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Yusuf Hamied Department of Chemistry

The N-terminal acetylation of α-synuclein slows down its aggregation process and alters the morphology of the resulting aggregates
R Bell, RJ Thrush, M Castellana-Cruz, M Oeller, R Staats, A Nene, P Flagmeier, CK Xu, S Satapathy, C Galvagnion, MR Wilson, CM Dobson, JR Kumita, M Vendruscolo
– Biochemistry
Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis
O Bilyk, GS Oliveira, RM de Angelo, MO Almeida, KM Honório, FJ Leeper, MVB Dias, PF Leadlay
– Journal of the American Chemical Society
Chemical and Enzymatic Methods for Post-Translational Protein–Protein Conjugation
RJ Taylor, MB Geeson, T Journeaux, GJL Bernardes
– Journal of the American Chemical Society
ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy.
C Olivieri, GC Li, Y Wang, M V S, C Walker, J Kim, C Camilloni, A De Simone, M Vendruscolo, DA Bernlohr, SS Taylor, G Veglia
– Science Advances
Adsorption free energy predicts amyloid protein nucleation rates.
Z Toprakcioglu, A Kamada, TCT Michaels, M Xie, J Krausser, J Wei, A Saric, M Vendruscolo, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
Metabolic Glycan Labelling of Cancer Cells using Variably Acetylated Monosaccharides
DR Parle, F Bulat, S Fouad, H Zecchini, KM Brindle, AA Neves, FJ Leeper
– Bioconjugate chemistry
Are casein micelles extracellular condensates formed by liquid‐liquid phase separation?
A Horvath, M Fuxreiter, M Vendruscolo, C Holt, JA Carver
– FEBS Letters
Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
H Mikolajek, M Weckener, ZF Brotzakis, J Huo, EV Dalietou, A Le Bas, P Sormanni, PJ Harrison, PN Ward, S Truong, L Moynie, DK Clare, M Dumoux, J Dormon, C Norman, N Hussain, V Vogirala, RJ Owens, M Vendruscolo, JH Naismith
– Proc Natl Acad Sci U S A
π‑Clamp-Mediated Homo- and Heterodimerization of Single-Domain Antibodies via Site-Specific Homobifunctional Conjugation
RJ Taylor, M Aguilar Rangel, MB Geeson, P Sormanni, M Vendruscolo, GJL Bernardes
– Journal of the American Chemical Society
Mechanistic insights into the rational design of masked antibodies.
CT Orozco, M Bersellini, LM Irving, WW Howard, D Hargreaves, PWA Devine, E Siouve, GJ Browne, NJ Bond, JJ Phillips, P Ravn, SE Jackson
– MAbs
Controlled masking and targeted release of redox-cycling ortho-quinones via a C-C bond-cleaving 1,6-elimination
L Dunsmore, CD Navo, J Becher, EG de Montes, A Guerreiro, E Hoyt, L Brown, V Zelenay, S Mikutis, J Cooper, I Barbieri, S Lawrinowitz, E Siouve, E Martin, PR Ruivo, T Rodrigues, FP da Cruz, O Werz, G Vassiliou, P Ravn, G Jiménez-Osés, GJL Bernardes
– Nature chemistry
Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity.
AHY Chan, I Fathoni, TCS Ho, KJ Saliba, FJ Leeper
– RSC Medicinal Chemistry
Platform for Orthogonal N‑Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents
A Istrate, MB Geeson, CD Navo, BB Sousa, MC Marques, RJ Taylor, T Journeaux, SR Oehler, MR Mortensen, MJ Deery, AD Bond, F Corzana, G Jiménez-Osés, GJL Bernardes
– J Am Chem Soc
A Small Molecule Stabilizes the Disordered Native State of the Alzheimer's Aβ Peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
– ACS Chemical Neuroscience
Determination of the structure and dynamics of the fuzzy coat of an amyloid fibril of IAPP using cryo-electron microscopy
F Brotzakis, T Löhr, S Truong, S Hoff, M Bonomi, M Vendruscolo
FuzDrop on AlphaFold: visualizing the sequence-dependent propensity of liquid-liquid phase separation and aggregation of proteins.
A Hatos, SCE Tosatto, M Vendruscolo, M Fuxreiter
– Nucleic Acids Research
Toward Rapid Aspartic Acid Isomer Localization in Therapeutic Peptides Using Cyclic Ion Mobility Mass Spectrometry.
K Gibson, DA Cooper-Shepherd, E Pallister, SE Inman, SE Jackson, V Lindo
– Journal of The American Society for Mass Spectrometry
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, M Mortensen, L Sakhnini, P Sormanni
The Impact of Activity‐Based Protein Profiling in Malaria Drug Discovery
LAR Carvalho, GJL Bernardes
– ChemMedChem
Conformational Entropy as a Potential Liability of Computationally Designed Antibodies.
T Löhr, P Sormanni, M Vendruscolo
– Biomolecules