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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation
P Sharma, R Mahen, M Rossmann, JE Stokes, B Hardwick, DJ Huggins, A Emery, DL Kunciw, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
– Scientific reports
(2019)
9,
15930
(DOI: 10.1038/s41598-019-50702-2)
Direct Synthesis of <i>N</i>-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling
A Renzetti, RN Rutherford, K Fukumoto, D Kunciw, HF Sore, DR Spring
– Synlett
(2019)
30,
2153
(DOI: 10.1055/s-0039-1690217)
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery
TA King, HL Stewart, KT Mortensen, AJP North, HF Sore, DR Spring
– European Journal of Organic Chemistry
(2019)
2019,
5219
(DOI: 10.1002/ejoc.201900847)
Hotspots API : a toolkit for the application of fragment hotspot mapping to structure-based drug discovery
P Curran, C Radoux, M Smilova, A Higueruelo, R Sykes, A Bradley, W Pitt, D Spring, T Blundell, J Cole
– Acta Crystallographica Section A Foundations and Advances
(2019)
75,
a225
(DOI: 10.1107/s0108767319097782)
Macrocyclisation and functionalisation of unprotected peptides: Via divinyltriazine cysteine stapling
NS Robertson, SJ Walsh, E Fowler, M Yoshida, SM Rowe, Y Wu, HF Sore, JS Parker, DR Spring
– Chem Commun (Camb)
(2019)
55,
9499
(DOI: 10.1039/c9cc05042f)
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
J Charoenpattarapreeda, YS Tan, J Iegre, SJ Walsh, E Fowler, RS Eapen, Y Wu, HF Sore, CS Verma, L Itzhaki, DR Spring
– Chemical Communications
(2019)
55,
7914
(DOI: 10.1039/c9cc04022f)
Strategies for the Diversity-Oriented Synthesis of Macrocycles
KT Mortensen, TJ Osberger, TA King, HF Sore, DR Spring
– Chemical Reviews
(2019)
119,
10288
(DOI: 10.1021/acs.chemrev.9b00084)
Cleavable linkers in antibody-drug conjugates.
JD Bargh, A Isidro-Llobet, JS Parker, DR Spring
– Chemical Society Reviews
(2019)
48,
4361
(DOI: 10.1039/c8cs00676h)
Spirocycles as Rigidified sp
A Sveiczer, AJP North, N Mateu, SL Kidd, HF Sore, DR Spring
– Organic letters
(2019)
21,
4600
(DOI: 10.1021/acs.orglett.9b01499)
Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction.
J Iegre, P Brear, DJ Baker, YS Tan, EL Atkinson, HF Sore, DH O' Donovan, CS Verma, M Hyvönen, DR Spring
– Chem Sci
(2019)
10,
5056
(DOI: 10.1039/c9sc00798a)
Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
Y Wu, A Kaur, E Fowler, MM Wiedmann, R Young, WRJD Galloway, L Olsen, HF Sore, A Chattopadhyay, TT-L Kwan, W Xu, SJ Walsh, P de Andrade, M Janecek, S Arumugam, LS Itzhaki, YH Lau, DR Spring
– ACS chemical biology
(2019)
14,
526
(DOI: 10.1021/acschembio.9b00063)
Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol.
RC Knighton, K Sharma, NS Robertson, DR Spring, M Wills
– ACS omega
(2019)
4,
2160
(DOI: 10.1021/acsomega.8b03634)
Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates.
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
– Chemical Science
(2019)
10,
633
(DOI: 10.1039/c8sc90248h)
Development of novel CK2 inhibitors: From small molecules to conformationally constrained peptides targeting allosteric binding sites
J Iegre, P Brear, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257,
Photoswitchable PROTACs: Visible light activated degradation of the androgen receptor
E Fowler, A Hock, D O'Donovan, J Gorman, G Fumagalli, R Friend, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
258,
A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates
SJ Walsh, S Omarjee, WRJD Galloway, TT-L Kwan, HF Sore, JS Parker, M Hyvönen, JS Carroll, DR Spring
– Chem Sci
(2019)
10,
694
(DOI: 10.1039/c8sc04645j)
Antimicrobial stapled peptide-drug conjugates
J Gaynord, J Parker, M Welch, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
258,
Designed analogues of the aplyronines for next-generation antibody-drug conjugates
R Porter, T Pettigrew, I Paterson, D Spring, J Parker
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
257,
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K Sharma, AV Strizhak, E Fowler, X Wang, W Xu, C Hatt Jensen, Y Wu, HF Sore, YH Lau, M Hyvönen, LS Itzhaki, DR Spring
– Organic & biomolecular chemistry
(2019)
17,
8014
(DOI: 10.1039/c9ob01745c)
Sulfatase-cleavable linkers for antibody-drug conjugates (ADCs)
J Bargh, S Walsh, A Isidro-Llobet, D Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
258,

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