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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

Expeditious Total Synthesis of Hemiasterlin through a Convergent Multicomponent Strategy and Its Use in Targeted Cancer Therapeutics
J Charoenpattarapreeda, SJ Walsh, JS Carroll, DR Spring
– Angewandte Chemie International Edition
(2020)
59,
23045
(DOI: 10.1002/anie.202010090)
Epidemiological insights from a large-scale investigation of intestinal helminths in Medieval Europe.
PG Flammer, H Ryan, SG Preston, S Warren, R Přichystalová, R Weiss, V Palmowski, S Boschert, K Fellgiebel, I Jasch-Boley, M-S Kairies, E Rümmele, D Rieger, B Schmid, B Reeves, R Nicholson, L Loe, C Guy, T Waldron, J Macháček, J Wahl, M Pollard, G Larson, AL Smith
– PLOS Neglected Tropical Diseases
(2020)
14,
e0008600
(DOI: 10.1371/journal.pntd.0008600)
Adventures in drugging undruggable targets
DR Spring
– JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2020)
63,
362
Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin-Resistant Staphylococcus aureus (MRSA)
JJ Freudenreich, S Bartlett, NS Robertson, SL Kidd, S Forrest, HF Sore, WRJD Galloway, M Welch, DR Spring
– ChemMedChem
(2020)
15,
1289
(DOI: 10.1002/cmdc.202000179)
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.
DA Russell, HR Bridges, R Serreli, SL Kidd, N Mateu, TJ Osberger, HF Sore, J Hirst, DR Spring
– Journal of Natural Products
(2020)
83,
1829
(DOI: 10.1021/acs.jnatprod.9b01224)
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
SL Kidd, E Fowler, T Reinhardt, T Compton, N Mateu, H Newman, D Bellini, R Talon, J McLoughlin, T Krojer, A Aimon, A Bradley, M Fairhead, P Brear, L Díaz-Sáez, K McAuley, HF Sore, A Madin, DH O'Donovan, KVM Huber, M Hyvönen, F von Delft, CG Dowson, DR Spring
– Chem Sci
(2020)
11,
10792
(DOI: 10.1039/d0sc01232g)
2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in <i>Pseudomonas aeruginosa</i>
AC McVey, S Bartlett, M Kajbaf, A Pellacani, V Gatta, P Tammela, DR Spring, M Welch
– International journal of molecular sciences
(2020)
21,
2490
(DOI: 10.3390/ijms21072490)
Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.
PR Curran, CJ Radoux, MD Smilova, RA Sykes, AP Higueruelo, AR Bradley, BD Marsden, DR Spring, TL Blundell, AR Leach, WR Pitt, JC Cole
– Journal of Chemical Information and Modeling
(2020)
60,
1911
(DOI: 10.1021/acs.jcim.9b00996)
Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
TR Pettigrew, RJ Porter, SJ Walsh, MP Housden, NYS Lam, JS Carroll, JS Parker, DR Spring, I Paterson
– Chemical communications (Cambridge, England)
(2020)
56,
1529
(DOI: 10.1039/c9cc09050a)
Sulfatase-cleavable linkers for antibody-drug conjugates
JD Bargh, SJ Walsh, A Isidro-Llobet, S Omarjee, JS Carroll, DR Spring
– Chemical Science
(2020)
11,
2375
(DOI: 10.1039/c9sc06410a)
Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction.
K Sharma, AV Strizhak, E Fowler, W Xu, B Chappell, HF Sore, WRJD Galloway, MN Grayson, YH Lau, LS Itzhaki, DR Spring
– ACS Omega
(2020)
5,
1157
(DOI: 10.1021/acsomega.9b03459)
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
HL Stewart, AR Hanby, TA King, AD Bond, TA Moss, HF Sore, DR Spring
– Chemical communications (Cambridge, England)
(2020)
56,
6818
(DOI: 10.1039/d0cc02728f)
Fsp 3 -rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring
– Chemical Communications
(2020)
56,
2280
(DOI: 10.1039/c9cc09796a)
C(sp<SUP>3</SUP>)-H arylation to construct all-<i>syn</i>cyclobutane-based heterobicyclic systems: a novel fragment collection
TJ Osberger, SL Kidd, TA King, DR Spring
– Chemical Communications
(2020)
56,
7423
(DOI: 10.1039/d0cc03237a)
Diarylethene moiety as an enthalpy-entropy switch: Photoisomerizable stapled peptides for modulating p53/MDM2 interaction
AV Strizhak, O Babii, S Afonin, I Bakanovich, T Pantelejevs, W Xu, E Fowler, R Eapen, K Sharma, MO Platonov, VV Hurmach, L Itzhaki, M Hyvönen, AS Ulrich, DR Spring, IV Komarov
– Organic and Biomolecular Chemistry
(2020)
18,
5359
(DOI: 10.1039/d0ob00831a)
General dual functionalisation of biomacromoleculesviaa cysteine bridging strategy
SJ Walsh, J Iegre, H Seki, JD Bargh, HF Sore, JS Parker, JS Carroll, DR Spring
– Organic & biomolecular chemistry
(2020)
18,
4224
(DOI: 10.1039/d0ob00907e)
Efficient and selective antibody modification with functionalised divinyltriazines.
AJ Counsell, SJ Walsh, NS Robertson, HF Sore, DR Spring
– Organic and Biomolecular Chemistry
(2020)
18,
4739
(DOI: 10.1039/d0ob01002b)
Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
– ACS omega
(2019)
5,
822
(DOI: 10.1021/acsomega.9b03626)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
A Venkitaraman
– Scientific Reports
(2019)
9,
(DOI: 10.1038/s41598-019-50702-2)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific Reports
(2019)
9,
15930
(DOI: 10.1038/s41598-019-50702-2)

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