Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry

S Boss, P Barker, J Field, A Peel

(2026)

(doi: 10.1039/9781837676347)

Prediction of antibody non-specificity using protein language models and biophysical parameters.

LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata

mAbs

(2026)

2678000

(doi: 10.1080/19420862.2026.2678000)

Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations

AAB Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer

(2026)

(doi: 10.64898/2026.05.22.727278)

Does the sequence of a disordered protein encode small molecule binding paths?

A Louet, G Hummer, M Vendruscolo

(2026)

(doi: 10.64898/2026.05.20.726646)

Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues

G Battistoni, S Torres-Garcia, CY Sia, S Corriero, C Boquetale, E Williams, A Cregeen, K Wasilewska, M Alini, N Hemmer, IMAXT Cancer Grand Challenge Consortium, S Balasubramanian, BC Nicholson, GJ Hannon, D Bressan

Proceedings of the National Academy of Sciences

(2026)

123

e2527896123

(doi: 10.1073/pnas.2527896123)

<i>In vitro</i> and <i>in vivo</i> inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.

MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos

Dalton Trans

(2026)

(doi: 10.1039/d5dt02853a)

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments.

R Blanco-Domínguez, AM Vaz-Pinto, L Barros, N Lopes, B Henriques-Alves, M Carreira, C Labão-Almeida, JC Ribot, GJL Bernardes, B Silva-Santos, S Mensurado

Journal of Experimental Medicine

(2026)

223

e20252133

(doi: 10.1084/jem.20252133)

Glutathione-responsive fragmentation of heteronorbornadiene-based thiovinyl sulfones in glioma cells

M Carranza, AT Carmona, E Gil de Montes, Y Méndez, I Černauskienė, GJL Bernardes, AJ Moreno-Vargas

Bioconjug Chem

(2026)

906

(doi: 10.1021/acs.bioconjchem.5c00581)

Spatially patterned, spectral single-molecule microscopy

JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee

(2026)

(doi: 10.64898/2026.04.08.715690)

Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin

V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo

Communications chemistry

(2026)

194

(doi: 10.1038/s42004-026-01950-7)

Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals

CM Lim, M Vendruscolo

(2026)

(doi: 10.64898/2026.04.05.716624)

Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2

A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni

mAbs

(2026)

2646361

(doi: 10.1080/19420862.2026.2646361)

Systems-level organization of extracellular proteostasis

CM Gomes, M Vendruscolo

Science (New York, N.Y.)

(2026)

391

1332

(doi: 10.1126/science.aed3712)

Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis.

H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes

ACS Chem Biol

(2026)

674

(doi: 10.1021/acschembio.5c00935)

Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras.

Z Wang, X He, X Zhang, J Spiegel, SM Flynn, S Balasubramanian

Nature chemistry

(2026)

1092

(doi: 10.1038/s41557-026-02111-y)

OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening

J Hanke, SP Ojeda, RW Cheong, LM Glasstetter, E Baker, H Lam, M Brezinova, A Louet, S Zhang, M Vendruscolo

(2026)

(doi: 10.64898/2026.03.17.712433)

The α-synuclein proteostasis network and its translational applications in Parkinson’s disease

CM Lim, M Vendruscolo

Proceedings of the National Academy of Sciences of the United States of America

(2026)

123

e2513317123

(doi: 10.1073/pnas.2513317123)

Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating

K Hu, S Srivastava, B Ma, Y Yang, H Wang, M Mangolini, J Hayre, E Souster, R Karattil, A Ramon, M Greenig, P Sormanni, S Cordoba, S Onuoha

(2026)

(doi: 10.64898/2026.03.10.710759)

FuzDrop: sequence-based prediction of the propensity of proteins for liquid–liquid phase separation and aggregation

M Vendruscolo, M Fuxreiter

Nat Protoc

(2026)

2016

(doi: 10.1038/s41596-025-01267-0)

Correction to “Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay”

A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo

Journal of the American Chemical Society

(2026)

148

12423

(doi: 10.1021/jacs.5c18723)

Rational Design of Nanobodies Targeting LINGO‐1

A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo

Applied Research

(2026)

e70071

(doi: 10.1002/appl.70071)

Toward a unified framework for determining conformational ensembles of disordered proteins

H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon

Nature methods

(2026)

705

(doi: 10.1038/s41592-026-03003-2)