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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid
M Vendruscolo, VR Chowdhury, R Horne, M Cali, Z Toprakcioglu, S Linse
(2025)
(DOI: 10.21203/rs.3.rs-6476074/v1)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo
– Communications Chemistry
(2025)
(DOI: 10.1038/S42004-025-01659-Z)
α-Synuclein driven cell susceptibility in Parkinson's disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(DOI: 10.1101/2025.08.19.670819)
[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems.
M Carranza, AT Carmona, C Maya, E Gil de Montes, AV Vasco, GJL Bernardes, AJ Moreno-Vargas
– Bioconjugate chemistry
(2025)
acs.bioconjchem.5c00371
(DOI: 10.1021/acs.bioconjchem.5c00371)
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA.
D Schmidl, SM Becker, JM Edgerton, S Balasubramanian
– Nat Chem
(2025)
1
(DOI: 10.1038/s41557-025-01925-6)
Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model
H Zhang, RI Horne, Z Faidon Brotzakis, C Harris, P Liò, M Vendruscolo
(2025)
(DOI: 10.1101/2025.08.16.670694)
Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders
MD Overath, A Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins
(2025)
(DOI: 10.1101/2025.08.14.670059)
Correction: Modifying recombinant purple acid phosphatase using computational design
A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
– European Biophysics Journal
(2025)
1
(DOI: 10.1007/s00249-025-01792-6)
Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification
A Santambrogio, MA Metrick, P Xu, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo
(2025)
(DOI: 10.1101/2025.08.05.25331458)
A Charge-Driven Strategy for Covalent Modification and Modula- tion of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
– Journal of the American Chemical Society
(2025)
147,
28558
(DOI: 10.1021/jacs.5c06625)
SCoTCH-seq reveals that 5-hydroxymethylcytosine encodes regulatory information across DNA strands.
S Balasubramanian, J Hardwick, S Dhir, A Kirchner, A Simeone, S Flynn, J Edgerton, R de Cesaris Araujo Tavares, I Esain Garcia, D Tannahill, P Golder, J Monahan, W Gosal
– Proceedings of the National Academy of Sciences
(2025)
122,
e2512204122
(DOI: 10.1073/pnas.2512204122)
Escherichia coli with a 57-codon genetic code.
WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin
– Science (New York, N.Y.)
(2025)
eady4368
(DOI: 10.1126/science.ady4368)
Recruitment of Aβ into α‑Synuclein Condensates Catalyzes Primary Nucleation of α‑Synuclein Aggregation
OM Morris, A Rontgen, Z Toprakcioglu, M Cali, S Dada, M Vendruscolo
– ACS Central Science
(2025)
11,
1481
(DOI: 10.1021/acscentsci.5c00614)
Sequence-based virtual screening using transformers
S Zhang, D Huo, RI Horne, Y Qi, S Pujalte Ojeda, A Yan, M Vendruscolo
– Nature Communications
(2025)
16,
6925
(DOI: 10.1038/S41467-025-61833-8)
A De Novo Luciferase Bioconjugate for the Cas13-based Detection of Influenza A
M Canzano, JL Harman, Y Méndez, A Quijano-Rubio, D-A Silva, GJL Bernardes
– JACS Au
(2025)
5,
3914
(DOI: 10.1021/jacsau.5c00576)
Aβ42 promotes the aggregation of α‐synuclein splice isoforms <i>via</i> heterogeneous nucleation
A Röntgen, Z Toprakcioglu, M Vendruscolo
– FEBS letters
(2025)
1873-3468.70118
(DOI: 10.1002/1873-3468.70118)
LuxSit Pro and sPro: Next-Generation Designed Luciferases for Bioluminescent Reporting and Complementation-Based Detection
R Vergara, J Wagner, P Kamalian, JL Harman, N Lara, ES Fischer, GJL Bernardes, A Quijano-Rubio, D-A Silva
(2025)
(DOI: 10.1101/2025.07.21.665742)
Tracking tau and cellular responses in human iPSC-microglia from uptake to seedable secretion in extracellular vesicles
MK Karabova, A del Ser-Badia, A Hedegaard, SJ Washer, Z Baykam, DP O’Brien, I Vendrell, SS Hester, R Fischer, E Johnson, CE Melia, TRS Matthews-Palmer, R Matadeen, A Santambrogio, MA Metrick, M Vendruscolo, S Keeling, KA Xian Cheam, WA McEwan, KS Kosik, TA Day, WS James, SA Cowley
(2025)
(DOI: 10.1101/2025.07.17.664991)
Amyloid-β modulates the phase separation and aggregation of α-synuclein
A Röntgen, Z Toprakcioglu, O Morris, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
(DOI: 10.1073/pnas.2501987122)
Amyloid-β modulates the phase separation and aggregation of α- synuclein
A Röntgen, Z Toprakcioglu, OM Morris, M Vendruscolo
– Proc Natl Acad Sci U S A
(2025)
122,
e2501987122
(DOI: 10.1073/pnas.2501987122)

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