Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
Spatially tunable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues.
G Battistoni, S Torres-Garcia, CY Sia, S Corriero, C Boquetale, E Williams, A Cregeen, K Wasilewska, M Alini, N Hemmer, IMAXT Cancer Grand Challenge Consortium, S Balasubramanian, BC Nicholson, GJ Hannon, D Bressan
Proceedings of the National Academy of Sciences
(2026)
123
Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2–deficient environments
R Blanco-Domínguez, AM Vaz-Pinto, L Barros, N Lopes, B Henriques-Alves, M Carreira, C Labão-Almeida, JC Ribot, GJL Bernardes, B Silva-Santos, S Mensurado
Journal of Experimental Medicine
(2026)
223
<i>In vitro</i> and <i>in vivo</i> inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.
MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos
Dalton transactions (Cambridge, England : 2003)
(2026)
Glutathione-Responsive Fragmentation of Heteronorbornadiene-Based Thiovinyl Sulfones in Glioma Cells.
M Carranza, AT Carmona, E Gil de Montes, Y Méndez, I Černauskienė, GJL Bernardes, AJ Moreno-Vargas
Bioconjugate Chemistry
(2026)
Spatially patterned, spectral single-molecule microscopy
JS Beckwith, B Cullinane, DF Heraghty, S Krokowski, CL Jones, S Yang, RC Gregory, RA Floto, AM Santos, SJ Davis, M Vendruscolo, D Klenerman, V Lindo, PK Sankaran, SF Lee
(2026)
Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin
V Roy Chowdhury, RI Horne, MP Cali, Z Toprakcioglu, S Linse, M Vendruscolo
Commun Chem
(2026)
Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals
CM Lim, M Vendruscolo
(2026)
Deep learning assessment of nativeness and pairing likelihood for antibody and nanobody design with AbNatiV2
A Ramon, N Frassetto, H Zhao, X Xu, M Greenig, S Onuoha, P Sormanni
MAbs
(2026)
18
Systems-level organization of extracellular proteostasis
CM Gomes, M Vendruscolo
Science
(2026)
391
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis
H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes
ACS Chem Biol
(2026)
21
Degradation of G-quadruplex-binding proteins in chromatin using G4-ligand-based proteolysis-targeting chimeras.
Z Wang, X He, X Zhang, J Spiegel, SM Flynn, S Balasubramanian
Nature Chemistry
(2026)
OmniBind: Proteome-Wide Promiscuity Predictions for Early-Stage Drug Screening
J Hanke, SP Ojeda, RW Cheong, LM Glasstetter, E Baker, H Lam, M Brezinova, A Louet, S Zhang, M Vendruscolo
(2026)
The α-synuclein proteostasis network and its translational applications in Parkinson's disease
CM Lim, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2026)
123
Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
K Hu, S Srivastava, B Ma, Y Yang, H Wang, M Mangolini, J Hayre, E Souster, R Karattil, A Ramon, M Greenig, P Sormanni, S Cordoba, S Onuoha
(2026)
FuzDrop: sequence-based prediction of the propensity of proteins for liquid–liquid phase separation and aggregation
M Vendruscolo, M Fuxreiter
Nat Protoc
(2026)
21
Rational Design of Nanobodies Targeting LINGO-1
A Röntgen, VR Chowdhury, A Ramon, M Greenig, X Xu, P Sormanni, M Vendruscolo
Applied Research
(2026)
5
Correction to “Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay”
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
Journal of the American Chemical Society
(2026)
148
Toward a unified framework for determining conformational ensembles of disordered proteins
H Ghafouri, P Kadeřávek, AM Melo, MC Aspromonte, P Bernadó, J Cortés, Z Dosztányi, G Erdős, M Feig, G Janson, K Lindorff-Larsen, FAA Mulder, P Nagy, R Pestell, D Piovesan, M Schiavina, B Schuler, N Sibille, G Tesei, P Tompa, M Vendruscolo, J Vondrasek, W Vranken, L Zidek, SCE Tosatto, AM Monzon
Nature Methods
(2026)
23
Structural Plausibility Without Binding Specificity: Limits of AI-Based Antibody-Antigen Structure Prediction Confidence Scores
E Smorodina, M Ali, KK Brumat, L Salicari, S Miklavc, A Kappassov, C Fu, P Sormanni, A de Marco, V Greiff
(2026)
Dissecting the binding interactions of the chromatin remodeller SMARCA4 with G-quadruplex DNA
SK Madden, D Tannahill, S Balasubramanian
Biochemistry
(2026)
65
Highly mutagenic continuous evolution in E. coli using a Φ29-based orthogonal replication system.
FBH Rehm, KC Liu, R Tian, JW Chin
Nat Biotechnol
(2026)
Structural defects in amyloid-β fibrils drive secondary nucleation.
J Hu, T Scheidt, D Thacker, E Axell, E Stemme, U Łapińska, S Wennmalm, G Meisl, S Curk, M Andreasen, M Vendruscolo, P Arosio, A Šarić, JD Schmit, TPJ Knowles, E Sparr, S Linse, TCT Michaels, AJ Dear
Nat Commun
(2026)
17
Distinct mechanistic pathways of early tauopathy revealed by MAPT mutations.
MS Foiani, RS Nirujogi, N Watamura, S Bez, E Tsefou, A Santambrogio, S Patel, H Davies, C Goulbourne, N Fatima, T Birkle, E Camporesi, G Brinkmalm, H Zetterberg, M Wilkinson, SE Radford, NA Ranson, P Maglio-Cauhy, E Turkes, A Avdic-Belltheus, I Rawlinson, X Prebibaj, L Panti, D Gavriouchkina, M Blunskyte-Hendley, T Saido, M Vendruscolo, R Frank, M Bourdenx, KE Duff
bioRxiv
(2026)
Classification of tauopathies from human brain homogenates through salt‐modulated tau amplification
A Santambrogio, MA Metrick, P Xu, NCT Gallagher, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo
Alzheimer's &amp; Dementia
(2026)
22