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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Preparation and Characterization of Zn(II)-Stabilized Aβ 42 Oligomers
A González Díaz, R Cataldi, B Mannini, M Vendruscolo
– ACS chemical neuroscience
(2024)
15,
2586
(DOI: 10.1021/acschemneuro.4c00084)
Step Forward Cross Validation for Bioactivity Prediction: Out of Distribution Validation in Drug Discovery.
US Saha, M Vendruscolo, AE Carpenter, S Singh, A Bender, S Seal
(2024)
(DOI: 10.1101/2024.07.02.601740)
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A.
C Olivieri, Y Wang, C Walker, MV Subrahmanian, KN Ha, D Bernlohr, J Gao, C Camilloni, M Vendruscolo, SS Taylor, G Veglia
– Elife
(2024)
12,
rp91506
(DOI: 10.7554/elife.91506)
The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A
C Olivieri, Y Wang, C Walker, MV Subrahmanian, KN Ha, D Bernlohr, J Gao, C Camilloni, M Vendruscolo, SS Taylor, G Veglia
– eLife
(2024)
12,
(DOI: 10.7554/elife.91506.3)
Capturing acyl-enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification.
J Luo, Y Yu, K Wang, S He, L Wang, F Liang, JW Chin, S Tang
– Nature Protocols
(2024)
1
(DOI: 10.1038/s41596-024-01006-x)
Identification of high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking
M Vendruscolo, M Brezinova, F Brotzakis, R Horne, VR Chowdhury, R Gregory, F Gentile
(2024)
(DOI: 10.21203/rs.3.rs-4512167/v1)
Energy Landscapes and Structural Ensembles of Glucagon-like Peptide-1 Monomers
AD Keith, EP Brichtová, JG Barber, DJ Wales, SE Jackson, K Röder
– J Phys Chem B
(2024)
128,
5601
(DOI: 10.1021/acs.jpcb.4c01794)
The diversity of<i>SNCA</i>transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
JR Evans, EK Gustavsson, I Doykov, D Murphy, GS Virdi, J Lachica, A Röntgen, MH Murtada, CW Pang, H Macpherson, AI Wernick, CE Toomey, D Athauda, ML Choi, J Hardy, NW Wood, M Vendruscolo, K Mills, W Heywood, M Ryten, S Gandhi
(2024)
(DOI: 10.1101/2024.05.30.596437)
Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues
G Battistoni, S Torres-Garcia, CY Sia, S Corriero, C Boquetale, E Williams, M Alini, N Hemmer, S Balasubramanian, BC Nicholson, G Hannon, D Bressan, IMAXT consortium
(2024)
(DOI: 10.1101/2024.05.20.595040)
Homogeneous multi-payload antibody-drug conjugates.
T Journeaux, GJL Bernardes
– Nature Chemistry
(2024)
16,
854
(DOI: 10.1038/s41557-024-01507-y)
Automated optimization of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
– Open Biology
(2024)
14,
240014
(DOI: 10.1098/rsob.240014)
Automated optimization of the solubility of a hyper-stable α-amylase
M Ali, M Greenig, M Oeller, M Atkinson, X Xu, P Sormanni
– Open Biol
(2024)
14,
240014
(DOI: 10.1098/rsob.240014)
Pharmacological inhibition of α-synuclein aggregation within liquid condensates
ST Dada, Z Toprakcioglu, MP Cali, A Röntgen, MC Hardenberg, OM Morris, LK Mrugalla, TPJ Knowles, M Vendruscolo
– Nat Commun
(2024)
15,
3835
(DOI: 10.1038/s41467-024-47585-x)
Discovery of potent inhibitors of α-synuclein aggregation using structure-based iterative learning.
RI Horne, EA Andrzejewska, P Alam, ZF Brotzakis, A Srivastava, A Aubert, M Nowinska, RC Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, TPJ Knowles, M Vendruscolo
– Nature Chemical Biology
(2024)
20,
634
(DOI: 10.1038/s41589-024-01580-x)
RASP: Optimal Single Puncta Detection in Complex Cellular Backgrounds.
B Fu, E Brock, R Andrews, J Breiter, R Tian, C Toomey, J Lachica, T Lashley, M Ryten, N Wood, M Vendruscolo, S Gandhi, L Weiss, J Beckwith, S Lee
– The Journal of Physical Chemistry B
(2024)
128,
3585
(DOI: 10.1021/acs.jpcb.4c00174)
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-<scp>d</scp>-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
AHY Chan, TCS Ho, I Fathoni, R Hamid, AKH Hirsch, KJ Saliba, FJ Leeper
– RSC medicinal chemistry
(2024)
15,
1773
(DOI: 10.1039/d4md00083h)
Understanding Biology in the Age of Artificial Intelligence
E Lawrence, A El-Shazly, S Seal, CK Joshi, P Liò, S Singh, A Bender, P Sormanni, M Greenig
(2024)
A Relationship Between Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
– ACS Chem Neurosci
(2024)
15,
1125
(DOI: 10.1021/acschemneuro.3c00718)
An Upstream G-Quadruplex DNA Structure Can Stimulate Gene Transcription.
Y Chen, A Simeone, L Melidis, SM Cuesta, D Tannahill, S Balasubramanian
– ACS chemical biology
(2024)
19,
736
(DOI: 10.1021/acschembio.3c00775)
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
(DOI: 10.21203/rs.3.rs-3947849/v1)

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