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Department of Chemistry

 
Promiscuous and Selective: How Intrinsically Disordered BH3 Proteins Interact with Their Pro-survival Partner MCL-1.
L Dahal, TOC Kwan, JJ Hollins, J Clarke
– Journal of molecular biology
(2018)
430,
2468
Structural differences between toxic and nontoxic HypF-N oligomers
C Capitini, JR Patel, A Natalello, C D'Andrea, A Relini, JA Jarvis, L Birolo, A Peduzzo, M Vendruscolo, P Matteini, CM Dobson, A De Simone, F Chiti
– Chemical communications (Cambridge, England)
(2018)
54,
8637
Structural Ensemble Modulation upon Small-Molecule Binding to Disordered Proteins.
GT Heller, M Bonomi, M Vendruscolo
– Journal of molecular biology
(2018)
430,
2288
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, MC Hardenberg, P Sormanni, T Müller, KL Saar, LWY Roode, J Habchi, G Vecchi, N Fernando, S Casford, EAA Nollen, M Vendruscolo, CM Dobson, TPJ Knowles
– J Neurosci Methods
(2018)
306,
57
Cucurbit[7]uril-based high-performance catalytic microreactors.
X Ren, Z Yu, Y Wu, J Liu, C Abell, OA Scherman
– Nanoscale
(2018)
Pyrophosphorylation via selective phosphoprotein derivatization
AM Marmelstein, JAM Morgan, M Penkert, DT Rogerson, JW Chin, E Krause, D Fiedler
– Chemical Science
(2018)
9,
5929
Determination of the conformational states of strychnine using NMR residual dipolar couplings in a tensor-free approach.
G Tomba, C Camilloni, M Vendruscolo
– Methods
(2018)
Site-selective installation of an electrophilic handle on proteins for bioconjugation.
B Lee, S Sun, E Jiménez-Moreno, AA Neves, GJL Bernardes
– Bioorganic & medicinal chemistry
(2018)
26,
3060
Detecting RNA G-Quadruplexes (rG4s) in the Transcriptome.
CK Kwok, G Marsico, S Balasubramanian
– Cold Spring Harbor Perspectives in Biology
(2018)
10,
a032284
Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils
JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion
– Chemical communications (Cambridge, England)
(2018)
54,
7854
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, GT Heller, G Meisl, SW Chen, JR Kumita, PK Challa, JB Kirkegaard, SIA Cohen, B Mannini, D Barbut, EAA Nollen, C Cecchi, N Cremades, TPJ Knowles, F Chiti, M Zasloff, M Vendruscolo, CM Dobson
– ACS Chem Biol
(2018)
Reversible inhibition of the ClpP protease via an N-terminal conformational switch
S Vahidi, ZA Ripstein, M Bonomi, T Yuwen, MF Mabanglo, JB Juravsky, K Rizzolo, A Velyvis, WA Houry, M Vendruscolo, JL Rubinstein, LE Kay
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
E6447
Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
MC Chen, R Tippana, NA Demeshkina, P Murat, S Balasubramanian, S Myong, AR Ferré-D'Amaré
– Nature
(2018)
558,
465
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
– Cell Rep
(2018)
23,
3492
Sequencing 5-hydroxymethyluracil at single-base resolution.
F Kawasaki, S Martínez Cuesta, D Beraldi, A Mahtey, RE Hardisty, M Carrington, S Balasubramanian
– Angew Chem Int Ed Engl
(2018)
57,
9694
Genetically Encoded Protein Phosphorylation in Mammalian Cells.
V Beránek, CD Reinkemeier, MS Zhang, AD Liang, G Kym, JW Chin
– Cell Chem Biol
(2018)
Cooperative Assembly of Hsp70 Subdomain Clusters
MA Wright, FA Aprile, MMJ Bellaiche, TCT Michaels, T Müller, P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
– Biochemistry
(2018)
57,
3641
Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs.
JCW Willis, JW Chin
– Nature Chemistry
(2018)
10,
831
A method for partitioning the information contained in a protein sequence between its structure and function.
A Possenti, M Vendruscolo, C Camilloni, G Tiana
– Proteins
(2018)
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells.
MN Bongiovanni, FA Aprile, P Sormanni, M Vendruscolo
– International journal of molecular sciences
(2018)
19,
1443