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Recent Publications from the Biological Research Interest Group

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature communications
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Focused surface acoustic waves induced microdroplets generation and its application for microgels
S Jin, X Wei, Z Liu, J Ren, Z Jiang, C Abell, Z Yu
– Sensors and Actuators, B: Chemical
(2019)
291,
1
(DOI: 10.1016/j.snb.2019.04.055)
Natural product-drug conjugates for modulation of TRPV1-expressing tumors.
C Baker, T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
– Bioorganic & medicinal chemistry
(2019)
27,
2531
(DOI: 10.1016/j.bmc.2019.03.025)
Determination of protein structural ensembles using cryo-electron microscopy
M Bonomi, M Vendruscolo
– Curr Opin Struct Biol
(2018)
56,
37
(DOI: 10.1016/j.sbi.2018.10.006)
Dissecting celastrol with machine learning to unveil dark pharmacology
T Rodrigues, BP de Almeida, NL Barbosa-Morais, GJL Bernardes
– Chemical Communications
(2019)
55,
6369
(DOI: 10.1039/c9cc03116b)
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.
C Torrini, RJ Cubero, E Dirkx, L Braga, H Ali, G Prosdocimo, MI Gutierrez, C Collesi, D Licastro, L Zentilin, M Mano, S Zacchigna, M Vendruscolo, M Marsili, A Samal, M Giacca
– Cell reports
(2019)
27,
2759
(DOI: 10.1016/j.celrep.2019.05.005)
Development of a self-immolative linker for tetrazine-triggered release of alcohols in cells.
S Davies, BL Oliveira, GJL Bernardes
– Organic & Biomolecular Chemistry
(2019)
(DOI: 10.1039/c9ob01167f)
Triaminopyrimidine derivatives as transmembrane HCl transporters
P Motloch, A Guerreiro, CQ Azeredo, GJL Bernardes, CA Hunter, I Kocsis
– Organic & Biomolecular Chemistry
(2019)
17,
5633
(DOI: 10.1039/c9ob00725c)
The toxicity of misfolded protein oligomers is independent of their secondary structure
M Vivoli Vega, R Cascella, SW Chen, G Fusco, A De Simone, CM Dobson, C Cecchi, F Chiti
– ACS chemical biology
(2019)
acschembio.9b00324
(DOI: 10.1021/acschembio.9b00324)
Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, RA Peralta
– Dalton Transactions
(2019)
48,
5574
(DOI: 10.1039/c9dt00616h)
Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies
R Cascella, M Perni, SW Chen, G Fusco, C Cecchi, M Vendruscolo, F Chiti, CM Dobson, A De Simone
– ACS Chemical Biology
(2019)
acschembio.9b00312
(DOI: 10.1021/acschembio.9b00312)
Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans.
C Huang, S Wagner-Valladolid, AD Stephens, R Jung, C Poudel, T Sinnige, MC Lechler, N Schlörit, M Lu, RF Laine, CH Michel, M Vendruscolo, CF Kaminski, GS Kaminski Schierle, DC David
– eLife
(2019)
8,
ARTN e43059
(DOI: 10.7554/eLife.43059)
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.
T Sinnige, P Ciryam, S Casford, CM Dobson, M de Bono, M Vendruscolo
– PLoS One
(2019)
14,
e0217746
(DOI: 10.1371/journal.pone.0217746)
Computational advances in combating colloidal aggregation in drug discovery
D Reker, GJL Bernardes, T Rodrigues
– Nature chemistry
(2019)
11,
402
(DOI: 10.1038/s41557-019-0234-9)
Total synthesis of Escherichia coli with a recoded genome.
J Fredens, K Wang, D de la Torre, LFH Funke, WE Robertson, Y Christova, T Chia, WH Schmied, DL Dunkelmann, V Beránek, C Uttamapinant, AG Llamazares, TS Elliott, JW Chin
– Nature
(2019)
569,
514
(DOI: 10.1038/s41586-019-1192-5)
Azabicyclic Vinyl Sulfones for Residue-specific Dual Protein Labelling
E Gil de Montes, E Jiménez-Moreno, BL Oliveira, CD Navo, PMSD Cal, G Jiménez-Osés, I Robina, AJ Moreno-Vargas, GJL Bernardes
– Chem Sci
(2019)
10,
4515
(DOI: 10.1039/c9sc00125e)
Identifying A- and P-site locations on ribosome-protected mRNA fragments using Integer Programming.
N Ahmed, P Sormanni, P Ciryam, M Vendruscolo, CM Dobson, EP O'Brien
– Scientific reports
(2019)
9,
6256
(DOI: 10.1038/s41598-019-42348-x)
Biophysical Techniques in Structural Biology.
CM Dobson
– Annu Rev Biochem
(2019)
88,
annurev-biochem-013118-111947
(DOI: 10.1146/annurev-biochem-013118-111947)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
– Sci Rep
(2019)
9,
5822
(DOI: 10.1038/s41598-019-41925-4)
Determination of the structural ensemble of the molten globule state of a protein by computer simulations.
M Shimizu, Y Kajikawa, K Kuwajima, CM Dobson, Y Okamoto
– Proteins: Structure, Function, and Bioinformatics
(2019)
prot.25688
(DOI: 10.1002/prot.25688)

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