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Recent Publications from the Biological Research Interest Group

Trodusquemine enhances A beta(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Ethynylbenziodoxolone Reactivity in Cysteine Bioconjugation
SR Adusumalli, GJL Bernardes
– Chem
(2019)
5,
1932
(DOI: 10.1016/j.chempr.2019.07.014)
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo
(2019)
(DOI: 10.1101/729392)
Evaluation of linker length effects on a BET bromodomain probe.
R Traquete, E Henderson, S Picaud, PMSD Cal, F Sieglitz, T Rodrigues, R Oliveira, P Filippakopoulos, GJL Bernardes
– Chem Commun (Camb)
(2019)
(DOI: 10.1039/c9cc05054j)
Promoting transparency and reproducibility in enhanced molecular simulations
PLUMED consortium
– Nat Methods
(2019)
16,
670
(DOI: 10.1038/s41592-019-0506-8)
The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli.
L Zhao, G Vecchi, M Vendruscolo, R Körner, M Hayer-Hartl, FU Hartl
– Cell reports
(2019)
28,
1335
(DOI: 10.1016/j.celrep.2019.06.081)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta Neuropathologica Communications
(2019)
7,
120
(DOI: 10.1186/s40478-019-0777-4)
Differential interactome and innate immune response activation of two structurally distinct misfolded protein oligomers.
B Mannini, G Vecchi, A Labrador-Garrido, B Fabre, G Fani, JM Franco, K Lilley, D Pozo, M Vendruscolo, F Chiti, CM Dobson, C Roodveldt
– ACS chemical neuroscience
(2019)
acschemneuro.9b00088
(DOI: 10.1021/acschemneuro.9b00088)
Focused surface acoustic waves induced microdroplets generation and its application for microgels
S Jin, X Wei, Z Liu, J Ren, Z Jiang, C Abell, Z Yu
– Sensors and Actuators B: Chemical
(2019)
291,
1
(DOI: 10.1016/j.snb.2019.04.055)
Development of Inhibitors against Mycobacterium abscessus tRNA (m1G37) Methyltransferase (TrmD) Using Fragment-Based Approaches.
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
– Journal of medicinal chemistry
(2019)
62,
7210
(DOI: 10.1021/acs.jmedchem.9b00809)
Defining α-synuclein species responsible for Parkinson disease phenotypes in mice
JM Froula, M Castellana-Cruz, NM Anabtawi, JD Camino, SW Chen, DR Thrasher, J Freire, AA Yazdi, S Fleming, CM Dobson, JR Kumita, N Cremades, LA Volpicelli-Daley
– Journal of Biological Chemistry
(2019)
294,
jbc.RA119.007743
(DOI: 10.1074/jbc.ra119.007743)
Overexpression of Osmosensitive Ca
MC Marques, IS Albuquerque, SH Vaz, GJL Bernardes
– Biochemistry
(2019)
58,
2861
(DOI: 10.1021/acs.biochem.9b00224)
Bioinspired hydrogel microfibres colour-encoded with colloidal crystals
Z-J Meng, J Zhang, X Deng, J Liu, Z Yu, C Abell
– Materials Horizons
(DOI: 10.1039/c9mh00528e)
Natural product–drug conjugates for modulation of TRPV1-expressing tumors
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
– Bioorganic & medicinal chemistry
(2019)
27,
2531
(DOI: 10.1016/j.bmc.2019.03.025)
Tetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug
S Davies, L Qiao, BL Oliveira, CD Navo, G Jiménez-Osés, GJL Bernardes
– ChemBioChem
(2019)
20,
1541
(DOI: 10.1002/cbic.201900098)
Efficient Phage Display with Multiple Distinct Non-Canonical Amino Acids Using Orthogonal Ribosome-Mediated Genetic Code Expansion.
B Oller-Salvia, JW Chin
– Angewandte Chemie - International Edition
(2019)
58,
10844
(DOI: 10.1002/anie.201902658)
Structure-guided fragmentbased drug discovery at the synchrotron: Screening binding sites and correlations with hotspot mapping
SE Thomas, P Collins, RH James, V Mendes, S Charoensutthivarakul, C Radoux, C Abell, AG Coyne, RA Floto, F von Delft, TL Blundell
– Philos Trans A Math Phys Eng Sci
(2019)
377,
20180422
(DOI: 10.1098/rsta.2018.0422)
Determination of protein structural ensembles using cryo-electron microscopy.
M Bonomi, M Vendruscolo
– Current opinion in structural biology
(2018)
56,
37
(DOI: 10.1016/j.sbi.2018.10.006)
Expression of the amyloid-beta peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response
T Sinnige, P Ciryam, S Casford, CM Dobson, M de Bono, M Vendruscolo
– PLoS One
(2019)
14,
e0217746
(DOI: 10.1371/journal.pone.0217746)
Dissecting celastrol with machine learning to unveil dark pharmacology.
T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
– Chemical Communications
(2019)
55,
6369
(DOI: 10.1039/c9cc03116b)

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