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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Physical Research Interest Group

Global kinetic model of lipid-induced <i>α</i>-synuclein aggregation and its inhibition by small molecules.
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
– Proceedings of the National Academy of Sciences
(2025)
122,
e2422427122
(DOI: 10.1073/pnas.2422427122)
On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles.
S Zilberzwige-Tal, A Levin, A Ezra, U Elia, G Finkelstein-Zuta, T Kreiser, L Gershon, M Goldsmith, E Kon, Y Navon, O Cohen, TPJ Knowles, D Peer, E Gazit
– Small (Weinheim an der Bergstrasse, Germany)
(2025)
e2500114
(DOI: 10.1002/smll.202500114)
First-Principles Dynamics of the Surface Fluorination of Diamond.
H Thake, SJ Jenkins
– Langmuir : the ACS journal of surfaces and colloids
(2025)
41,
16315
(DOI: 10.1021/acs.langmuir.5c01587)
Patch deconvolution for Fourier light-field microscopy
B Fu, C Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, L Weiss, R Fernandes, S Lee
(2025)
(DOI: 10.1101/2025.06.13.659385)
Small tau aggregates exhibit disease-specific molecular profiles across tauopathies
D Böken, M Huang, Y Wu, E Fertan, JYL Lam, G Meisl, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman
(2025)
(DOI: 10.1101/2025.06.10.658934)
Volumetric single-molecule tracking inside subcellular structures
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
(2025)
(DOI: 10.1101/2025.06.09.658280)
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, PS George-Hyslop, J MacKay, LA Ju, T Knowles, D Vigolo, Y Shen
(2025)
(DOI: 10.1101/2025.06.03.657213)
Transcript Identification Using Arrayed Hydrogels with TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri-Marthi, JD Brenton, CJ Thomas, TPJ Knowles
– Advanced Materials Technologies
(2025)
e01953
(DOI: 10.1002/admt.202401953)
Lysosomal stress induces amyloid-β aggregate release and reactive transformation in human astrocytes
S Goldsworthy, E Fertan, P Dyal, S Domoney, FJ Livesey, D Klenerman, R Patani, C Hung
(2025)
(DOI: 10.1101/2025.05.27.656416)
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency.
A Leithner, O Staufer, T Mitra, F Liberta, S Valvo, M Kutuzov, H Dada, J Spaeth, W Zhou, F Schiele, S Reindl, H Nar, S Hoerer, M Crames, S Comeau, D Young, S Low, E Jenkins, SJ Davis, D Klenerman, A Nixon, N Pefaur, D Wyatt, O Dushek, S Kasturirangan, ML Dustin
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2425781122
(DOI: 10.1073/pnas.2425781122)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
– Communications Medicine
(2025)
5,
195
(DOI: 10.1038/s43856-025-00918-3)
Detection of p53 aggregates in plasma of glioma patients
Y Wu, JYL Lam, M Pitoulias, D Böken, Z Zhang, R Chintapalli, E Fertan, Z Xia, JSH Danial, G Tsang-Pells, E Fysh, L Julian, KM Brindle, R Mair, D Klenerman
– Communications medicine
(2025)
5,
195
(DOI: 10.1038/s43856-025-00918-3)
Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GS Kaminski Schierle, LS Itzhaki, JR Kumita
– Protein science : a publication of the Protein Society
(2025)
34,
e70150
(DOI: 10.1002/pro.70150)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(DOI: 10.48550/arxiv.2505.08850)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro.
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
– Proceedings of the National Academy of Sciences
(2025)
122,
e2412218122
(DOI: 10.1073/pnas.2412218122)
Molecular characterization of organic aerosols in urban and forested areas of Paris using high-resolution mass spectrometry
DL Pereira, C Giorio, A Gratien, A Zherebker, G Noyalet, S Chevaillier, S Alage, E Almarj, A Bergé, T Bertin, M Cazaunau, P Coll, L Di Antonio, S Harb, J Heuser, C Gaimoz, O Guillemant, B Language, O Lauret, C Macias, F Maisonneuve, B Picquet-Varrault, R Torres, S Triquet, P Zapf, L Hawkins, D Pronovost, S Riley, PM Flaud, E Perraudin, P Pouyes, E Villenave, A Albinet, O Favez, R Aujay-Plouzeau, V Michoud, C Cantrell, M Cirtog, CD Di Biagio, JF Doussin, P Formenti
– Atmospheric Chemistry and Physics
(2025)
25,
4885
(DOI: 10.5194/acp-25-4885-2025)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
– Chemical science
(2025)
16,
10532
(DOI: 10.1039/d5sc00903k)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
– Communications chemistry
(2025)
8,
133
(DOI: 10.1038/s42004-025-01524-z)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
– Alzheimer's & Dementia
(2025)
21,
e70086
(DOI: 10.1002/alz.70086)
Aggregation of α-synuclein splice isoforms through a phase separation pathway
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science advances
(2025)
11,
eadq5396
(DOI: 10.1126/sciadv.adq5396)

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