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Recent Publications from the Synthesis Research Interest Group

A tutored discourse on microcontrollers, single board computers and their applications to monitor and control chemical reactions
DE Fitzpatrick, M O'Brien, SV Ley
– Reaction Chemistry & Engineering
(2020)
5,
201
(DOI: 10.1039/c9re00407f)
Rapid Syntheses of (-)-FR901483 and (+)-TAN1251C Enabled by Complexity-Generating Photocatalytic Olefin Hydroaminoalkylation.
D Reich, A Trowbridge, MJ Gaunt
– Angewandte Chemie (International ed. in English)
(2020)
59,
2256
(DOI: 10.1002/anie.201912010)
Sulfatase-cleavable linkers for antibody-drug conjugates
JD Bargh, SJ Walsh, A Isidro-Llobet, S Omarjee, JS Carroll, DR Spring
– Chemical Science
(2020)
(DOI: 10.1039/c9sc06410a)
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction
K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring
– ACS omega
(2020)
5,
1157
(DOI: 10.1021/acsomega.9b03459)
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti‐Trypanosomal Macrolides
MJ Anketell, TM Sharrock, I Paterson
– Angewandte Chemie
(2020)
132,
1588
(DOI: 10.1002/ange.201914042)
Editorial 2020: Changing publishing and academic culture
JKM Sanders
– Royal Society Open Science
(2020)
7,
192197
(DOI: 10.1098/rsos.192197)
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
– ACS omega
(2020)
5,
822
(DOI: 10.1021/acsomega.9b03626)
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents.
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chemical communications (Cambridge, England)
(2020)
56,
1529
(DOI: 10.1039/c9cc09050a)
A Practical Method for Continuous Production of sp3-Rich Compounds from (Hetero)Aryl Halides and Redox-Active Esters.
E Watanabe, Y Chen, O May, SV Ley
– Chemistry
(2020)
26,
186
(DOI: 10.1002/chem.201905048)
Catalytic C(sp3)-H bond activation in tertiary alkylamines.
J Rodrigalvarez, M Nappi, H Azuma, NJ Flodén, ME Burns, MJ Gaunt
– Nature Chemistry
(2020)
12,
76
(DOI: 10.1038/s41557-019-0393-8)
Structural Alerts and Random Forest Models in a Consensus Approach for Receptor Binding Molecular Initiating Events.
AJ Wedlake, M Folia, S Piechota, TEH Allen, JM Goodman, S Gutsell, PJ Russell
– Chemical Research in Toxicology
(2020)
acs.chemrestox.9b00325
(DOI: 10.1021/acs.chemrestox.9b00325)
Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring
– Chem Commun (Camb)
(2020)
(DOI: 10.1039/c9cc09796a)
Quantitative Predictions for Molecular Initiating Events using 3D Quantitative Structure-Activity Relationships.
TEH Allen, JM Goodman, S Gutsell, PJ Russell
– Chemical Research in Toxicology
(2019)
acs.chemrestox.9b00136
(DOI: 10.1021/acs.chemrestox.9b00136)
Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines
JP Reid, RSJ Proctor, MS Sigman, RJ Phipps
– J Am Chem Soc
(2019)
141,
19178
(DOI: 10.1021/jacs.9b11658)
Two-component assembly of recognition-encoded oligomers that form stable H-bonded duplexes.
L Gabrielli, D Núñez-Villanueva, CA Hunter
– Chemical Science
(2020)
11,
561
(DOI: 10.1039/c9sc04250d)
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-Trypanosomal Macrolides.
MJ Anketell, TM Sharrock, I Paterson
– Angewandte Chemie International Edition
(2020)
59,
1572
(DOI: 10.1002/anie.201914042)
A Synthetic Vesicle-to-Vesicle Communication System
Y Ding, NH Williams, CA Hunter
– J Am Chem Soc
(2019)
141,
17847
(DOI: 10.1021/jacs.9b09102)
Molecular replication using covalent base-pairs with traceless linkers
D Núñez-Villanueva, CA Hunter
– Organic & Biomolecular Chemistry
(2019)
17,
9660
(DOI: 10.1039/c9ob02336d)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Sci Rep
(2019)
9,
15930
(DOI: 10.1038/s41598-019-50702-2)
A New World for Chemical Synthesis?
SV Ley, Y Chen, DE Fitzpatrick, O May
– CHIMIA International Journal for Chemistry
(2019)
73,
792
(DOI: 10.2533/chimia.2019.792)

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