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Recent Publications from the Biological Research Interest Group

Single molecule secondary structure determination of proteins through infrared absorption nanospectroscopy
FS Ruggeri, B Mannini, R Schmid, M Vendruscolo, TPJ Knowles
– Nat Commun
(2020)
11,
2945
(DOI: 10.1038/s41467-020-16728-1)
The antidiabetic drug lobeglitazone has the potential to inhibit PTP1B activity
RF Rocha, T Rodrigues, ACO Menegatti, GJL Bernardes, H Terenzi
– Bioorg Chem
(2020)
100,
103927
(DOI: 10.1016/j.bioorg.2020.103927)
Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles.
T Hakala, F Bialas, Z Toprakcioglu, B Bräuer, KN Baumann, A Levin, GJL Bernardes, CFW Becker, TPJ Knowles
– ACS Appl Mater Interfaces
(2020)
acsami.0c09226
(DOI: 10.1021/acsami.0c09226)
Rationally designed antibodies as research tools to study the > structure-toxicity relationship of amyloid-b oligomers
R Limbocker, B Mannini, R Cataldi, S Chhangur, AK Wright, RP Kreiser, JA Albright, S Chia, J Habchi, P Sormanni, JR Kumita, FS Ruggeri, CM Dobson, F Chiti, FA Aprile, M Vendruscolo
– International journal of molecular sciences
(2020)
21,
4542
(DOI: 10.3390/ijms21124542)
Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling
B Bernardim, L Dunsmore, H Li, B Hocking, R Nuñez-Franco, CD Navo, G Jiménez-Osés, ACB Burtoloso, GJL Bernardes
– Bioconjugate chemistry
(2020)
31,
1604
(DOI: 10.1021/acs.bioconjchem.0c00232)
Tetrazine carbon nanotubes for pretargeted in vivo 'click-to-release' bioorthogonal tumour imaging.
H Li, J Conde, A Guerreiro, GJL Bernardes
– Angew Chem Int Ed Engl
(2020)
ange.202008012
(DOI: 10.1002/anie.202008012)
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
FA Aprile, P Sormanni, M Podpolny, S Chhangur, L-M Needham, FS Ruggeri, M Perni, R Limbocker, GT Heller, T Sneideris, T Scheidt, B Mannini, J Habchi, SF Lee, PC Salinas, TPJ Knowles, CM Dobson, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2020)
117,
13509
(DOI: 10.1073/pnas.1919464117)
Platinum-triggered Bond-cleavage of Pentynoyl amide and N-propargyl handles for Drug-Activation
BL Oliveira, BJ Stenton, VB Unnikrishnan, CR de Almeida, J Conde, M Negrão, FSS Schneider, C Cordeiro, MG Ferreira, GF Caramori, JB Domingos, R Fior, GJL Bernardes
– Journal of the American Chemical Society
(2020)
142,
10869
(DOI: 10.1021/jacs.0c01622)
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors
K McAulay, EA Hoyt, M Thomas, M Schimpl, MS Bodnarchuk, HJ Lewis, D Barratt, D Bhavsar, DM Robinson, MJ Deery, DJ Ogg, GJL Bernardes, RA Ward, MJ Waring, JG Kettle
– J Am Chem Soc
(2020)
142,
10358
(DOI: 10.1021/jacs.9b13391)
Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids
DL Dunkelmann, JCW Willis, AT Beattie, JW Chin
– Nature chemistry
(2020)
12,
535
(DOI: 10.1038/s41557-020-0472-x)
Reduced proteasome activity in the aging brain results in ribosome stoichiometry loss and aggregation.
E Kelmer Sacramento, JM Kirkpatrick, M Mazzetto, M Baumgart, A Bartolome, S Di Sanzo, C Caterino, M Sanguanini, N Papaevgeniou, M Lefaki, D Childs, S Bagnoli, E Terzibasi Tozzini, D Di Fraia, N Romanov, PH Sudmant, W Huber, N Chondrogianni, M Vendruscolo, A Cellerino, A Ori
– Molecular Systems Biology
(2020)
16,
e9596
(DOI: 10.15252/msb.20209596)
Machine learning for target discovery in drug development
T Rodrigues, GJL Bernardes
– Current opinion in chemical biology
(2020)
56,
16
(DOI: 10.1016/j.cbpa.2019.10.003)
Sequence-based prediction of protein binding mode landscapes
A Horvath, M Miskei, V Ambrus, M Vendruscolo, M Fuxreiter
– PLOS Computational Biology
(2020)
16,
e1007864
(DOI: 10.1371/journal.pcbi.1007864)
Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform
M Koopman, Q Peter, RI Seinstra, M Perni, M Vendruscolo, CM Dobson, TPJ Knowles, EAA Nollen
– Nature protocols
(2020)
15,
2071
(DOI: 10.1038/s41596-020-0321-9)
A sweet galactose transfer - Metabolic oligosaccharide engineering as a tool to study glycans in Plasmodium infection
A Kitowski, GJL Bernardes
– Chembiochem : a European journal of chemical biology
(2020)
cbic.202000226
(DOI: 10.1002/cbic.202000226)
A Microfluidic Co-Flow Route for Human Serum Albumin-Drug-Nanoparticle Assembly.
TA Hakala, S Davies, Z Toprakcioglu, B Bernardim, GJL Bernardes, TPJ Knowles
– Chemistry: A European Journal
(2020)
26,
5965
(DOI: 10.1002/chem.202001146)
Editorial overview: Toward smart medicines.
GJL Bernardes, R Rodriguez
– Current Opinion in Chemical Biology
(2020)
56,
A1
(DOI: 10.1016/j.cbpa.2020.04.011)
Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects.
I Mahú, A Barateiro, E Rial-Pensado, N Martinéz-Sánchez, SH Vaz, PMSD Cal, B Jenkins, T Rodrigues, C Cordeiro, MF Costa, R Mendes, E Seixas, MMA Pereira, N Kubasova, V Gres, I Morris, C Temporão, M Olivares, Y Sanz, A Koulman, F Corzana, AM Sebastião, M López, GJL Bernardes, AI Domingos
– Cell Metab
(2020)
31,
1120
(DOI: 10.1016/j.cmet.2020.04.013)
Complexity in Lipid Membrane Composition Induces Resilience to A beta(42) Aggregation
M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, M Vendruscolo
– ACS Chem Neurosci
(2020)
11,
1347
(DOI: 10.1021/acschemneuro.0c00101)
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, SIA Cohen, CM Dobson, M Vendruscolo, S Linse, TPJ Knowles
– Nat Chem
(2020)
12,
445
(DOI: 10.1038/s41557-020-0452-1)

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