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Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Erratum to: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation (Scientific Reports, (2017), 7, 1, (9039), 10.1038/s41598-017-08324-z)
FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
– Scientific reports
(2018)
8,
11848
(DOI: 10.1038/s41598-018-29893-7)
Third generation antibody discovery methods: in silico rational design.
P Sormanni, FA Aprile, M Vendruscolo
– Chemical Society reviews
(2018)
(DOI: 10.1039/c8cs00523k)
Radical-mediated thiol-ene strategy for photoactivation of thiol-containing drugs in cancer cells
S Sun, B Oliveira, G Jiménez-Osés, GJL Bernardes
– Angew Chem Int Ed Engl
(2018)
(DOI: 10.1002/anie.201811338)
DNA G-quadruplex structures mould the DNA methylome
S-Q Mao, AT Ghanbarian, J Spiegel, S Martínez Cuesta, D Beraldi, M Di Antonio, G Marsico, R Hänsel-Hertsch, D Tannahill, S Balasubramanian
– Nat Struct Mol Biol
(2018)
25,
951
(DOI: 10.1038/s41594-018-0131-8)
An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells
V Beránek, JCW Willis, JW Chin
– Biochemistry
(2018)
(DOI: 10.1021/acs.biochem.8b00808)
SAR by kinetics for drug discovery in protein misfolding diseases.
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, TPJ Knowles, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
(DOI: 10.1073/pnas.1807884115)
Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts.
B Herdy, C Mayer, D Varshney, G Marsico, P Murat, C Taylor, C D'Santos, D Tannahill, S Balasubramanian
– Nucleic acids research
(2018)
(DOI: 10.1093/nar/gky861)
Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.
FS Ruggeri, J Charmet, T Kartanas, Q Peter, S Chia, J Habchi, CM Dobson, M Vendruscolo, TPJ Knowles
– Nature Communications
(2018)
9,
3890
(DOI: 10.1038/s41467-018-06345-4)
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation.
M Baumdick, M Gelléri, C Uttamapinant, V Beránek, JW Chin, PIH Bastiaens
– Nature Communications
(2018)
9,
3847
(DOI: 10.1038/s41467-018-06299-7)
Determination of the conformational states of strychnine in solution using NMR residual dipolar couplings in a tensor-free approach.
G Tomba, C Camilloni, M Vendruscolo
– Methods
(2018)
148,
4
(DOI: 10.1016/j.ymeth.2018.07.005)
Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis
CA Waudby, T Wlodarski, M-E Karyadi, AME Cassaignau, SHS Chan, AS Wentink, JM Schmidt-Engler, C Camilloni, M Vendruscolo, LD Cabrita, J Christodoulou
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
9744
(DOI: 10.1073/pnas.1716252115)
Unexpected stability of aqueous dispersions of raspberry-like colloids
Y Lan, A Caciagli, G Guidetti, Z Yu, J Liu, VE Johansen, M Kamp, C Abell, S Vignolini, OA Scherman, E Eiser
– Nature Communications
(2018)
9,
3614
(DOI: 10.1038/s41467-018-05560-3)
Obituary: Nico van Nuland 1961-2017 OBITUARY
A Matagne, CM Dobson
– European biophysics journal : EBJ
(2018)
47,
597
(DOI: 10.1007/s00249-018-1326-y)
Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.
MJ Matos, C Labão-Almeida, C Sayers, O Dada, M Tacke, GJL Bernardes
– Chemistry
(2018)
24,
12250
(DOI: 10.1002/chem.201800872)
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release.
M Mukherjee, S Sabir, L O'Regan, J Sampson, MW Richards, N Huguenin-Dezot, JR Ault, JW Chin, A Zhuravleva, AM Fry, R Bayliss
– Sci Signal
(2018)
11,
ARTN eaao2464
(DOI: 10.1126/scisignal.aao2464)
Structural differences between toxic and nontoxic HypF-N oligomers
C Capitini, JR Patel, A Natalello, C D'Andrea, A Relini, JA Jarvis, L Birolo, A Peduzzo, M Vendruscolo, P Matteini, CM Dobson, A De Simone, F Chiti
– Chemical communications (Cambridge, England)
(2018)
54,
8637
(DOI: 10.1039/c8cc03446j)
Stabilization and Characterization of Cytotoxic Aβ
B Mannini, J Habchi, S Chia, FS Ruggeri, M Perni, TPJ Knowles, CM Dobson, M Vendruscolo
– ACS Chemical Neuroscience
(2018)
(DOI: 10.1021/acschemneuro.8b00141)
Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.
GT Heller, M Bonomi, M Vendruscolo
– Journal of molecular biology
(2018)
430,
2288
(DOI: 10.1016/j.jmb.2018.03.015)
Promiscuous and Selective: How Intrinsically Disordered BH3 Proteins Interact with Their Pro-survival Partner MCL-1.
L Dahal, TOC Kwan, JJ Hollins, J Clarke
– Journal of molecular biology
(2018)
430,
2468
(DOI: 10.1016/j.jmb.2018.04.004)
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
306,
57
(DOI: 10.1016/j.jneumeth.2018.02.005)

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