Recent Publications from the Physical Chemistry Research Interest Group

Toll-like receptor signalling outcome is determined by the stoichiometry of the endogenous TRIFosome

MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant

Science Advances

(2026)

eaeb9507

(doi: 10.1126/sciadv.aeb9507)

Chemical Softness as a Predictor for Reactivity at Metal Surfaces

A Gunton, SJ Jenkins

Physical Chemistry, Chemical Physics - PCCP

(2026)

(doi: 10.1039/d5cp03378k)

Charge-triggered switching mechanism in selenium selector enabling ultralow leakage current

Y Sun, T Gotoh, J Zhao, M Zhang, S Shi, H Zhang, Z Liu, J Shen, R Dronskowski, Z Song, SR Elliott, M Zhu

Nature Materials

(2026)

(doi: 10.1038/s41563-026-02499-5)

Development of Fully Interactive Hydrogen with Methane in UKESM1.0

M Brown

Geoscientific Model Development

(2026)

1537

(doi: 10.5194/gmd-19-1537-2026)

Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies.

D Böken, M Huang, Y Wu, E Fertan, MW Cotton, G Meisl, JYL Lam, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman

Cell reports

(2026)

116934

(doi: 10.1016/j.celrep.2026.116934)

A universal phase-plane model for in vivo protein aggregation

MW Cotton, A Goriely, D Klenerman, G Meisl

The Journal of chemical physics

(2026)

164

075101

(doi: 10.1063/5.0312752)

Structural defects in amyloid-β fibrils drive secondary nucleation

J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Šarić, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear

Nature communications

(2026)

1933

(doi: 10.1038/s41467-026-69377-1)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

(2026)

(doi: 10.48550/arxiv.2508.15046)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, 黃士桓, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

PRX Life

(2026)

013021

(doi: 10.1103/f9hz-xvpr)

Input and output files supporting Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions

LSD Jacob, BEH Harvey, C Giorio, A Archibald

(2026)

(doi: 10.17863/CAM.124752)

Phase separation and the tumor microenvironment

W Liu, L Yu, J Xu, Y Yao, TPJ Knowles, Y-L Zhang

Cell communication and signaling : CCS

(2026)

(doi: 10.1186/s12964-026-02712-7)

Prediction of Double Dihydrogen Bonds at Two Semiconductor Surfaces

H Thake, SJ Jenkins

Journal of Physical Chemistry C

(2026)

130

2793

(doi: 10.1021/acs.jpcc.5c07848)

Physicochemical and Toxicological Characterization of Airborne Brake Wear Particles Reveals Oxidative Stress-Mediated DNA Damage

S Hyman, S Saladin, Y Tsybrii, O Nosko, M Williams, A Zherebker, K Risby, D Topping, A Boies, C Giorio, M Roursgaard, P Møller

Environ Sci Technol

(2026)

4955

(doi: 10.1021/acs.est.5c10783)

Effect of Pressure on Liquid-Phase Adsorption on a Solid Surface.

MI Sciancalepore, SM Clarke, PJ Camp

Langmuir

(2026)

5001

(doi: 10.1021/acs.langmuir.5c06132)

Molecularly specific solubilization of therapeutic antibodies

Z Han, NA Erkamp, R Scrutton, G Licari, O Predeina, A Evers, P Sormanni, TPJ Knowles

(2026)

(doi: 10.64898/2026.01.29.702671)

Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization

H Ausserwöger, R Scrutton, CM Fischer, T Sneideris, D Qian, E de Csilléry, I Baronaite, KL Saar, AZ Białek, M Oeller, G Krainer, TM Franzmann, S Wittmann, JM Iglesias-Artola, G Invernizzi, AA Hyman, S Alberti, N Lorenzen, TPJ Knowles

Nature chemistry

(2026)

246

(doi: 10.1038/s41557-025-02039-9)

Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease

E Fertan, S Kedia, G Nolan, G Meisl, MW Cotton, KH Müller, Z Zhang, L Muresan, A Quaegebeur, MG Spillantini, D Klenerman

Acta Neuropathologica

(2026)

151

(doi: 10.1007/s00401-026-02977-9)

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti-CEACAM5 CAR T-Cell Efficacy Against Colorectal Cancer

D Banik, CJ Ward, S Chakraborty, Z Zhang, D Heraghty, P Suresh, B Li, S Kedia, J Pramanik, SJ Davis, JP Roy, MA Chapman, B Mahata, D Klenerman

Advanced Science

(2026)

e09762

(doi: 10.1002/advs.202509762)

Patch deconvolution for Fourier light-field microscopy

B Fu, CL Jones, D Heraghty, S Yang, C O'Brien-Ball, V Junghans, H Yang, D Klenerman, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee

Biophysical journal

(2026)

125

1305

(doi: 10.1016/j.bpj.2026.01.034)

Flow behavior of a droplet in viscous fluids through asymmetric bifurcating microchannels

H Yang, TPJ Knowles

Physics of Fluids

(2026)

012011

(doi: 10.1063/5.0309289)

Oligomers mediate the spatial transmission of Aβ peptide aggregation.

Q Peter, C Taylor, U Lapinska, J Wei, TCT Michaels, P Arosio, S Linse, TPJ Knowles

Communications chemistry

(2026)

(doi: 10.1038/s42004-025-01837-z)

Supplementary material to "Deciphering the impacts of meteorology on surface ozone variability in eastern China using explainable machine learning models"

X Ye, L Zhang, X Wang, N Lu, S Hickman, G Luo, AT Archibald

(2026)

(doi: 10.5194/egusphere-2026-74-supplement)

Volumetric Single‐Molecule Tracking Inside Subcellular Structures

S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee

Small

(2026)

e09162

(doi: 10.1002/smll.202509162)

Deciphering the impacts of meteorology on surface ozone variability in eastern China using explainable machine learning models

X Ye, L Zhang, X Wang, N Lu, S Hickman, G Luo, AT Archibald

(2026)