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Recent Publications from the Physical Research Interest Group

Trodusquemine enhances Aβ<inf>42</inf> aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Role of carbon-rings in polycrystalline GeSb<inf>2</inf>Te<inf>4</inf> phase-change material
G Wang, J Zhou, SR Elliott, Z Sun
– Journal of Alloys and Compounds
(2019)
782,
852
(DOI: 10.1016/j.jallcom.2018.12.228)
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
– Sensors and Actuators B: Chemical
(2019)
281,
960
(DOI: 10.1016/j.snb.2018.11.052)
Competitive Adsorption of a Multifunctional Amine and Phenol Surfactant with Ethanol on Hematite from Nonaqueous Solution.
C-L Chia, RM Alloway, I Jephson, SM Clarke, SV Filip, FR Siperstein, C Avendaño
– The Journal of Physical Chemistry B
(2019)
acs.jpcb.8b09704
(DOI: 10.1021/acs.jpcb.8b09704)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
– Acta Neuropathologica
(2019)
137,
103
(DOI: 10.1007/s00401-018-1907-y)
Exploring How Eruption Source Parameters Affect Volcanic Radiative Forcing Using Statistical Emulation
L Marshall, JS Johnson, GW Mann, L Lee, SS Dhomse, L Regayre, M Yoshioka, KS Carslaw, A Schmidt
– Journal of Geophysical Research: Atmospheres
(2019)
(DOI: 10.1029/2018JD028675)
ROOOH: A missing piece of the puzzle for OH measurements in low-NO environments?
C Fittschen, M Al Ajami, S Batut, V Ferracci, S Archer-Nicholls, AA Archibald, C Schoemaecker
– Atmospheric Chemistry and Physics
(2019)
19,
349
(DOI: 10.5194/acp-19-349-2019)
Physical determinants of amyloid assembly in biofilm formation
M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles
– MBio
(2019)
10,
(DOI: 10.1128/mbio.02279-18)
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease.
S De, D Klenerman
– Biochimica et Biophysica Acta - Proteins and Proteomics
(2019)
(DOI: 10.1016/j.bbapap.2018.12.010)
Filamentous aggregates are fragmented by the proteasome holoenzyme
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
– Cell Reports
(2019)
(DOI: 10.1016/j.celrep.2019.01.096)
Oligomer diversity during the aggregation of the repeat-region of tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
– ACS Chemical Neuroscience
(2018)
9,
3060
(DOI: 10.1021/acschemneuro.8b00250)
Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Chemical Neuroscience
(2018)
9,
2959
(DOI: 10.1021/acschemneuro.8b00141)
Ultrafast Nanoscale Phase-Change Memory Enabled By Single-Pulse Conditioning
DK Loke, JM Skelton, TH Lee, R Zhao, T-C Chong, SR Elliott
– ACS Applied Materials and Interfaces
(2018)
10,
41855
(DOI: 10.1021/acsami.8b16033)
Mapping Surface Hydrophobicity of alpha-Synuclein Oligomers at the Nanoscale
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
– Nano Lett
(2018)
18,
7494
(DOI: 10.1021/acs.nanolett.8b02916)
Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.
C Bortolini, T Kartanas, D Copic, I Condado Morales, Y Zhang, PK Challa, Q Peter, T Jávorfi, R Hussain, M Dong, G Siligardi, TPJ Knowles, J Charmet
– Lab Chip
(2019)
19,
50
(DOI: 10.1039/c8lc00757h)
Use of networks of low cost air quality sensors to quantify air quality in urban settings
OAM Popoola, D Carruthers, C Lad, VB Bright, MI Mead, MEJ Stettler, JR Saffell, RL Jones
– Atmospheric Environment
(2018)
194,
58
(DOI: 10.1016/j.atmosenv.2018.09.030)
Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics
C Bertulli, M Gerigk, N Piano, Y Liu, D Zhang, T Müller, TJ Knowles, YYS Huang
– Scientific Reports
(2018)
8,
12480
(DOI: 10.1038/s41598-018-30776-0)
Recruitment of patients with Chronic Obstructive Pulmonary Disease (COPD) from the Clinical Practice Research Datalink (CPRD) for research
JK Quint, E Moore, A Lewis, M Hashmi, K Sultana, M Wright, L Smeeth, L Chatzidiakou, R Jones, S Beevers, S Kolozali, F Kelly, B Barratt
– npj Primary Care Respiratory Medicine
(2018)
28,
21
(DOI: 10.1038/s41533-018-0089-3)
alpha-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease
MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
– Nat Commun
(2018)
9,
2293
(DOI: 10.1038/s41467-018-04422-2)
Recent multivariate changes in the North Atlantic climate system, with a focus on 2005–2016
J Robson, RT Sutton, A Archibald, F Cooper, M Christensen, LJ Gray, NP Holliday, C Macintosh, M McMillan, B Moat, M Russo, R Tilling, K Carslaw, D Desbruyères, O Embury, DL Feltham, DP Grosvenor, S Josey, B King, A Lewis, GD McCarthy, C Merchant, AL New, CH O'Reilly, SM Osprey, K Read, A Scaife, A Shepherd, B Sinha, D Smeed, D Smith, A Ridout, T Woollings, M Yang
– International Journal of Climatology
(2018)
38,
5050
(DOI: 10.1002/joc.5815)

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