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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Physical Research Interest Group

Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
A Leithner, O Staufer, T Mitra, F Liberta, S Valvo, M Kutuzov, H Dada, J Spaeth, W Zhou, F Schiele, S Reindl, H Nar, S Hoerer, M Crames, S Comeau, D Young, S Low, E Jenkins, SJ Davis, D Klenerman, A Nixon, N Pefaur, D Wyatt, O Dushek, S Kasturirangan, ML Dustin
– Proceedings of the National Academy of Sciences
(2025)
122,
e2425781122
(DOI: 10.1073/pnas.2425781122)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
– Communications Medicine
(2025)
5,
195
(DOI: 10.1038/s43856-025-00918-3)
Detection of p53 aggregates in plasma of glioma patients.
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
– Communications Medicine
(2025)
5,
195
(DOI: 10.1038/s43856-025-00918-3)
Using a stable protein scaffold to display peptides that bind to alpha‐synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GS Kaminski Schierle, LS Itzhaki, JR Kumita
– Protein science : a publication of the Protein Society
(2025)
34,
e70150
(DOI: 10.1002/pro.70150)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2412218122
(DOI: 10.1073/pnas.2412218122)
Molecular characterization of organic aerosols in urban and forested areas of Paris using high-resolution mass spectrometry
DL Pereira, C Giorio, A Gratien, A Zherebker, G Noyalet, S Chevaillier, S Alage, E Almarj, A Bergé, T Bertin, M Cazaunau, P Coll, L Di Antonio, S Harb, J Heuser, C Gaimoz, O Guillemant, B Language, O Lauret, C Macias, F Maisonneuve, B Picquet-Varrault, R Torres, S Triquet, P Zapf, L Hawkins, D Pronovost, S Riley, PM Flaud, E Perraudin, P Pouyes, E Villenave, A Albinet, O Favez, R Aujay-Plouzeau, V Michoud, C Cantrell, M Cirtog, CD Di Biagio, JF Doussin, P Formenti
– Atmospheric Chemistry and Physics
(2025)
25,
4885
(DOI: 10.5194/acp-25-4885-2025)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates.
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
– Chemical science
(2025)
(DOI: 10.1039/d5sc00903k)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner.
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
– Communications chemistry
(2025)
8,
133
(DOI: 10.1038/s42004-025-01524-z)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
– Alzheimer's & Dementia
(2025)
21,
e70086
(DOI: 10.1002/alz.70086)
Aggregation of α-synuclein splice isoforms through a phase separation pathway.
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science Advances
(2025)
11,
eadq5396
(DOI: 10.1126/sciadv.adq5396)
Design and sustainability of polypeptide material systems
SK Yorke, Z Yang, EG Wiita, A Kamada, TPJ Knowles, MJ Buehler
– Nature Reviews Materials
(2025)
1
(DOI: 10.1038/s41578-025-00793-3)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates.
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwöger, TJ Krug, G Chauhan, DA Weitz, MD Lew, TPJ Knowles, RV Pappu
– Nature Communications
(2025)
16,
3463
(DOI: 10.1038/s41467-025-58736-z)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
K D’Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
– Science Advances
(2025)
11,
eadp8504
(DOI: 10.1126/sciadv.adp8504)
Scaling relations of multicomponent phase coexistence boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
(2025)
(DOI: 10.1101/2025.04.02.645070)
Multi‐Model Assessment of Future Hydrogen Soil Deposition and Lifetime Using CMIP6 Data
MAJ Brown, NJ Warwick, AT Archibald
– Geophysical Research Letters
(2025)
52,
e2024GL113653
(DOI: 10.1029/2024gl113653)
Multi‐Model Assessment of Future Hydrogen Soil Deposition and Lifetime Using CMIP6 Data
MAJ Brown, NJ Warwick, AT Archibald
– Geophysical Research Letters
(2025)
52,
(DOI: 10.1029/2024GL113653)
Structural defects in amyloid-β fibrils drive secondary nucleation
J Hu, TJ Scheidt, D Thacker, E Axell, E Stemme, U Lapinska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Saric, J Schmit, T Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
(2025)
(DOI: 10.1101/2025.03.31.646415)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(DOI: 10.48550/arxiv.2503.20941)
Learning the rules of peptide self-assembly through data mining with large language models
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
– Science Advances
(2025)
11,
eadv1971
(DOI: 10.1126/sciadv.adv1971)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen.
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
– Commun Biol
(2025)
8,
466
(DOI: 10.1038/s42003-025-07909-z)

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