Yusuf Hamied Department of Chemistry

Recent Publications from the Synthetic Chemistry Research Interest Group

Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Cova-lent Binder
RM West, RCB Nicolescu, P Brear, JM Wagstaff, BK Blaszczyk, T Deingruber, MG Sanders, FJ Pérez-Areales, DR Spring, M Hyvönen
(2025)
(doi: 10.64898/2025.12.17.694903)
An allantoin-inducible glyoxylate utilization pathway in <i>Pseudomonas aeruginosa</i>.
SL Parkhill, O Little, I Askenasy, E Labrini, M Wang, PD Brear, W Cai, T Deingruber, T Yang, DR Spring, M Welch
Microbiology
(2025)
171
(doi: 10.1099/mic.0.001635)
MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody–drug conjugates
AJ Counsell, SJ Walsh, N Ashman, M Park, FM Dannheim, TA King, T Wharton, JS Carroll, DR Spring
Chemical science
(2025)
(doi: 10.1039/d5sc06664f)
Advancing Structure Elucidation with a Flexible Multi-Spectral AI Model
M Priessner, RJ Lewis, I Lemurell, MJ Johansson, J Goodman, JP Janet, A Tomberg
Angewandte Chemie
(2025)
(doi: 10.1002/ange.202517611)
Towards a glutathione-cleavable azobenzene linker for antibody-drug conjugates
M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
Chem Commun (Camb)
(2025)
61
(doi: 10.1039/d5cc05824d)
Highly E-Selective Alkene Isomerization Using Me₄NF at Room Temperature
L Webster, RA Shoetan, CM Alder, RL Webster
J Org Chem
(2025)
90
(doi: 10.1021/acs.joc.5c02159)
Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
K Zhu, DR Spring, B-F Shi, F Zhang
Chemical Society reviews
(2025)
54
(doi: 10.1039/d5cs00235d)
Reactivity of Iron(II) Bis(imino)pyridine Complexes with PH3
S Lau, M Mahon, R Webster
Canadian Journal of Chemistry
(2025)
(doi: 10.1139/cjc-2025-0189)
Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.
PA Glossop, P Brear, S Wright, N Flanagan, MS Glossop, CAL Lane, RP Butt, DR Spring, M Hyvönen, D Cawkill
J Med Chem
(2025)
68
(doi: 10.1021/acs.jmedchem.5c01807)
Towards automatically verifying chemical structures: the powerful combination of 1H NMR and IR spectroscopy
J Goodman, R Lewis, JB Rowlands, L Jonsson, P Howe, W Czechtizky, T Leek
Chemical Science
(2025)
16
(doi: 10.1039/d5sc06866e)
Continuous Flow Techniques in the Total Synthesis of Jaspine B: Part II
M Gurský, D Trnovcová, P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
J Org Chem
(2025)
90
(doi: 10.1021/acs.joc.5c01799)
β-Lactamase cleavable antimicrobial peptide-drug conjugates
T Deingruber, JS Gaynord, BH Gan, KA Kostadinova, TJ O'Brien, YS Tan, JS Parker, TA Hunt, JS Carroll, M Welch, DR Spring
Chemical Science
(2025)
16
(doi: 10.1039/d5sc06369h)
Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, DR Spring, C Lindon, C Phillips, LS Itzhaki
eLife
(2025)
14
(doi: 10.7554/elife.104238.3)
A Dynamic Silver(I) Nanocluster Holds Together a 3 x 3 Self-Assembled Grid
AW Heard, L Pesce, PT Gierth, S Adorinni, TK Ronson, B Rossi, JD Thoburn, T Deingruber, M Welch, DR Spring, S Marchesan, GM Pavan, JR Nitschke
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c07271)
Selective <i>endo</i>-Cyclic α-Functionalization of Saturated <i>N</i>-Alkyl Piperidines.
RC Phillips, JCK Chu, AA Rafaniello, MJ Gaunt
The Journal of Organic Chemistry
(2025)
90
(doi: 10.1021/acs.joc.5c01742)
Chirality-Assisted Self-Assembly of Low-Symmetry Noncovalent Capsules with Quantitative Diastereoisomeric Selection.
G Markiewicz, X Qiu, G Avci, EH Wolpert, KE Jelfs, JKM Sanders, AR Stefankiewicz
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c10523)
Allylic Amination of Alkenyl Alcohols: Simultaneous Control of Chemoselectivity and Enantioselectivity in Nitrene Transfer Using Ion-Paired Catalysts.
HK Adams, A Fanourakis, A Dahiya, I Băltăreţu, RJ Phipps
ACS Catalysis
(2025)
15
(doi: 10.1021/acscatal.5c04140)
Structural and Gas Uptake Studies on Iron(II) β-Diketiminate Metallomacrocycles
AN Barrett, L Webster, D Gasperini, R Castaing, MF Mahon, RL Webster
Organometallics
(2025)
44
(doi: 10.1021/acs.organomet.5c00208)
Intercepting Methanimine for the Synthesis of Piperidine-based N-Heterocycles in Aqueous Medium
E Pocock, M Diefenbach, TM Hood, M Nunn, V Krewald, SE Lewis, RL Webster
The Journal of Organic Chemistry
(2025)
90
(doi: 10.1021/acs.joc.5c01213)
Enantioselective Formal Synthesis of (-)-Aflatoxin B2 Enabled by Pd-Catalyzed Carboetherification of 2,3-Dihydrofuran
M Kadarauch, RJ Phipps
Organic letters
(2025)
27
(doi: 10.1021/acs.orglett.5c02618)
Asymmetric Aziridination of Allylic Carbamates Using Ion‐Paired Rhodium Complexes and Extrapolation to C─H Amination of Phenethyl Carbamates
AR Lit, S Takano, C Zachau, I Băltărețu, RJ Phipps
Angewandte Chemie International Edition
(2025)
64
(doi: 10.1002/anie.202507532)
Asymmetric Aziridination of Allylic Carbamates Using Ion‐Paired Rhodium Complexes and Extrapolation to C─H Amination of Phenethyl Carbamates
AR Lit, S Takano, C Zachau, I Băltărețu, RJ Phipps
Angewandte Chemie
(2025)
137
(doi: 10.1002/ange.202507532)
Dehomologative C-C Borylation of Aldehydes and Alcohols via a Rh-Catalyzed Dehydroformylation-Borylation Relay.
K Das, N Kuźnik, P Dydio
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c02181)
Machine Learning-Driven Optimization of Continuous-Flow Photoredox Amine Synthesis.
P Jorayev, S Soritz, S Sung, MI Jeraal, D Russo, A Barthelme, FC Toussaint, MJ Gaunt, AA Lapkin
Organic process research & development
(2025)
29
(doi: 10.1021/acs.oprd.4c00533)
One-carbon homologation of alkenes.
MC Grocott, MJ Gaunt
Nature
(2025)
643
(doi: 10.1038/s41586-025-09159-9)
Yusuf Hamied Department of Chemistry
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