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Recent Publications from the Biological Research Interest Group

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Determination of protein structural ensembles using cryo-electron microscopy.
M Bonomi, M Vendruscolo
– Curr Opin Struct Biol
(2018)
56,
37
(DOI: 10.1016/j.sbi.2018.10.006)
Computational advances in combating colloidal aggregation in drug discovery.
D Reker, GJL Bernardes, T Rodrigues
– Nat Chem
(2019)
(DOI: 10.1038/s41557-019-0234-9)
The free energy landscape of the oncogene protein E7 of human papillomavirus type 16 reveals a complex interplay between ordered and disordered regions.
P Kukic, GM Lo Piccolo, MO Nogueira, DI Svergun, M Vendruscolo, IC Felli, R Pierattelli
– Sci Rep
(2019)
9,
5822
(DOI: 10.1038/s41598-019-41925-4)
Determination of the Structural Ensemble of the Molten Globule State of a Protein by Computer Simulations
M Shimizu, Y Kajikawa, K Kuwajima, CM Dobson, Y Okamoto
– Proteins
(2019)
prot.25688
(DOI: 10.1002/prot.25688)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nature communications
(2019)
10,
1541
(DOI: 10.1038/s41467-019-09477-3)
The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.
JJ Yerbury, L Ooi, IP Blair, P Ciryam, CM Dobson, M Vendruscolo
– Neuroscience letters
(2019)
704,
89
(DOI: 10.1016/j.neulet.2019.04.001)
Synthesis, characterization and biological evaluation of new manganese metal carbonyl compounds that contain sulfur and selenium ligands as a promising new class of CORMs
AL Amorim, MM Peterle, A Guerreiro, DF Coimbra, RS Heying, GF Caramori, AL Braga, AJ Bortoluzzi, A Neves, GJL Bernardes, RA Peralta
– Dalton Transactions
(2019)
(DOI: 10.1039/c9dt00616h)
The Amyloid Phenomenon and Its Significance in Biology and Medicine.
CM Dobson, TPJ Knowles, M Vendruscolo
– Cold Spring Harbor Perspectives in Biology
(2019)
a033878
(DOI: 10.1101/cshperspect.a033878)
Human pregnancy zone protein stabilises misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide
JH Cater, JR Kumita, R Zeineddine Abdallah, G Zhao, A Bernardo-Gancedo, A Henry, W Winata, M Chi, BSF Grenyer, ML Townsend, M Ranson, CS Buhimschi, DS Charnock-Jones, CM Dobson, MR Wilson, IA Buhimschi, AR Wyatt
– Proceedings of the National Academy of Sciences
(2019)
116,
6101
(DOI: 10.1073/pnas.1817298116)
Norbornene Probes for the Detection of Cysteine Sulfenic Acid in Cells.
LJ Alcock, BL Oliveira, MJ Deery, TL Pukala, MV Perkins, GJL Bernardes, JM Chalker
– ACS Chem Biol
(2019)
acschembio.8b01104
(DOI: 10.1021/acschembio.8b01104)
Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.
MJ Matos, CD Navo, T Hakala, X Ferhati, A Guerreiro, D Hartmann, B Bernardim, KL Saar, I Compañón, F Corzana, TPJ Knowles, G Jiménez-Osés, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2019)
(DOI: 10.1002/anie.201901405)
A fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
P Akkapeddi, R Fragoso, JA Hixon, AS Ramalho, ML Oliveira, T Carvalho, A Gloger, M Matasci, F Corzana, SK Durum, D Neri, GJL Bernardes, JT Barata
– Leukemia
(2019)
(DOI: 10.1038/s41375-019-0434-8)
Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, JR Kumita, M Andreasen, CM Dobson, U Shimanovich, TPJ Knowles
– Macromol Rapid Commun
(2019)
1800898
(DOI: 10.1002/marc.201800898)
A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.
K Sanagavarapu, E Nüske, I Nasir, G Meisl, JN Immink, P Sormanni, M Vendruscolo, TPJ Knowles, A Malmendal, C Cabaleiro-Lago, S Linse
– Scientific reports
(2019)
9,
3680
(DOI: 10.1038/s41598-019-39216-z)
Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis
P Sormanni, M Vendruscolo
– Cold Spring Harbor perspectives in biology
(2019)
a033845
(DOI: 10.1101/cshperspect.a033845)
Contemporary approaches to site-selective protein modification
EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes
– Nature Reviews Chemistry
(2019)
3,
147
(DOI: 10.1038/s41570-019-0079-1)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
– ACS chemical neuroscience
(2019)
acschemneuro.8b00676
(DOI: 10.1021/acschemneuro.8b00676)
Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage.
I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana
– J Am Chem Soc
(2019)
141,
4063
(DOI: 10.1021/jacs.8b13503)
The AAA plus protease ClpXP can easily degrade a 3(1) and a 5(2)-knotted protein
EM Sivertsson, SE Jackson, LS Itzhaki
– Sci Rep
(2019)
9,
2421
(DOI: 10.1038/s41598-018-38173-3)

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