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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
– ACS Central Science
(2021)
acscentsci.1c00070
(DOI: 10.1021/acscentsci.1c00070)
A mistranslation-prone transcriptome underlying polyglutamine expansion diseases.
F Buhr, PS Ciryam, M Vendruscolo
– Nat Rev Mol Cell Biol
(2021)
1
(DOI: 10.1038/s41580-021-00368-4)
Interactions of alpha-synuclein oligomers with lipid membranes
G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles
– Biochimica et Biophysica Acta (BBA) - Biomembranes
(2021)
1863,
183536
(DOI: 10.1016/j.bbamem.2020.183536)
Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation
GS Biggs, OJ Klein, SL Maslen, JM Skehel, TJ Rutherford, SMV Freund, F Hollfelder, SR Boss, PD Barker
– Angewandte Chemie
(2021)
ange.202015834
(DOI: 10.1002/ange.202015834)
Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation.
GS Biggs, OJ Klein, SL Maslen, JM Skehel, TJ Rutherford, SMV Freund, F Hollfelder, SR Boss, PD Barker
– Angewandte Chemie - International Edition
(2021)
anie.202015834
(DOI: 10.1002/anie.202015834)
The role of reversible and irreversible covalent chemistry in targeted protein degradation
H Kiely-Collins, GE Winter, GJL Bernardes
– Cell chemical biology
(2021)
(DOI: 10.1016/j.chembiol.2021.03.005)
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease.
M Perni, A van der Goot, R Limbocker, TJ van Ham, FA Aprile, CK Xu, P Flagmeier, K Thijssen, P Sormanni, G Fusco, SW Chen, PK Challa, JB Kirkegaard, RF Laine, KY Ma, MBD Müller, T Sinnige, JR Kumita, SIA Cohen, R Seinstra, GS Kaminski Schierle, CF Kaminski, D Barbut, A De Simone, TPJ Knowles, M Zasloff, EAA Nollen, M Vendruscolo, CM Dobson
– Frontiers in Cell and Developmental Biology
(2021)
9,
552549
(DOI: 10.3389/fcell.2021.552549)
Selective CRAF Inhibition Elicits Transactivation.
CW Morgan, IL Dale, AP Thomas, J Hunt, JW Chin
– J Am Chem Soc
(2021)
143,
4600
(DOI: 10.1021/jacs.0c11958)
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans
T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, RI Morimoto
– Proc Natl Acad Sci U S A
(2021)
118,
e2021888118
(DOI: 10.1073/pnas.2021888118)
Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures
T Ikenoue, FA Aprile, P Sormanni, M Vendruscolo
– Frontiers in neuroscience
(2021)
15,
623097
(DOI: 10.3389/fnins.2021.623097)
TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions.
R Broome, I Chernukhin, S Jamieson, K Kishore, EK Papachristou, S-Q Mao, CG Tejedo, A Mahtey, V Theodorou, AJ Groen, C D'Santos, S Balasubramanian, AM Farcas, R Siersbæk, JS Carroll
– Cell reports
(2021)
34,
108776
(DOI: 10.1016/j.celrep.2021.108776)
A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms
F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
(2021)
(DOI: 10.21203/rs.3.rs-215084/v1)
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases
K Kulenkampff, AM Wolf Perez, P Sormanni, J Habchi, M Vendruscolo
– Nature Reviews Chemistry
(2021)
1
(DOI: 10.1038/s41570-021-00254-9)
The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition.
WK Man, B Tahirbegi, MD Vrettas, S Preet, L Ying, M Vendruscolo, A De Simone, G Fusco
– Nat Commun
(2021)
12,
927
(DOI: 10.1038/s41467-021-21027-4)
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
DE Scott, NJ Francis-Newton, ME Marsh, AG Coyne, G Fischer, T Moschetti, AR Bayly, TD Sharpe, KT Haas, L Barber, CR Valenzano, R Srinivasan, DJ Huggins, M Lee, A Emery, B Hardwick, M Ehebauer, C Dagostin, A Esposito, L Pellegrini, T Perrior, G McKenzie, TL Blundell, M Hyvönen, J Skidmore, AR Venkitaraman, C Abell
– Cell Chem Biol
(2021)
28,
1
(DOI: 10.1016/j.chembiol.2021.02.006)
A beta Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors
G Fani, B Mannini, G Vecchi, R Cascella, C Cecchi, CM Dobson, M Vendruscolo, F Chiti
– ACS Chem Neurosci
(2021)
12,
766
(DOI: 10.1021/acschemneuro.0c00811)
Chris Abell 1957–2020
FJ Leeper, AG Coyne
– The Biochemist
(2021)
43,
45
(DOI: 10.1042/bio_2021_106)
Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles
– Nat Commun
(2021)
12,
688
(DOI: 10.1038/s41467-020-20782-0)
A dopamine metabolite stabilizes neurotoxic amyloid-beta oligomers (vol 4, 19, 2021)
R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, S Sarwat, P Joshi, JR Kumita, S Linse, J Habchi, TPJ Knowles, B Mannini, CM Dobson, M Vendruscolo
– Communications Biology
(2021)
4,
154
(DOI: 10.1038/s42003-021-01680-7)
Systematic Activity Maturation of a Single-Domain Antibody with Non-Canonical Amino Acids through Chemical Mutagenesis
PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo
– Cell chemical biology
(2021)
28,
70
(DOI: 10.1016/j.chembiol.2020.11.002)

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