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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules.
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2422427122
(DOI: 10.1073/pnas.2422427122)
Proteostasis signatures in human diseases
CM Lim, M Vendruscolo
– Plos Computational Biology
(2025)
21,
e1013155
(DOI: 10.1371/journal.pcbi.1013155)
Mechanically knocking out titin reveals protein tension loss as a trigger of muscle disease
R Silva-Rojas, N Vicente, M Gavilán-Herrera, V Labrador-Cantarero, J Sicilia, O Giménez-Sáez, AC Dumitru, MI Sánchez, M Gato-Vilaseca, D Velázquez-Carreras, JA López, J Vázquez, E Herrero-Galán, MA López-Unzu, MR Pricolo, J Alegre-Cebollada
– Nature Biomedical Engineering
(2025)
1
(DOI: 10.1038/s41551-025-01403-x)
DNA G-quadruplex structures act as functional elements in ⍺- and ß-globin enhancers
C Doyle, K Herka, SM Flynn, L Melidis, S Dhir, S Schoenfelder, D Tannahill, S Balasubramanian
– Genome biology
(2025)
26,
155
(DOI: 10.1186/s13059-025-03627-1)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
(2025)
(DOI: 10.1101/2025.05.27.656333)
Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies
M Ghirardello, A Guerreiro, C Bretón, I Compañón, J Zabalza, V Mangini, JM Peregrina, GJL Bernardes, F Corzana
– Chemistry - A European Journal
(2025)
e202501286
(DOI: 10.1002/chem.202501286)
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases
T Yin, A Ramon, M Greenig, P Sormanni, L D’Adamio
– mAbs
(2025)
17,
2498164
(DOI: 10.1080/19420862.2025.2498164)
An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes.
ME Hazemi, MB Geeson, FM Müller, S Mikutis, AJ Enright, GJL Bernardes
– JACS Au
(2025)
5,
2309
(DOI: 10.1021/jacsau.5c00249)
The thermodynamic hypothesis of protein aggregation
M Vendruscolo
– Molecular aspects of medicine
(2025)
103,
101364
(DOI: 10.1016/j.mam.2025.101364)
Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
(2025)
(DOI: 10.1101/2025.04.28.650927)
Rational Design of Single-Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo-A
V Roy Chowdhury, A Röntgen, M Greenig, Y Méndez Gómez, SP Spiegel, M Nowinska, A Ramon, P Sormanni, A Chan, M Vendruscolo
– Wiley Interdisciplinary Reviews: RNA
(2025)
4,
e70012
(DOI: 10.1002/appl.70012)
Aggregation of α-Synuclein Splice Isoforms through a Phase Separation Pathway
A Roentgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science Advances
(2025)
(DOI: 10.1126/sciadv.adq5396)
Aggregation of α-synuclein splice isoforms through a phase separation pathway.
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science Advances
(2025)
11,
eadq5396
(DOI: 10.1126/sciadv.adq5396)
Linking Aβ and tau in the amyloid cascade through the intersection of their proteostasis networks
CM Lim, J Hardy, M Vendruscolo
(2025)
(DOI: 10.1101/2025.03.28.646065)
Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch
X Zhang, S Dhir, L Melidis, Y Chen, Z Yu, A Simeone, J Spiegel, S Adhikari, S Balasubramanian
– Nature chemistry
(2025)
17,
875
(DOI: 10.1038/s41557-025-01792-1)
Serial amplification of tau filaments using Alzheimer’s brain homogenates and C322A or C322S recombinant tau
A Santambrogio, S Lövestam, MA Metrick, TS Lohr, P Xu, B Caughey, SHW Scheres, M Vendruscolo
(2025)
(DOI: 10.1101/2025.03.29.646137)
IgCraft: A versatile sequence generation framework for antibody discovery and engineering
M Greenig, H Zhao, V Radenkovic, A Ramon, P Sormanni
(2025)
Natural aminosterols inhibit <scp>NMDA</scp> receptors with low nanomolar potency
G Fani, E Coppi, S Errico, F Cherchi, M Gennari, D Barbut, M Vendruscolo, M Zasloff, AM Pugliese, F Chiti
– The FEBS Journal
(2025)
(DOI: 10.1111/febs.70072)
Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H Provides a Generalized Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets.
M Penner, OJ Klein, M Gantz, FEH Nintzel, A-C Prowald, S Boss, P Barker, P Dupree, F Hollfelder
– Journal of the American Chemical Society
(2025)
147,
10903
(DOI: 10.1021/jacs.4c11804)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nature Communications
(2025)
16,
2814
(DOI: 10.1038/s41467-025-58142-5)

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