Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Communications chemistry
(2026)
Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals
CM Lim, M Vendruscolo
(2026)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2.
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
mAbs
(2026)
18
Systems-level organization of extracellular proteostasis
CM Gomes, M Vendruscolo
Science
(2026)
391
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis
H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes
ACS Chem Biol
(2026)
21
Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras
Z Wang, X He, X Zhang, J Spiegel, SM Flynn, S Balasubramanian
Nat Chem
(2026)
OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening
J Hanke, SP Ojeda, RW Cheong, LM Glasstetter, E Baker, H Lam, M Brezinova, A Louet, S Zhang, M Vendruscolo
(2026)
The α-synuclein proteostasis network and its translational applications in Parkinson's disease.
CM Lim, M Vendruscolo
Proceedings of the National Academy of Sciences
(2026)
123
Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
K Hu, S Srivastava, B Ma, Y Yang, H Wang, M Mangolini, J Hayre, E Souster, R Karattil, A Ramon, M Greenig, P Sormanni, S Cordoba, S Onuoha
(2026)
FuzDrop: sequence-based prediction of the propensity of proteins for liquid–liquid phase separation and aggregation
M Vendruscolo, M Fuxreiter
Nature Protocols
(2026)
Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay".
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
J Am Chem Soc
(2026)
148
Toward a unified framework for determining conformational ensembles of disordered proteins
H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon
Nat Methods
(2026)
23
Rational Design of Nanobodies Targeting LINGO‐1
A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo
Applied Research
(2026)
5
Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores
E Smorodina, M Ali, KK Brumat, L Salicari, S Miklavc, A Kappassov, C Fu, P Sormanni, A de Marco, V Greiff
(2026)
Dissecting the Binding Interactions of the Chromatin Remodeler SMARCA4 with G‑Quadruplex DNA
SK Madden, D Tannahill, S Balasubramanian
Biochemistry
(2026)
65
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system
FBH Rehm, KC Liu, R Tian, JW Chin
Nature biotechnology
(2026)
Structural defects in amyloid-β fibrils drive secondary nucleation.
J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Šarić, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
Nat Commun
(2026)
17
Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations
MS Foiani, RS Nirujogi, N Watamura, S Bez, E Tsefou, A Santambrogio, S Patel, H Davies, C Goulbourne, N Fatima, T Birkle, E Camporesi, G Brinkmalm, H Zetterberg, M Wilkinson, SE Radford, NA Ranson, P Maglio-Cauhy, E Turkes, A Avdic-Belltheus, I Rawlinson, X Prebibaj, L Panti, D Gavriouchkina, M Blunskyte-Hendley, T Saido, M Vendruscolo, R Frank, M Bourdenx, KE Duff
bioRxiv
(2026)
Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification
A Santambrogio, MA Metrick, P Xu, NCT Gallagher, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo
Alzheimer's & Dementia
(2026)
22
Disulphide and sequence-encoded conformational priors guide nanobody structure prediction
M Ali, M Jaskolowski, M Greenig, TH Nguyen, M Crnogaj, E Smorodina, A Ramon, H Zhao, ML Fernández-Quintero, E Ghedin, V Greiff, P Sormanni
(2026)
Metadiffusion: inference-time meta-energy biasing of biomolecular diffusion models
HYI Lam, SP Ojeda, M Brezinova, J Hanke, XE Ong, Y Mu, M Vendruscolo
(2026)
Sequencing DNA methylation and hydroxymethylation at co-occurring chromatin features.
RDC Araujo Tavares, S Dhir, X He, J Monahan, M Taipale, P Golder, A Ciau-Uitz, W Gosal, D Tannahill, S Balasubramanian
Nature communications
(2026)
17
Understanding Biology with Machine Learning: Compression, Intelligibility, and Dependency
E Lawrence, A El-Shazly, S Seal, CK Joshi, P Liò, A Bender, S Singh, P Sormanni, O Spjuth, M Greenig
Artificial Intelligence in the Life Sciences
(2026)
9
A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex.
CAT Brega, BA Craig, S Mikutis, RSJ Proctor, Y Vyborna, G Ivey, M Eleftheriou, K Tzelepis, M Yang, S Parmar, J Bonet-Aleta, JS Schneekloth, GJL Bernardes
Chemistry A European Journal
(2026)