Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules
BM da S Santos, FG Finelli, DR Spring
Organic letters
(2024)
26
(doi: 10.1021/acs.orglett.4c01019)
Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome
R Eapen, C Okoye, C Stubbs, M Schimpl, T Tischer, EJ Fisher, M Zacharopoulou, F Ferrer, D Barford, D Spring, C Lindon, C Phillips, LS Itzhaki
(2024)
(doi: 10.1101/2024.04.30.590460)
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay‐Williams, T Schober, RA Floto, DR Spring
Angewandte Chemie
(2024)
136
(doi: 10.1002/ange.202402267)
Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
T Wharton, F Crawshay-Williams, T Schober, RA Floto, DR Spring
Angewandte Chemie (International ed. in English)
(2024)
63
(doi: 10.1002/anie.202402267)
CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
S Day-Riley, RM West, PD Brear, M Hyvönen, DR Spring
Kinases and Phosphatases
(2024)
2
(doi: 10.3390/kinasesphosphatases2020007)
Site-selective peptide functionalisation mediated via vinyl-triazine linchpins
JD Sydenham, H Seki, S Krajcovicova, L Zeng, T Schober, T Deingruber, DR Spring
Chem Commun (Camb)
(2024)
60
(doi: 10.1039/d3cc05213c)
Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
RSC Chemical Biology
(2024)
5
(doi: 10.1039/d3cb00176h)
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase
T Pantelejevs, P Zuazua-Villar, O Koczy, AJ Counsell, SJ Walsh, NS Robertson, DR Spring, JA Downs, M Hyvönen
Chem Sci
(2023)
14
(doi: 10.1039/d3sc03331g)
Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution.
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
RSC Chem Biol
(2023)
5
(doi: 10.1039/d3cb00176h)
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction
J Iegre, S Krajcovicova, A Gunnarsson, L Wissler, H Kaeck, A Luchniak, S Tangefjord, F Narjes, DR Spring
CHEMICAL SCIENCE
(2023)
14
(doi: 10.1039/d3sc04083f)
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction
J Iegre, S Krajcovicova, A Gunnarsson, L Wissler, H Käck, A Luchniak, S Tångefjord, F Narjes, DR Spring
Chemical Science
(2023)
14
(doi: 10.1039/d3sc04083f)
Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
TA King, SJ Walsh, M Kapun, T Wharton, S Krajcovicova, MS Glossop, DR Spring
Chem Commun (Camb)
(2023)
59
(doi: 10.1039/d3cc02980h)
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
S Krajcovicova, DR Spring
Angewandte Chemie
(2023)
135
(doi: 10.1002/ange.202307782)
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation
S Krajcovicova, DR Spring
Angewandte Chemie International Edition
(2023)
62
(doi: 10.1002/anie.202307782)
Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy
KT Mortensen, DSY Wong, TA King, HF Sore, DR Spring
Organic & Biomolecular Chemistry
(2023)
21
(doi: 10.1039/d3ob00351e)
Identification of macrocyclic peptides which activate bacterial cylindrical proteases.
R Walther, LM Westermann, S Carmali, SE Jackson, H Brötz-Oesterhelt, DR Spring
RSC Medicinal Chemistry
(2023)
14
(doi: 10.1039/d3md00136a)
Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase
G Zenkevičiūtė, W Xu, J Iegre, H Seki, YS Tan, PJE Rowling, F Ferrer, C Verma, DR Spring, H Laman, LS Itzhaki
(2023)
(doi: 10.1101/2023.04.27.535981)
Selective Aurora A-TPX2 interaction inhibitors have in vivo efficacy as targeted anti-mitotic agents
SR Stockwell, DE Scott, G Fischer, E Guarino, TPC Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, TR Perrior, TL Blundell, DR Spring, G McKenzie, C Abell, J Skidmore, AR Venkitaraman, M Hyvönen
(2023)
(doi: 10.1101/2023.03.22.533679)
A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
T Pantelejevs, P Zuazua-Villar, O Koczy, A Counsell, SJ Walsh, NS Robertson, DR Spring, J Downs, M Hyvönen
(2023)
(doi: 10.1101/2023.02.24.529929)
The human proton pump inhibitors inhibit <i>Mycobacterium tuberculosis</i> rifampicin efflux and macrophage-induced rifampicin tolerance.
MA Lake, KN Adams, F Nie, E Fowler, AK Verma, S Dei, E Teodori, DR Sherman, PH Edelstein, DR Spring, M Troll, L Ramakrishnan
Proc Natl Acad Sci U S A
(2023)
120
(doi: 10.1073/pnas.2215512120)
Yusuf Hamied Department of Chemistry
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