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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Chem-map profiles drug binding to chromatin in cells.
Z Yu, J Spiegel, L Melidis, WWI Hui, X Zhang, A Radzevičius, S Balasubramanian
– Nature Biotechnology
(2023)
(DOI: 10.1038/s41587-022-01636-0)
A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species
C Tang, AR Coelho, M Rebelo, H Kiely-Collins, T Carvalho, GJL Bernardes
– ACS Central Science
(2023)
(DOI: 10.1021/acscentsci.2c01243)
Enhanced surface nano-analytics of transient biomolecular processes
A Miller, S Chia, Z Toprakcioglu, T Hakala, R Schmid, Y Feng, T Kartanas, A Kamada, M Vendruscolo, FS Ruggeri, TPJ Knowles
– Science advances
(2023)
9,
eabq3151
(DOI: 10.1126/sciadv.abq3151)
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ42 Aggregation
KN Baumann, G Šneiderienė, M Sanguanini, M Schneider, O Rimon, A González Díaz, H Greer, D Thacker, S Linse, TPJ Knowles, M Vendruscolo
– ACS Chem Neurosci
(2022)
14,
323
(DOI: 10.1021/acschemneuro.2c00765)
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
M Spinck, C Piedrafita, WE Robertson, TS Elliott, D Cervettini, D de la Torre, JW Chin
– Nature Chemistry
(2022)
15,
1
(DOI: 10.1038/s41557-022-01082-0)
DNA G‑Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody
S Galli, L Melidis, SM Flynn, D Varshney, A Simeone, J Spiegel, SK Madden, D Tannahill, S Balasubramanian
– Journal of the American Chemical Society
(2022)
144,
23096
(DOI: 10.1021/jacs.2c10656)
Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA
IC Navarro, KM Suen, D Bensaddek, A Tanpure, A Lamond, S Balasubramanian, EA Miska
– Wellcome Open Research
(2022)
7,
282
(DOI: 10.12688/wellcomeopenres.17893.1)
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α‑Synuclein Aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
– Mol Pharm
(2022)
20,
183
(DOI: 10.1021/acs.molpharmaceut.2c00548)
Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
– Angewandte Chemie
(2022)
134,
(DOI: 10.1002/ange.202208543)
Fragment-based computational design of antibodies targeting structured epitopes.
M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
– Science advances
(2022)
8,
eabp9540
(DOI: 10.1126/sciadv.abp9540)
Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates.
A Horvath, M Vendruscolo, M Fuxreiter
– Biochemistry
(2022)
61,
2461
(DOI: 10.1021/acs.biochem.2c00499)
Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors
BB Sousa, CR de Almeida, AF Barahona, R Lopes, A Martins-Logrado, M Cavaco, V Neves, LAR Carvalho, C Labão-Almeida, AR Coelho, M Leal Bento, RMRM Lopes, BL Oliveira, MARB Castanho, P Neumeister, A Deutsch, GI Vladimer, N Krall, C João, F Corzana, JD Seixas, R Fior, GJL Bernardes
– ACS Pharmacology & Translational Science
(2022)
5,
1156
(DOI: 10.1021/acsptsci.2c00163)
Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase.
FJ Leeper, AHY Chan, TCS Ho, K Agyei-Owusu
– Organic and Biomolecular Chemistry
(2022)
20,
8855
(DOI: 10.1039/D2OB01819E)
Refactored genetic codes enable bidirectional genetic isolation.
JF Zürcher, WE Robertson, T Kappes, G Petris, TS Elliott, GPC Salmond, JW Chin
– Science (New York, N.Y.)
(2022)
378,
516
(DOI: 10.1126/science.add8943)
Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones
CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes
– Angewandte Chemie (International ed. in English)
(2022)
61,
e202208543
(DOI: 10.1002/anie.202208543)
An antibody scanning method for the detection of alpha-synuclein oligomers in the serum of Parkinson's disease patients
K Kulenkampff, D Emin, R Staats, YP Zhang, L Sakhnini, A Kouli, O Rimon, E Lobanova, CH Williams-Gray, FA Aprile, P Sormanni, D Klenerman, M Vendruscolo
– Chemical Science
(2022)
13,
13815
(DOI: 10.1039/d2sc00066k)
Protein condensation diseases: therapeutic opportunities.
M Vendruscolo, M Fuxreiter
– Nature communications
(2022)
13,
5550
(DOI: 10.1038/s41467-022-32940-7)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
– Nature Communications
(2022)
13,
5512
(DOI: 10.1038/s41467-022-33252-6)
Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease
D Emin, YP Zhang, E Lobanova, A Miller, X Li, Z Xia, H Dakin, DI Sideris, JYL Lam, RT Ranasinghe, A Kouli, Y Zhao, S De, TPJ Knowles, M Vendruscolo, FS Ruggeri, FI Aigbirhio, CH Williams-Gray, D Klenerman
– Nature Communications
(2022)
13,
5512
(DOI: 10.1038/s41467-022-33252-6)
Effects of N-terminal acetylation on the aggregation of disease-related α-synuclein variants
R Bell, M Castellana-Cruz, A Nene, RJ Thrush, CK Xu, JR Kumita, M Vendruscolo
– Journal of molecular biology
(2022)
435,
167825
(DOI: 10.1016/j.jmb.2022.167825)

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