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Yusuf Hamied Department of Chemistry

 

Publications by Professor Jason Chin FMedSci FRS

Detecting RNA base methylations in single cells by in situ hybridization
RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman
– Nature Communications
(2018)
9,
655
(DOI: 10.1038/s41467-017-02714-7)
Labeling and identifying cell-specific proteomes in the mouse brain.
TP Krogager, RJ Ernst, TS Elliott, L Calo, V Beránek, E Ciabatti, MG Spillantini, M Tripodi, MH Hastings, JW Chin
– Nature Biotechnology
(2018)
36,
156
(DOI: 10.1038/nbt.4056)
Toward an orthogonal central dogma.
CC Liu, MC Jewett, JW Chin, CA Voigt
– Nat Chem Biol
(2018)
14,
103
(DOI: 10.1038/nchembio.2554)
Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.
A Liaunardy-Jopeace, BL Murton, M Mahesh, JW Chin, JR James
– Nature structural & molecular biology
(2017)
24,
1155
(DOI: 10.1038/nsmb.3492)
Expanding and reprogramming the genetic code.
JW Chin
– Nature
(2017)
550,
53
(DOI: 10.1038/nature24031)
Correction: Computationally guided discovery of a reactive, hydrophilic trans -5-oxocene dienophile for bioorthogonal labeling
WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace
– Org Biomol Chem
(2017)
15,
7476
(DOI: 10.1039/c7ob90144e)
Computationally guided discovery of a reactive, hydrophilic <i>trans</i>-5-oxocene dienophile for bioorthogonal labeling
WD Lambert, SL Scinto, O Dmitrenko, SJ Boyd, R Magboo, RA Mehl, JW Chin, JM Fox, S Wallace
– Organic & biomolecular chemistry
(2017)
15,
6640
(DOI: 10.1039/c7ob01707c)
Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis.
JA Gramespacher, AJ Stevens, DP Nguyen, JW Chin, TW Muir
– J Am Chem Soc
(2017)
139,
8074
(DOI: 10.1021/jacs.7b02618)
Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing
MS Zhang, SF Brunner, N Huguenin-Dezot, AD Liang, WH Schmied, DT Rogerson, JW Chin
– Nat Methods
(2017)
14,
729
(DOI: 10.1038/nmeth.4302)
Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst.
TT-L Kwan, O Boutureira, EC Frye, SJ Walsh, MK Gupta, S Wallace, Y Wu, F Zhang, HF Sore, WRJD Galloway, JW Chin, M Welch, GJL Bernardes, DR Spring
– Chemical science
(2017)
8,
3871
(DOI: 10.1039/c6sc05313k)
Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET
L Perdios, AR Lowe, G Saladino, TD Bunney, N Thiyagarajan, Y Alexandrov, C Dunsby, PMW French, JW Chin, FL Gervasio, EW Tate, M Katan
– Scientific Reports
(2017)
7,
39841
(DOI: 10.1038/srep39841)
Mitotic phosphorylation of Hsp72 uncouples ATP binding from substrate release and clusters amplified centrosomes in cancer cells.
M Mukherjee, J Sampson, S Sabir, L O'Regan, MW Richards, N Huguenin-Dezot, MJ Dyer, JW Chin, A Zhuravleva, AM Fry, R Bayliss
– MOLECULAR BIOLOGY OF THE CELL
(2017)
28,
Defining synonymous codon compression schemes by genome recoding
K Wang, J Fredens, SF Brunner, SH Kim, T Chia, JW Chin
– Nature
(2016)
539,
59
(DOI: 10.1038/nature20124)
Genetic code expansion in the mouse brain.
RJ Ernst, TP Krogager, ES Maywood, R Zanchi, V Beránek, TS Elliott, NP Barry, MH Hastings, JW Chin
– Nature chemical biology
(2016)
12,
776
(DOI: 10.1038/nchembio.2160)
Tagging and Enriching Proteins Enables Cell-Specific Proteomics
TS Elliott, A Bianco, FM Townsley, SD Fried, JW Chin
– Cell Chemical Biology
(2016)
23,
805
(DOI: 10.1016/j.chembiol.2016.05.018)
Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity
N Huguenin-Dezot, V De Cesare, J Peltier, A Knebel, YA Kristaryianto, DT Rogerson, Y Kulathu, M Trost, JW Chin
– Cell Rep
(2016)
16,
1180
(DOI: 10.1016/j.celrep.2016.06.064)
Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
OS Walker, SJ Elsässer, M Mahesh, M Bachman, S Balasubramanian, JW Chin
– Journal of the American Chemical Society
(2016)
138,
718
(DOI: 10.1021/jacs.5b07627)
Genetic code expansion in stable cell lines enables encoded chromatin modification.
SJ Elsässer, RJ Ernst, OS Walker, JW Chin
– Nat Methods
(2016)
13,
158
(DOI: 10.1038/nmeth.3701)
Genetically encoded optical activation of DNA recombination in human cells.
J Luo, E Arbely, J Zhang, C Chou, R Uprety, JW Chin, A Deiters
– Chemical Communications
(2016)
52,
8529
(DOI: 10.1039/c6cc03934k)
Structural and Mechanistic Insights into the Regulation of the Fundamental Rho Regulator RhoGDIα by Lysine Acetylation*
N Kuhlmann, S Wroblowski, P Knyphausen, S de Boor, J Brenig, AY Zienert, K Meyer-Teschendorf, GJK Praefcke, H Nolte, M Krüger, M Schacherl, U Baumann, LC James, JW Chin, M Lammers
– The Journal of biological chemistry
(2015)
291,
5484
(DOI: 10.1074/jbc.m115.707091)

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