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Recent Publications from the Biological Research Interest Group

The N-terminal Acetylation of α-Synuclein Changes the Affinity for Lipid Membranes but not the Structural Properties of the Bound State
M Runfola, A De Simone, M Vendruscolo, CM Dobson, G Fusco
– Sci Rep
(2020)
10,
204
(DOI: 10.1038/s41598-019-57023-4)
Machine learning for target discovery in drug development
T Rodrigues, GJL Bernardes
– Curr Opin Chem Biol
(2020)
56,
16
(DOI: 10.1016/j.cbpa.2019.10.003)
Complexity in lipid membrane composition induces resilience to Aβ42 aggregation.
M Sanguanini, KN Baumann, S Preet, S Chia, J Habchi, TPJ Knowles, M Vendruscolo
– ACS Chem Neurosci
(2020)
acschemneuro.0c00101
(DOI: 10.1021/acschemneuro.0c00101)
Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GGL Bernandes, TPJ Knowles
– Soft Matter
(2020)
16,
3082
(DOI: 10.1039/c9sm02274k)
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.
MR Hodskinson, A Bolner, K Sato, AN Kamimae-Lanning, K Rooijers, M Witte, M Mahesh, J Silhan, M Petek, DM Williams, J Kind, JW Chin, KJ Patel, P Knipscheer
– Nature
(2020)
579,
1
(DOI: 10.1038/s41586-020-2059-5)
A Cell- and Tissue-Specific Weakness of the Protein Homeostasis System Underlies Brain Vulnerability to Protein Aggregation.
R Kundra, CM Dobson, M Vendruscolo
– iScience
(2020)
23,
100934
(DOI: 10.1016/j.isci.2020.100934)
Sequence-based determinants and prediction of fuzzy interactions in protein complexes
M Miskei, A Horvath, M Vendruscolo, M Fuxreiter
– Journal of molecular biology
(2020)
(DOI: 10.1016/j.jmb.2020.02.017)
A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseases.
MA Metrick, NDC Ferreira, E Saijo, A Kraus, K Newell, G Zanusso, M Vendruscolo, B Ghetti, B Caughey
– Acta Neuropathol Commun
(2020)
8,
22
(DOI: 10.1186/s40478-020-0887-z)
Substrate Flexibility of the Flavin‐Dependent Dihydropyrrole Oxidases PigB and HapB Involved in Antibiotic Prodigiosin Biosynthesis
M Couturier, HD Bhalara, SR Chawrai, R Monson, NR Williamson, GPC Salmond, FJ Leeper
– Chembiochem
(2020)
21,
523
(DOI: 10.1002/cbic.201900424)
Polyglutamine Aggregation in a Living Animal is Governed by Biophysical Parameters
T Sinnige, T Michaels, M Vendruscolo, RI Morimoto
– BIOPHYSICAL JOURNAL
(2020)
118,
372A
Rational Design of Conformation-Specific Antibodies for Tau Oligomers
K Kulenkampff, FA Aprile, P Sormanni, RT Ranasinghe, D Klenerman, M Vendruscolo
– BIOPHYSICAL JOURNAL
(2020)
118,
370A
Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers.
SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, R Cascella, CM Dobson, M Vendruscolo, TPJ Knowles, F Chiti
– Biomacromolecules
(2020)
21,
1112
(DOI: 10.1021/acs.biomac.9b01475)
Chris Dobson (1949-2019).
TPJ Knowles, M Vendruscolo
– Nature chemical biology
(2020)
16,
105
(DOI: 10.1038/s41589-019-0456-6)
A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles.
WK Man, A De Simone, JD Barritt, M Vendruscolo, CM Dobson, G Fusco
– Frontiers in neuroscience
(2020)
14,
18
(DOI: 10.3389/fnins.2020.00018)
Stable pyrrole-linked bioconjugates through tetrazine-triggered azanorbornadiene fragmentation
E Gil de Montes, A Istrate, CD Navo, E Jiménez-Moreno, EA Hoyt, F Corzana, I Robina, G Jiménez-Osés, AJ Moreno-Vargas, GJL Bernardes
– Angewandte Chemie International Edition
(2020)
59,
6196
(DOI: 10.1002/anie.201914529)
Stable Pyrrole‐Linked Bioconjugates through Tetrazine‐Triggered Azanorbornadiene Fragmentation
E Gil de Montes, A Istrate, CD Navo, E Jiménez‐Moreno, EA Hoyt, F Corzana, I Robina, G Jiménez‐Osés, AJ Moreno‐Vargas, GJL Bernardes
– Angewandte Chemie
(2020)
ange.201914529
(DOI: 10.1002/ange.201914529)
Widespread remodeling of proteome solubility in response to different protein homeostasis stresses
X Sui, DEV Pires, AR Ormsby, D Cox, S Nie, G Vecchi, M Vendruscolo, DB Ascher, GE Reid, DM Hatters
– Proc Natl Acad Sci U S A
(2020)
117,
2422
(DOI: 10.1073/pnas.1912897117)
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
T Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, A Dear, S Cohen, M Vendruscolo, C Dobson, S Linse, T Knowles
(2020)
(DOI: 10.1101/2020.01.08.897488)
Proteome-wide observation of the phenomenon of life on the edge of solubility.
G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, FU Hartl, M Vendruscolo
– Proceedings of the National Academy of Sciences of the United States of America
(2020)
117,
1015
(DOI: 10.1073/pnas.1910444117)
Inherent biophysical properties modulate the toxicity of soluble amyloidogenic light chains
M Maritan, M Romeo, L Oberti, P Sormanni, M Tasaki, R Russo, A Ambrosetti, P Motta, P Rognoni, G Mazzini, A Barbiroli, G Palladini, M Vendruscolo, L Diomede, M Bolognesi, G Merlini, F Lavatelli, S Ricagno
– Journal of molecular biology
(2020)
432,
845
(DOI: 10.1016/j.jmb.2019.12.015)

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