Yusuf Hamied Department of Chemistry

Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
(doi: 10.1039/9781837676347)
Postoperative Changes in Cervical Hemodynamics and Cognitive Function Following Cervical Lymphatic-Venous Surgery in Alzheimer’s Disease
X Zheng, C Tang, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, Q Shi, GJL Bernardes
Journal of Alzheimer's Disease
(2026)
(doi: 10.1177/13872877261459037)
Preserving Native Cellulose-Xylan Architecture Enables Structure-Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials
PK Deralia, R Cresswell, Y Yoshimi, T Kuga, A Echevarria-Poza, P Howell, A Dickson, M-J Le Guen, E Wagner, ACS de Alcantara, CGT Batista, N Follain, A Miller, M Vendruscolo, SJ Hill, J Beaugrand, MS Skaf, DJ Cosgrove, SP Brown, JA Elliott, R Dupree, P Dupree
(2026)
(doi: 10.64898/2026.06.07.730583)
Dynamic palladium speciation governs prodrug activation by nanoparticles in vitro and in vivo.
E Latocheski, GMD Forno, JP Agnes, J Konč, A Zanotto-Filho, GJL Bernardes, JB Domingos
Colloids and Surfaces B: Biointerfaces
(2026)
267
(doi: 10.1016/j.colsurfb.2026.115902)
In vitro and in vivo inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.
MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos
Dalton Trans
(2026)
55
(doi: 10.1039/d5dt02853a)
Prediction of antibody non-specificity using protein language models and biophysical parameters.
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
Mabs
(2026)
18
(doi: 10.1080/19420862.2026.2678000)
Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations
A Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer
(2026)
(doi: 10.64898/2026.05.22.727278)
Does the sequence of a disordered protein encode small molecule binding paths?
A Louet, G Hummer, M Vendruscolo
(2026)
(doi: 10.64898/2026.05.20.726646)
Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues
G Battistoni, S Torres-Garcia, CY Sia, S Corriero, C Boquetale, E Williams, A Cregeen, K Wasilewska, M Alini, N Hemmer, IMAXT Cancer Grand Challenge Consortium, S Balasubramanian, BC Nicholson, GJ Hannon, D Bressan
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2527896123)
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments
R Blanco-Domínguez, AM Vaz-Pinto, L Barros, N Lopes, B Henriques-Alves, M Carreira, C Labão-Almeida, JC Ribot, GJL Bernardes, B Silva-Santos, S Mensurado
Journal of Experimental Medicine
(2026)
223
(doi: 10.1084/jem.20252133)
Glutathione-responsive fragmentation of heteronorbornadiene-based thiovinyl sulfones in glioma cells
M Carranza, AT Carmona, E Gil de Montes, Y Méndez, I Černauskienė, GJL Bernardes, AJ Moreno-Vargas
Bioconjugate Chemistry
(2026)
37
(doi: 10.1021/acs.bioconjchem.5c00581)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
(doi: 10.64898/2026.04.08.715690)
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin.
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Commun Chem
(2026)
9
(doi: 10.1038/s42004-026-01950-7)
Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals
CM Lim, M Vendruscolo
(2026)
(doi: 10.64898/2026.04.05.716624)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
Mabs
(2026)
18
(doi: 10.1080/19420862.2026.2646361)
Systems-level organization of extracellular proteostasis
CM Gomes, M Vendruscolo
Science (New York, N.Y.)
(2026)
391
(doi: 10.1126/science.aed3712)
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis.
H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes
ACS chemical biology
(2026)
21
(doi: 10.1021/acschembio.5c00935)
Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras
Z Wang, X He, X Zhang, J Spiegel, SM Flynn, S Balasubramanian
Nat Chem
(2026)
18
(doi: 10.1038/s41557-026-02111-y)
OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening
J Hanke, SP Ojeda, RW Cheong, LM Glasstetter, E Baker, H Lam, M Brezinova, A Louet, S Zhang, M Vendruscolo
(2026)
(doi: 10.64898/2026.03.17.712433)
The α-synuclein proteostasis network and its translational applications in Parkinson's disease
CM Lim, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
(doi: 10.1073/pnas.2513317123)
Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
K Hu, S Srivastava, B Ma, Y Yang, H Wang, M Mangolini, J Hayre, E Souster, R Karattil, A Ramon, M Greenig, P Sormanni, S Cordoba, S Onuoha
(2026)
(doi: 10.64898/2026.03.10.710759)
FuzDrop: sequence-based prediction of the propensity of proteins for liquid-liquid phase separation and aggregation.
M Vendruscolo, M Fuxreiter
Nature protocols
(2026)
21
(doi: 10.1038/s41596-025-01267-0)
Rational Design of Nanobodies Targeting LINGO-1
A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo
Applied Research
(2026)
5
(doi: 10.1002/appl.70071)
Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay".
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
J Am Chem Soc
(2026)
148
(doi: 10.1021/jacs.5c18723)
Toward a unified framework for determining conformational ensembles of disordered proteins
H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon
Nat Methods
(2026)
23
(doi: 10.1038/s41592-026-03003-2)
Yusuf Hamied Department of Chemistry
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enquiries@ch.cam.ac.uk
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