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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Physical Research Interest Group

A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
– Proceedings of the National Academy of Sciences
(2025)
122,
e2412218122
(DOI: 10.1073/pnas.2412218122)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
– Communications chemistry
(2025)
8,
133
(DOI: 10.1038/s42004-025-01524-z)
Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
– Alzheimer's & dementia : the journal of the Alzheimer's Association
(2025)
21,
e70086
(DOI: 10.1002/alz.70086)
Aggregation of α-synuclein splice isoforms through a phase separation pathway.
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science Advances
(2025)
11,
eadq5396
(DOI: 10.1126/sciadv.adq5396)
Design and sustainability of polypeptide material systems
SK Yorke, Z Yang, EG Wiita, A Kamada, TPJ Knowles, MJ Buehler
– Nature Reviews Materials
(2025)
1
(DOI: 10.1038/s41578-025-00793-3)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
K D’Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
– Science advances
(2025)
11,
eadp8504
(DOI: 10.1126/sciadv.adp8504)
Differential interactions determine anisotropies at interfaces of RNA-based biomolecular condensates.
NA Erkamp, M Farag, Y Qiu, D Qian, T Sneideris, T Wu, TJ Welsh, H Ausserwöger, TJ Krug, G Chauhan, DA Weitz, MD Lew, TPJ Knowles, RV Pappu
– Nature communications
(2025)
16,
3463
(DOI: 10.1038/s41467-025-58736-z)
Scaling relations of multicomponent phase coexistence boundaries
D Qian, J Acker, RM Scrutton, CM Fischer, S Qamar, T Sneideris, A Borodavka, TPJ Knowles
(2025)
(DOI: 10.1101/2025.04.02.645070)
Multi‐Model Assessment of Future Hydrogen Soil Deposition and Lifetime Using CMIP6 Data
MAJ Brown, NJ Warwick, AT Archibald
– Geophysical Research Letters
(2025)
52,
e2024GL113653
(DOI: 10.1029/2024gl113653)
Multi-Model Assessment of Future Hydrogen Soil Deposition and Lifetime Using CMIP6 Data
MAJ Brown, NJ Warwick, AT Archibald
– Geophysical Research Letters
(2025)
52,
(DOI: 10.1029/2024GL113653)
Structural defects in amyloid-β fibrils drive secondary nucleation
J Hu, TJ Scheidt, D Thacker, E Axell, E Stemme, U Lapinska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Saric, J Schmit, T Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
(2025)
(DOI: 10.1101/2025.03.31.646415)
Learning the rules of peptide self-assembly through data mining with large language models
Z Yang, SK Yorke, TPJ Knowles, MJ Buehler
– Science advances
(2025)
11,
eadv1971
(DOI: 10.1126/sciadv.adv1971)
Kinetics of seeded protein aggregation: theory and application
AJ Dear, G Meisl, J Hu, TPJ Knowles, S Linse
(2025)
(DOI: 10.48550/arxiv.2503.20941)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
– Communications biology
(2025)
8,
466
(DOI: 10.1038/s42003-025-07909-z)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nature communications
(2025)
16,
2814
(DOI: 10.1038/s41467-025-58142-5)
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Y Yao, N Erkamp, T Sneideris, X Yang, R Scrutton, MM Schneider, CM Fischer, E Schoenmakers, N Schoenmakers, TPJ Knowles
– Communications Biology
(2025)
8,
466
(DOI: 10.1038/s42003-025-07909-z)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nature Communications
(2025)
16,
2814
(DOI: 10.1038/s41467-025-58142-5)
Short-lived reactive components substantially contribute to particulate matter oxidative potential
SJ Campbell, B Utinger, A Barth, Z Leni, Z-H Zhang, J Resch, K Li, SS Steimer, C Banach, B Gfeller, FPH Wragg, J Westwood, K Wolfer, N Bukowiecki, M Ihalainen, P Yli-Pirilä, M Somero, M Kortelainen, J Louhisalmi, M Sklorz, H Czech, S di Bucchianico, T Streibel, MN Delaval, C Ruger, N Baumlin, M Salathe, Z Fang, M Pardo, S D'Aronco, C Giorio, Z Shi, RM Harrison, DC Green, FJ Kelly, Y Rudich, SE Paulson, O Sippula, R Zimmermann, M Geiser, M Kalberer
– Science Advances
(2025)
11,
eadp8100
(DOI: 10.1126/sciadv.adp8100)
Oxidative Potential of Indoor Particulate Matter Collected During Campaigns in the UK, Slovenia, and Sweden
A Zherebker, M Williams, C Giorio
(2025)
(DOI: 10.5194/egusphere-egu25-19806)
The UK Environmental Impacts of Hydrogen Energy Programme
N Warwick, A Archibald, P Dodds, E Nemitz, H ApSimon, J Drewer
(2025)
(DOI: 10.5194/egusphere-egu25-10785)

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