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Recent Publications from the Biological Research Interest Group

Thermodynamics of polypeptide supramolecular assembly in the short chain limit.
TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell
– Journal of the American Chemical Society
(2017)
Absolute Quantification of Amyloid Propagons by Digital Microfluidics.
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sanchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, AA Aguzzi, S Hornemann
– Anal Chem
(2017)
Gradient-free determination of isoelectric points of proteins on chip.
U Łapińska, KL Saar, EV Yates, TW Herling, T Müller, PK Challa, CM Dobson, TPJ Knowles
– Physical chemistry chemical physics : PCCP
(2017)
19,
23060
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.
BIM Wicky, SL Shammas, J Clarke
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
9882
Methods of probing the interactions between small molecules and disordered proteins.
GT Heller, FA Aprile, M Vendruscolo
– Cellular and Molecular Life Sciences
(2017)
74,
3225
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, M Vendruscolo
– Journal of molecular biology
(2017)
429,
2772
Correction: Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling.
WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace
– Org Biomol Chem
(2017)
15,
7476
Nickel-Catalyzed Azide-Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water.
WG Kim, ME Kang, JB Lee, MH Jeon, S Lee, J Lee, B Choi, PMSD Cal, S Kang, J-M Kee, GJL Bernardes, J-U Rohde, W Choe, SY Hong
– Journal of the American Chemical Society
(2017)
139,
12121
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress alpha-synuclein aggregation
FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
– Scientific reports
(2017)
7,
9039
Rapid and accurate in silico solubility screening of a monoclonal antibody library.
P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic
– Scientific reports
(2017)
7,
8200
Sequential Release of Proteins from Structured Multishell Microcapsules
U Shimanovich, TCT Michaels, E De Genst, D Matak-Vinkovic, CM Dobson, TPJ Knowles
– Biomacromolecules
(2017)
THERAPEUTICS Click and discover
GS Vassiliou, S Balasubramanian
– Nature
(2017)
548,
162
Computationally guided discovery of a reactive, hydrophilic trans-5-oxocene dienophile for bioorthogonal labeling
WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace
– Org Biomol Chem
(2017)
15,
6640
Monomeric and fibrillar alpha-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of A beta 42 aggregates
S Chia, P Flagmeier, J Habchi, V Lattanzi, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
8005
Silk micrococoons for protein stabilisation and molecular encapsulation
U Shimanovich, FS Ruggeri, E De Genst, J Adamcik, TP Barros, D Porter, T Müller, R Mezzenga, CM Dobson, F Vollrath, C Holland, TPJ Knowles
– Nature Communications
(2017)
8,
15902
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703
The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases.
N Cremades, CM Dobson
– Neurobiology of disease
(2017)
Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species
M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
57
Inverse electron demand Diels-Alder reactions in chemical biology
BL Oliveira, Z Guo, GJL Bernardes
– Chemical Society reviews
(2017)
46,
4895
Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
R Kundra, P Ciryam, RI Morimoto, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2017)
114,
E5703