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Yusuf Hamied Department of Chemistry

 

Publications

Sequence-Based Drug Design Using Transformers
M Vendruscolo, S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan
(2024)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity.
RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo
– Journal of Chemical Information and Modeling
(2024)
64,
590
Bayesian Optimization in the Latent Space of a Variational Autoencoder for the Generation of Selective FLT3 Inhibitors.
R Chandra, RI Horne, M Vendruscolo
– Journal of Chemical Theory and Computation
(2023)
20,
469
Sequence-based drug design using transformers
S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan, M Vendruscolo
(2023)
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
– Journal of the American Chemical Society
(2023)
145,
25776
Molecular mechanism of α-synuclein aggregation on lipid membranes revealed
A Dear, X Teng, S Ball, J Lewin, R Horne, D Clow, N Harper, K Yahya, TCT Michaels, S Linse, T Knowles, X Yang, S Brewerton, J Thomson, J Habchi, G Meisl
(2023)
Drug discovery for misfolding diseases using structure-based iterative learning
R Horne
(2023)
Optimization of a small molecule inhibitor of secondary nucleation in α-synuclein aggregation.
R Staats, ZF Brotzakis, S Chia, RI Horne, M Vendruscolo
– Frontiers in Molecular Biosciences
(2023)
10,
1155753
Secondary Processes Dominate the Quiescent, Spontaneous Aggregation of α-Synuclein at Physiological pH with Sodium Salts.
RI Horne, MA Metrick, W Man, DJ Rinauro, ZF Brotzakis, S Chia, G Meisl, M Vendruscolo
– ACS Chemical Neuroscience
(2023)
14,
3125
Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
S Sandler, R Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, F Brotzakis, R Gregory, S Chia, G Bernardes, U Keyser, M Vendruscolo
(2023)
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Research Group

Telephone number

01223 763284

Email address

rih29@cam.ac.uk