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Recent Publications from the Synthesis Research Interest Group

Structural Alerts and Random Forest Models in a Consensus Approach for Receptor Binding Molecular Initiating Events
AJ Wedlake, M Folia, S Piechota, TEH Allen, JM Goodman, S Gutsell, PJ Russell
– Chemical Research in Toxicology
(2020)
acs.chemrestox.9b00325
(DOI: 10.1021/acs.chemrestox.9b00325)
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chemical Communications
(2020)
(DOI: 10.1039/c9cc09050a)
Catalytic C(sp(3))-H bond activation in tertiary alkylamines
J Rodrigalvarez, M Nappi, H Azuma, NJ Flodén, ME Burns, MJ Gaunt
– Nat Chem
(2020)
12,
76
(DOI: 10.1038/s41557-019-0393-8)
Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
– ACS Omega
(2020)
acsomega.9b03626
(DOI: 10.1021/acsomega.9b03626)
Rapid syntheses of (−)-FR901483 and (+)-TAN1251C enabled by complexity-generating photocatalytic olefin hydroaminoalkylation
D Reich, A Trowbridge, MJ Gaunt
– Angewandte Chemie International Edition
(2019)
(DOI: 10.1002/anie.201912010)
Quantitative Predictions for Molecular Initiating Events Using Three-Dimensional Quantitative Structure-Activity Relationships
TEH Allen, JM Goodman, S Gutsell, PJ Russell
– Chemical Research in Toxicology
(2019)
acs.chemrestox.9b00136
(DOI: 10.1021/acs.chemrestox.9b00136)
A Practical Method for Continuous Production of sp3‐Rich Compounds from (Hetero)Aryl Halides and Redox‐Active Esters
E Watanabe, Y Chen, O May, SV Ley
– Chemistry – A European Journal
(2019)
26,
186
(DOI: 10.1002/chem.201905048)
Predictive Multivariate Linear Regression Analysis Guides Successful Catalytic Enantioselective Minisci Reactions of Diazines
JP Reid, RSJ Proctor, MS Sigman, RJ Phipps
– J Am Chem Soc
(2019)
141,
19178
(DOI: 10.1021/jacs.9b11658)
Two-component assembly of recognition-encoded oligomers that form stable H-bonded duplexes.
L Gabrielli, D Núñez-Villanueva, CA Hunter
– Chemical Science
11,
561
(DOI: 10.1039/c9sc04250d)
A Unified Total Synthesis of the Actinoallolides, a Family of Potent Anti-Trypanosomal Macrolides.
MJ Anketell, TM Sharrock, I Paterson
– Angewandte Chemie - International Edition
(2019)
(DOI: 10.1002/anie.201914042)
Molecular replication using covalent base-pairs with traceless linkers.
D Núñez-Villanueva, CA Hunter
– Organic & Biomolecular Chemistry
(2019)
17,
9660
(DOI: 10.1039/c9ob02336d)
A Synthetic Vesicle-to-Vesicle Communication System
Y Ding, NH Williams, CA Hunter
– Journal of the American Chemical Society
(2019)
141,
17847
(DOI: 10.1021/jacs.9b09102)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific Reports
(2019)
9,
15930
(DOI: 10.1038/s41598-019-50702-2)
Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.
P Lopatka, M Markovič, P Koóš, SV Ley, T Gracza
– The Journal of Organic Chemistry
(2019)
84,
14394
(DOI: 10.1021/acs.joc.9b02453)
Gaining insight into toxicity predicting machine learning algorithms
TEH Allen, E Gelzinyte, AJ Wedlake, JM Goodman, S Gutsell, PJ Russell
– TOXICOLOGY LETTERS
(2019)
314,
S280
An Activatable Cancer-Targeted Hydrogen Peroxide Probe for Photoacoustic and Fluorescence Imaging
J Weber, L Bollepalli, AM Belenguer, MD Antonio, N De Mitri, J Joseph, S Balasubramanian, CA Hunter, SE Bohndiek
– Cancer research
(2019)
79,
5407
(DOI: 10.1158/0008-5472.CAN-19-0691)
Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products
NYS Lam, I Paterson
– European Journal of Organic Chemistry
(2019)
(DOI: 10.1002/ejoc.201901243)
Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation.
MT Mihai, BD Williams, RJ Phipps
– Journal of the American Chemical Society
(2019)
141,
15477
(DOI: 10.1021/jacs.9b07267)
Molecular Transformer: A Model for Uncertainty-Calibrated Chemical Reaction Prediction
P Schwaller, T Laino, T Gaudin, P Bolgar, CA Hunter, C Bekas, AA Lee
– ACS Central Science
(2019)
5,
1572
(DOI: 10.1021/acscentsci.9b00576)
Recent Advances in Minisci-Type Reactions
RSJ Proctor, RJ Phipps
– Angewandte Chemie (International ed. in English)
(2019)
58,
13666
(DOI: 10.1002/anie.201900977)

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