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Recent Publications from the Biological Research Interest Group

Targeting multiple effector pathways in pancreatic ductal adenocarcinoma with a G-quadruplex-binding small molecule
C Marchetti, KG Zyner, SA Ohnmacht, M Robson, SM Haider, JP Morton, G Marsico, T Vo, S Laughlin-Toth, AA Ahmed, G Di Vita, I Pazitna, M Gunaratnam, RJ Besser, ACG Andrade, S Diocou, JA Pike, D Tannahill, RB Pedley, TRJ Evans, WD Wilson, S Balasubramanian, S Neidle
– J Med Chem
(2018)
Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles.
S Abalde-Cela, P Taladriz-Blanco, MG de Oliveira, C Abell
– Sci Rep
(2018)
8,
2440
Supramolecular Nested Microbeads as Building Blocks for Macroscopic Self-healing Scaffolds.
Z Yu, J Liu, CSY Tan, OA Scherman, C Abell
– Angew Chem Int Ed Engl
(2018)
Rapid and efficient generation of stable antibody-drug conjugates via an encoded cyclopropene and an inverse electron demand Diels-Alder reaction.
B Oller-Salvia, G Kym, JW Chin
– Angew Chem Int Ed Engl
(2018)
Optical structural analysis of individual α-synuclein oligomers.
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, S Lee
– Angew Chem Int Ed Engl
(2018)
Toward an orthogonal central dogma
CC Liu, MC Jewett, JW Chin, CA Voigt
– Nature Chemical Biology
(2018)
14,
103
Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
H Gang, C Galvagnion, G Meisl, T Müller, M Pfammatter, AK Buell, A Levin, CM Dobson, B Mu, TPJ Knowles
– Anal Chem
(2018)
Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity.
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
– ACS Chem Biol
(2018)
Development of Antibody-Directed Therapies: Quo Vadis?
T Rodrigues, GJL Bernardes
– Angew Chem Int Ed Engl
(2018)
57,
2032
The use of fluoroproline in MUC1 antigen enables efficient detection of antibodies in patients with prostate cancer
VJ Somovilla, IA Bermejo, IS Albuquerque, N Martínez-Sáez, J Castro-López, F García-Martín, I Compañón, H Hinou, S-I Nishimura, J Jiménez-Barbero, JL Asensio, A Avenoza, JH Busto, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, F Corzana
– Journal of the American Chemical Society
(2017)
139,
18255
Labeling and identifying cell-specific proteomes in the mouse brain
TP Krogager, RJ Ernst, TS Elliott, L Calo, V Beránek, E Ciabatti, MG Spillantini, M Tripodi, MH Hastings, JW Chin
– Nature Biotechnology
(2017)
36,
156
Structural basis of membrane disruption and cellular toxicity by alpha-synuclein oligomers
G Fusco, SW Chen, PTF Williamson, R Cascella, M Perni, JA Jarvis, C Cecchi, M Vendruscolo, F Chiti, N Cremades, L Ying, CM Dobson, A De Simone
– Science
(2017)
358,
1440
Factors affecting the physical stability (aggregation) of peptide therapeutics
KL Zapadka, FJ Becher, AL Gomes Dos Santos, SE Jackson
– Interface focus
(2017)
7,
20170030
Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.
AM Freedy, MJ Matos, O Boutureira, F Corzana, A Guerreiro, P Akkapeddi, VJ Somovilla, T Rodrigues, K Nicholls, B Xie, G Jiménez-Osés, KM Brindle, AA Neves, GJL Bernardes
– Journal of the American Chemical Society
(2017)
139,
18365
pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.
L Dahal, TOC Kwan, SL Shammas, J Clarke
– Biophys J
(2017)
113,
2713
Inhibiting the Ca2+Influx Induced by Human CSF.
A Drews, S De, P Flagmeier, DC Wirthensohn, W-H Chen, DR Whiten, M Rodrigues, C Vincke, S Muyldermans, RW Paterson, CF Slattery, NC Fox, JM Schott, H Zetterberg, CM Dobson, S Gandhi, D Klenerman
– Cell Rep
(2017)
21,
3310
Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex
L Dahal, SL Shammas, J Clarke
– Biophys J
(2017)
113,
2706
Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites.
J Dadová, K-J Wu, PG Isenegger, JC Errey, GJL Bernardes, JM Chalker, L Raich, C Rovira, BG Davis
– ACS central science
(2017)
3,
1168
MobiDB 3.0: More annotations for intrinsic disorder, conformational diversity and interactions in proteins
D Piovesan, F Tabaro, L Paladin, M Necci, I Micetic, C Camilloni, N Davey, Z Dosztányi, B Mészáros, AM Monzon, G Parisi, E Schad, P Sormanni, P Tompa, M Vendruscolo, WF Vranken, SCE Tosatto
– Nucleic acids research
(2017)
46,
D471
Delivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
M Perni, FA Aprile, S Casford, B Mannini, P Sormanni, CM Dobson, M Vendruscolo
– Scientific reports
(2017)
7,
15045