Yusuf Hamied Department of Chemistry

Publications by Professor David Spring

Specific inhibition of CK2α from an anchor outside the active site.
P Brear, C De Fusco, K Hadje Georgiou, NJ Francis-Newton, CJ Stubbs, HF Sore, AR Venkitaraman, C Abell, DR Spring, M Hyvönen
Chem Sci
(2016)
7
(doi: 10.1039/c6sc02335e)
Discovery of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells
B Morkunas, B Gal, WRJD Galloway, JT Hodgkinson, BM Ibbeson, YS Tan, M Welch, DR Spring
Beilstein Journal of Organic Chemistry
(2016)
12
(doi: 10.3762/bjoc.12.137)
Multiple-parameter Optimization in Drug Discovery: Example of the 5-HT1B GPCR.
RC Glen, WRJD Galloway, DR Spring, G Liwiki
Mol Inform
(2016)
35
(doi: 10.1002/minf.201600056)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n2m3
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(doi: 10.2210/pdb5bxo/pdb)
Human Tankyrase-2 in Complex with Macrocyclised Extended Peptide cp4n4m5
W Xu, G Fischer, M Hyvonen, L Itzhaki
(2016)
(doi: 10.2210/pdb5bxu/pdb)
Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2.
M Janeček, M Rossmann, P Sharma, A Emery, DJ Huggins, SR Stockwell, JE Stokes, YS Tan, EG Almeida, B Hardwick, AJ Narvaez, M Hyvönen, DR Spring, GJ McKenzie, AR Venkitaraman
Sci Rep
(2016)
6
(doi: 10.1038/srep28528)
Structural and calorimetric studies demonstrate that the hepatocyte nuclear factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence
MM Wiedmann, S Aibara, DR Spring, M Stewart, JD Brenton
J Struct Biol
(2016)
195
(doi: 10.1016/j.jsb.2016.06.018)
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.
A Chattopadhyay, CJ O'Connor, F Zhang, C Galvagnion, WRJD Galloway, YS Tan, JE Stokes, T Rahman, C Verma, DR Spring, LS Itzhaki
Scientific Reports
(2016)
6
(doi: 10.1038/srep23732)
Diversity-Oriented Synthesis of Macrocycle Libraries for Drug Discovery and Chemical Biology
D Spring, S Collins, S Bartlett, F Nie, H Sore
Synthesis Germany
(2016)
48
(doi: 10.1055/s-0035-1561414)
Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.
Y Wu, LB Olsen, YH Lau, CH Jensen, M Rossmann, YR Baker, HF Sore, S Collins, DR Spring
Chembiochem
(2016)
17
(doi: 10.1002/cbic.201500648)
Divergent Total Syntheses of Flavonoid Natural Products Isolated from Rosa rugosa and Citrus unshiu
D Spring, T Sum, T Sum, W Galloway
Synlett
(2016)
27
(doi: 10.1055/s-0035-1561851)
Structure of the Stapled Peptide Bound to Mdm2
YH Lau, Y Wu, M Rossmann, P de Andrade, YS Tan, GJ McKenzie, AR Venkitaraman, M Hyvonen, DR Spring
(2016)
(doi: 10.2210/pdb5afg/pdb)
A new Pseudomonas quinolone signal (PQS) binding partner: MexG
JT Hodgkinson, J Gross, YR Baker, DR Spring, M Welch
Chemical science
(2016)
7
(doi: 10.1039/c5sc04197j)
Divergent synthesis of six biologically active 4-quinolone natural products isolated from Pseudonocardia sp CL38489
S Geddis, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
252
NEW ADVANCES IN DIVERSITY-ORIENTED SYNTHESIS
WRJD Galloway, JE Stokes, DR Spring
(2016)
The reductive cleavage of picolinic amides
DHO Donovan, C De Fusco, DR Spring
Tetrahedron Letters
(2016)
57
(doi: 10.1016/j.tetlet.2016.05.068)
Synthesis of diverse semi-saturated bicyclic heteroaromatics
H Stewart, D Spring, T Moss
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
252
Partially saturated heteroaromatics as an sp3 enriched fragment collection
S Mitchell, D Twigg, N Kondo, D Spring
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
252
Targeting transcription factor HNF1β in ovarian cancer using stapled peptides
M Wiedmann, D Spring, J Brenton
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2016)
251
The Synthesis of Quinolone Natural Products from Pseudonocardia sp.
F Salvaggio, JT Hodgkinson, L Carro, SM Geddis, WRJD Galloway, M Welch, DR Spring
European Journal of Organic Chemistry
(2015)
2016
(doi: 10.1002/ejoc.201501400)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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