Yusuf Hamied Department of Chemistry

Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
(doi: 10.1039/9781837676347)
5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer.
F Puddu, A Johansson, A Modat, J Scotcher, R Sethi, S Yu, N Harding, M Hill, E Lleshi, C Lumby, J Teyssandier, M Wilson, R Crawford, T Charlesworth, P Creed, S Balasubramanian, RJ Osborne
Communications medicine
(2026)
6
(doi: 10.1038/s43856-025-01278-8)
Cryo-EM structures of NHEJ assemblies with nucleosomes.
C Hall, P Frit, A Kefala-Stavridi, A Pelletier, SW Hardwick, H Amin, MK Bilyard, T Maia De Oliviera, A Tariq, S Zahid, DY Chirgadze, S Balasubramanian, K Meek, V Ropars, J-B Charbonnier, M Modesti, P Calsou, S Britton, TL Blundell, T Schalch, AK Chaplin
Nature communications
(2025)
17
(doi: 10.1038/s41467-025-67376-2)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
Journal of Physical Chemistry Letters
(2025)
16
(doi: 10.1021/acs.jpclett.5c03467)
Commentary on ‘Untargeted CUT&Tag reads are enriched at accessible chromatin and restrict identification of potential G4-forming sequences in G4-targeted CUT&Tag experiments’
L Melidis, R de Cesaris Araujo Tavares, X He, S Dhir, D Tannahill, S Balasubramanian
Nucleic Acids Res
(2025)
53
(doi: 10.1093/nar/gkaf1337)
Single-molecule imaging of small aggregates of IAPP in type 2 diabetes serum with rationally-designed antibody-like scaffolds.
J Lin, YP Zhang, S Chia, D Klenerman, P Sormanni, M Vendruscolo
Chem Sci
(2025)
(doi: 10.1039/d5sc01427a)
High-fidelity human chromosome transfer and elimination.
G Petris, S Grazioli, L van Bijsterveldt, P Murat, KC Liu, J Birnbaum, JE Sale, JW Chin
Science
(2025)
390
(doi: 10.1126/science.adv9797)
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity.
SJ Resnick, S Qamar, P Krishna, V Korobeynikov, H Ausserwoger, A Miller, P Esposito, JA Varela, J Sheng, LH Huang, J Nixon-Abell, S Melore, CW Chung, NF Läubli, S Kapsiani, X Li, J Wang, N Zhang, MM Alam, AS Burguete, TC Swayne, Y Chen, Y-C Liao, NA Shneider, M Vendruscolo, TPJ Knowles, CF Kaminski, FS Ruggeri, GS Kaminski Schierle, P St George-Hyslop, A Chavez
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-65178-0)
Binding Paths: Describing Small Molecule Interactions with Disordered Proteins via Markov State Models
A Louet, G Hummer, M Vendruscolo
(2025)
(doi: 10.1101/2025.11.19.688850)
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding.
Y-H Lee, T Saio, M Watabe, M Matsusaki, S Kanemura, Y Lin, T Mannen, T Kuramochi, Y Kamada, K Iuchi, M Tajiri, K Suzuki, Y Li, Y Heo, K Ishii, K Arai, K Ban, M Hashimoto, S Oshita, S Ninagawa, Y Hattori, H Kumeta, A Takeuchi, S Kajimoto, H Abe, E Mori, T Muraoka, T Nakabayashi, S Akashi, T Okiyoneda, M Vendruscolo, K Inaba, M Okumura
Nature cell biology
(2025)
27
(doi: 10.1038/s41556-025-01794-8)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking
M Brezinova, ZF Brotzakis, RI Horne, V Roy Chowdhury, RC Gregory, Y Bian, A González Díaz, F Gentile, M Vendruscolo
Molecular systems biology
(2025)
22
(doi: 10.1038/S44320-025-00159-5)
Escherichia coli with a 57-codon genetic code
WE Robertson, FBH Rehm, M Spinck, RL Schumann, R Tian, W Liu, Y Gu, AA Kleefeldt, CF Day, KC Liu, Y Christova, JF Zürcher, FL Böge, J Birnbaum, L van Bijsterveldt, JW Chin
Science
(2025)
390
(doi: 10.1126/science.ady4368)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(doi: 10.21203/rs.3.rs-7375981/v1)
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nature biomedical engineering
(2025)
(doi: 10.1038/s41551-025-01496-4)
Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau.
A Santambrogio, S Lövestam, MA Metrick, T Löhr, P Xu, NCT Gallagher, B Ghetti, B Caughey, SHW Scheres, M Vendruscolo
FEBS Lett
(2025)
599
(doi: 10.1002/1873-3468.70141)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, T Knowles, M Vendruscolo
Commun Chem
(2025)
8
(doi: 10.1038/s42004-025-01659-z)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
S De, E Prescott, J Wei, E Garland, A Urbanek, F Capriglia, W Molenkamp, D Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, M Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, J Highley, T Knowles, H Mortiboys
(2025)
(doi: 10.21203/rs.3.rs-7657706/v1)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De
(2025)
(doi: 10.1101/2025.09.17.676873)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay.
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
J Am Chem Soc
(2025)
147
(doi: 10.1021/jacs.5c12812)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(doi: 10.1101/2025.08.25.671921)
Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid
M Vendruscolo, VR Chowdhury, R Horne, M Cali, Z Toprakcioglu, S Linse
(2025)
(doi: 10.21203/rs.3.rs-6476074/v1)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(doi: 10.1101/2025.08.19.670819)
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA
D Schmidl, SM Becker, JM Edgerton, S Balasubramanian
Nature chemistry
(2025)
17
(doi: 10.1038/s41557-025-01925-6)
Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model
H Zhang, RI Horne, ZF Brotzakis, C Harris, P Liò, M Vendruscolo
(2025)
(doi: 10.1101/2025.08.16.670694)
Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders
MD Overath, ASH Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins
(2025)
(doi: 10.1101/2025.08.14.670059)
Yusuf Hamied Department of Chemistry
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