Yusuf Hamied Department of Chemistry

Recent Publications from the Synthetic Chemistry Research Interest Group

DP5 without DFT: uncertainty-calibrated graph neural net accelerates structure confirmation via NMR
R Kotlyarov, A Howarth, J Goodman
Chemical Science
(2026)
(doi: 10.1039/D5SC06988B)
Bismuth Bicycles
S Voss, A Sagar, A Tiberghien, RJL Hughes, L Chen, I Rioja, M Frigerio, MJ Skynner, DR Spring
Journal of Peptide Science
(2026)
32
(doi: 10.1002/psc.70071)
Oligomerisation and stereoselective polymerisation of alkenes and alkynes using pyridyl-based Al( iii ) catalysts
D Choudhury, R Danylyuk, A Terzopoulos, NS Potter, OA Scherman, JM Goodman, DS Wright
Chem Sci
(2026)
2026
(doi: 10.1039/D5SC07624B)
Prediction of Protein-Ligand Binding Affinities Using Atomic Surface Site Interaction Points.
KJ Zator, MC Storer, CA Hunter
Journal of Chemical Information and Modeling
(2026)
66
(doi: 10.1021/acs.jcim.5c02628)
Uncertainty-aware machine learning to predict non-cancer human toxicity for the global chemicals market.
K von Borries, KV Beckwith, JM Goodman, WA Chiu, O Jolliet, P Fantke
Nature communications
(2026)
17
(doi: 10.1038/s41467-025-67374-4)
Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor
MC Misuraca, CA Hunter
Chemical Science
(2026)
(doi: 10.1039/d6sc01693f)
Enhancing molecular structure elucidation with reasoning-capable LLMs
M Priessner, RJ Lewis, MJ Johansson, JM Goodman, JP Janet, A Tomberg
Digital Discovery
(2026)
5
(doi: 10.1039/d5dd00359h)
Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos
H Sharif, LA McCall, MG Sanders, RJ Phipps
Angewandte Chemie
(2025)
138
(doi: 10.1002/ange.202520698)
Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos
H Sharif, LA McCall, MG Sanders, RJ Phipps
Angewandte Chemie International Edition
(2025)
65
(doi: 10.1002/anie.202520698)
Catalytic Deracemization of 1,2-Aminoalcohols Through Enanti-oselective Hydrogen Atom Abstraction
DJ Davies, ASK Lahdenperä, RJ Phipps
Journal of the American Chemical Society
(2025)
148
(doi: 10.1021/jacs.5c20160)
Effect of the [Fe(salen)]2-μ-oxo Catalyst Electronic Structure on Reductive Hydroamination
E Pocock, NJ Buxton, M Diefenbach, AD Bond, SE Lewis, V Krewald, RL Webster
Inorg Chem
(2025)
65
(doi: 10.1021/acs.inorgchem.5c05628)
Ketone-derived Diazo-iodonium Salts as Reagents for Methionine-selective Functionalization
Z-H Goh, MJ Gaunt
Synlett
(2025)
37
(doi: 10.1055/a-2760-7405)
Reactivity of Iron(II) Bis(imino)pyridine Complexes with PH3
S Lau, MF Mahon, RL Webster
Canadian Journal of Chemistry
(2025)
(doi: 10.1139/cjc-2025-0189)
Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder
RM West, RCB Nicolescu, P Brear, J Wagstaff, BK Blaszczyk, T Deingruber, MG Sanders, FJ Pérez-Areales, DR Spring, M Hyvönen
(2025)
(doi: 10.64898/2025.12.17.694903)
An allantoin-inducible glyoxylate utilization pathway in Pseudomonas aeruginosa
SL Parkhill, O Little, I Askenasy, E Labrini, M Wang, PD Brear, W Cai, T Deingruber, T Yang, DR Spring, M Welch
Microbiology (Reading, England)
(2025)
171
(doi: 10.1099/mic.0.001635)
A career with a natural interest in total synthesis
SV Ley, S Greed
Nature Reviews Chemistry
(2025)
10
(doi: 10.1038/s41570-025-00787-3)
MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody-drug conjugates.
AJ Counsell, SJ Walsh, N Ashman, M Park, FM Dannheim, TA King, T Wharton, JS Carroll, DR Spring
Chem Sci
(2025)
17
(doi: 10.1039/d5sc06664f)
Advancing Structure Elucidation with a Flexible Multi‐Spectral AI Model
M Priessner, RJ Lewis, I Lemurell, MJ Johansson, J Goodman, JP Janet, A Tomberg
Angewandte Chemie International Edition
(2025)
138
(doi: 10.1002/anie.202517611)
Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates.
M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
Chemical Communications
(2025)
61
(doi: 10.1039/d5cc05824d)
Highly E‑Selective Alkene Isomerization Using Me4NF at Room Temperature
L Webster, RA Shoetan, CM Alder, RL Webster
The Journal of organic chemistry
(2025)
90
(doi: 10.1021/acs.joc.5c02159)
Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
K Zhu, DR Spring, B-F Shi, F Zhang
Chemical Society reviews
(2025)
54
(doi: 10.1039/d5cs00235d)
Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors
PA Glossop, P Brear, S Wright, N Flanagan, MS Glossop, CAL Lane, RP Butt, DR Spring, M Hyvönen, D Cawkill
Journal of medicinal chemistry
(2025)
68
(doi: 10.1021/acs.jmedchem.5c01807)
Towards automatically verifying chemical structures: the powerful combination of <sup>1</sup>H NMR and IR spectroscopy.
J Goodman, R Lewis, JB Rowlands, L Jonsson, P Howe, W Czechtizky, T Leek
Chemical science
(2025)
16
(doi: 10.1039/D5SC06866E)
Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II.
M Gurský, D Trnovcová, P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
J Org Chem
(2025)
90
(doi: 10.1021/acs.joc.5c01799)
β-Lactamase cleavable antimicrobial peptide-drug conjugates
T Deingruber, JS Gaynord, BH Gan, KA Kostadinova, TJ O'Brien, YS Tan, JS Parker, TA Hunt, JS Carroll, M Welch, DR Spring
Chem Sci
(2025)
16
(doi: 10.1039/d5sc06369h)
Yusuf Hamied Department of Chemistry
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