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Yusuf Hamied Department of Chemistry

 

Publications

Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
S Sandler, R Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, F Brotzakis, R Gregory, S Chia, G Bernardes, U Keyser, M Vendruscolo
(2023)
Exploration and Exploitation Approaches Based on Generative Machine Learning to Identify Potent Small Molecule Inhibitors of α-Synuclein Secondary Nucleation
RI Horne, MH Murtada, D Huo, ZF Brotzakis, RC Gregory, A Possenti, S Chia, M Vendruscolo
– Journal of Chemical Theory and Computation
(2023)
19,
4701
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α‑Synuclein Aggregates
S Chia, Z Faidon Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
– Mol Pharm
(2022)
20,
183
A Machine Learning Approach to Identify Small Molecule Inhibitors of Secondary Nucleation in α-Synuclein Aggregation
R Horne, A Possenti, S Chia, F Brotzakis, R Staats, M Nowinska, M Vendruscolo
(2022)
Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of α-synuclein aggregates
S Chia, ZF Brotzakis, RI Horne, A Possenti, B Mannini, R Cataldi, M Nowinska, R Staats, S Linse, TPJ Knowles, J Habchi, M Vendruscolo
(2021)
Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning
R Horne, E Andrzejewska, P Alam, F Brotzakis, A Srivastava, A Aubert, M Nowinska, R Gregory, R Staats, A Possenti, S Chia, P Sormanni, B Ghetti, B Caughey, T Knowles, M Vendruscolo
(2021)
2021.11.10.468009
Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Ab42 Oligomers
FS Ruggeri, J Habchi, S Chia, RI Horne, M Vendruscolo, TPJ Knowles
– Nature communications
(2021)
12,
688
Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter.
R Staats, TCT Michaels, P Flagmeier, S Chia, RI Horne, J Habchi, S Linse, TPJ Knowles, CM Dobson, M Vendruscolo
– Commun Chem
(2020)
3,
191
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Research Group

Telephone number

01223 763284

Email address

rih29@cam.ac.uk