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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

Red-light modulated <i>ortho</i>-chloro azobenzene photoswitch for peptide stapling <i>via</i> aromatic substitution
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
– RSC Chemical Biology
(2024)
5,
49
(DOI: 10.1039/d3cb00176h)
A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase
T Pantelejevs, P Zuazua-Villar, O Koczy, AJ Counsell, SJ Walsh, NS Robertson, DR Spring, JA Downs, M Hyvönen
– Chemical Science
(2023)
14,
13915
(DOI: 10.1039/d3sc03331g)
Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution
M Kapun, FJ Pérez-Areales, N Ashman, PJE Rowling, T Schober, E Fowler, LS Itzhaki, DR Spring
– RSC Chemical Biology
(2023)
5,
49
(DOI: 10.1039/d3cb00176h)
A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction.
J Iegre, S Krajcovicova, A Gunnarsson, L Wissler, H Käck, A Luchniak, S Tångefjord, F Narjes, DR Spring
– Chemical Science
(2023)
14,
10800
(DOI: 10.1039/d3sc04083f)
Disulfide re-bridging reagents for single-payload antibody-drug conjugates.
TA King, SJ Walsh, M Kapun, T Wharton, S Krajcovicova, MS Glossop, DR Spring
– Chemical communications (Cambridge, England)
(2023)
59,
9868
(DOI: 10.1039/d3cc02980h)
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
S Krajcovicova, DR Spring
– Angewandte Chemie (International ed. in English)
(2023)
62,
e202307782
(DOI: 10.1002/anie.202307782)
Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
S Krajcovicova, DR Spring
– Angewandte Chemie
(2023)
135,
e202307782
(DOI: 10.1002/ange.202307782)
Synthesis of sp<SUP>3</SUP>-rich heterocyclic frameworks by a divergent synthesis strategy
KT Mortensen, DSY Wong, TA King, HF Sore, DR Spring
– Organic & biomolecular chemistry
(2023)
21,
4591
(DOI: 10.1039/d3ob00351e)
Identification of macrocyclic peptides which activate bacterial cylindrical proteases
R Walther, LM Westermann, S Carmali, SE Jackson, H Brötz-Oesterhelt, DR Spring
– RSC Medicinal Chemistry
(2023)
14,
1186
(DOI: 10.1039/d3md00136a)
Development of constrained peptide inhibitors targeting an oncogenic E3 ubiquitin ligase
G Zenkevičiūtė, W Xu, J Iegre, H Seki, YS Tan, PJE Rowling, F Ferrer, C Verma, D Spring, H Laman, L Itzhaki
(2023)
(DOI: 10.1101/2023.04.27.535981)
Selective Aurora A-TPX2 interaction inhibitors have in vivo efficacy as targeted anti-mitotic agents
S Stockwell, D Scott, G Fischer, E Guarino, T Rooney, T-S Feng, T Moschetti, R Srinivasan, E Alza, A Asteian, C Dagostin, A Alcaide, M Rocaboy, B Blaszczyk, A Higueruelo, X Wang, M Rossmann, T Perrior, T Blundell, D Spring, G McKenzie, C Abell, J Skidmore, A Venkitaraman, M Hyvönen
(2023)
(DOI: 10.1101/2023.03.22.533679)
A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
T Pantelejevs, P Zuazua-Villar, O Koczy, A Counsell, S Walsh, N Robertson, D Spring, J Downs, M Hyvönen
(2023)
(DOI: 10.1101/2023.02.24.529929)
The human proton pump inhibitors inhibit <i>Mycobacterium tuberculosis</i> rifampicin efflux and macrophage-induced rifampicin tolerance.
MA Lake, KN Adams, F Nie, E Fowler, AK Verma, S Dei, E Teodori, DR Sherman, PH Edelstein, DR Spring, M Troll, L Ramakrishnan
– Proceedings of the National Academy of Sciences of USA
(2023)
120,
e2215512120
(DOI: 10.1073/pnas.2215512120)
Peroxide-cleavable linkers for antibody-drug conjugates
N Ashman, JD Bargh, SJ Walsh, RD Greenwood, A Tiberghien, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2023)
59,
1841
(DOI: 10.1039/d2cc06677g)
Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in <i>in vitro</i> Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
RCB Nicolescu, ZR Maylin, FJ Pérez‐Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
(2023)
18,
(DOI: 10.1002/cmdc.202200703)
Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI-001 in <i>in vitro</i> Models of Prostate Cancer Drug Resistance
RCB Nicolescu, ZR Maylin, FJ Pérez-Areales, J Iegre, HS Pandha, M Asim, DR Spring
– ChemMedChem
(2022)
18,
e202200548
(DOI: 10.1002/cmdc.202200548)
Non-internalising antibody–drug conjugates
N Ashman, JD Bargh, DR Spring
– Chemical Society reviews
(2022)
51,
9182
(DOI: 10.1039/d2cs00446a)
A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action.
P Brear, C De Fusco, EL Atkinson, J Iegre, NJ Francis-Newton, AR Venkitaraman, M Hyvönen, DR Spring
– RSC Medicinal Chemistry
(2022)
13,
1420
(DOI: 10.1039/d2md00161f)
Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy
AR Hanby, SJ Walsh, AJ Counsell, N Ashman, KT Mortensen, JS Carroll, DR Spring
– Chemical communications (Cambridge, England)
(2022)
58,
9401
(DOI: 10.1039/d2cc02515a)
All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading.
FM Dannheim, SJ Walsh, CT Orozco, AH Hansen, JD Bargh, SE Jackson, NJ Bond, JS Parker, JS Carroll, DR Spring
– Chemical Science
(2022)
13,
8781
(DOI: 10.1039/d2sc02198f)

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