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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Synthesis Research Interest Group

Modular Synthesis of Heterobenzylic Amines via Carbonyl Azinylative Amination
AA Rafaniello, R Kumar, RC Phillips, MJ Gaunt
– Angewandte Chemie
(2024)
(DOI: 10.1002/ange.202408287)
Introduction to Computational Organic Chemistry.
JM Goodman, JP Reid, JI Wu
– Organic & Biomolecular Chemistry
(2024)
22,
7072
(DOI: 10.1039/d4ob90102a)
Selective Aurora A-TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents.
SR Stockwell, DE Scott, G Fischer, E Guarino, TPC Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, TR Perrior, TL Blundell, DR Spring, G McKenzie, C Abell, J Skidmore, AR Venkitaraman, M Hyvönen
– J Med Chem
(2024)
67,
15521
(DOI: 10.1021/acs.jmedchem.4c01165)
Versatile, Modular, and General Strategy for the Synthesis of α‑Amino Carbonyls
J Liu, MJ Gaunt
– Journal of the American Chemical Society (JACS)
(2024)
146,
24699
(DOI: 10.1021/jacs.4c09434)
Modular synthesis of α-branched secondary alkylamines via visible-light-mediated carbonyl alkylative amination.
MA Smith, RJD Kang, R Kumar, B Roy, MJ Gaunt
– Chemical Science
(2024)
(DOI: 10.1039/d4sc03916e)
Novel immunotherapeutics against LGR5 to target multiple cancer types
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Godsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
– EMBO Molecular Medicine
(2024)
16,
1
(DOI: 10.1038/s44321-024-00121-2)
A Modular Dual‐Catalytic Aryl‐Chlorination of Alkenes
B Li, A Bunescu, D Drazen, K Rolph, J Michalland, MJ Gaunt
– Angewandte Chemie
(2024)
136,
(DOI: 10.1002/ange.202405939)
A Modular Dual‐Catalytic Aryl‐Chlorination of Alkenes
B Li, A Bunescu, D Drazen, K Rolph, J Michalland, MJ Gaunt
– Angewandte Chemie International Edition
(2024)
63,
(DOI: 10.1002/anie.202405939)
Enantioselective Nitrene Transfer to Hydrocinnamyl Alcohols and Allylic Alcohols Enabled by Systematic Exploration of the Structure of Ion-Paired Rhodium Catalysts.
NJ Hodson, S Takano, A Fanourakis, RJ Phipps
– J Am Chem Soc
(2024)
146,
22629
(DOI: 10.1021/jacs.4c07117)
A Modular Dual-Catalytic Aryl-Chlorination of Alkenes
B Li, A Bunescu, D Drazen, K Rolph, J Michalland, MJ Gaunt
– Angew Chem Int Ed Engl
(2024)
63,
e202405939
(DOI: 10.1002/anie.202405939)
Synthetic and Mechanistic Studies into the Reductive Functionalization of Nitro Compounds Catalyzed by an Iron(salen) Complex
E Pocock, M Diefenbach, TM Hood, M Nunn, E Richards, V Krewald, RL Webster
– J Am Chem Soc
(2024)
146,
19839
(DOI: 10.1021/jacs.4c02797)
A Merger of Relay Catalysis with Dynamic Kinetic Resolution Enables Enantioselective β-C(sp<sup>3</sup>)−H Arylation of Alcohols
B Lainer, S Li, F Mammadova, P Dydio
– Angewandte Chemie (International ed. in English)
(2024)
63,
e202408418
(DOI: 10.1002/anie.202408418)
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs †
R Walther, M Park, N Ashman, M Welch, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2024)
60,
7025
(DOI: 10.1039/d4cc01558d)
Negative cooperativity in the formation of H-bond networks involving primary anilines.
FE Hanna, AJ Root, M Schade, CA Hunter
– Chem Sci
(2024)
15,
12036
(DOI: 10.1039/d4sc03719g)
Carbonylative transformations with Pd catalysts supported on bio-degradable urea-based polymer – Part A
M Markovič, P Lopatka, P Koóš, T Soták, A Ház, T Gracza, SV Ley, M Králik
– Catalysis Today
(2024)
441,
114903
(DOI: 10.1016/j.cattod.2024.114903)
Towards the Targeted Protein Degradation of PRMT1
PL Martin, FJ Pérez-Areales, SV Rao, SJ Walsh, JS Carroll, DR Spring
– ChemMedChem
(2024)
19,
e202400269
(DOI: 10.1002/cmdc.202400269)
Multi-Stimuli-Responsive Network of Multicatalytic Reactions using a Single Palladium/Platinum Catalyst
G Kurpik, A Walczak, P Dydio, AR Stefankiewicz
– Angewandte Chemie (International ed. in English)
(2024)
63,
e202404684
(DOI: 10.1002/anie.202404684)
Palladium catalysts supported on biodegradable urea-based polymers in synthesis with CO – Part B
M Markovič, P Lopatka, P Koóš, T Soták, A Ház, T Gracza, SV Ley, M Králik
– Catalysis Today
(2024)
440,
114831
(DOI: 10.1016/j.cattod.2024.114831)
Leveraging Language Model Multitasking To Predict C-H Borylation Selectivity.
R Kotlyarov, K Papachristos, GPF Wood, JM Goodman
– Journal of chemical information and modeling
(2024)
64,
4286
(DOI: 10.1021/acs.jcim.4c00137)
Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules.
BM da S Santos, FG Finelli, DR Spring
– Org Lett
(2024)
26,
4065
(DOI: 10.1021/acs.orglett.4c01019)

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