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Recent Publications from the Physical Research Interest Group

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Role of carbon-rings in polycrystalline GeSb <inf>2</inf> Te <inf>4</inf> phase-change material
G Wang, J Zhou, SR Elliott, Z Sun
– Journal of Alloys and Compounds
(2019)
782,
852
(DOI: 10.1016/j.jallcom.2018.12.228)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nature Communications
(2019)
10,
1541
(DOI: 10.1038/s41467-019-09477-3)
Citrullination of HP1γ chromodomain affects association with chromatin.
M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides
– Epigenetics & chromatin
(2019)
12,
21
(DOI: 10.1186/s13072-019-0265-x)
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
CM Dobson, TPJ Knowles, M Vendruscolo
– Cold Spring Harbor Perspectives in Biology
(2019)
a033878
(DOI: 10.1101/cshperspect.a033878)
Direct Injection Liquid Chromatography High-Resolution Mass Spectrometry for Determination of Primary and Secondary Terrestrial and Marine Biomarkers in Ice Cores
ACF King, C Giorio, E Wolff, E Thomas, M Roverso, M Schwikowski, A Tapparo, S Bogialli, M Kalberer
– Analytical chemistry
(2019)
91,
5051
(DOI: 10.1021/acs.analchem.8b05224)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
– Chemical Science
(DOI: 10.1039/c8sc05627g)
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie International Edition
(2019)
(DOI: 10.1002/anie.201901405)
Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
– ACS Nano
(2019)
acsnano.9b00274
(DOI: 10.1021/acsnano.9b00274)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
– Macromol Rapid Commun
(2019)
1800898
(DOI: 10.1002/marc.201800898)
A method of predicting the in vitro fibril formation propensity of A beta 40 mutants based on their inclusion body levels in E-coli
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
– Scientific Reports
(2019)
9,
3680
(DOI: 10.1038/s41598-019-39216-z)
Quantifying Chemical Structure and Machine-Learned Atomic Energies in Amorphous and Liquid Silicon.
N Bernstein, B Bhattarai, G Csányi, DA Drabold, SR Elliott, V Deringer
– Angewandte Chemie - International Edition
(2019)
(DOI: 10.1002/anie.201902625)
Direct target and non-target analysis of urban aerosol sample extracts using atmospheric pressure photoionisation high-resolution mass spectrometry.
C Giorio, C Bortolini, I Kourtchev, A Tapparo, S Bogialli, M Kalberer
– Chemosphere
(2019)
224,
786
(DOI: 10.1016/j.chemosphere.2019.02.151)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
– ACS Chem Neurosci
(2019)
acschemneuro.8b00676
(DOI: 10.1021/acschemneuro.8b00676)
Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
– Cell Rep
(2019)
26,
2140
(DOI: 10.1016/j.celrep.2019.01.096)
Targeting the Formation of Amyloid Oligomers using Rationally Designed Antibodies
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TP Knowles, CM Dobson, M Vendruscolo
– Biophysical Journal
(2019)
116,
28a
(DOI: 10.1016/j.bpj.2018.11.196)
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
– Sensors and Actuators, B: Chemical
(2019)
281,
960
(DOI: 10.1016/j.snb.2018.11.052)
Atomic force microscopy for single molecule characterisation of protein aggregation.
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
– Archives of Biochemistry and Biophysics
(2019)
664,
134
(DOI: 10.1016/j.abb.2019.02.001)
Competitive Adsorption of a Multifunctional Amine and Phenol Surfactant with Ethanol on Hematite from Nonaqueous Solution
C-L Chia, RM Alloway, I Jephson, SM Clarke, SV Filip, FR Siperstein, C Avendaño
– The Journal of Physical Chemistry B
(2019)
123,
1375
(DOI: 10.1021/acs.jpcb.8b09704)
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson’s disease pathogenesis
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
– Acta neuropathologica
(2018)
137,
103
(DOI: 10.1007/s00401-018-1907-y)

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