A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.
– ACS Chem Neurosci
(2024)
(DOI: 10.1021/acschemneuro.3c00718)
An upstream G-quadruplex DNA structure can stimulate gene transcription
– ACS Chem Biol
(2024)
19,
736
(DOI: 10.1021/acschembio.3c00775)
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
– Molecular Neurodegeneration
(2024)
19,
20
(DOI: 10.1186/s13024-023-00651-2)
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
(2024)
(DOI: 10.1101/2024.02.17.580698)
Cathepsin B Processing is Required for the in vivo Efficacy of Albumin-Drug Conjugates
– Bioconjugate Chemistry
(2024)
35,
132
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
– Proceedings of the National Academy of Sciences of the United States of America
(2024)
121,
e2313465121
(DOI: 10.1073/pnas.2313465121)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils.
– Communications biology
(2024)
7,
153
(DOI: 10.1038/s42003-024-05858-7)
G-quadruplex DNA structure is a positive regulator of <i>MYC</i> transcription.
– Proceedings of the National Academy of Sciences of the United States of America
(2024)
121,
e2320240121
(DOI: 10.1073/pnas.2320240121)
Imaging Aβ aggregation by liquid-phase transmission electron microscopy
(2024)
(DOI: 10.1101/2024.01.29.577710)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
(2024)
(DOI: 10.21203/rs.3.rs-3847495/v1)
Establishing a synthetic orthogonal replication system enables accelerated evolution in <i>E. coli</i>.
– Science (New York, N.Y.)
(2024)
383,
421
(DOI: 10.1126/science.adk1281)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity
– Journal of Chemical Information and Modeling
(2024)
64,
590
(DOI: 10.1021/acs.jcim.3c01777)
Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV
– Nature Machine Intelligence
(2024)
6,
74
(DOI: 10.1038/s42256-023-00778-3)
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism.
– Nature
(2024)
625,
603
(DOI: 10.1038/s41586-023-06897-6)
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1.
– Chembiochem
(2024)
25,
e202300736
(DOI: 10.1002/cbic.202300736)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
(2024)
(DOI: 10.1101/2024.01.08.574772)
Combining experiment and energy landscapes to explore anaerobic heme breakdown in multifunctional hemoproteins.
– Physical Chemistry Chemical Physics
(2024)
26,
695
(DOI: 10.1039/d3cp03897a)
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms.
– ACS Chem Biol
(2023)
19,
217
(DOI: 10.1021/acschembio.3c00725)