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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Towards sequence-based principles for protein phase separation predictions
M Vendruscolo, M Fuxreiter
– Current opinion in chemical biology
(2023)
75,
102317
(DOI: 10.1016/j.cbpa.2023.102317)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
– Proceedings of the National Academy of Sciences
(2023)
120,
e2216234120
(DOI: 10.1073/pnas.2216234120)
Selective Functionalisation of 5‐Methylcytosine by Organic Photoredox Catalysis
MM Simpson, CC Lam, JM Goodman, S Balasubramanian
– Angewandte Chemie
(2023)
(DOI: 10.1002/ange.202304756)
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation
AHY Chan, TCS Ho, R Irfan, RAA Hamid, ES Rudge, A Iqbal, A Turner, AKH Hirsch, FJ Leeper
– Bioorganic chemistry
(2023)
138,
106602
(DOI: 10.1016/j.bioorg.2023.106602)
Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie
(2023)
(DOI: 10.1002/ange.202304449)
Unlocking the Potential of Bio-Based Nitrogen-Rich Furanic Platforms as Biomass Synthons.
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
– Angewandte Chemie International Edition
(2023)
e202304449
(DOI: 10.1002/anie.202304449)
A photoredox reaction for the selective modification of 5-carboxycytosine in DNA
BJ Mortishire-Smith, SM Becker, A Simeone, L Melidis, S Balasubramanian
– J Am Chem Soc
(2023)
145,
10505
(DOI: 10.1021/jacs.2c12558)
Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions
GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes
– Journal of the American Chemical Society
(2023)
145,
10790
(DOI: 10.1021/jacs.3c01960)
Glucagon-like peptide 1 aggregates into low-molecular-weight oligomers off-pathway to fibrillation
E Přáda Brichtová, M Krupová, P Bouř, V Lindo, A Gomes Dos Santos, SE Jackson
– Biophys J
(2023)
S0006-3495(23)00298-9
(DOI: 10.1016/j.bpj.2023.04.027)
Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.
MM Simpson, CC Lam, JM Goodman, S Balasubramanian
– Angewandte Chemie International Edition
(2023)
e202304756
(DOI: 10.1002/anie.202304756)
Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.
S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes
– ACS central science
(2023)
9,
892
(DOI: 10.1021/acscentsci.3c00015)
Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases.
R Limbocker, N Cremades, R Cascella, PM Tessier, M Vendruscolo, F Chiti
– Acc Chem Res
(2023)
(DOI: 10.1021/acs.accounts.3c00045)
Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module
AC Murphy, M Corney, RE Monson, MA Matilla, GPC Salmond, FJ Leeper
– ACS Chemical Biology
(2023)
18,
1148
(DOI: 10.1021/acschembio.2c00947)
Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
AHY Chan, TCS Ho, I Fathoni, R Pope, KJ Saliba, FJ Leeper
– ACS medicinal chemistry letters
(2023)
14,
621
(DOI: 10.1021/acsmedchemlett.3c00047)
Automated optimisation of solubility and conformational stability of antibodies and proteins.
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
– Nature communications
(2023)
14,
1937
(DOI: 10.1038/s41467-023-37668-6)
Automated optimisation of solubility and conformational stability of antibodies and proteins
A Rosace, A Bennett, M Oeller, MM Mortensen, L Sakhnini, N Lorenzen, C Poulsen, P Sormanni
– Nature Communications
(2023)
14,
1937
(DOI: 10.1038/s41467-023-37668-6)
FuzPred: a web server for the sequence-based prediction of the context-dependent binding modes of proteins
A Hatos, JM Teixeira, S Barrera-Vilarmau, A Horvath, SCE Tosatto, M Vendruscolo, M Fuxreiter
– Nucleic acids research
(2023)
gkad214
(DOI: 10.1093/nar/gkad214)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– bioRxiv
(2023)
(DOI: 10.1101/2023.03.22.533832)
Sequence-based prediction of the solubility of peptides containing non-natural amino acids
M Oeller, R Kang, H Bolt, AGD Santos, A Weinmann, A Nikitidis, P Zlatoidsky, W Su, W Czechtizky, L De Maria, P Sormanni, M Vendruscolo
(2023)
(DOI: 10.21203/rs.3.rs-2661708/v1)
AlphaFold Prediction of Structural Ensembles of Disordered Proteins
F Brotzakis, S Zhang, M Vendruscolo
(2023)
(DOI: 10.21203/rs.3.rs-2659892/v1)

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