Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Macrocyclized Extended Peptides: Inhibiting the Substrate Recognition Domain of Tankyrase
W Xu, YH Lau, G Fischer, YS Tan, A Chattopadhyay, M de la Roche, M Hyvönen, C Verma, DR Spring, LS Itzhaki
J Am Chem Soc
(2017)
139
(doi: 10.1021/jacs.6b10234)
Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
Angewandte Chemie (International ed. in English)
(2017)
56
(doi: 10.1002/anie.201609427)
Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
MM Wiedmann, YS Tan, Y Wu, S Aibara, W Xu, HF Sore, CS Verma, L Itzhaki, M Stewart, JD Brenton, DR Spring
Angewandte Chemie
(2017)
129
(doi: 10.1002/ange.201609427)
A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.
JJ Ciardiello, HL Stewart, HF Sore, WRJD Galloway, DR Spring
Bioorg Med Chem
(2017)
25
(doi: 10.1016/j.bmc.2017.02.060)
Glyoxylate shunt as an antibacterial drug target
S Bartlett, A McVey, A Crousilles, M Welch, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
253
Strain-promoted double-click functionalised stapled peptides for inhibiting protein-protein interactions
K Sharma, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
254
Identification and development of small molecule inhibitors of the aggregation of amyloid β
S Collins, F Gielen, L van Vliet, G Kaminski, F Hollfelder, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2017)
253
Divergent Synthesis of Quinolone Natural Products from $\textit{Pseudonocardia}$ sp. CL38489
SM Geddis, L Carro Santos, JT Hodgkinson, DR Spring
European J Org Chem
(2016)
2016
(doi: 10.1002/ejoc.201601195)
C-H activation: Complex peptides made simple
S Bartlett, DR Spring
Nature chemistry
(2016)
9
(doi: 10.1038/nchem.2701)
Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5cu0/pdb)
Crystal structure of CK2alpha with 2-hydroxy-5-methylbenzoic acid and (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoat bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5cu2/pdb)
Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5cx9/pdb)
Crystal structure of CK2alpha with N-(3-(3-chloro-4-(phenyl)benzylamino)propyl)acetamide bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5ctp/pdb)
Crystal structure of CK2alpha with 3-(3-chloro-4-(phenyl)benzylamino)propan-1-ol bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5ct0/pdb)
Importin-alpha in complex with HNF1-beta peptide
MM Wiedmann, S Aibara, DR Spring, M Stewart, J Brenton
(2016)
(doi: 10.2210/pdb5k9s/pdb)
Combinatorial Synthesis of Structurally Diverse Triazole-Bridged Flavonoid Dimers and Trimers
TH Sum, TJ Sum, WRJD Galloway, S Collins, DG Twigg, F Hollfelder, DR Spring
Molecules
(2016)
21
(doi: 10.3390/molecules21091230)
Partially Saturated Bicyclic Heteroaromatics as an sp3-Enriched Fragment Collection
DG Twigg, N Kondo, SL Mitchell, WRJD Galloway, HF Sore, A Madin, DR Spring
Angewandte Chemie International Edition
(2016)
55
(doi: 10.1002/anie.201606496)
A Multidimensional Diversity-Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles
F Nie, DL Kunciw, D Wilcke, JE Stokes, WRJD Galloway, S Bartlett, HF Sore, DR Spring
Angewandte Chemie (International ed. in English)
(2016)
55
(doi: 10.1002/anie.201605460)
Crystal Structure of CK2alpha with Compound 6 bound
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5csv/pdb)
Crystal Structure of CK2alpha with a novel closed conformation of the aD loop
P Brear, C De Fusco, KH Georgiou, D Spring, M Hyvonen
(2016)
(doi: 10.2210/pdb5cvg/pdb)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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enquiries@ch.cam.ac.uk
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