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Recent Publications from the Synthesis Research Interest Group

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery
TA King, HL Stewart, KT Mortensen, AJP North, HF Sore, DR Spring
– European Journal of Organic Chemistry
(2019)
2019,
5219
(DOI: 10.1002/ejoc.201900847)
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
– Organic & biomolecular chemistry
(2019)
17,
8014
(DOI: 10.1039/c9ob01745c)
An activatable cancer-targeted hydrogen peroxide probe for photoacoustic and fluorescence imaging.
J Weber, L Bollepalli, AM Belenguer, M Di Antonio, N De Mitri, J Joseph, S Balasubramanian, CA Hunter, SE Bohndiek
– Cancer Res
(2019)
canres.0691.2019
(DOI: 10.1158/0008-5472.CAN-19-0691)
Macrocyclisation and functionalisation of unprotected peptides: Via divinyltriazine cysteine stapling
NS Robertson, SJ Walsh, E Fowler, M Yoshida, SM Rowe, Y Wu, HF Sore, JS Parker, DR Spring
– Chemical Communications
(2019)
55,
9499
(DOI: 10.1039/c9cc05042f)
Cleavable linkers in antibody–drug conjugates
JD Bargh, A Isidro-Llobet, JS Parker, DR Spring
– Chemical Society reviews
(2019)
48,
4361
(DOI: 10.1039/c8cs00676h)
Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation.
MT Mihai, BD Williams, RJ Phipps
– J Am Chem Soc
(2019)
jacs.9b07267
(DOI: 10.1021/jacs.9b07267)
Bulk synthesis of graphene-like materials possessing turbostratic graphite and graphene nanodomains via combustion of magnesium in carbon dioxide
TH Kim, CR Merritt, C Ducati, AD Bond, N Bampos, CL Brown
– Carbon
(2019)
149,
582
(DOI: 10.1016/j.carbon.2019.04.035)
A counterintuitive stereochemical outcome from a chelation-controlled vinymetal aldehyde addition leads to the configurational reassignment of phormidolide A
NYS Lam, G Muir, VR Challa, R Britton, I Paterson
– Chemical Communications
(2019)
55,
9717
(DOI: 10.1039/c9cc05067a)
A Photoredox Coupling Reaction of Benzylboronic Esters and Carbonyl Compounds in Batch and Flow
Y Chen, O May, DC Blakemore, SV Ley
– Org Lett
(2019)
21,
6140
(DOI: 10.1021/acs.orglett.9b02307)
Capping Strategies for Covalent Template-Directed Synthesis of Linear Oligomers Using CuAAC
M Ciaccia, D Núñez-Villanueva, CA Hunter
– J Am Chem Soc
(2019)
141,
10862
(DOI: 10.1021/jacs.9b04973)
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
J Charoenpattarapreeda, YS Tan, J Iegre, SJ Walsh, E Fowler, RS Eapen, Y Wu, HF Sore, CS Verma, L Itzhaki, DR Spring
– Chemical communications (Cambridge, England)
(2019)
55,
7914
(DOI: 10.1039/C9CC04022F)
Carboxylate-Assisted Oxidative Addition to Aminoalkyl Pd<sup>II</sup> Complexes: C(sp<sup>3</sup>)−H Arylation of Alkylamines by Distinct Pd<sup>II</sup>/Pd<sup>IV</sup> Pathway
WG Whitehurst, JH Blackwell, GN Hermann, MJ Gaunt
– Angewandte Chemie International Edition
(2019)
58,
9054
(DOI: 10.1002/anie.201902838)
The optimal DFT approach in DP4 NMR structure analysis-pushing the limits of relative configuration elucidation
K Ermanis, KEB Parkes, T Agback, JM Goodman
– Organic & Biomolecular Chemistry
(2019)
17,
5886
(DOI: 10.1039/c9ob00840c)
Strategies for the Diversity-Oriented Synthesis of Macrocycles.
KT Mortensen, TJ Osberger, TA King, HF Sore, DR Spring
– Chem Rev
(2019)
119,
10288
(DOI: 10.1021/acs.chemrev.9b00084)
H-Bond Donor Parameters for Cations
SJ Pike, E Lavagnini, LM Varley, JL Cook, CA Hunter
– Chemical Science
(2019)
10,
5943
(DOI: 10.1039/c9sc00721k)
Triaminopyrimidine derivatives as transmembrane HCl transporters
P Motloch, A Guerreiro, CQ Azeredo, GJL Bernardes, CA Hunter, I Kocsis
– Organic & Biomolecular Chemistry
(2019)
17,
5633
(DOI: 10.1039/c9ob00725c)
Understanding the unexpected effect of frequency on the kinetics of a covalent reaction under ball-milling conditions
AM Belenguer, AAL Michalchuk, GI Lampronti, JKM Sanders
– Beilstein J Org Chem
(2019)
15,
1226
(DOI: 10.3762/bjoc.15.120)
Guest Binding via N-H center dot center dot center dot pi Bonding and Kinetic Entrapment by an Inorganic Macrocycle
AJ Plajer, FJ Rizzuto, H-C Niu, S Lee, JM Goodman, DS Wright
– Angewandte Chemie International Edition
(2019)
58,
10655
(DOI: 10.1002/anie.201905771)
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
A Sveiczer, AJP North, N Mateu, SL Kidd, HF Sore, DR Spring
– Organic Letters
(2019)
21,
4600
(DOI: 10.1021/acs.orglett.9b01499)
Emergent Supramolecular Assembly Properties of a Recognition-Encoded Oligoester
FT Szczypiński, L Gabrielli, CA Hunter
– Chemical Science
(2019)
10,
5397
(DOI: 10.1039/c9sc01669d)

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