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Yusuf Hamied Department of Chemistry

 

Recent Publications from the Biological Research Interest Group

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A
V Roy Chowdhury, A Röntgen, M Greenig, Y Méndez Gómez, SP Spiegel, M Nowinska, A Ramon, P Sormanni, A Chan, M Vendruscolo
– Wiley Interdisciplinary Reviews: RNA
(2025)
4,
e70012
(DOI: 10.1002/appl.70012)
Aggregation of α-synuclein splice isoforms through a phase separation pathway.
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
– Science Advances
(2025)
11,
eadq5396
(DOI: 10.1126/sciadv.adq5396)
Serial amplification of tau filaments using Alzheimer’s brain homogenates and C322A or C322S recombinant tau
A Santambrogio, S Lövestam, MA Metrick, TS Lohr, P Xu, B Caughey, SHW Scheres, M Vendruscolo
(2025)
(DOI: 10.1101/2025.03.29.646137)
Linking Aβ and tau in the amyloid cascade through the intersection of their proteostasis networks
CM Lim, J Hardy, M Vendruscolo
(2025)
(DOI: 10.1101/2025.03.28.646065)
Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch
X Zhang, S Dhir, L Melidis, Y Chen, Z Yu, A Simeone, J Spiegel, S Adhikari, S Balasubramanian
– Nat Chem
(2025)
1
(DOI: 10.1038/s41557-025-01792-1)
Natural aminosterols inhibit NMDA receptors with low nanomolar potency.
G Fani, E Coppi, S Errico, F Cherchi, M Gennari, D Barbut, M Vendruscolo, M Zasloff, AM Pugliese, F Chiti
– The FEBS journal
(2025)
(DOI: 10.1111/febs.70072)
Fluorogenic, Subsingle-Turnover Monitoring of Enzymatic Reactions Involving NAD(P)H Provides a Generalized Platform for Directed Ultrahigh-Throughput Evolution of Biocatalysts in Microdroplets.
M Penner, OJ Klein, M Gantz, FEH Nintzel, A-C Prowald, S Boss, P Barker, P Dupree, F Hollfelder
– Journal of the American Chemical Society
(2025)
147,
10903
(DOI: 10.1021/jacs.4c11804)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nat Commun
(2025)
16,
2814
(DOI: 10.1038/s41467-025-58142-5)
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes
J Nixon-Abell, FS Ruggeri, S Qamar, TW Herling, MA Czekalska, Y Shen, G Wang, C King, MS Fernandopulle, T Sneideris, JL Watson, VVS Pillai, W Meadows, JW Henderson, JE Chambers, JL Wagstaff, SH Williams, H Coyle, G Šneiderienė, Y Lu, S Zhang, SJ Marciniak, SMV Freund, E Derivery, ME Ward, M Vendruscolo, TPJ Knowles, P St George-Hyslop
– Nature Communications
(2025)
16,
2814
(DOI: 10.1038/s41467-025-58142-5)
The α-Synuclein Proteostasis Network and its Translational Applications in Parkinson’s disease
CM Lim, M Vendruscolo
(2025)
(DOI: 10.1101/2025.03.17.643594)
Conditional Activation of Protein Therapeutics by Templated Removal of Peptide Nucleic Acid Masking Groups
G Lopes Bernardes, B Gless, E Jones
– Angewandte Chemie
(2025)
(DOI: 10.1002/ange.202502268)
Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy
V Sabatino, S Fleisch, C Tang, FM Müller, C Labão-Almeida, WT Khaw, S Hogan, DR Hicks, M Fontes, AR Coelho, W Yang, I Sarkar, D Shome, AV Vidal, M Cabeza-Cabrerizo, T Rohm, RM Reijmers, D Kaymak, F Gerster, D Baker, R Fior, G Hutter, GJL Bernardes
(2025)
(DOI: 10.1101/2025.03.13.642658)
Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay
A Santambrogio, RI Horne, MA Metrick, ZF Brotzakis, D Rinauro, E Vourkou, K Papanikolopoulou, EMC Skoulakis, S Linse, B Caughey, M Vendruscolo
(2025)
(DOI: 10.1101/2025.03.09.642189)
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
O Predeina, M Atkinson, O Wissett, M Ali, C Visentin, S Ricagno, AH Keeble, MR Howarth, P Sormanni
(2025)
(DOI: 10.1101/2025.03.06.641810)
Detection of protein oligomers with nanopores
RI Horne, SE Sandler, M Vendruscolo, UF Keyser
– Nat Rev Chem
(2025)
9,
224
(DOI: 10.1038/s41570-025-00694-7)
PLUMED Tutorials: A collaborative, community-driven learning ecosystem.
GA Tribello, M Bonomi, G Bussi, C Camilloni, BI Armstrong, A Arsiccio, S Aureli, F Ballabio, M Bernetti, L Bonati, SGH Brookes, ZF Brotzakis, R Capelli, M Ceriotti, K-T Chan, P Cossio, S Dasetty, D Donadio, B Ensing, AL Ferguson, G Fraux, JD Gale, FL Gervasio, T Giorgino, NSM Herringer, GM Hocky, SE Hoff, M Invernizzi, O Languin-Cattoën, V Leone, V Limongelli, O Lopez-Acevedo, F Marinelli, P Febrer Martinez, M Masetti, S Mehdi, A Michaelides, MH Murtada, M Parrinello, PM Piaggi, A Pietropaolo, F Pietrucci, S Pipolo, C Pritchard, P Raiteri, S Raniolo, D Rapetti, V Rizzi, J Rydzewski, M Salvalaglio, C Schran, A Seal, A Shayesteh Zadeh, TFD Silva, V Spiwok, G Stirnemann, D Sucerquia, P Tiwary, O Valsson, M Vendruscolo, GA Voth, AD White, J Wu
– The Journal of chemical physics
(2025)
162,
092501
(DOI: 10.1063/5.0251501)
Design of Protein Sequences with Precisely Tuned Kinetic Properties
ZF Brotzakis, M Vendruscolo, G Skretas
(2025)
(DOI: 10.1101/2025.02.13.638027)
AlphaFold prediction of structural ensembles of disordered proteins
ZF Brotzakis, S Zhang, MH Murtada, M Vendruscolo
– Nat Commun
(2025)
16,
1632
(DOI: 10.1038/s41467-025-56572-9)
Correction to "Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform".
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Analytical chemistry
(2025)
97,
4251
(DOI: 10.1021/acs.analchem.5c00703)
Lipid-induced condensate formation from the Alzheimer's Aβ peptide triggers amyloid aggregation.
G Šneiderienė, A González Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
– Proceedings of the National Academy of Sciences of the United States of America
(2025)
122,
e2401307122
(DOI: 10.1073/pnas.2401307122)

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