Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Peroxide-cleavable linkers for antibody–drug conjugates †
N Ashman, JD Bargh, SJ Walsh, RD Greenwood, A Tiberghien, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2023)
59
(doi: 10.17863/CAM.93203)
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
RCB Nicolescu, ZR Maylin, FJ Pérez‐Areales, J Iegre, HS Pandha, M Asim, DR Spring
ChemMedChem
(2023)
18
(doi: 10.1002/cmdc.202200703)
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
RCB Nicolescu, ZR Maylin, FJ Pérez-Areales, J Iegre, HS Pandha, M Asim, DR Spring
Chemmedchem
(2022)
18
(doi: 10.1002/cmdc.202200548)
Non-internalising antibody-drug conjugates.
N Ashman, JD Bargh, DR Spring
Chemical Society Reviews
(2022)
13
(doi: 10.1039/d2cs00446a)
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
RSC medicinal chemistry
(2022)
13
(doi: 10.1039/d2md00161f)
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
Chemical Communications
(2022)
58
(doi: 10.1039/d2cc02515a)
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
Chemical Science
(2022)
13
(doi: 10.1039/d2sc02198f)
Reconstructing the history of helminth prevalence in the UK.
H Ryan, PG Flammer, R Nicholson, L Loe, B Reeves, E Allison, C Guy, IL Doriga, T Waldron, D Walker, C Kirchhelle, G Larson, AL Smith
PLoS Negl Trop Dis
(2022)
16
(doi: 10.1371/journal.pntd.0010312)
Development of small cyclic peptides targeting the CK2α/β interface
EL Atkinson, J Iegre, C D'Amore, P Brear, M Salvi, M Hyvönen, DR Spring
Chem Commun (Camb)
(2022)
58
(doi: 10.1039/d2cc00707j)
A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
S Collins, LV Vliet, F Gielen, M Janeček, SW Valladolid, C Poudel, G Fusco, A De Simone, C Michel, C Kaminski, D Spring, F Hollfelder, GSK Schierle
(2022)
(doi: 10.21203/rs.3.rs-1478521/v1)
Divinylpyrimidine reagents generate antibody-drug conjugates with excellent <i>in vivo</i> efficacy and tolerability.
SJ Walsh, S Omarjee, FM Dannheim, D-L Couturier, D Bexheti, L Mendil, G Cronshaw, T Fewster, C Gregg, C Brodie, JL Miller, R Houghton, JS Carroll, DR Spring
Chemical Communications
(2022)
58
(doi: 10.1039/d1cc06766d)
Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
Chemical Society reviews
(2022)
51
(doi: 10.1039/d1cs90109e)
Energetics of lipid transport by the ABC transporter MsbA is lipid dependent.
D Guo, H Singh, A Shimoyama, C Guffick, Y Tang, SM Rowe, T Noel, DR Spring, K Fukase, HW van Veen
Communications biology
(2021)
4
(doi: 10.1038/s42003-021-02902-8)
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides
G Fumagalli, RJ Carbajo, JWM Nissink, J Tart, R Dou, AP Thomas, DR Spring
Journal of Medicinal Chemistry
(2021)
64
(doi: 10.1021/acs.jmedchem.1c01334)
Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
M Bourdon, J Gaynord, KH Müller, G Evans, S Wallis, P Aston, DR Spring, R Wightman
BMC plant biology
(2021)
21
(doi: 10.1186/s12870-021-03010-9)
Rapid and robust cysteine bioconjugation with vinylheteroarenes
H Seki, SJ Walsh, JD Bargh, JS Parker, J Carroll, DR Spring
Chemical Science
(2021)
12
(doi: 10.1039/d1sc02722k)
Historical Demographic Processes Dominate Genetic Variation in Ancient Atlantic Cod Mitogenomes
L Martínez-García, G Ferrari, T Oosting, R Ballantyne, I van der Jagt, I Ystgaard, J Harland, R Nicholson, S Hamilton-Dyer, HT Baalsrud, MSO Brieuc, LM Atmore, F Burns, U Schmölcke, KS Jakobsen, S Jentoft, D Orton, AK Hufthammer, JH Barrett, B Star
Frontiers in Ecology and Evolution
(2021)
9
(doi: 10.3389/fevo.2021.671281)
The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions
BH Gan, J Gaynord, SM Rowe, T Deingruber, DR Spring
Chemical Society reviews
(2021)
50
(doi: 10.1039/d0cs00729c)
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study.
EL Atkinson, J Iegre, PD Brear, EA Zhabina, M Hyvönen, DR Spring
Molecules (Basel, Switzerland)
(2021)
26
(doi: 10.3390/molecules26071977)
A dual-enzyme cleavable linker for antibody–drug conjugates
JD Bargh, SJ Walsh, N Ashman, A Isidro-Llobet, JS Carroll, DR Spring
Chem Commun (Camb)
(2021)
57
(doi: 10.1039/d1cc00957e)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
Contacts
Directions

Privacy and cookie policy

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge