Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Diarylethene moiety as an enthalpy-entropy switch: Photoisomerizable stapled peptides for modulating p53/MDM2 interaction
AV Strizhak, O Babii, S Afonin, I Bakanovich, T Pantelejevs, W Xu, E Fowler, R Eapen, K Sharma, MO Platonov, VV Hurmach, L Itzhaki, M Hyvönen, AS Ulrich, DR Spring, IV Komarov
Organic & Biomolecular Chemistry
(2020)
18
(doi: 10.1039/d0ob00831a)
C(sp 3 )–H arylation to construct all- syn cyclobutane-based heterobicyclic systems: a novel fragment collection
TJ Osberger, SL Kidd, TA King, DR Spring
Chem Commun (Camb)
(2020)
56
(doi: 10.1039/d0cc03237a)
Efficient and selective antibody modification with functionalised divinyltriazines.
AJ Counsell, SJ Walsh, NS Robertson, HF Sore, DR Spring
Org Biomol Chem
(2020)
18
(doi: 10.1039/d0ob01002b)
General dual functionalisation of biomacromolecules via a cysteine bridging strategy
SJ Walsh, J Iegre, H Seki, JD Bargh, HF Sore, JS Parker, JS Carroll, DR Spring
Organic & Biomolecular Chemistry
(2020)
18
(doi: 10.1039/d0ob00907e)
Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery.
AR Hanby, NS Troelsen, TJ Osberger, SL Kidd, KT Mortensen, DR Spring
Chemical Communications
(2020)
56
(doi: 10.1039/c9cc09796a)
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1
DJ Huggins, BS Hardwick, P Sharma, A Emery, L Laraia, F Zhang, AJ Narvaez, M Roberts-Thomson, AT Crooks, RG Boyle, R Boyce, DW Walker, N Mateu, GJ McKenzie, DR Spring, AR Venkitaraman
ACS omega
(2019)
5
(doi: 10.1021/acsomega.9b03626)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation.
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
Sci Rep
(2019)
9
(doi: 10.1038/s41598-019-50702-2)
A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
A Venkitaraman
Scientific Reports
(2019)
9
(doi: 10.1038/s41598-019-50702-2)
Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling
A Renzetti, RN Rutherford, K Fukumoto, D Kunciw, HF Sore, DR Spring
Synlett
(2019)
30
(doi: 10.1055/s-0039-1690217)
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.
TA King, HL Stewart, KT Mortensen, AJP North, HF Sore, DR Spring
European J Org Chem
(2019)
2019
(doi: 10.1002/ejoc.201900847)
Hotspots API: A toolkit for the application of Fragment Hotspot Mapping to Structure Based Drug Discovery
P Curran, C Radoux, M Smilova, A Higueruelo, R Sykes, A Bradley, W Pitt, D Spring, T Blundell, J Cole
Acta Crystallographica Section A Foundations and Advances
(2019)
75
(doi: 10.1107/S0108767319097782)
Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
NS Robertson, SJ Walsh, E Fowler, M Yoshida, SM Rowe, Y Wu, HF Sore, JS Parker, DR Spring
Chem Commun (Camb)
(2019)
55
(doi: 10.1039/c9cc05042f)
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
J Charoenpattarapreeda, YS Tan, J Iegre, SJ Walsh, E Fowler, RS Eapen, Y Wu, HF Sore, CS Verma, L Itzhaki, DR Spring
Chemical communications (Cambridge, England)
(2019)
55
(doi: 10.1039/C9CC04022F)
Strategies for the Diversity-Oriented Synthesis of Macrocycles.
KT Mortensen, TJ Osberger, TA King, HF Sore, DR Spring
Chemical Reviews
(2019)
119
(doi: 10.1021/acs.chemrev.9b00084)
Cleavable linkers in antibody–drug conjugates
JD Bargh, A Isidro-Llobet, JS Parker, DR Spring
Chemical Society Reviews
(2019)
48
(doi: 10.1039/c8cs00676h)
Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection.
A Sveiczer, AJP North, N Mateu, SL Kidd, HF Sore, DR Spring
Org Lett
(2019)
21
(doi: 10.1021/acs.orglett.9b01499)
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
Chemical Science
(2019)
10
(doi: 10.1039/c9sc00798a)
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides
Y Wu, A Kaur, E Fowler, MM Wiedmann, R Young, WRJD Galloway, L Olsen, HF Sore, A Chattopadhyay, TT-L Kwan, W Xu, SJ Walsh, P de Andrade, M Janecek, S Arumugam, LS Itzhaki, YH Lau, DR Spring
ACS chemical biology
(2019)
14
(doi: 10.1021/acschembio.9b00063)
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol.
RC Knighton, K Sharma, NS Robertson, DR Spring, M Wills
ACS Omega
(2019)
4
(doi: 10.1021/acsomega.8b03634)
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates (vol 10, 2019)
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
Chem Sci
(2019)
10
(doi: 10.1039/c8sc90248h)
Yusuf Hamied Department of Chemistry
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