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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process.
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes
– Angew Chem Int Ed Engl
(2023)
e202311186
(DOI: 10.1002/anie.202311186)
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts
RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, M Vendruscolo
– ACS Chem Neurosci
(2023)
14,
3125
(DOI: 10.1021/acschemneuro.3c00282)
Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, ZF Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
(2023)
(DOI: 10.1101/2023.08.09.552642)
Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes.
AHY Chan, TCS Ho, FJ Leeper
– Organic & Biomolecular Chemistry
(2023)
21,
6531
(DOI: 10.1039/d3ob00884c)
Targeted protein editing with an antibody-based system
O Rimon, J Konc, VR Chowdhury, GJL Bernardes, M Vendruscolo
(2023)
(DOI: 10.1101/2023.07.28.551006)
Determination of the Structure and Dynamics of the Fuzzy Coat of an Amyloid Fibril of IAPP Using Cryo-Electron Microscopy.
Z Faidon Brotzakis, T Löhr, S Truong, S Hoff, M Bonomi, M Vendruscolo
– Biochemistry
(2023)
62,
2407
(DOI: 10.1021/acs.biochem.3c00010)
Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes.
S Errico, G Lucchesi, D Odino, EY Osman, R Cascella, L Neri, C Capitini, M Calamai, F Bemporad, C Cecchi, WA Kinney, D Barbut, A Relini, C Canale, G Caminati, R Limbocker, M Vendruscolo, M Zasloff, F Chiti
– Journal of Medicinal Chemistry
(2023)
66,
9519
(DOI: 10.1021/acs.jmedchem.3c00182)
Continuous synthesis of E. coli genome sections and Mb-scale human DNA assembly
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
– Nature
(2023)
619,
555
(DOI: 10.1038/s41586-023-06268-1)
Amyloid formation as a protein phase transition
TCT Michaels, D Qian, A Šarić, M Vendruscolo, S Linse, TPJ Knowles
– Nature Reviews Physics
(2023)
5,
379
(DOI: 10.1038/s42254-023-00598-9)
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNAPyl pairs
AT Beattie, DL Dunkelmann, JW Chin
– Nat Chem
(2023)
15,
948
(DOI: 10.1038/s41557-023-01232-y)
Thermodynamic and kinetic approaches for drug discovery to target protein misfolding and aggregation
M Vendruscolo
– Expert Opinion on Drug Discovery
(2023)
18,
881
(DOI: 10.1080/17460441.2023.2221024)
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes
– J Infect Dis
(2023)
jiad135
(DOI: 10.1093/infdis/jiad135)
Unlocking the Potential of Bio-Based Nitrogen-Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie (International ed. in English)
(2023)
62,
e202304449
(DOI: 10.1002/anie.202304449)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie
(2023)
135,
(DOI: 10.1002/ange.202304449)
Towards sequence-based principles for protein phase separation predictions
M Vendruscolo, M Fuxreiter
– Curr Opin Chem Biol
(2023)
75,
102317
(DOI: 10.1016/j.cbpa.2023.102317)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2023)
120,
e2216234120
(DOI: 10.1073/pnas.2216234120)
Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis
MM Simpson, CC Lam, JM Goodman, S Balasubramanian
– Angewandte Chemie (International ed. in English)
(2023)
62,
e202304756
(DOI: 10.1002/anie.202304756)
Selective Functionalisation of 5‐Methylcytosine by Organic Photoredox Catalysis
MM Simpson, CC Lam, JM Goodman, S Balasubramanian
– Angewandte Chemie
(2023)
135,
(DOI: 10.1002/ange.202304756)
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation.
AHY Chan, TCS Ho, R Irfan, RAA Hamid, ES Rudge, A Iqbal, A Turner, AKH Hirsch, FJ Leeper
– Bioorganic chemistry
(2023)
138,
106602
(DOI: 10.1016/j.bioorg.2023.106602)
A Photoredox Reaction for the Selective Modification of 5-Carboxycytosine in DNA
BJ Mortishire-Smith, SM Becker, A Simeone, L Melidis, S Balasubramanian
– J Am Chem Soc
(2023)
145,
10505
(DOI: 10.1021/jacs.2c12558)

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