Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds.
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chemical science
(2025)
Exposures in Indoor Air Affecting Health.
M Hartiala, V Elenius, AA Pesquera, S Androulakis, I Annesi-Maesano, A Badyda, S Brandsma, I Chatziprodromidou, G Gajski, J Garcia-Aymerich, C Giorio, T Hugg, JJK Jaakkola, S Koch, PEG Leonards, A Matrali, L Melymuk, N Mueller, A Muszyński, J Opbroek, I Paciência, SN Pandis, S Pozdniakova, AK Rantala, SR Sufuentes, L Schenk, E Sugeng, A Sunyer-Caldú, A Vantarakis, A Zherebker, E Alfaro-Moreno, PB Nizzetto, JF Dominguez, S Karatzas, F Mureddu, H Salonen, N Papadopoulos, T Jartti, IDEAL Consortium
Allergy. European Journal of Allergy and Clinical Immunology
(2025)
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
GG Agsu, Y Cao, D Jain, SE Strawbridge, S Daly, Z Zhang, A Wurmser, K Bowers, IO De Almeida, G Nikolenyi, S Berger, M Jonaitis, K Guma’a, T Pauzaite, S Maretvadakethope, L Bates, JA Nathan, BD Hendrich, R Perez-Carrasco, KJ Chalut, D Klenerman, TE Boroviak, SF Lee, D Holcman, S Basu
(2025)
In vitro liquid-liquid phase separation induced by respiratory syncytial virus proteins and RNA
V Basse, T Agarwal, T Sneideris, C-A Richard, J Troussier, J-J Vasseur, F Debart, J-F Eléouët, E de Csillery, T Knowles, M Galloux
(2025)
Mapping high resolution, multidimensional phase diagrams of physiological protein condensates
T Agarwal, T Sneideris, F Svara, K Jermakovs, H Coyle, S Qamar, E Kava, R Scrutton, N Pleschka, P Peres, G Cereghetti, E Andrzejewska, A Diaz-Barreiro, G Palmer, AJ Costa-Filho, G Krainer, TP Knowles, J Nixon-Abell
(2025)
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez
Nat Commun
(2025)
16
The Liquid State of RIM1α and RBP Condensates is Maintained by Lipids
CM Fischer, Z Toprakcioglu, E de Csilléry, GS Kaminski Schierle, TPJ Knowles
ACS Nano
(2025)
19
Contrasting solubility and speciation of metal ions in total suspended particulate matter and fog from the coast of Namibia - Part 1
C Giorio, A Monod, V Di Marco, P Herckes, D Napolitano, A Sullivan, G Landrot, D Warnes, M Nasti, S D'Aronco, A Gérardin, N Brun, K Desboeufs, S Triquet, S Chevaillier, C Di Biagio, F Battaglia, F Burnet, SJ Piketh, A Namwoonde, J-F Doussin, P Formenti
Atmospheric Chemistry and Physics
(2025)
25
Elemental composition, iron mineralogy, and solubility of anthropogenic and natural mineral dust aerosols in Namibia: A case study analysis from the AEROCLO-sA campaign - Part 2
P Formenti, C Giorio, K Desboeufs, A Zherebker, M Gaetani, C Baldo, G Landrot, S Montebello, S Chevaillier, S Triquet, G Siour, C Di Biagio, F Battaglia, J-F Doussin, A Feron, A Namwoonde, SJ Piketh
Atmospheric Chemistry and Physics
(2025)
25
Rethinking neurodegeneration through a co-proteinopathy lens.
YP Zhang, S Kedia, D Klenerman
Trends in neurosciences
(2025)
48
PhaseXplorer Creates High-Dimensional Phase Diagrams with Closed-Loop Active Learning.
SAH Jansen, LSA Dreyer, J van Basten, Y Yao, DE Otzen, TFA de Greef, TPJ Knowles, EW Meijer, NA Erkamp
ACS nano
(2025)
19
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
Droplet-based microfluidics uncovers hidden kinetic pathways of protein condensates: divergent routes to amyloids and amorphous aggregates.
J Kawakami, T Ozawa, Y Maruyama, H Ishikawa, K Yamauchi, K Kobayashi, S Kajimoto, T Nakabayashi, S Tomita, T Agarwal, T Sneideris, K Nakajima, K Shiraki, H Taguchi, A Hibara, T Knowles, E Chatani, Y Mizuno, Y Ohhashi, M Fukuyama
(2025)
A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TP Knowles, JB Rowe, D Klenerman, G Meisl
Advanced Science
(2025)
Tuning the morphology of aerosolised cellulose nanocrystal particulates via controlled aggregation
D Warnes, W Xu, JH Lim, RM Parker, B Frka-Petesic, R Freshwater, C Honorato-Rios, Y Ogawa, C Giorio, S Vignolini
Carbohydr Polym
(2025)
373
Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions
LSD Jacob, BEH Harvey, C Giorio, AT Archibald
(2025)
Supplementary material to "Determining the key sources of uncertainty in dimethyl sulfide and methanethiol oxidation under tropical, temperate, and polar marine conditions"
LSD Jacob, BEH Harvey, C Giorio, AT Archibald
(2025)
YTHDC1 inhibition as a therapeutic strategy with potent preclinical activity alone and in combination with BCL-2 inhibitors
RC Centore, M Charles, M Arora, M Rebmann, J Cattin, A Howarth, N Bharatham, M Rawling, P Radhakrishnan, S Qamar, M Watson, L Andraghetti, A Seeber, S Cohen, M Kulander, T Knowles, S Arora
Molecular Cancer Therapeutics
(2025)
24
Tau catalyzes amyloid-β aggregation in a fold-dependent manner
M Mosconi, C Leonardi, Z Armour-Garb, B Rocutto, M Beeg, G Meisl, L Ortigosa-Pascual, L Broggini, M Salmona, S Ricagno, TPJ Knowles, L Diomede
(2025)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
Beyond prion-like spreading in neurodegenerative disease
G Meisl, JB Rowe, D Klenerman
Alzheimer's & dementia : the journal of the Alzheimer's Association
(2025)
21
Multi-state Protein Design with DynamicMPNN
A Abrudan, SP Ojeda, CK Joshi, M Greenig, F Engelberger, A Khmelinskaia, J Meiler, M Vendruscolo, TPJ Knowles
(2025)
Oxidative stress generated DNA damage by 6PPD and other tyre additives in A549 human lung epithelial cells
S Hyman, R Bilić, A Jensen, S Saladin, Y Tsybrii, O Nosko, D Topping, A Boies, C Giorio, M Roursgaard, P Møller
Scientific Reports
(2025)
15
Formation and composition of organic aerosols from the uptake of glyoxal on natural mineral dust aerosols: a laboratory study
F Battaglia, P Formenti, C Giorio, M Cazaunau, E Pangui, A Bergé, A Gratien, DL Pereira, T Bertin, JF de Brito, MN Romanias, V Michoud, C Baldo, S Chevaillier, G Noyalet, P Decorse, B Picquet-Varrault, J-F Doussin
Atmospheric Chemistry and Physics
(2025)
25