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Recent Publications from the Biological Research Interest Group

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
AJ Parry, M Hoare, D Bihary, R Hänsel-Hertsch, S Smith, K Tomimatsu, E Mannion, A Smith, P D'Santos, IA Russell, S Balasubramanian, H Kimura, SA Samarajiwa, M Narita
– Nature Communications
(2018)
9,
1840
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
B Lee, S Sun, E Jiménez-Moreno, AA Neves, GJL Bernardes
– Bioorganic & medicinal chemistry
(2018)
26,
3060
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
MC Chen, R Tippana, NA Demeshkina, P Murat, S Balasubramanian, S Myong, AR Ferré-D'Amaré
– Nature
(2018)
Sequencing 5-hydroxymethyluracil at single-base resolution.
F Kawasaki, S Martínez Cuesta, D Beraldi, A Mahtey, RE Hardisty, M Carrington, S Balasubramanian
– Angew Chem Int Ed Engl
(2018)
Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs.
JCW Willis, JW Chin
– Nature Chemistry
(2018)
1
A method for partitioning the information contained in a protein sequence between its structure and function.
A Possenti, M Vendruscolo, C Camilloni, G Tiana
– Proteins
(2018)
Patterned Arrays of Supramolecular Microcapsules
J Zhang, J Liu, Z Yu, S Chen, OA Scherman, C Abell
– Advanced Functional Materials
(2018)
28,
ARTN 1800550
Cooperative Assembly of Hsp70 Subdomain Clusters.
MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biochemistry
(2018)
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
MN Bongiovanni, FA Aprile, P Sormanni, M Vendruscolo
– International journal of molecular sciences
(2018)
19,
Cholesterol catalyses A beta 42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, FS Ruggeri, M Sanguanini, I Idini, JR Kumita, E Sparr, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Nature Chemistry
(2018)
10,
673
Droplet-based microfluidic analysis and screening of single plant cells
Z Yu, CR Boehm, JM Hibberd, C Abell, J Haseloff, SJ Burgess, I Reyna-Llorens
– PLoS One
(2018)
13,
e0196810
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins.
MD Crabtree, CATF Mendonça, QR Bubb, J Clarke
– J Biol Chem
(2018)
Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1
PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows
– Cell
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines
MGJ Baud, MR Bauer, L Verduci, FA Dingler, KJ Patel, D Horil Roy, AC Joerger, AR Fersht
– Eur J Med Chem
(2018)
152,
101
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
C Dickson, AJ Fletcher, M Vaysburd, J-C Yang, DL Mallery, J Zeng, CM Johnson, SH McLaughlin, M Skehel, S Maslen, J Cruickshank, N Huguenin-Dezot, JW Chin, D Neuhaus, LC James
– eLife
(2018)
7,
ARTN e32660
Parapred: Antibody Paratope Prediction using Convolutional and Recurrent Neural Networks.
E Liberis, P Velickovic, P Sormanni, M Vendruscolo, P Liò
– Bioinformatics (Oxford, England)
(2018)
Promiscuous and Selective: How Intrinsically Disordered BH3 Proteins Interact with Their Pro-survival Partner MCL-1.
L Dahal, TOC Kwan, JJ Hollins, J Clarke
– Journal of molecular biology
(2018)
Simultaneous Determination of Protein Structure and Dynamics Using Cryo-Electron Microscopy.
M Bonomi, R Pellarin, M Vendruscolo
– Biophys J
(2018)
114,
1604
On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.
Y Zhang, EV Yates, L Hong, KL Saar, G Meisl, CM Dobson, TPJ Knowles
– Chemical Science
(2018)
9,
3503
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
F El Turk, E De Genst, T Guilliams, B Fauvet, M Hejjaoui, J Di Trani, A Chiki, A Mittermaier, M Vendruscolo, HA Lashuel, CM Dobson
– Protein Science
(2018)