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Department of Chemistry

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature Communications
Determination of protein structural ensembles using cryo-electron microscopy.
M Bonomi, M Vendruscolo
– Curr Opin Struct Biol
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action
B Bestgen, I Kufareva, W Seetoh, C Abell, RW Hartmann, R Abagyan, M Le Borgne, O Filhol, C Cochet, T Lomberget, M Engel
– Journal of medicinal chemistry
Atomic force microscopy for single molecule characterisation of protein aggregation
FS Ruggeri, T Šneideris, M Vendruscolo, TPJ Knowles
– Archives of biochemistry and biophysics
Chemical and mechanistic analysis of photodynamic inhibition of Alzheimer's β-amyloid aggregation
M Ahn, BI Lee, S Chia, J Habchi, JR Kumita, M Vendruscolo, CM Dobson, CB Park
– Chemical communications (Cambridge, England)
Erratum: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs (Genome Biol (2018) 19 (229) DOI: 10.1186/s13059-018-1602-2)
P Murat, G Marsico, B Herdy, AT Ghanbarian, G Portella, S Balasubramanian
– Genome Biology
De novo design of potent and selective mimics of IL-2 and IL-15
D-A Silva, S Yu, UY Ulge, JB Spangler, KM Jude, C Labão-Almeida, LR Ali, A Quijano-Rubio, M Ruterbusch, I Leung, T Biary, SJ Crowley, E Marcos, CD Walkey, BD Weitzner, F Pardo-Avila, J Castellanos, L Carter, L Stewart, SR Riddell, M Pepper, GJL Bernardes, M Dougan, KC Garcia, D Baker
– Nature
Physical Determinants of Amyloid Assembly in Biofilm Formation
M Andreasen, G Meisl, JD Taylor, TCT Michaels, A Levin, DE Otzen, MR Chapman, CM Dobson, SJ Matthews, TPJ Knowles
– mBio
Adaptation of Proteins to the Cold in Antarctic Fish: A Role for Methionine?
C Berthelot, J Clarke, T Desvignes, H William Detrich, P Flicek, LS Peck, M Peters, JH Postlethwait, MS Clark
– Genome biology and evolution
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology.
H Fu, A Possenti, R Freer, Y Nakano, NCH Villegas, M Tang, PVM Cauhy, BA Lassus, S Chen, SL Fowler, HY Figueroa, ED Huey, GVW Johnson, M Vendruscolo, KE Duff
– Nat Neurosci
RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs
P Murat, G Marsico, B Herdy, AT Ghanbarian, G Portella, S Balasubramanian
– Genome biology
A superposition free method for protein conformational ensemble analyses and local clustering based on a differential geometry representation of backbone.
AM da Silva Neto, SR Silva, M Vendruscolo, C Camilloni, RW Montalvão
– Proteins: Structure, Function and Bioinformatics
Stabilization and Characterization of Cytotoxic A beta(40) Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Chem Neurosci
Structure of a (3+1) hybrid G-quadruplex in the PARP1 promoter.
A Sengar, JJ Vandana, VS Chambers, M Di Antonio, FR Winnerdy, S Balasubramanian, AT Phan
– Nucleic Acids Res
One-pot stapling of interchain disulfides of antibodies using an isobutylene motif.
S Sun, P Akkapeddi, MC Marques, N Martínez-Sáez, VM Torres, C Cordeiro, O Boutureira, GJL Bernardes
– Organic & biomolecular chemistry
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid
N Huguenin-Dezot, DA Alonzo, GW Heberlig, M Mahesh, DP Nguyen, MH Dornan, CN Boddy, TM Schmeing, JW Chin
– Nature
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
– Nano letters
In vitro and in silico assessment of the developability of a designed monoclonal antibody library.
A-M Wolf Pérez, P Sormanni, JS Andersen, LI Sakhnini, I Rodriguez-Leon, JR Bjelke, AJ Gajhede, L De Maria, DE Otzen, M Vendruscolo, N Lorenzen
– MAbs
Controlling orthogonal ribosome subunit interactions enables evolution of new function
WH Schmied, Z Tnimov, C Uttamapinant, CD Rae, SD Fried, JW Chin
– Nature
Development of targeted imaging agents for detecting tumour cell death
F Bulat, A Neves, D Soloviev, B Xie, F Aigbirhio, F Leeper, K Brindle