Recent Publications from the Physical Chemistry Research Interest Group

Formation of S- and Z-twist supramolecular micro-ropes by peptide stereoisomers

H Yuan, Z Yang, C Yuan, S Shankar, A Levin, T Lv, Z Wang, W Sun, J Sitton, P-A Cazade, Y Dan, Y Tang, L Adler-Abramovich, Y Cao, S Rencus-Lazar, D Thompson, D Kurouski, TPJ Knowles, LJW Shimon, G Wei, B Xue, R Yang, E Gazit

Nat Commun

(2026)

(doi: 10.1038/s41467-026-71043-5)

Tau catalyzes amyloid-β aggregation and toxicity in a polymorph-dependent manner.

M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede

Proceedings of the National Academy of Sciences

(2026)

123

e2532775123

(doi: 10.1073/pnas.2532775123)

Chemical softness as a predictor for reactivity at metal surfaces

AL Gunton, SJ Jenkins

Physical Chemistry, Chemical Physics - PCCP

(2026)

7561

(doi: 10.1039/d5cp03378k)

Evaluation of UKESM aerosol size and composition using ATom measurements indicates missing marine aerosol formation mechanisms

X-C He, NL Abraham, H Ding, MR Russo, DP Grosvenor, Y Ge, X Wang, AC Jones, P Campuzano-Jost, B Nault, A Kupc, D Blake, JL Jimenez, CJ Williamson, J Weber, AT Archibald, H Gordon

Atmospheric Chemistry and Physics (ACP)

(2026)

3805

(doi: 10.5194/acp-26-3805-2026)

Chemical composition differences in gas- and particle-phase organic and DMS-derived oxidation products between a pristine marine environment and a wildfire-influenced marine air mass

F Sari Doré, R Wu, E Matthews, C Wu, T Bannan, H Coe, A Archibald, M Hallquist

(2026)

(doi: 10.5194/egusphere-egu26-21632)

Organic matter in dust-dominated aerosols over Namibia influenced by biomass burning and marine emissions

A Zherebker, C Baldo, P Formenti, C Giorio

(2026)

(doi: 10.5194/egusphere-egu26-10531)

Reversibility and β-sheet formation are decoupled in tau condensate aging

CM Fischer, IA Edu, T Šneideris, I Baronaite, Z Toprakcioglu, L-T Deck, D Qian, R Scrutton, L Dreyer, J Wen, DE Otzen, S Wu, S Perrett, TPJ Knowles

Proc Natl Acad Sci U S A

(2026)

123

e2522993123

(doi: 10.1073/pnas.2522993123)

Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions

LSD Jacob, BEH Harvey, C Giorio, AT Archibald

Atmospheric Chemistry and Physics (ACP)

(2026)

3567

(doi: 10.5194/acp-26-3567-2026)

Constructing a single-objective oblique plane microscope (OPM) for fast, multi-colour, high-resolution volumetric fluorescence imaging

Z Zhang, W Hong, Y Wu, A Dey, A Shevchuk, D Klenerman

(2026)

(doi: 10.64898/2026.03.04.709686)

Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome.

MC Moncrieffe, P Suresh, J Boyle, Y Cui, B Nawalpuri, B Verstak, YP Zhang, Z Zhang, M Taylor, EH Egelman, N Gay, D Klenerman, C Bryant

Science advances

(2026)

eaeb9507

(doi: 10.1126/sciadv.aeb9507)

Scaling Relations of Multicomponent Phase Coexistence Boundaries

D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles

PRX Life

(2026)

013026

(doi: 10.1103/t2v5-49k4)

Charge-triggered switching mechanism in selenium selector enabling ultralow leakage current.

Y Sun, T Gotoh, J Zhao, M Zhang, S Shi, H Zhang, Z Liu, J Shen, R Dronskowski, Z Song, SR Elliott, M Zhu

Nat Mater

(2026)

651

(doi: 10.1038/s41563-026-02499-5)

Development of fully interactive hydrogen with methane in UKESM1.0

M Brown

Geoscientific Model Development

(2026)

1537

(doi: 10.5194/gmd-19-1537-2026)

BPS2026 – Nucleation kinetics reveals a distinct biological function space of biomolecular condensates

L-T Deck, SN Pacheco, H Ausserwöger, D Frenkel, NA Erkamp, TPJ Knowles

Biophysical Journal

(2026)

125

240a

(doi: 10.1016/j.bpj.2025.11.1572)

Nanoscopic tau aggregates are not shared intermediates but disease-specific entities across tauopathies

D Böken, M Huang, Y Wu, E Fertan, MW Cotton, G Meisl, JYL Lam, S Baig, JB Rowe, C Smith, A Quaegebeur, D Cox, WA McEwan, D Klenerman

Cell reports

(2026)

116934

(doi: 10.1016/j.celrep.2026.116934)

A universal phase-plane model for in vivo protein aggregation

MW Cotton, A Goriely, D Klenerman, G Meisl

J Chem Phys

(2026)

164

075101

(doi: 10.1063/5.0312752)

Structural defects in amyloid-β fibrils drive secondary nucleation

J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Šarić, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear

Nature communications

(2026)

1933

(doi: 10.1038/s41467-026-69377-1)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

(2026)

(doi: 10.48550/arxiv.2508.15046)

A cell-level model to predict the spatiotemporal dynamics of neurodegenerative disease

S-H Huang, 黃士桓, MW Cotton, TPJ Knowles, D Klenerman, G Meisl

PRX Life

(2026)

013021

(doi: 10.1103/f9hz-xvpr)

Input and output files supporting Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions

LSD Jacob, BEH Harvey, C Giorio, A Archibald

(2026)

(doi: 10.17863/CAM.124752)

Phase separation and the tumor microenvironment

W Liu, L Yu, J Xu, Y Yao, TPJ Knowles, Y-L Zhang

Cell Commun Signal

(2026)

(doi: 10.1186/s12964-026-02712-7)