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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir Shankar Balasubramanian FMedSci FRS

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA
P Sarkies, P Murat, LG Phillips, KJ Patel, S Balasubramanian, JE Sale
– Nucleic Acids Research
(2011)
40,
1485
(DOI: 10.1093/nar/gkr868)
A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.
D Koirala, S Dhakal, B Ashbridge, Y Sannohe, R Rodriguez, H Sugiyama, S Balasubramanian, H Mao
– Nature Chemistry
(2011)
3,
782
(DOI: 10.1038/NCHEM.1126)
The transcription factor FOXM1 is a cellular target of the natural product thiostrepton.
NS Hegde, DA Sanders, R Rodriguez, S Balasubramanian
– Nature chemistry
(2011)
3,
725
(DOI: 10.1038/nchem.1114)
A LIN28-Dependent Structural Change in pre-let-7g Directly Inhibits Dicer Processing
HL Lightfoot, A Bugaut, J Armisen, NJ Lehrbach, EA Miska, S Balasubramanian
– Biochemistry
(2011)
50,
7514
(DOI: 10.1021/bi200851d)
A Sequence-Independent Analysis of the Loop Length Dependence of Intramolecular RNA G-Quadruplex Stability and Topology
AYQ Zhang, A Bugaut, S Balasubramanian
– Biochemistry
(2011)
50,
7251
(DOI: 10.1021/bi200805j)
Sequencing nucleic acids: From chemistry to medicine
S Balasubramanian
– Chem Commun (Camb)
(2011)
47,
7281
(DOI: 10.1039/c1cc11078k)
Targeting G-quadruplexes in gene promoters: A novel anticancer strategy?
S Balasubramanian, LH Hurley, S Neidle
– Nat Rev Drug Discov
(2011)
10,
261
(DOI: 10.1038/nrd3428)
Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae
JS Smith, Q Chen, LA Yatsunyk, JM Nicoludis, MS Garcia, R Kranaster, S Balasubramanian, D Monchaud, MP Teulade-Fichou, L Abramowitz, DC Schultz, FB Johnson
– Nature Structural and Molecular Biology
(2011)
18,
478
(DOI: 10.1038/nsmb.2033)
Synthesis and Binding Studies of Novel Diethynyl-Pyridine Amides with Genomic Promoter DNA G-Quadruplexes
J Dash, ZAE Waller, GD Pantoş, S Balasubramanian
– Chemistry A European Journal
(2011)
17,
4571
(DOI: 10.1002/chem.201003157)
G-quadruplex-binding benzo[a]phenoxazines down-regulate c-KIT expression in human gastric carcinoma cells.
KIE McLuckie, ZAE Waller, DA Sanders, D Alves, R Rodriguez, J Dash, GJ McKenzie, AR Venkitaraman, S Balasubramanian
– Journal of the American Chemical Society
(2011)
133,
2658
(DOI: 10.1021/ja109474c)
Diversity of Human Copy Number Variation and Multicopy Genes
PH Sudmant, JO Kitzman, F Antonacci, C Alkan, M Malig, A Tsalenko, N Sampas, L Bruhn, J Shendure, 1000 Genomes Project, EE Eichler
– Science
(2010)
330,
641
(DOI: 10.1126/science.1197005)
Targeting the <i>c</i>-<i>Kit</i> Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines (vol 1, pg 306, 2010)
M Bejugam, M Gunaratnam, S Müller, DA Sanders, S Sewitz, JA Fletcher, S Neidle, S Balasubramanian
– ACS Medicinal Chemistry Letters
(2010)
1,
546
(DOI: 10.1021/ml100241w)
Small-molecule-mediated G-quadruplex isolation from human cells.
S Müller, S Kumari, R Rodriguez, S Balasubramanian
– Nature chemistry
(2010)
2,
1095
(DOI: 10.1038/nchem.842)
Distinct functions of maternal and somatic Pat1 protein paralogs
A Marnef, M Maldonado, A Bugaut, S Balasubramanian, M Kress, D Weil, N Standart
– RNA (New York, N.Y.)
(2010)
16,
2094
(DOI: 10.1261/rna.2295410)
The <i>BCL</i>-<i>2 5</i>′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression
R Shahid, A Bugaut, S Balasubramanian
– Biochemistry
(2010)
49,
8300
(DOI: 10.1021/bi100957h)
Targeting the c-Kit promoter g-quadruplexes with 6-substituted indenoisoquinolines
M Bejugam, M Gunaratnam, S Müller, DA Sanders, S Sewitz, JA Fletcher, S Neidle, S Balasubramanian
– ACS Med Chem Lett
(2010)
1,
306
(DOI: 10.1021/ml100062z)
Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.
A Bugaut, R Rodriguez, S Kumari, S-TD Hsu, S Balasubramanian
– Org Biomol Chem
(2010)
8,
2771
(DOI: 10.1039/c002418j)
RNA conformation in catalytically active human telomerase
JA Yeoman, A Orte, B Ashbridge, D Klenerman, S Balasubramanian
– J Am Chem Soc
(2010)
132,
2852
(DOI: 10.1021/ja909383n)
Ensemble and single molecule FRET analysis of the structure and unfolding kinetics of the c-kit promoter quadruplexes.
A Fegan, PS Shirude, L Ying, S Balasubramanian
– Chemical communications (Cambridge, England)
(2009)
46,
946
(DOI: 10.1039/b920680a)
Single-molecule analysis of the human telomerase RNA.dyskerin interaction and the effect of dyskeratosis congenita mutations.
B Ashbridge, A Orte, JA Yeoman, M Kirwan, T Vulliamy, I Dokal, D Klenerman, S Balasubramanian
– Biochemistry
(2009)
48,
10858
(DOI: 10.1021/bi901373e)

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