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Department of Chemistry

 
The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State.
M Runfola, A De Simone, M Vendruscolo, CM Dobson, G Fusco
– Sci Rep
(2020)
10,
204
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
T Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, A Dear, S Cohen, M Vendruscolo, C Dobson, S Linse, T Knowles
(2020)
Proteome-wide observation of the phenomenon of life on the edge of solubility
G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, FU Hartl, M Vendruscolo
– Proc Natl Acad Sci U S A
(2019)
117,
201910444
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains
M Maritan, M Romeo, L Oberti, P Sormanni, M Tasaki, R Russo, A Ambrosetti, P Motta, P Rognoni, G Mazzini, A Barbiroli, G Palladini, M Vendruscolo, L Diomede, M Bolognesi, G Merlini, F Lavatelli, S Ricagno
– Journal of molecular biology
(2019)
Homage to Chris Dobson.
J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia
– Front Mol Biosci
(2019)
6,
137
Determination of a Structural Ensemble Representing the Dynamics of a G-Quadruplex DNA.
G Portella, M Orozco, M Vendruscolo
– Biochemistry
(2019)
acs.biochem.9b00493
Proteome-wide survey of cysteine oxidation using a norbornene probe.
LJ Alcock, M Langini, K Stühler, M Remke, MV Perkins, GJL Bernardes, JM Chalker
– Chembiochem : a European journal of chemical biology
(2019)
cbic.201900729
A metastable subproteome underlies inclusion formation in muscle proteinopathies.
P Ciryam, M Antalek, F Cid, GG Tartaglia, CM Dobson, A-K Guettsches, B Eggers, M Vorgerd, K Marcus, RA Kley, RI Morimoto, M Vendruscolo, CC Weihl
– Acta neuropathologica communications
(2019)
7,
197
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
Machine learning for target discovery in drug development.
T Rodrigues, GJL Bernardes
– Curr Opin Chem Biol
(2019)
56,
16
Unexpected enzyme-catalysed [4+2] cycloaddition and rearrangement in polyether antibiotic biosynthesis
R Little, FCR Paiva, R Jenkins, H Hong, Y Sun, Y Demydchuk, M Samborskyy, M Tosin, FJ Leeper, MVB Dias, PF Leadlay
– Nature Catalysis
(2019)
2,
1045
Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.
R Freer, P Sormanni, P Ciryam, B Rammner, SO Rizzoli, CM Dobson, M Vendruscolo
– Heliyon
(2019)
5,
e02589
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons
MA Metrick, N do Carmo Ferreira, E Saijo, AG Hughson, A Kraus, C Orrú, MW Miller, G Zanusso, B Ghetti, M Vendruscolo, B Caughey
– Proceedings of the National Academy of Sciences of the United States of America
(2019)
116,
23029
Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.
DC Delivoria, S Chia, J Habchi, M Perni, I Matis, N Papaevgeniou, M Reczko, N Chondrogianni, CM Dobson, M Vendruscolo, G Skretas
– Science Advances
(2019)
5,
eaax5108
Probing the dynamic stalk region of the ribosome using solution NMR
X Wang, JP Kirkpatrick, HMM Launay, A de Simone, D Häussinger, CM Dobson, M Vendruscolo, LD Cabrita, CA Waudby, J Christodoulou
– Sci Rep
(2019)
9,
13528
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, TPJ Knowles, M Nelson, MA Czekalska, G Musteikyte, MA Gachechiladze, CA Stephens, HA Pasolli, LR Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
– Cell
(2019)
179,
147
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– J Med Chem
(2019)
62,
10586
Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.
FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
– Journal of visualized experiments : JoVE
(2019)
ARTN e60108
(DOI: 10.3791/60108)
Structural insights into Escherichia coli phosphopantothenoylcysteine synthetase by native ion mobility–mass spectrometry
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MVB Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– The Biochemical journal
(2019)
476,
3125
Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly.
K Wang, D de la Torre, WE Robertson, JW Chin
– Science (New York, N.Y.)
(2019)
365,
922