
Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction.
DJ Cole, M Janecek, JE Stokes, M Rossmann, JC Faver, GJ McKenzie, AR Venkitaraman, M Hyvönen, DR Spring, DJ Huggins, WL Jorgensen
Chemical communications (Cambridge, England)
(2017)
53
(doi: 10.1039/c7cc05379g)
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
C De Fusco, P Brear, J Iegre, KH Georgiou, HF Sore, M Hyvönen, DR Spring
Bioorganic & Medicinal Chemistry
(2017)
25
(doi: 10.1016/j.bmc.2017.04.037)
An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics
JJ Ciardiello, WRJD Galloway, CJ O'Connor, HF Sore, JE Stokes, Y Wu, DR Spring
Tetrahedron
(2017)
72
(doi: 10.1016/j.tet.2015.10.061)
Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes
A Guarnieri-Ibáñez, F Medina, C Besnard, SL Kidd, DR Spring, J Lacour
Chemical science
(2017)
8
(doi: 10.1039/c7sc00964j)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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