Recent Publications from the Physical Research Interest Group

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi

– Nature Communications

(2018)

2293

(DOI: 10.1038/s41467-018-04422-2)

Recruitment of patients with Chronic Obstructive Pulmonary Disease (COPD) from the Clinical Practice Research Datalink (CPRD) for research

JK Quint, E Moore, A Lewis, M Hashmi, K Sultana, M Wright, L Smeeth, L Chatzidiakou, R Jones, S Beevers, S Kolozali, F Kelly, B Barratt

– NPJ Prim Care Respir Med

(2018)

28,

(DOI: 10.1038/s41533-018-0089-3)

Characterisation of particle-surface interactions via anharmonic acoustic transduction

C da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

– Sensors and Actuators, B: Chemical

(2018)

272,

175

(DOI: 10.1016/j.snb.2018.05.016)

Solution Fibre Spinning Technique for the Fabrication of Tuneable Decellularised Matrix-Laden Fibres and Fibrous Micromembranes.

Z Li, J Tuffin, IM Lei, FS Ruggeri, NS Lewis, EL Gill, T Savin, L Huleihel, SF Badylak, T Knowles, SC Satchell, GI Welsh, MA Saleem, Y Yan Shery Huang

– Acta Biomater

(2018)

(DOI: 10.1016/j.actbio.2018.08.010)

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery

M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles

– J Neurosci Methods

(2018)

306,

(DOI: 10.1016/j.jneumeth.2018.02.005)

Anionic surfactant induced desorption of a cationic surfactant from mica

FJ Allen, CL Truscott, RJL Welbourn, SM Clarke

– Applied Clay Science

(2018)

160,

276

(DOI: 10.1016/j.clay.2018.02.010)

Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation.

C Månsson, RTP van Cruchten, U Weininger, X Yang, R Cukalevski, P Arosio, CM Dobson, T Knowles, M Akke, S Linse, C Emanuelsson

– Biochemistry

(2018)

(DOI: 10.1021/acs.biochem.8b00353)

Extrinsic Amyloid-Binding Dyes for the Detection of Individual Protein Aggregates in Solution.

CG Taylor, G Meisl, MH Horrocks, H Zetterberg, TPJ Knowles, D Klenerman

– Anal Chem

(2018)

(DOI: 10.1021/acs.analchem.8b02226)

Nanoscopic characterization of individual endogenous protein aggregates in human neuronal cells.

M Horrocks, DR Whiten, Y Zuo, L Calo, M-L Choi, S De, P Flagmeier, DC Wirthensohn, F Kundel, SF Lee, C Dobson, S Gandhi, M Spillantini, D Klenerman, RT Ranasinghe, SE Sanchez, D Athauda

– Chembiochem

(2018)

(DOI: 10.1002/cbic.201800209)

Synthesis of transparent dispersions of aluminium hydroxide nanoparticles.

B Chen, J-X Wang, D Wang, X-F Zeng, SM Clarke, J-F Chen

– Nanotechnology

(2018)

29,

305605

(DOI: 10.1088/1361-6528/aac371)

Observations of sesquiterpenes and their oxidation products in central Amazonia during the wet and dry seasons

LD Yee, G Isaacman-VanWertz, RA Wernis, M Meng, V Rivera, NM Kreisberg, SV Hering, MS Bering, M Glasius, MA Upshur, A Gray Bé, RJ Thomson, FM Geiger, JH Offenberg, M Lewandowski, I Kourtchev, M Kalberer, S De Sá, ST Martin, ML Alexander, BB Palm, W Hu, P Campuzano-Jost, DA Day, JL Jimenez, Y Liu, KA McKinney, P Artaxo, J Viegas, A Manzi, MB Oliveira, R De Souza, LAT Machado, K Longo, AH Goldstein

– Atmospheric Chemistry and Physics

(2018)

18,

10433

(DOI: 10.5194/acp-18-10433-2018)

Origin of metastable oligomers and their effects on amyloid fibril self-assembly

F Hasecke, T Miti, C Perez, J Barton, D Schoelzel, L Gremer, CSR Gruening, G Matthews, G Meisl, TPJ Knowles, D Willbold, P Neudecker, H Heise, G Ullah, W Hoyer, M Muschol

– Chemical Science

(2018)

5937

(DOI: 10.1039/c8sc01479e)

Secondary nucleation in amyloid formation

M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, SIA Cohen, TPJ Knowles, S Linse

– Chemical communications (Cambridge, England)

(2018)

54,

8667

(DOI: 10.1039/c8cc02204f)

The Interactive Stratospheric Aerosol Model Intercomparison Project (ISA-MIP): Motivation and experimental design

C Timmreck, GW Mann, V Aquila, R Hommel, LA Lee, A Schmidt, C Brühl, S Carn, M Chin, SS Dhomse, T Diehl, JM English, MJ Mills, R Neely, J Sheng, M Toohey, D Weisenstein

– Geoscientific Model Development

(2018)

11,

2581

(DOI: 10.5194/gmd-11-2581-2018)

Potential impacts of emissions associated with unconventional hydrocarbon extraction on UK air quality and human health

AT Archibald, C Ordóñez, E Brent, ML Williams

– Air Quality, Atmosphere & Health

(2018)

11,

627

(DOI: 10.1007/s11869-018-0570-8)

1064 nm Dispersive Raman Micro-Spectroscopy and Optical Trapping of Pharmaceutical Aerosols

PJ Gallimore, NM Davidson, M Kalberer, FD Pope, AD Ward

– Anal Chem

(2018)

(DOI: 10.1021/acs.analchem.8b00817)

Gaussian approximation potential modeling of lithium intercalation in carbon nanostructures

S Fujikake, VL Deringer, TH Lee, M Krynski, SR Elliott, G Csányi

– The Journal of chemical physics

(2018)

148,

241714

(DOI: 10.1063/1.5016317)

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson

– ACS Chem Biol

(2018)

(DOI: 10.1021/acschembio.8b00466)