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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

Crystal Structure of CK2alpha with Compound 3 bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(DOI: 10.2210/pdb5cs6/pdb)
Crystal Structure of CK2alpha with Compound 6 bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(DOI: 10.2210/pdb5csv/pdb)
Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dr6/pdb)
Aurora A Kinase in complex with ATP in space group P41212
M Janecek, M Rossmann, P Sharma, A Emery, G McKenzie, D Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, A Venkitaraman
(2016)
(DOI: 10.2210/pdb5dnr/pdb)
Aurora A Kinase in Complex with AA29 and JNJ-7706621 in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dr9/pdb)
Aurora A Kinase in Complex with ATP in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dt3/pdb)
Aurora A Kinase in Complex with JNJ-7706621 in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dt0/pdb)
Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dos/pdb)
Aurora A Kinase in Complex with ATP in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5drd/pdb)
Aurora A in complex with ATP and AA35.
M Janecek, M Rossmann, P Sharma, A Emery, G McKenzie, D Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, A Venkitaraman
(2016)
(DOI: 10.2210/pdb5dn3/pdb)
Aurora A Kinase in Complex with AA30 and ATP in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dr2/pdb)
Aurora A Kinase in Complex with AA35 and JNJ-7706621 in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dpv/pdb)
Aurora A Kinase in Complex with AA35 and ATP in Space Group P6122
M Janecek, M Rossmann, P Sharma, A Emery, GJ McKenzie, DJ Huggins, S Stockwell, JA Stokes, EG Almeida, B Hardwick, AJ Narvaez, M Hyvonen, DR Spring, AR Venkitaraman
(2016)
(DOI: 10.2210/pdb5dt4/pdb)
Specific inhibition of CK2α from an anchor outside the active site.
P Brear, C De Fusco, K Hadje Georgiou, NJ Francis-Newton, CJ Stubbs, HF Sore, AR Venkitaraman, C Abell, DR Spring, M Hyvönen
– Chemical Science
(2016)
7,
6839
(DOI: 10.1039/c6sc02335e)
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells
B Morkunas, B Gal, WRJD Galloway, JT Hodgkinson, BM Ibbeson, YS Tan, M Welch, DR Spring
– Beilstein J Org Chem
(2016)
12,
1428
(DOI: 10.3762/bjoc.12.137)
Multiple‐parameter Optimization in Drug Discovery: Example of the 5‐HT1B GPCR
RC Glen, WRJD Galloway, DR Spring, G Liwiki
– Molecular informatics
(2016)
35,
599
(DOI: 10.1002/minf.201600056)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(DOI: 10.2210/pdb5bxo/pdb)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(DOI: 10.2210/pdb5bxu/pdb)
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, JE Stokes, YS Tan, EG Almeida, B Hardwick, AJ Narvaez, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific reports
(2016)
6,
28528
(DOI: 10.1038/srep28528)
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
MM Wiedmann, S Aibara, DR Spring, M Stewart, JD Brenton
– Journal of Structural Biology
(2016)
195,
273
(DOI: 10.1016/j.jsb.2016.06.018)

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