Dr Georg Krainer

Research Associate

Publications

Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR

SJ Bose, G Krainer, DRS Ng, M Schenkel, H Shishido, JS Yoon, PM Haggie, M Schlierf, DN Sheppard, WR Skach

– J Cyst Fibros

(2020)

19 Suppl 1,

S25

(doi: 10.1016/j.jcf.2019.12.009)

CFTR transmembrane segments are impaired in their conformational adaptability by a pathogenic loop mutation and dynamically stabilized by Lumacaftor

G Krainer, M Schenkel, A Hartmann, D Ravamehr-Lake, CM Deber, M Schlierf

– Journal of Biological Chemistry

(2019)

295,

1985

(doi: 10.1074/jbc.ac119.011360)

Enhancing the stability of DNA origami nanostructures: Staple strand redesign: Versus enzymatic ligation

S Ramakrishnan, L Schärfen, K Hunold, S Fricke, G Grundmeier, M Schlierf, A Keller, G Krainer

– Nanoscale

(2019)

11,

16270

(doi: 10.1039/c9nr04460d)

Structural dynamics of membrane-protein folding from single-molecule FRET

G Krainer, S Keller, M Schlierf

– Current opinion in structural biology

(2019)

58,

124

(doi: 10.1016/j.sbi.2019.05.025)

Repeatability, precision, and accuracy of the enthalpies and Gibbs energies of a protein–ligand binding reaction measured by isothermal titration calorimetry

V Paketurytė, V Linkuvienė, G Krainer, W-Y Chen, D Matulis

– European Biophysics Journal

(2018)

48,

139

(doi: 10.1007/s00249-018-1341-z)

A minimal helical-hairpin motif provides molecular-level insights into misfolding and pharmacological rescue of CFTR

G Krainer, A Treff, A Hartmann, TA Stone, M Schenkel, S Keller, CM Deber, M Schlierf

– Commun Biol

(2018)

154

(doi: 10.1038/s42003-018-0153-0)

Conformational Dynamics Govern the Free-Energy Landscape of a Membrane-Interacting Protein.

E Frotscher, G Krainer, A Hartmann, M Schlierf, S Keller

– ACS Omega

(2018)

12026

(doi: 10.1021/acsomega.8b01609)

Precision and accuracy of single-molecule FRET measurements—a multi-laboratory benchmark study

B Hellenkamp, S Schmid, O Doroshenko, O Opanasyuk, R Kühnemuth, S Rezaei Adariani, B Ambrose, M Aznauryan, A Barth, V Birkedal, ME Bowen, H Chen, T Cordes, T Eilert, C Fijen, C Gebhardt, M Götz, G Gouridis, E Gratton, T Ha, P Hao, CA Hanke, A Hartmann, J Hendrix, LL Hildebrandt, V Hirschfeld, J Hohlbein, B Hua, CG Hübner, E Kallis, AN Kapanidis, J-Y Kim, G Krainer, DC Lamb, NK Lee, EA Lemke, B Levesque, M Levitus, JJ McCann, N Naredi-Rainer, D Nettels, T Ngo, R Qiu, NC Robb, C Röcker, H Sanabria, M Schlierf, T Schröder, B Schuler, H Seidel, L Streit, J Thurn, P Tinnefeld, S Tyagi, N Vandenberk, AM Vera, KR Weninger, B Wünsch, IS Yanez-Orozco, J Michaelis, CAM Seidel, TD Craggs, T Hugel

– Nature methods

(2018)

15,

669

(doi: 10.1038/s41592-018-0085-0)