Yusuf Hamied Department of Chemistry

Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
(doi: 10.1039/9781837676347)
Protein rheostasis: quality control in metastable proteomes
M Vendruscolo
Philosophical Transactions of the Royal Society B Biological Sciences
(2026)
381
(doi: 10.1098/rstb.2025.0279)
Binding without Docking: Small-Molecule Binding Paths on Disordered Proteins
A Louet, G Hummer, M Vendruscolo
Journal of the American Chemical Society
(2026)
(doi: 10.1021/jacs.6c05891)
Single-Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance.
C Bretón, A Guerreiro, P Oroz, N Osés, I Ginés-Alcober, FJ Cañada, R Hurtado-Guerrero, JL Asensio, JM Peregrina, GJL Bernardes, F Corzana
Angewandte Chemie International Edition
(2026)
(doi: 10.1002/anie.8540595)
Single-Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance
C Bretón, A Guerreiro, P Oroz, N Osés, I Ginés‐Alcober, FJ Cañada, R Hurtado‐Guerrero, JL Asensio, JM Peregrina, GJL Bernardes, F Corzana
Angewandte Chemie
(2026)
(doi: 10.1002/ange.8540595)
Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression
V Sabatino, C Tang, RC Acúrcio, AR Coelho, FM Müller, M Fontes, WT Khaw, C Labão-Almeida, DR Hicks, W Yang, A Vasco Vidal, I Sarkar, D Shome, M Cabeza-Cabrerizo, TV Rohm, S Fleisch, A Gerber, SA Hogan, F Gerster, D Kaymak, S Pantelyushin, J Vom Berg, L Li, RM Reijmers, R Fior, D Baker, HF Florindo, G Hutter, GJL Bernardes
Cancer Res
(2026)
(doi: 10.1158/0008-5472.can-25-5578)
Downregulation of FBXO2 is associated with Aβ aggregation, tau hyperphosphorylation and network impairment in human cortical neurons
M Vendruscolo, AG Diaz, A Possenti, G Urritia, Y Bian, S Kedia, D Boeken, C Lim, D Licastro, B Mannini, D Klenerman
(2026)
(doi: 10.21203/rs.3.rs-10790732/v1)
Melanin Suppresses Aβ Aggregation and Toxicity
A Röntgen, JL Heise, M Vendruscolo, Z Toprakcioglu
(2026)
(doi: 10.64898/2026.09.01.748646)
Plasmodium thiamine pyrophosphokinase is essential for sporozoite formation and activation of an antiplasmodial thiamine analogue.
I Fathoni, ÜY Kina, AHY Chan, J Lee, TCS Ho, M Rauch, P Martin, EA Meissner, T Stach, FJ Leeper, M Rug, K Matuschewski, KJ Saliba
Proc Natl Acad Sci U S A
(2026)
123
(doi: 10.1073/pnas.2534594123)
Multimerization of a rationally designed nanobody for enhanced avidity toward Aβ42 oligomers
M Nowinska, E Suh, C Mogilevsky, M Vendruscolo
Protein Sci
(2026)
35
(doi: 10.1002/pro.70754)
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression (vol 7, pg 868, 2021)
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, S H Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
ACS Central Science
(2026)
12
(doi: 10.1021/acscentsci.6c01291)
Structure-Activity Relationship Study of Protoberberine Alkaloids Reveals Molecular Planarity as a Key Determinant of Membrane Interaction and Protection from Misfolded Protein Oligomers.
S Errico, A Bigi, G Fani, M Ambrosino, E Galmiche, F Bemporad, M Vendruscolo, B Mannini, F Chiti
J Med Chem
(2026)
69
(doi: 10.1021/acs.jmedchem.6c01682)
Perceptions on Accessible Mentorship and Barriers to Subspecialty Training: A Comparison Study in URiM and Non-URiM Pediatric Cardiology Trainees.
OM Cox, P Yalavarthi, A Duimstra, R Lowery, S Yu, CS Goldberg, CA Gilliam, S Balasubramanian, AD McCormick
Pediatr Cardiol
(2026)
(doi: 10.1007/s00246-026-04385-y)
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson’s disease brain tissue
A Röntgen, G Fusco, J Breiter, JS Beckwith, J Lachica, CE Toomey, J Singh, O Klementieva, S Gandhi, S Lee, A De Simone, Z Toprakcioglu, M Vendruscolo
(2026)
(doi: 10.64898/2026.07.05.736591)
Complex coacervation reshapes the aggregation landscape of tau
Z Han, P Xu, Y Ou, D Qian, Z Xiao, Y Wu, A Santambrogio, M Vendruscolo, TPJ Knowles
(2026)
(doi: 10.64898/2026.06.27.734011)
Proteoforms modulate the co-condensation of amyloid proteins
A Rontgen, Z Toprakcioglu, O Morris, M Vendruscolo
FEBS OPEN BIO
(2026)
16
Benchmarking and optimisation of human iPSC-based neuronal models for Alzheimer's disease
M Gennari, A Cinuzzi, ZW Terlikowska, M Vendruscolo, F Chiti, B Mannini
FEBS OPEN BIO
(2026)
16
Postoperative changes in cervical hemodynamics and cognitive function following cervical lymphatic-venous surgery in Alzheimer's disease.
X Zheng, C Tang, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, Q Shi, GJL Bernardes
Journal of Alzheimer's Disease
(2026)
112
(doi: 10.1177/13872877261459037)
Editorial overview: Folding, binding and protein design.
J Christodoulou, M Vendruscolo
Current Opinion in Structural Biology
(2026)
99
(doi: 10.1016/j.sbi.2026.103306)
Preserving Native Cellulose–Xylan Architecture Enables Structure–Property Control in Holocellulose Nanofibrils and High-Performance Sustainable Materials
PK Deralia, R Cresswell, Y Yoshimi, T Kuga, A Echevarría-Poza, P Howell, A Dickson, MJ Le Guen, E Wagner, ACS de Alcântara, CGT Batista, N Follain, A Miller, M Vendruscolo, SJ Hill, J Beaugrand, MS Skaf, DJ Cosgrove, SP Brown, JA Elliott, R Dupree, P Dupree
(2026)
(doi: 10.64898/2026.06.07.730583)
Dynamic palladium speciation governs prodrug activation by nanoparticles in vitro and in vivo.
E Latocheski, GMD Forno, JP Agnes, J Konč, A Zanotto-Filho, GJL Bernardes, JB Domingos
Colloids and surfaces. B, Biointerfaces
(2026)
267
(doi: 10.1016/j.colsurfb.2026.115902)
In vitro and in vivo inhibition of amyloid β aggregation by a Ru(ii)–naphthalene diimide complex
MA Tiburcio, MP Cali, LMB Pereira, AE Graminha, I Atienza-Navarro, M Vendruscolo, M Garcia-Alloza, RM Carlos
Dalton transactions (Cambridge, England : 2003)
(2026)
55
(doi: 10.1039/d5dt02853a)
Prediction of antibody non-specificity using protein language models and biophysical parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
Mabs
(2026)
18
(doi: 10.1080/19420862.2026.2678000)
Effects of PTMs on Tau Protein Aggregation: Insights from HCG and Atomistic MD Simulations
A Louet, J Stuke, L Pietrek, M Vendruscolo, G Hummer
(2026)
(doi: 10.64898/2026.05.22.727278)
Does the sequence of a disordered protein encode small molecule binding paths?
A Louet, G Hummer, M Vendruscolo
(2026)
(doi: 10.64898/2026.05.20.726646)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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