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Yusuf Hamied Department of Chemistry

 

Publications by Professor David Spring

Chemical library screening approaches to aid the design of protein–protein inhibitors
G Zinzalla, L Laraia, DR Spring
(2013)
32
(DOI: 10.4155/ebo.13.151)
Chemical library screening approaches to aid the design of protein–protein inhibitors
L Laraia, DR Spring
(2013)
32
(DOI: 10.4155/EBO.13.151)
Virulence in <i><scp>P</scp>ectobacterium atrosepticum</i> is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)pp<scp>G</scp>pp
SD Bowden, A Eyres, JCS Chung, RE Monson, A Thompson, GPC Salmond, DR Spring, M Welch
– Molecular Microbiology
(2013)
90,
457
(DOI: 10.1111/mmi.12369)
Design and synthesis of a biotinylated chemical probe for detecting the molecular targets of an inhibitor of the production of the Pseudomonas aeruginosa virulence factor pyocyanin.
YR Baker, WRJD Galloway, JT Hodgkinson, DR Spring
– Molecules (Basel, Switzerland)
(2013)
18,
11783
(DOI: 10.3390/molecules181011783)
Surface swarming motility by Pectobacterium atrosepticum is a latent phenotype that requires O antigen and is regulated by quorum sensing
SD Bowden, N Hale, JCS Chung, JT Hodgkinson, DR Spring, M Welch
– Microbiology (Reading)
(2013)
159,
2375
(DOI: 10.1099/mic.0.070748-0)
Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials
KMG O'Connell, JT Hodgkinson, HF Sore, M Welch, GPC Salmond, DR Spring
– Angewandte Chemie - International Edition
(2013)
52,
10706
(DOI: 10.1002/anie.201209979)
A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.
HSG Beckmann, F Nie, CE Hagerman, H Johansson, YS Tan, D Wilcke, DR Spring
– Nature chemistry
(2013)
5,
861
(DOI: 10.1038/NCHEM.1729)
Ligand Binding Kinetics of the Quorum Sensing Regulator PqsR
M Welch, JT Hodgkinson, J Gross, DR Spring, T Sams
– Biochemistry
(2013)
52,
4433
(DOI: 10.1021/bi400315s)
A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells
T Liu, Z Xu, DR Spring, J Cui
– Org Lett
(2013)
15,
2310
(DOI: 10.1021/ol400973v)
Mild and efficient synthesis of benzo-fused seven- and eight-membered ring lactams: A convenient approach to biologically interesting chemotypes
JL Kenwright, WRJD Galloway, L Wortmann, DR Spring
– Synthetic Communications
(2013)
43,
1508
(DOI: 10.1080/00397911.2011.643439)
Dynamic combinatorial chemistry with novel dithiol building blocks: Towards new structurally diverse and adaptive screening collections
TM Postma, WRJD Galloway, FBL Cougnon, GD Pantoş, JE Stokes, DR Spring
– Synlett
(2013)
24,
765
(DOI: 10.1055/s-0032-1318407)
Investigations into the Ullmann biaryl ether synthesis
MJ Scott, JS Parker, DR Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
Hydrosilylation in water: A new bioorthogonal reaction?
EC Frye, DR Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
Diversity-oriented synthesis and phenotypic screening identifies novel small molecule regulators of mitosis
L Laraia, AR Venkitaraman, DR Spring
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
Design, synthesis, and biological evaluation of Polo-box domain (PBD) phosphopeptidomimetics
JE Stokes, A Emery, B Hardwick, AJ Narvaez, E Alza, J Balmer, G McKenzie, DR Spring, A Venkitaraman
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2013)
245,
The structure of the polo-box domain (PBD) of polo-like kinase 1 (Plk1) in complex with hydrocinnamoyl-derivatized PLHSpTA peptide
P Sledz, M Hyvonen, YS Tan, S Lang, D Spring, C Abell, RB Best
(2012)
(DOI: 10.2210/pdb4e67/pdb)
A two-directional strategy for the diversity-oriented synthesis of macrocyclic scaffolds.
KMG O'Connell, HSG Beckmann, L Laraia, HT Horsley, A Bender, AR Venkitaraman, DR Spring
– Organic and Biomolecular Chemistry
(2012)
10,
7545
(DOI: 10.1039/c2ob26272j)
Inhibition of the production of the Pseudomonas aeruginosa virulence factor pyocyanin in wild-type cells by quorum sensing autoinducer-mimics.
B Morkunas, WRJD Galloway, M Wright, BM Ibbeson, JT Hodgkinson, KMG O'Connell, N Bartolucci, M Della Valle, M Welch, DR Spring
– Organic and Biomolecular Chemistry
(2012)
10,
8452
(DOI: 10.1039/c2ob26501j)
Using ligand-mapping simulations to design a ligand selectively targeting a cryptic surface pocket of polo-like kinase 1.
YS Tan, P Śledź, S Lang, CJ Stubbs, DR Spring, C Abell, RB Best
– Angewandte Chemie International Edition
(2012)
51,
10078
(DOI: 10.1002/anie.201205676)
Applications of small molecule activators and inhibitors of quorum sensing in Gram-negative bacteria
WRJD Galloway, JT Hodgkinson, S Bowden, M Welch, DR Spring
– Trends in Microbiology
(2012)
20,
449
(DOI: 10.1016/j.tim.2012.06.003)

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