Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Towards a glutathione-cleavable azobenzene linker for antibody–drug conjugates
M Kapun, R Patel, M Park, FJ Pérez-Areales, KA Kostadinova, T Wharton, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2025)
(doi: 10.1039/d5cc05824d)
Recent progress towards catalytic asymmetric construction of inherently chiral scaffolds.
K Zhu, DR Spring, B-F Shi, F Zhang
Chemical Society Reviews
(2025)
54
(doi: 10.1039/d5cs00235d)
Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors.
PA Glossop, P Brear, S Wright, N Flanagan, MS Glossop, CAL Lane, RP Butt, DR Spring, M Hyvönen, D Cawkill
Journal of medicinal chemistry
(2025)
68
(doi: 10.1021/acs.jmedchem.5c01807)
β-Lactamase cleavable antimicrobial peptide-drug conjugates
T Deingruber, JS Gaynord, BH Gan, KA Kostadinova, TJ O'Brien, YS Tan, JS Parker, TA Hunt, JS Carroll, M Welch, DR Spring
Chem Sci
(2025)
16
(doi: 10.1039/d5sc06369h)
Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, DR Spring, C Lindon, C Phillips, LS Itzhaki
eLife
(2025)
14
(doi: 10.7554/elife.104238)
A Dynamic Silver(I) Nanocluster Holds Together a 3 x 3 Self-Assembled Grid
AW Heard, L Pesce, PT Gierth, S Adorinni, TK Ronson, B Rossi, JD Thoburn, T Deingruber, M Welch, DR Spring, S Marchesan, GM Pavan, JR Nitschke
Journal of the American Chemical Society
(2025)
147
(doi: 10.1021/jacs.5c07271)
A Platform for SpyCatcher Conjugation to Native Antibodies
S Krajcovicova, T Wharton, CL Driscoll, TA King, MR Howarth, DR Spring
Chem Sci
(2025)
16
(doi: 10.1039/d5sc02286j)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2025)
(doi: 10.7554/elife.104238.2)
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
T Wharton, DR Spring
Chemmedchem
(2025)
20
(doi: 10.1002/cmdc.202500132)
Pseudomonas aeruginosa acyl-CoA dehydrogenases and structure-guided inversion of their substrate specificity
M Wang, P Medarametla, T Kronenberger, T Deingruber, P Brear, W Figueroa, P-M Ho, T Krueger, JC Pearce, A Poso, JG Wakefield, DR Spring, M Welch
Nature Communications
(2025)
16
(doi: 10.1038/s41467-025-57532-z)
Pseudomonas aeruginosa PfpI is a methylglyoxalase.
L Grimm, A Wijaya, I Askenasy, RR Nazeer, H Seki, PD Brear, W Figueroa, DR Spring, M Welch
Journal of Biological Chemistry
(2025)
301
(doi: 10.1016/j.jbc.2025.108374)
The 2-methylcitrate cycle and the glyoxylate shunt in Pseudomonas aeruginosa are linked through enzymatic redundancy.
AJ Wijaya, SK Dolan, M Kohlstedt, L Gläser, P Brear, S Geddis, C Wittmann, DR Spring, M Welch
J Biol Chem
(2025)
301
(doi: 10.1016/j.jbc.2025.108355)
Advances in the Release of Amide-Containing Molecules
T Wharton, DR Spring
Chemistry (Weinheim an der Bergstrasse, Germany)
(2025)
31
(doi: 10.1002/chem.202404413)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, E McCall, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2025)
(doi: 10.7554/elife.104238.1)
MMP-Cleavable Linker Platform for Tumour-Responsive Homo- and Heterobivalent Antibody-Drug Conjugates
AJ Counsell, SJ Walsh, N Ashman, M Park, FM Dannheim, TA King, T Wharton, JS Carroll, DR Spring
Chemical Science
(2025)
(doi: 10.1039/d5sc06664f)
Publisher Correction: Novel immunotherapeutics against LGR5 to target multiple cancer types.
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Ghodsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
EMBO Molecular Medicine
(2024)
16
(doi: 10.1038/s44321-024-00139-6)
Selective Aurora A‑TPX2 Interaction Inhibitors Have In Vivo Efficacy as Targeted Antimitotic Agents
SR Stockwell, DE Scott, G Fischer, E Guarino, TPC Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, TR Perrior, TL Blundell, DR Spring, G McKenzie, C Abell, J Skidmore, AR Venkitaraman, M Hyvönen
J Med Chem
(2024)
67
(doi: 10.1021/acs.jmedchem.4c01165)
Novel immunotherapeutics against LGR5 to target multiple cancer types
H-C Chen, N Mueller, K Stott, C Kapeni, E Rivers, CM Sauer, F Beke, SJ Walsh, N Ashman, L O'Brien, A Rafati Fard, A Ghodsinia, C Li, F Joud, O Giger, I Zlobec, I Olan, SJ Aitken, M Hoare, R Mair, E Serrao, JD Brenton, A Garcia-Gimenez, SE Richardson, B Huntly, DR Spring, M-O Skjoedt, K Skjødt, M de la Roche, M de la Roche
EMBO molecular medicine
(2024)
16
(doi: 10.1038/s44321-024-00121-2)
Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs
R Walther, M Park, N Ashman, M Welch, JS Carroll, DR Spring
Chemical communications (Cambridge, England)
(2024)
60
(doi: 10.1039/d4cc01558d)
Towards the Targeted Protein Degradation of PRMT1.
PL Martin, FJ Pérez-Areales, SV Rao, SJ Walsh, JS Carroll, DR Spring
Chemmedchem
(2024)
19
(doi: 10.1002/cmdc.202400269)
Yusuf Hamied Department of Chemistry
Lensfield Road
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CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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