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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Understanding Transition Metal Chemistry
S Boss, P Barker, J Field, A Peel
(2026)
(DOI: 10.1039/9781837676347)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(DOI: 10.21203/rs.3.rs-7375981/v1)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking
M Brezinova, F Brotzakis, R Horne, V Roy Chowdhury, R Gregory, A Gonzalez Diaz, F Gentile, M Vendruscolo
– Molecular Systems Biology
(2025)
(DOI: 10.1038/S44320-025-00159-5)
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using Deep Docking
M Brezinova, F Brotzakis, R Horne, V Roy Chowdhury, R Gregory, Y Bian, A Gonzalez Diaz, F Gentile, M Vendruscolo
– Molecular Systems Biology
(2025)
(DOI: 10.1038/S44320-025-00159-5)
Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
– Nat Biomed Eng
(2025)
1
(DOI: 10.1038/s41551-025-01496-4)
Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates.
A Miller, Z Toprakcioglu, S Qamar, P St George-Hyslop, FS Ruggeri, TPJ Knowles, M Vendruscolo
– Communications chemistry
(2025)
8,
284
(DOI: 10.1038/s42004-025-01659-z)
Advances in Proximity-Assisted Bioconjugation
M Canzano, GJL Bernardes
– Accounts of chemical research
(2025)
58,
2939
(DOI: 10.1021/acs.accounts.5c00368)
Secondary nucleation of α-Synuclein drives Mitochondria dysfunctions and Lewy body formation in Parkinson’s Disease
EE Prescott, J Wei, EF Garland, A Urbanek, F Capriglia, WH Molenkamp, DP Rhodes, L Heywood, A Schwartzentruber, E Stephen, R Hughes, O Bandmann, MO Collins, S Linse, A Abelein, J Johansson, M Vendruscolo, JR Highly, TPJ Knowles, H Mortiboys, S De
(2025)
(DOI: 10.1101/2025.09.17.676873)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
A Santambrogio, RI Horne, MA Metrick, NCT Gallagher, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
– J Am Chem Soc
(2025)
147,
35942
(DOI: 10.1021/jacs.5c12812)
Tumor-Specific STING Agonist Synthesis via a Two-Component Prodrug System
N-S Hsu, C Tang, RV Mendes, C Labão-Almeida, CV Dos Reis, AR Coelho, MC Marques, M Cabeza Cabrerizo, R Misteli, TPC Rooney, M Hyvönen, F Corzana, R Fior, GJL Bernardes
– Nat Chem
(2025)
1
(DOI: 10.1038/s41557-025-01930-9)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(DOI: 10.1101/2025.08.25.671921)
Rapid elongation drives the exceptionally fast aggregation of medin, the most common localized human amyloid
M Vendruscolo, VR Chowdhury, R Horne, M Cali, Z Toprakcioglu, S Linse
(2025)
(DOI: 10.21203/rs.3.rs-6476074/v1)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(DOI: 10.1101/2025.08.19.670819)
[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems
M Carranza, AT Carmona, C Maya, E Gil de Montes, AV Vasco, GJL Bernardes, AJ Moreno-Vargas
– Bioconjugate Chemistry
(2025)
36,
2079
(DOI: 10.1021/acs.bioconjchem.5c00371)
An unnatural base pair for the detection of epigenetic cytosine modifications in DNA
D Schmidl, SM Becker, JM Edgerton, S Balasubramanian
– Nat Chem
(2025)
1
(DOI: 10.1038/s41557-025-01925-6)
Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model
H Zhang, RI Horne, ZF Brotzakis, C Harris, P Liò, M Vendruscolo
(2025)
(DOI: 10.1101/2025.08.16.670694)
Predicting Experimental Success in De Novo Binder Design: A Meta-Analysis of 3,766 Experimentally Characterised Binders
MD Overath, ASH Rygaard, CP Jacobsen, V Brasas, O Morell, P Sormanni, TP Jenkins
(2025)
(DOI: 10.1101/2025.08.14.670059)
Correction: Modifying recombinant purple acid phosphatase using computational design
A Venkatramani, M Ali, O Predeina, JC Molloy, P Sormanni, EAH Hall
– Eur Biophys J
(2025)
1
(DOI: 10.1007/s00249-025-01792-6)
Classification of Tauopathies from Human Brain Homogenates through Salt-Modulated Tau Amplification
A Santambrogio, MA Metrick, P Xu, S Koga, B Ghetti, DW Dickson, B Caughey, M Vendruscolo
(2025)
(DOI: 10.1101/2025.08.05.25331458)
A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates
Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes
– J Am Chem Soc
(2025)
147,
28558
(DOI: 10.1021/jacs.5c06625)

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