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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Conformational Entropy as a Potential Liability of Computationally Designed Antibodies
T Löhr, P Sormanni, M Vendruscolo
– Biomolecules
(2022)
12,
718
(DOI: 10.3390/biom12050718)
The Impact of Activity-Based Protein Profiling in Malaria Drug Discovery.
LAR Carvalho, GJL Bernardes
– ChemMedChem
(2022)
e202200174
(DOI: 10.1002/cmdc.202200174)
Structural insights into TRPV2 activation by small molecules
RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, GJL Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell
– Nature communications
(2022)
13,
2334
(DOI: 10.1038/s41467-022-30083-3)
Structural insights into TRPV2 activation by small molecules
RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, G Lopes Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell
– Nature Communications
(2022)
13,
(DOI: 10.1038/s41467-022-30083-3)
Author Correction: Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles (Scientific Reports, (2018), 8, 1, (2440), 10.1038/s41598-018-20754-x)
S Abalde-Cela, P Taladriz-Blanco, MG de Oliveira, C Abell
– Scientific Reports
(2022)
12,
6559
(DOI: 10.1038/s41598-022-10761-4)
Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo
TCL Kohs, SR Olson, J Pang, KR Jordan, TJ Zheng, A Xie, J Hodovan, M Muller, C McArthur, J Johnson, BB Sousa, M Wallisch, P Kievit, JE Aslan, JD Seixas, GJL Bernardes, MT Hinds, JR Lindner, OJT McCarty, C Puy, JJ Shatzel
– Cellular and Molecular Bioengineering
(2022)
15,
1
(DOI: 10.1007/s12195-022-00723-1)
A Brain-Permeable Aminosterol Regulates Cell Membranes to Mitigate the Toxicity of Diverse Pore-Forming Agents
RP Kreiser, AK Wright, LR Sasser, DJ Rinauro, JM Gabriel, CM Hsu, JA Hurtado, TL McKenzie, S Errico, JA Albright, L Richardson, VA Jaffett, DE Riegner, LT Nguyen, K LeForte, M Zasloff, JE Hollows, F Chiti, M Vendruscolo, R Limbocker
– ACS Chem Neurosci
(2022)
13,
1219
(DOI: 10.1021/acschemneuro.1c00840)
Early detection of cancer
D Crosby, S Bhatia, KM Brindle, LM Coussens, C Dive, M Emberton, S Esener, RC Fitzgerald, SS Gambhir, P Kuhn, TR Rebbeck, S Balasubramanian
– Science (New York, N.Y.)
(2022)
375,
eaay9040
(DOI: 10.1126/science.aay9040)
Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry
X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana
– Journal of the American Chemical Society
(2022)
144,
5284
(DOI: 10.1021/jacs.1c07675)
Potential therapeutic targets from Mycobacterium abscessus ( Mab ): recently reported efforts towards the discovery of novel antibacterial agents to treat Mab infections
W Addison, M Frederickson, AG Coyne, C Abell
– RSC Medicinal Chemistry
(2022)
13,
392
(DOI: 10.1039/d1md00359c)
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
JA Douthwaite, CA Brown, JR Ferdinand, R Sharma, J Elliott, MA Taylor, NT Malintan, H Duvoisin, T Hill, O Delpuech, AL Orton, H Pitt, F Kuenzi, S Fish, DJ Nicholls, A Cuthbert, I Richards, G Ratcliffe, A Upadhyay, A Marklew, C Hewitt, D Ross-Thriepland, C Brankin, M Chodorge, G Browne, PK Mander, RM DeWildt, S Weaver, PA Smee, J van Kempen, JG Bartlett, PM Allen, EL Koppe, CA Ashby, JD Phipps, N Mehta, DJ Brierley, DG Tew, MV Leveridge, SM Baddeley, IG Goodfellow, C Green, C Abell, A Neely, I Waddell, S Rees, PH Maxwell, MN Pangalos, R Howes, R Clark
– Scientific reports
(2022)
12,
3114
(DOI: 10.1038/s41598-022-06873-6)
RBBP6 activates the pre-mRNA 3' end processing machinery in humans
V Boreikaite, TS Elliott, JW Chin, LA Passmore
– Genes & development
(2022)
36,
210
(DOI: 10.1101/gad.349223.121)
Mechanism-based traps enable protease and hydrolase substrate discovery
S Tang, AT Beattie, L Kafkova, G Petris, N Huguenin-Dezot, M Fiedler, M Freeman, JW Chin
– Nature
(2022)
602,
701
(DOI: 10.1038/s41586-022-04414-9)
Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates
G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo
– Chemical Science
(2022)
(DOI: 10.1039/D1SC01928G)
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
D Aggarwal, B Warne, AS Jahun, WL Hamilton, T Fieldman, L du Plessis, V Hill, B Blane, E Watkins, E Wright, G Hall, C Ludden, R Myers, M Hosmillo, Y Chaudhry, ML Pinckert, I Georgana, R Izuagbe, D Leek, O Nsonwu, GJ Hughes, S Packer, AJ Page, M Metaxaki, S Fuller, G Weale, J Holgate, CA Brown, Cambridge Covid-19 testing Centre, University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium, COVID-19 Genomics UK (COG-UK) Consortium, R Howes, D McFarlane, G Dougan, OG Pybus, DD Angelis, PH Maxwell, SJ Peacock, MP Weekes, C Illingworth, EM Harrison, NJ Matheson, IG Goodfellow
– Nature communications
(2022)
13,
751
(DOI: 10.1038/s41467-021-27942-w)
Discovery of Novel Inhibitors of Uridine Diphosphate- N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
M Acebrón-García-de-Eulate, J Mayol-Llinàs, MTO Holland, SY Kim, KP Brown, C Marchetti, J Hess, O Di Pietro, V Mendes, C Abell, RA Floto, AG Coyne, TL Blundell
– Journal of medicinal chemistry
(2022)
65,
2149
(DOI: 10.1021/acs.jmedchem.1c01684)
Transition metal mediated bioorthogonal release
V Sabatino, VB Unnikrishnan, GJL Bernardes
– Chem Catalysis
(2022)
2,
39
(DOI: 10.1016/j.checat.2021.12.007)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.
NJ Smyllie, J Bagnall, AA Koch, D Niranjan, L Polidarova, JE Chesham, JW Chin, CL Partch, ASI Loudon, MH Hastings
– Proc Natl Acad Sci U S A
(2022)
119,
e2113845119
(DOI: 10.1073/pnas.2113845119)
Development of Inhibitors of SAICAR Synthetase (PurC) from <i>Mycobacterium abscessus</i> Using a Fragment-Based Approach.
S Charoensutthivarakul, SE Thomas, A Curran, KP Brown, JM Belardinelli, AJ Whitehouse, M Acebrón-García-de-Eulate, J Sangan, SG Gramani, M Jackson, V Mendes, RA Floto, TL Blundell, AG Coyne, C Abell
– ACS Infect Dis
(2022)
8,
296
(DOI: 10.1021/acsinfecdis.1c00432)
Sequence Determinants of the Aggregation of Proteins Within Condensates Generated by Liquid-liquid Phase Separation.
M Vendruscolo, M Fuxreiter
– Journal of molecular biology
(2022)
434,
167201
(DOI: 10.1016/j.jmb.2021.167201)

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