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Department of Chemistry

 
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
Determination of protein structural ensembles using cryo-electron microscopy.
M Bonomi, M Vendruscolo
– Curr Opin Struct Biol
(2018)
56,
37
Computational advances in combating colloidal aggregation in drug discovery.
D Reker, GJL Bernardes, T Rodrigues
– Nat Chem
(2019)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
– Sci Rep
(2019)
9,
5822
Determination of the Structural Ensemble of the Molten Globule State of a Protein by Computer Simulations
M Shimizu, Y Kajikawa, K Kuwajima, CM Dobson, Y Okamoto
– Proteins
(2019)
prot.25688
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nature communications
(2019)
10,
1541
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
– Neuroscience letters
(2019)
704,
89
Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, RA Peralta
– Dalton Transactions
(2019)
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
CM Dobson, TPJ Knowles, M Vendruscolo
– Cold Spring Harbor Perspectives in Biology
(2019)
a033878
Human pregnancy zone protein stabilises misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
– Proceedings of the National Academy of Sciences
(2019)
116,
6101
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
– ACS Chem Biol
(2019)
acschembio.8b01104
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2019)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
– Leukemia
(2019)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
– Macromol Rapid Commun
(2019)
1800898
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
– Scientific reports
(2019)
9,
3680
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis
P Sormanni, M Vendruscolo
– Cold Spring Harbor perspectives in biology
(2019)
a033845
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
– Nature Reviews Chemistry
(2019)
3,
147
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
– ACS chemical neuroscience
(2019)
acschemneuro.8b00676
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage.
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
– J Am Chem Soc
(2019)
141,
4063
The AAA plus protease ClpXP can easily degrade a 3(1) and a 5(2)-knotted protein
EM Sivertsson, SE Jackson, LS Itzhaki
– Sci Rep
(2019)
9,
2421