Yusuf Hamied Department of Chemistry

Recent Publications from the Synthetic Chemistry Research Interest Group

Biphasic Solar Reforming of Lignin to Aromatics and CO for In Situ Carbonylation of Organics.
D Mittal, S Mitra, E Bonvin, DR Spring, SA Bonke, E Reisner
J Am Chem Soc
(2026)
148
(doi: 10.1021/jacs.6c10525)
Programmable remodelling of carbon–nitrogen connectivity in amines
JD Robinson, F Richard, KA Ratkovich, JM Phelps, MJ Gaunt
Nature
(2026)
(doi: 10.1038/s41586-026-11009-1)
Frontispiece: Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
JL Venne, S Krajcovicova, G Davies, H Bolt, J Revell, DR Spring
Angewandte Chemie
(2026)
138
(doi: 10.1002/ange.2026-m2607093600)
Frontispiece: Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
JL Venne, S Krajcovicova, G Davies, H Bolt, J Revell, DR Spring
Angewandte Chemie International Edition
(2026)
65
(doi: 10.1002/anie.2026-m2607093600)
Diarylethene-Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation
A Iampolska, S Afonin, O Babii, M Park, J Estévez‐Gallego, MO Steinmetz, AE Prota, AS Ulrich, DR Spring, IV Komarov
European Journal of Organic Chemistry
(2026)
(doi: 10.1002/ejoc.70755)
Stereoselective Epimerization of 1,3-Diols using a Chiral Hydrogen Atom Abstraction Catalyst
M Lemmerer, DC Emmet, ASK Lahdenperä, DJ Davies, A Dahiya, K Ermanis, RJ Phipps
J Am Chem Soc
(2026)
148
(doi: 10.1021/jacs.6c10166)
Finding REMO: A Sequencing Method for Recognition-Encoded Melamine Oligomers
B Iddon, PH Grab, JT Smith, ON Evans, A-L Cotîrlan, CA Hunter
Chem Sci
(2026)
(doi: 10.1039/d6sc05680f)
Selective Inhibition of CK2: Emerging Strategies and Future Directions
AR Sokhal, S Krajcovicova, J Iegre, P Brear, C De Fusco, PA Glossop, D Cawkill, M Hyvönen, DR Spring
Journal of medicinal chemistry
(2026)
69
(doi: 10.1021/acs.jmedchem.6c00643)
Hybrid QM/ML approaches for the prediction of regioselectivity in Minisci C–H functionalisation reactions
SG Espley, M Šiaučiulis, N Palmer, JEH Day, JM Goodman, R Grainger, C Poelking
(2026)
(doi: 10.26434/chemrxiv.15006275/v1)
Recent advances in antibody–drug conjugates
JD Sydenham, T Wharton, DR Spring
Curr Opin Chem Biol
(2026)
94
(doi: 10.1016/j.cbpa.2026.102727)
Active Templating by Mechanochemistry
ON Evans, AM Belenguer, CA Hunter
Org Lett
(2026)
28
(doi: 10.1021/acs.orglett.6c02540)
Sequence-Dependent Folding of Recognition-Encoded Melamine Oligomers
A-L Cotîrlan, CJ Anderson, NEJ Eyre, DO Soloviev, B Iddon, F Balduzzi, CA Hunter
J Am Chem Soc
(2026)
148
(doi: 10.1021/jacs.6c07701)
Optimization of a Resolution Process Allowing Access to Both Enantiomers of the Versatile Chiral Phosphine Ligand sSPhos on Scale
H Sharif, TD Svejstrup, S Karlsson, RJ Phipps
Organic process research & development
(2026)
30
(doi: 10.1021/acs.oprd.6c00142)
An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis
M Kadarauch, PT Jirsch, HE Diepers, H Sharif, RJ Phipps
Angewandte Chemie
(2026)
138
(doi: 10.1002/ange.8602143)
An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis
M Kadarauch, PT Jirsch, HE Diepers, H Sharif, RJ Phipps
Angewandte Chemie International Edition
(2026)
65
(doi: 10.1002/anie.8602143)
Regio- and Enantioselective Alkoxycarbonylation of Unactivated Terminal Alkenes under Palladium-Bromide-Monophosphine Catalysis.
M Sigrist, K Das, G Kurpik, W Tian, J Huang, A Covas, AD Bond, W Tang, P Dydio
J Am Chem Soc
(2026)
148
(doi: 10.1021/jacs.6c10237)
Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
KA Kostadinova, JL Venne, S Krajcovicova, J Dodgson, WFJ Hogendorf, TE Nielsen, D Hymel, H Bolt, A Collinson, J Day, J Revell, DR Spring
Chemistry – A European Journal
(2026)
(doi: 10.1002/chem.71280)
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
JL Venne, S Krajcovicova, G Davies, H Bolt, J Revell, DR Spring
Angewandte Chemie
(2026)
138
(doi: 10.1002/ange.9595531)
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
JL Venne, S Krajcovicova, G Davies, H Bolt, J Revell, DR Spring
Angew Chem Int Ed Engl
(2026)
65
(doi: 10.1002/anie.9595531)
On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation
S Krajcovicova, T Wharton, DR Spring
Nature Protocols
(2026)
(doi: 10.1038/s41596-026-01376-4)
Cysteine Re-bridging Using Divinyl Pyrimidine Reagents for the Generation of Antibody-Drug Conjugates.
T Wharton, S Krajcovicova, DR Spring
Methods Mol Biol
(2026)
3009
(doi: 10.1007/978-1-0716-5112-4_10)
Properties of [Fe(salen)] 2 ‐μ‐Oxo Derivatives and Their Effect on Catalytic Hydrophosphination
NJ Buxton, EO Dadge, OS Matys, MAA Entwisle, RL Webster
European Journal of Organic Chemistry
(2026)
29
(doi: 10.1002/ejoc.202600013)
Boosting peptide half-life: enabling efficient generation of Fc-peptide conjugates.
M Park, FM Dannheim, MA Papworth, R Kay, E Tsonou, D Trajkovski, SJ Walsh, D Hovdal, T Wharton, A-C Nassoy, JS Parker, DR Spring
Chem Sci
(2026)
17
(doi: 10.1039/d6sc02646j)
Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder
RM West, RC Bizga Nicolescu, P Brear, J Wagstaff, BK Blaszczyk, T Deingruber, MG Sanders, FJ Pérez-Areales, DR Spring, M Hyvönen
J Med Chem
(2026)
69
(doi: 10.1021/acs.jmedchem.5c03818)
Quantifying Carboxylate Burial in Synthetic Hydrophobic Pockets in Water
EA Valencia, L Escobar, G Aragay, CA Hunter, P Ballester
ChemistryEurope
(2026)
4
(doi: 10.1002/ceur.70286)
Yusuf Hamied Department of Chemistry
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