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Recent Publications from the Biological Research Interest Group

Trodusquemine enhances Aβ
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
(DOI: 10.1038/s41467-018-07699-5)
Different soluble aggregates of A beta 42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nat Commun
(2019)
10,
1541
(DOI: 10.1038/s41467-019-09477-3)
Probing the dynamic stalk region of the ribosome using solution NMR
X Wang, JP Kirkpatrick, HMM Launay, A de Simone, D Häussinger, CM Dobson, M Vendruscolo, LD Cabrita, CA Waudby, J Christodoulou
– Scientific Reports
(2019)
9,
13528
(DOI: 10.1038/s41598-019-49190-1)
RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether
Y-C Liao, MS Fernandopulle, G Wang, H Choi, L Hao, CM Drerup, R Patel, S Qamar, J Nixon-Abell, Y Shen, W Meadows, M Vendruscolo, TPJ Knowles, M Nelson, MA Czekalska, G Musteikyte, MA Gachechiladze, CA Stephens, HA Pasolli, LR Forrest, P St George-Hyslop, J Lippincott-Schwartz, ME Ward
– Cell
(2019)
179,
147
(DOI: 10.1016/j.cell.2019.08.050)
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.
AJ Whitehouse, MDJ Libardo, M Kasbekar, PD Brear, G Fischer, CJ Thomas, CE Barry, HIM Boshoff, AG Coyne, C Abell
– Journal of Medicinal Chemistry
(2019)
acs.jmedchem.9b01203
(DOI: 10.1021/acs.jmedchem.9b01203)
Characterising Individual Amyloid Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
FS Ruggeri, T Šneideris, S Chia, M Vendruscolo, TPJ Knowles
– Journal of visualized experiments : JoVE
(2019)
(DOI: 10.3791/60108)
Structural Insights into Escherichia coli  Phosphopantothenoylcysteine Synthetase by Native Ion Mobility-Mass Spectrometry.
DS-H Chan, J Hess, E Shaw, C Spry, R Starley, C Dagostin, MV Dias, R Kale, V Mendes, TL Blundell, AG Coyne, C Abell
– Biochem J
(2019)
BCJ20190318
(DOI: 10.1042/bcj20190318)
Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly.
K Wang, D de la Torre, WE Robertson, JW Chin
– Science (New York, N.Y.)
(2019)
365,
922
(DOI: 10.1126/science.aay0737)
Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification
PR Lindstedt, FA Aprile, MJ Matos, M Perni, JB Bertoldo, B Bernardim, Q Peter, G Jiménez-Osés, TPJ Knowles, CM Dobson, F Corzana, M Vendruscolo, GJL Bernardes
– ACS Central Science
(2019)
5,
1417
(DOI: 10.1021/acscentsci.9b00467)
Substrate flexibility of the flavin-dependent dihydropyrrole oxidases PigB and HapB involved in antibiotic prodigiosin biosynthesis.
M Couturier, H Bhalara, S Chawrai, R Monson, N Williamson, G Salmond, FJ Leeper
– ChemBioChem
(2019)
cbic.201900424
(DOI: 10.1002/cbic.201900424)
Motile Artificial Chromatophores: Light‐Triggered Nanoparticles for Microdroplet Locomotion and Color Change
AR Salmon, S Cormier, W Wang, C Abell, JJ Baumberg
– Advanced Optical Materials
(2019)
1900951
(DOI: 10.1002/adom.201900951)
Evaluation of linker length effects on a BET bromodomain probe
R Traquete, E Henderson, S Picaud, PMSD Cal, F Sieglitz, T Rodrigues, R Oliveira, P Filippakopoulos, GJL Bernardes
– Chemical communications (Cambridge, England)
(2019)
55,
10128
(DOI: 10.1039/c9cc05054j)
Ethynylbenziodoxolone Reactivity in Cysteine Bioconjugation
SR Adusumalli, GJL Bernardes
– Chem
(2019)
5,
1932
(DOI: 10.1016/j.chempr.2019.07.014)
Small molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
G Heller, F Aprile, T Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, A De Simone, I Felli, R Pierattelli, T Knowles, C Dobson, M Vendruscolo
(2019)
(DOI: 10.1101/729392)
Promoting transparency and reproducibility in enhanced molecular simulations
PLUMED consortium
– Nat Methods
(2019)
16,
670
(DOI: 10.1038/s41592-019-0506-8)
The Hsp70 Chaperone System Stabilizes a Thermo-sensitive Subproteome in E. coli
L Zhao, G Vecchi, M Vendruscolo, R Körner, M Hayer-Hartl, FU Hartl
– Cell reports
(2019)
28,
1335
(DOI: 10.1016/j.celrep.2019.06.081)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta Neuropathol Commun
(2019)
7,
120
(DOI: 10.1186/s40478-019-0777-4)
Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers
B Mannini, G Vecchi, A Labrador-Garrido, B Fabre, G Fani, JM Franco, K Lilley, D Pozo, M Vendruscolo, F Chiti, CM Dobson, C Roodveldt
– ACS chemical neuroscience
(2019)
10,
3464
(DOI: 10.1021/acschemneuro.9b00088)
Focused surface acoustic waves induced microdroplets generation and its application for microgels
S Jin, X Wei, Z Liu, J Ren, Z Jiang, C Abell, Z Yu
– Sensors and Actuators B Chemical
(2019)
291,
1
(DOI: 10.1016/j.snb.2019.04.055)
Development of inhibitors against Mycobacterium abscessus tRNA (m1G37) methyltransferase (TrmD) using fragment-based approaches.
AJ Whitehouse, SE Thomas, KP Brown, A Fanourakis, DS-H Chan, MDJ Libardo, V Mendes, HIM Boshoff, RA Floto, C Abell, TL Blundell, AG Coyne
– Journal of Medicinal Chemistry
(2019)
62,
7210
(DOI: 10.1021/acs.jmedchem.9b00809)

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