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Recent Publications from the Biological Research Interest Group

Detecting RNA base methylations in single cells by in situ hybridization.
RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman
– Nature Communications
(2018)
9,
655
(DOI: 10.1038/s41467-017-02714-7)
Molecular determinants of the interaction of EGCG with ordered and disordered proteins
G Fusco, M Sanz-Hernandez, FS Ruggeri, M Vendruscolo, CM Dobson, A De Simone
– Biopolymers
(2018)
e23117
(DOI: 10.1002/bip.23117)
Exploring the role of post-translational modifications in regulating α-synuclein interactions by studying the effects of phosphorylation on nanobody binding
F El Turk, E De Genst, T Guilliams, B Fauvet, M Hejjaoui, J Di Trani, A Chiki, A Mittermaier, M Vendruscolo, HA Lashuel, CM Dobson
– Protein Science
(2018)
(DOI: 10.1002/pro.3412)
A structural ensemble modulation mechanism of small molecule binding to disordered proteins
GT Heller, M Bonomi, M Vendruscolo
– Journal of molecular biology
(2018)
(DOI: 10.1016/j.jmb.2018.03.015)
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide
SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse
– Nature Chemistry
(2018)
1
(DOI: 10.1038/s41557-018-0023-x)
Chemo- and Regioselective Lysine Modification on Native Proteins.
MJ Matos, BL Oliveira, N Martínez-Sáez, A Guerreiro, PMSD Cal, J Bertoldo, M Maneiro, E Perkins, J Howard, MJ Deery, JM Chalker, F Corzana, G Jiménez-Osés, GJL Bernardes
– Journal of the American Chemical Society
(2018)
140,
4004
(DOI: 10.1021/jacs.7b12874)
A fragment-based approach to targeting inosine-5´- monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis
A Trapero, A Pacitto, V Singh, M Sabbah, AG Coyne, V Mizrahi, TL Blundell, DB Ascher, C Abell
– J Med Chem
(2018)
(DOI: 10.1021/acs.jmedchem.7b01622)
Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations (vol 8, 2017)
F Paul, C Wehmeyer, ET Abualrous, H Wu, MD Crabtree, J Schöneberg, J Clarke, C Freund, TR Weikl, F Noé
– Nat Commun
(2018)
9,
1073
(DOI: 10.1038/s41467-018-03452-0)
Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.
SG Burgess, M Mukherjee, S Sabir, N Joseph, C Gutiérrez-Caballero, MW Richards, N Huguenin-Dezot, JW Chin, EJ Kennedy, M Pfuhl, SJ Royle, F Gergely, R Bayliss
– EMBO Journal
(2018)
(DOI: 10.15252/embj.201797902)
Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.
TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
– Annu Rev Phys Chem
(2018)
(DOI: 10.1146/annurev-physchem-050317-021322)
TEMPORARY REMOVAL: Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, NW Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
(DOI: 10.1016/j.jneumeth.2018.02.005)
Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule
C Marchetti, KG Zyner, SA Ohnmacht, M Robson, SM Haider, JP Morton, G Marsico, T Vo, S Laughlin-Toth, AA Ahmed, G Di Vita, I Pazitna, M Gunaratnam, RJ Besser, ACG Andrade, S Diocou, JA Pike, D Tannahill, RB Pedley, TRJ Evans, WD Wilson, S Balasubramanian, S Neidle
– J Med Chem
(2018)
61,
2500
(DOI: 10.1021/acs.jmedchem.7b01781)
Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles.
S Abalde-Cela, P Taladriz-Blanco, MG de Oliveira, C Abell
– Scientific reports
(2018)
8,
2440
(DOI: 10.1038/s41598-018-20754-x)
Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Ghandi, SE Bohndiek, TN Snaddon, SF Lee
– Royal Society open science
(2018)
5,
171399
(DOI: 10.1098/rsos.171399)
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
E Madan, TM Parker, MR Bauer, A Dhiman, CJ Pelham, M Nagane, ML Kuppusamy, M Holmes, TR Holmes, K Shaik, K Shee, S Kiparoidze, SD Smith, Y-SA Park, JJ Gomm, LJ Jones, AR Tomás, AC Cunha, K Selvendiran, LA Hansen, AR Fersht, K Hideg, R Gogna, P Kuppusamy
– J Biol Chem
(2018)
293,
4262
(DOI: 10.1074/jbc.RA117.000950)
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity.
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
– J Biol Chem
(2018)
293,
4486
(DOI: 10.1074/jbc.M117.813865)
Biophotonics of Native Silk Fibrils.
U Shimanovich, D Pinotsi, K Shimanovich, N Yu, S Bolisetty, J Adamcik, R Mezzenga, J Charmet, F Vollrath, E Gazit, CM Dobson, GK Schierle, C Holland, CF Kaminski, TPJ Knowles
– Macromolecular Bioscience
(2018)
18,
e1700295
(DOI: 10.1002/mabi.201700295)
Supramolecular Nested Microbeads as Building Blocks for Macroscopic Self-Healing Scaffolds
Z Yu, J Liu, CSY Tan, OA Scherman, C Abell
– Angew Chem Int Ed Engl
(2018)
57,
3079
(DOI: 10.1002/anie.201711522)
Microfluidic approaches for probing amyloid assembly and behaviour
TW Herling, A Levin, KL Saar, CM Dobson, TPJ Knowles
– Lab on a chip
(2018)
18,
999
(DOI: 10.1039/c7lc01241a)
Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction
B Oller-Salvia, G Kym, JW Chin
– Angew Chem Int Ed Engl
(2018)
57,
2831
(DOI: 10.1002/anie.201712370)
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