Yusuf Hamied Department of Chemistry

Recent Publications from the Synthetic Chemistry Research Interest Group

Recent advances in antibody–drug conjugates
JD Sydenham, T Wharton, DR Spring
Curr Opin Chem Biol
(2026)
94
(doi: 10.1016/j.cbpa.2026.102727)
Active Templating by Mechanochemistry
ON Evans, AM Belenguer, CA Hunter
Organic Letters
(2026)
(doi: 10.1021/acs.orglett.6c02540)
Sequence-DependentFolding of Recognition-EncodedMelamine Oligomers
A-L Cotîrlan, CJ Anderson, NEJ Eyre, DO Soloviev, B Iddon, F Balduzzi, CA Hunter
Journal of the American Chemical Society
(2026)
148
(doi: 10.1021/jacs.6c07701)
Optimization of a Resolution Process Allowing Access to Both Enan-tiomers of the Versatile Chiral Phosphine Ligand sSPhos on Scale
H Sharif, TD Svejstrup, S Karlsson, RJ Phipps
Organic Process Research & Development
(2026)
30
(doi: 10.1021/acs.oprd.6c00142)
An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis
M Kadarauch, PT Jirsch, HE Diepers, H Sharif, RJ Phipps
Angewandte Chemie
(2026)
(doi: 10.1002/ange.8602143)
An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis
M Kadarauch, PT Jirsch, HE Diepers, H Sharif, RJ Phipps
Angewandte Chemie International Edition
(2026)
(doi: 10.1002/anie.8602143)
Peptide Marriages: Modular Assembly of Multi-Agonist Therapeutics
KA Kostadinova, JL Venne, S Krajcovicova, J Dodgson, WFJ Hogendorf, TE Nielsen, D Hymel, H Bolt, A Collinson, J Day, J Revell, DR Spring
Chemistry A European Journal
(2026)
(doi: 10.1002/chem.71280)
Regio- and Enantioselective Alkoxycarbonylation of Unactivated Terminal Alkenes under Palladium-Bromide-Monophosphine Catalysis.
M Sigrist, K Das, G Kurpik, W Tian, J Huang, A Covas, AD Bond, W Tang, P Dydio
Journal of the American Chemical Society
(2026)
148
(doi: 10.1021/jacs.6c10237)
Multicomponent Stapling of Glucagon-Like Peptide-1 Enables Receptor-Guided PROTAC Delivery.
JL Venne, S Krajcovicova, G Davies, H Bolt, J Revell, DR Spring
Angew Chem Int Ed Engl
(2026)
(doi: 10.1002/anie.9595531)
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
JL Venne, S Krajcovicova, G Davies, H Bolt, J Revell, DR Spring
Angewandte Chemie
(2026)
(doi: 10.1002/ange.9595531)
On-resin assembly of cysteine-reactive linkers for controlled site-selective antibody bioconjugation
S Krajcovicova, T Wharton, DR Spring
Nat Protoc
(2026)
(doi: 10.1038/s41596-026-01376-4)
Properties of [Fe(salen)] 2 ‐μ‐Oxo Derivatives and Their Effect on Catalytic Hydrophosphination
NJ Buxton, EO Dadge, OS Matys, MAA Entwisle, RL Webster
European Journal of Organic Chemistry
(2026)
(doi: 10.1002/ejoc.202600013)
Boosting peptide half-life: enabling efficient generation of Fc-peptide conjugates.
M Park, FM Dannheim, MA Papworth, R Kay, E Tsonou, D Trajkovski, SJ Walsh, D Hovdal, T Wharton, A-C Nassoy, JS Parker, DR Spring
Chem Sci
(2026)
17
(doi: 10.1039/d6sc02646j)
Targeting a Pleckstrin Homology Domain with a Lysine-Reactive Covalent Binder
RM West, RC Bizga Nicolescu, P Brear, J Wagstaff, BK Blaszczyk, T Deingruber, MG Sanders, FJ Pérez-Areales, DR Spring, M Hyvönen
J Med Chem
(2026)
69
(doi: 10.1021/acs.jmedchem.5c03818)
Quantifying Carboxylate Burial in Synthetic Hydrophobic Pockets in Water
EA Valencia, L Escobar, G Aragay, CA Hunter, P Ballester
ChemistryEurope
(2026)
4
(doi: 10.1002/ceur.70286)
Towards the targeted protein degradation of CK2: design and synthesis of CAM4066-based PROTACs.
S Day-Riley, S Krajcovicova, AR Sokhal, JL Venne, P Brear, M Hyvönen, BC Whitehurst, JS Carroll, DR Spring
Beilstein J Org Chem
(2026)
22
(doi: 10.3762/BJOC.22.47)
DP5 without DFT: Uncertainty-calibrated graph neural net accelerates structure confirmation via NMR
R Kotlyarov, A Howarth, J Goodman
Chemical science
(2026)
17
(doi: 10.1039/D5SC06988B)
Bismuth Bicycles.
S Voss, A Sagar, A Tiberghien, RJL Hughes, L Chen, I Rioja, M Frigerio, MJ Skynner, DR Spring
J Pept Sci
(2026)
32
(doi: 10.1002/psc.70071)
Oligomerisation and stereoselective polymerisation of alkenes and alkynes using pyridyl-based Al(iii) catalysts
D Choudhury, R Danylyuk, A Terzopoulos, NS Potter, OA Scherman, JM Goodman, DS Wright
Chemical science
(2026)
2026
(doi: 10.1039/d5sc07624b)
Prediction of Protein-Ligand Binding Affinities Using Atomic Surface Site Interaction Points
KJ Zator, MC Storer, CA Hunter
Journal of Chemical Information and Modeling
(2026)
66
(doi: 10.1021/acs.jcim.5c02628)
Uncertainty-aware machine learning to predict non-cancer human toxicity for the global chemicals market.
K von Borries, KV Beckwith, JM Goodman, WA Chiu, O Jolliet, P Fantke
Nature communications
(2026)
17
(doi: 10.1038/s41467-025-67374-4)
Enhancing molecular structure elucidation with reasoning-capable LLMs
M Priessner, RJ Lewis, MJ Johansson, JM Goodman, JP Janet, A Tomberg
Digital Discovery
(2026)
5
(doi: 10.1039/d5dd00359h)
Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor
MC Misuraca, CA Hunter
Chemical Science
(2026)
17
(doi: 10.1039/d6sc01693f)
Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos
H Sharif, LA McCall, MG Sanders, RJ Phipps
Angewandte Chemie International Edition
(2025)
65
(doi: 10.1002/anie.202520698)
Atroposelective Suzuki–Miyaura Coupling to Form 2‐Amino‐2′‐Hydroxybiphenyls Enabled by sRuPhos
H Sharif, LA McCall, MG Sanders, RJ Phipps
Angewandte Chemie
(2025)
138
(doi: 10.1002/ange.202520698)
Yusuf Hamied Department of Chemistry
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