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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis.
PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo
– ACS chemical neuroscience
(2021)
acschemneuro.0c00761
(DOI: 10.1021/acschemneuro.0c00761)
A kinetic ensemble of the Alzheimer’s Aβ peptide
T Löhr, K Kohlhoff, GT Heller, C Camilloni, M Vendruscolo
– Nature Computational Science
(2021)
1,
71
(DOI: 10.1038/s43588-020-00003-w)
A dopamine metabolite stabilizes neurotoxic amyloid-β oligomers
R Cataldi, S Chia, K Pisani, FS Ruggeri, CK Xu, T Šneideris, M Perni, S Sarwat, P Joshi, JR Kumita, S Linse, J Habchi, TPJ Knowles, B Mannini, CM Dobson, M Vendruscolo
– Communications biology
(2021)
4,
19
(DOI: 10.1038/s42003-020-01490-3)
Observation of an α-1synuclein liquid droplet state and its maturation into Lewy body-like assemblies
MC Hardenberg, T Sinnige, S Casford, S Dada, C Poudel, EA Robinson, M Fuxreiter, C Kaminksi, GS Kaminski-Schierle, EAA Nollen, CM Dobson, M Vendruscolo
– Journal of molecular cell biology
(2021)
mjaa075-
(DOI: 10.1093/jmcb/mjaa075)
A method of incorporating rate constants as kinetic constraints in molecular dynamics simulations
ZF Brotzakis, M Vendruscolo, PG Bolhuis
– Proc Natl Acad Sci U S A
(2020)
118,
e2012423118
(DOI: 10.1073/pnas.2012423118)
Interactions of α-synuclein oligomers with lipid membranes.
G Musteikytė, AK Jayaram, CK Xu, M Vendruscolo, G Krainer, TPJ Knowles
– Biochimica et biophysica acta. Biomembranes
(2020)
183536
(DOI: 10.1016/j.bbamem.2020.183536)
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Communications Chemistry
(2020)
3,
191
(DOI: 10.1038/s42004-020-00412-y)
Widespread occurrence of the droplet state of proteins in the human proteome
M Hardenberg, A Horvath, V Ambrus, M Fuxreiter, M Vendruscolo
– Proceedings of the National Academy of Sciences
(2020)
117,
33254
(DOI: 10.1073/pnas.2007670117)
Reprogramming the genetic code
D de la Torre, JW Chin
– Nature Reviews Genetics
(2020)
21,
1
(DOI: 10.1038/s41467-019-12916-w)
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry
VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes
– Bioconjugate chemistry
(2020)
32,
121
(DOI: 10.1021/acs.bioconjchem.0c00551)
Sequence determinants for the aggregation and cytotoxicity of proteins within condensates generated by liquid-liquid phase separation
M Vendruscolo, M Fuxreiter
(2020)
(DOI: 10.1101/2020.12.07.414409)
Development of targeted imaging agents for detecting tumour cell death
F Bulat, A Neves, F Hesse, D-E Hu, F Aigbirhio, F Leeper, K Brindle
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
63,
615
18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography
F Bulat, F Hesse, D-E Hu, S Ros, W-H Connor, B Xie, B Attili, D Soloviev, F Aigbirhio, F Leeper, K Brindle, A Neves
– EJNMMI Research
(2020)
Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis
PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo
– Cell chemical biology
(2020)
(DOI: 10.1016/j.chembiol.2020.11.002)
Biophysical studies of protein misfolding and aggregation in <i>in vivo</i> models of Alzheimer's and Parkinson's diseases - ERRATUM.
T Sinnige, K Stroobants, CM Dobson, M Vendruscolo
– Quarterly reviews of biophysics
(2020)
53,
e13
(DOI: 10.1017/s0033583520000104)
Therapeutic Strategies to Reduce the Toxicity of Misfolded Protein Oligomers
RP Kreiser, AK Wright, NR Block, JE Hollows, LT Nguyen, K LeForte, B Mannini, M Vendruscolo, R Limbocker
– Int J Mol Sci
(2020)
21,
8651
(DOI: 10.3390/ijms21228651)
Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody
J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana
– Chem Commun (Camb)
(2020)
56,
15137
(DOI: 10.1039/d0cc06349e)
A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms
F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo
– biorxiv
(2020)
(DOI: 10.1101/2020.11.10.376285)
Structure of a protective epitope reveals the importance of acetylation of <i>Neisseria meningitidis</i> serogroup A capsular polysaccharide.
P Henriques, L Dello Iacono, A Gimeno, A Biolchi, MR Romano, A Arda, GJL Bernardes, J Jimenez-Barbero, F Berti, R Rappuoli, R Adamo
– Proceedings of the National Academy of Sciences
(2020)
117,
29795
(DOI: 10.1073/pnas.2011385117)
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro
D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, KS Rankin, SM Cologna, JR Kumita, N Cenac, E St John Smith
– Aging
(2020)
12,
22266
(DOI: 10.18632/aging.202138)

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