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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation
K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle
– J Med Chem
(2021)
acs.jmedchem.1c00806
(DOI: 10.1021/acs.jmedchem.1c00806)
Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions
Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes
– Bioconjugate chemistry
(2021)
acs.bioconjchem.1c00276
(DOI: 10.1021/acs.bioconjchem.1c00276)
Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans
M Perni, B Mannini, CK Xu, JR Kumita, CM Dobson, F Chiti, M Vendruscolo
– Scientific reports
(2021)
11,
14391
(DOI: 10.1038/s41598-021-93527-8)
Two human metabolites rescue a C. elegans model of Alzheimer's disease via a cytosolic unfolded protein response
P Joshi, M Perni, R Limbocker, B Mannini, S Casford, S Chia, J Habchi, J Labbadia, CM Dobson, M Vendruscolo
– Communications Biology
(2021)
4,
843
(DOI: 10.1038/s42003-021-02218-7)
Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates
V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes
– Bioconjug Chem
(2021)
acs.bioconjchem.1c00317
(DOI: 10.1021/acs.bioconjchem.1c00317)
Chemical profiling of DNA G-quadruplex-interacting proteins in live cells
S Balasubramanian, X Zhang, J Spiegel, S Adhikari, S Martinez Cuesta
– Nature Chemistry
(2021)
13,
626
(DOI: 10.1038/s41557-021-00736-9)
Distinct responses of human peripheral blood cells to different misfolded protein oligomers.
M Leal-Lasarte, B Mannini, F Chiti, M Vendruscolo, CM Dobson, C Roodveldt, D Pozo
– Immunology
(2021)
imm.13377
(DOI: 10.1111/imm.13377)
Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers.
R Limbocker, R Staats, S Chia, FS Ruggeri, B Mannini, CK Xu, M Perni, R Cascella, A Bigi, LR Sasser, NR Block, AK Wright, RP Kreiser, ET Custy, G Meisl, S Errico, J Habchi, P Flagmeier, T Kartanas, JE Hollows, LT Nguyen, K LeForte, D Barbut, JR Kumita, C Cecchi, M Zasloff, TPJ Knowles, CM Dobson, F Chiti, M Vendruscolo
– Front Neurosci
(2021)
15,
680026
(DOI: 10.3389/fnins.2021.680026)
Generic nature of the condensed states of proteins.
M Fuxreiter, M Vendruscolo
– Nature cell biology
(2021)
23,
587
(DOI: 10.1038/s41556-021-00697-8)
Sense codon reassignment enables viral resistance and encoded polymer synthesis
WE Robertson, LFH Funke, D de la Torre, J Fredens, TS Elliott, M Spinck, Y Christova, D Cervettini, FL Böge, KC Liu, S Buse, S Maslen, GPC Salmond, JW Chin
– Science (New York, N.Y.)
(2021)
372,
1057
(DOI: 10.1126/science.abg3029)
Reduced Bisulfite Sequencing: Quantitative Base-Resolution Sequencing of 5-Formylcytosine5-formylcytosine (5fC)
MJ Booth, S Balasubramanian
– Methods in molecular biology (Clifton, N.J.)
(2021)
2272,
3
(DOI: 10.1007/978-1-0716-1294-1_1)
Promoter G-quadruplex folding precedes transcription and is controlled by chromatin
J Shen, D Varshney, A Simeone, X Zhang, S Adhikari, D Tannahill, S Balasubramanian
– Genome Biol
(2021)
22,
143
(DOI: 10.1186/s13059-021-02346-7)
Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS
WE Robertson, LFH Funke, D de la Torre, J Fredens, K Wang, JW Chin
– Nature Protocols
(2021)
16,
2345
(DOI: 10.1038/s41596-020-00464-3)
G-quadruplexes are transcription factor binding hubs in human chromatin.
J Spiegel, SM Cuesta, S Adhikari, R Hänsel-Hertsch, D Tannahill, S Balasubramanian
– Genome Biol
(2021)
22,
117
(DOI: 10.1186/s13059-021-02324-z)
Critical assessment of protein intrinsic disorder prediction.
M Necci, D Piovesan, CAID Predictors, DisProt Curators, SCE Tosatto
– Nat Methods
(2021)
18,
472
(DOI: 10.1038/s41592-021-01117-3)
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
– ACS Cent Sci
(2021)
7,
868
(DOI: 10.1021/acscentsci.1c00070)
A mistranslation-prone transcriptome underlying polyglutamine expansion diseases
F Buhr, PS Ciryam, M Vendruscolo
– Nature Reviews Molecular Cell Biology
(2021)
1
(DOI: 10.1038/s41580-021-00368-4)
Tau AD fragment aggregates proliferate through autocatalytic secondary nucleation
DR Camargo, E Sileikis, S Chia, E Axell, K Bernfur, R Cataldi, S Cohen, G Meisl, J Habchi, T Knowles, M Vendruscolo, S Linse
(2021)
(DOI: 10.21203/rs.3.rs-351489/v1)
Interactions of alpha-synuclein oligomers with lipid membranes
G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles
– Biochim Biophys Acta Biomembr
(2021)
1863,
183536
(DOI: 10.1016/j.bbamem.2020.183536)
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
D Georgopoulou, M Callari, OM Rueda, A Shea, A Martin, A Giovannetti, F Qosaj, A Dariush, S-F Chin, LS Carnevalli, E Provenzano, W Greenwood, G Lerda, E Esmaeilishirazifard, M O'Reilly, V Serra, D Bressan, IMAXT Consortium, GB Mills, HR Ali, SS Cosulich, GJ Hannon, A Bruna, C Caldas
– Nature Communications
(2021)
12,
1998
(DOI: 10.1038/s41467-021-22303-z)

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