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Recent Publications from the Biological Research Interest Group

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State.
M Runfola, A De Simone, M Vendruscolo, CM Dobson, G Fusco
– Sci Rep
(2020)
10,
204
(DOI: 10.1038/s41598-019-57023-4)
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
T Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, A Dear, S Cohen, M Vendruscolo, C Dobson, S Linse, T Knowles
(2020)
(DOI: 10.1101/2020.01.08.897488)
Proteome-wide observation of the phenomenon of life on the edge of solubility
G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, FU Hartl, M Vendruscolo
– Proc Natl Acad Sci U S A
(2019)
117,
201910444
(DOI: 10.1073/pnas.1910444117)
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains
M Maritan, M Romeo, L Oberti, P Sormanni, M Tasaki, R Russo, A Ambrosetti, P Motta, P Rognoni, G Mazzini, A Barbiroli, G Palladini, M Vendruscolo, L Diomede, M Bolognesi, G Merlini, F Lavatelli, S Ricagno
– Journal of molecular biology
(2019)
(DOI: 10.1016/j.jmb.2019.12.015)
Homage to Chris Dobson.
J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia
– Front Mol Biosci
(2019)
6,
137
(DOI: 10.3389/fmolb.2019.00137)
Determination of a Structural Ensemble Representing the Dynamics of a G-Quadruplex DNA.
G Portella, M Orozco, M Vendruscolo
– Biochemistry
(2019)
acs.biochem.9b00493
(DOI: 10.1021/acs.biochem.9b00493)
Proteome-wide survey of cysteine oxidation using a norbornene probe.
LJ Alcock, M Langini, K Stühler, M Remke, MV Perkins, GJL Bernardes, JM Chalker
– Chembiochem : a European journal of chemical biology
(2019)
cbic.201900729
(DOI: 10.1002/cbic.201900729)
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
P Ciryam, M Antalek, F Cid, GG Tartaglia, CM Dobson, A-K Guettsches, B Eggers, M Vorgerd, K Marcus, RA Kley, RI Morimoto, M Vendruscolo, CC Weihl
– Acta neuropathologica communications
(2019)
7,
197
(DOI: 10.1186/s40478-019-0853-9)
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Machine learning for target discovery in drug development.
T Rodrigues, GJL Bernardes
– Curr Opin Chem Biol
(2019)
56,
16
(DOI: 10.1016/j.cbpa.2019.10.003)
Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis
R Little, FCR Paiva, R Jenkins, H Hong, Y Sun, Y Demydchuk, M Samborskyy, M Tosin, FJ Leeper, MVB Dias, PF Leadlay
– Nature Catalysis
(2019)
2,
1045
(DOI: 10.1038/s41929-019-0351-2)
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.
R Freer, P Sormanni, P Ciryam, B Rammner, SO Rizzoli, CM Dobson, M Vendruscolo
– Heliyon
(2019)
5,
e02589
(DOI: 10.1016/j.heliyon.2019.e02589)
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons
MA Metrick, N do Carmo Ferreira, E Saijo, AG Hughson, A Kraus, C Orrú, MW Miller, G Zanusso, B Ghetti, M Vendruscolo, B Caughey
– Proceedings of the National Academy of Sciences of the United States of America
(2019)
116,
23029
(DOI: 10.1073/pnas.1909322116)
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.
DC Delivoria, S Chia, J Habchi, M Perni, I Matis, N Papaevgeniou, M Reczko, N Chondrogianni, CM Dobson, M Vendruscolo, G Skretas
– Science Advances
(2019)
5,
eaax5108
(DOI: 10.1126/sciadv.aax5108)
Probing the dynamic stalk region of the ribosome using solution NMR
X Wang, JP Kirkpatrick, HMM Launay, A de Simone, D Häussinger, CM Dobson, M Vendruscolo, LD Cabrita, CA Waudby, J Christodoulou
– Sci Rep
(2019)
9,
13528
(DOI: 10.1038/s41598-019-49190-1)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, TPJ Knowles, M Nelson, MA Czekalska, G Musteikyte, MA Gachechiladze, CA Stephens, HA Pasolli, LR Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
– Cell
(2019)
179,
147
(DOI: 10.1016/j.cell.2019.08.050)
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– J Med Chem
(2019)
62,
10586
(DOI: 10.1021/acs.jmedchem.9b01203)
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.
FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
– Journal of visualized experiments : JoVE
(2019)
ARTN e60108
(DOI: 10.3791/60108)
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– The Biochemical journal
(2019)
476,
3125
(DOI: 10.1042/BCJ20190318)
Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly.
K Wang, D de la Torre, WE Robertson, JW Chin
– Science (New York, N.Y.)
(2019)
365,
922
(DOI: 10.1126/science.aay0737)

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