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Yusuf Hamied Department of Chemistry

 

Publications by Professor Jason Chin FMedSci FRS

Reprogramming the genetic code.
D de la Torre, JW Chin
– Nature reviews. Genetics
(2020)
22,
169
(DOI: 10.1038/s41576-020-00307-7)
Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids
DL Dunkelmann, JCW Willis, AT Beattie, JW Chin
– Nature chemistry
(2020)
12,
535
(DOI: 10.1038/s41557-020-0472-x)
Rapid discovery and evolution of orthogonal aminoacyl-tRNA synthetase-tRNA pairs
D Cervettini, S Tang, SD Fried, JCW Willis, LFH Funke, LJ Colwell, JW Chin
– Nature Biotechnology
(2020)
38,
989
(DOI: 10.1038/s41587-020-0479-2)
Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms
MR Hodskinson, A Bolner, K Sato, AN Kamimae-Lanning, K Rooijers, M Witte, M Mahesh, J Silhan, M Petek, DM Williams, J Kind, JW Chin, KJ Patel, P Knipscheer
– Nature
(2020)
579,
603
(DOI: 10.1038/s41586-020-2059-5)
Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly
K Wang, D de la Torre, WE Robertson, JW Chin
– Science (New York, N.Y.)
(2019)
365,
922
(DOI: 10.1126/science.aay0737)
Efficient Phage Display with Multiple Distinct Non‐Canonical Amino Acids Using Orthogonal Ribosome‐Mediated Genetic Code Expansion
B Oller-Salvia, JW Chin
– Angewandte Chemie - International Edition
(2019)
58,
10844
(DOI: 10.1002/anie.201902658)
Total synthesis of Escherichia coli with a recoded genome.
J Fredens, K Wang, D de la Torre, LFH Funke, WE Robertson, Y Christova, T Chia, WH Schmied, DL Dunkelmann, V Beránek, C Uttamapinant, AG Llamazares, TS Elliott, JW Chin
– Nature
(2019)
569,
514
(DOI: 10.1038/s41586-019-1192-5)
Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid.
N Huguenin-Dezot, DA Alonzo, GW Heberlig, M Mahesh, DP Nguyen, MH Dornan, CN Boddy, TM Schmeing, JW Chin
– Nature
(2018)
565,
112
(DOI: 10.1038/s41586-018-0781-z)
Controlling orthogonal ribosome subunit interactions enables evolution of new function.
WH Schmied, Z Tnimov, C Uttamapinant, CD Rae, SD Fried, JW Chin
– Nature
(2018)
564,
444
(DOI: 10.1038/s41586-018-0773-z)
Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.
ES Maywood, TS Elliott, AP Patton, TP Krogager, JE Chesham, RJ Ernst, V Beránek, M Brancaccio, JW Chin, MH Hastings
– Proceedings of the National Academy of Sciences of the United States of America
(2018)
115,
e12388
(DOI: 10.1073/pnas.1811438115)
Correction to “Genetic Code Expansion Enables Live-Cell and Super-Resolution Imaging of Site-Specifically Labeled Cellular Proteins”
C Uttamapinant, JD Howe, K Lang, V Beránek, L Davis, M Mahesh, NP Barry, JW Chin
– J Am Chem Soc
(2018)
140,
13986
(DOI: 10.1021/jacs.8b10479)
An Evolved Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase/tRNA Pair Is Highly Active and Orthogonal in Mammalian Cells.
V Beránek, JCW Willis, JW Chin
– Biochemistry
(2018)
58,
387
(DOI: 10.1021/acs.biochem.8b00808)
A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation
M Baumdick, M Gelléri, C Uttamapinant, V Beránek, JW Chin, PIH Bastiaens
– Nature Communications
(2018)
9,
3847
(DOI: 10.1038/s41467-018-06299-7)
Mitotic phosphorylation regulates Hsp72 spindle localization by uncoupling ATP binding from substrate release
M Mukherjee, S Sabir, L O'Regan, J Sampson, MW Richards, N Huguenin-Dezot, JR Ault, JW Chin, A Zhuravleva, AM Fry, R Bayliss
– Sci Signal
(2018)
11,
eaao2464
(DOI: 10.1126/scisignal.aao2464)
Genetically Encoded Protein Phosphorylation in Mammalian Cells.
V Beránek, CD Reinkemeier, MS Zhang, AD Liang, G Kym, JW Chin
– Cell Chem Biol
(2018)
25,
1067
(DOI: 10.1016/j.chembiol.2018.05.013)
Pyrophosphorylation via selective phosphoprotein derivatization
AM Marmelstein, JAM Morgan, M Penkert, DT Rogerson, JW Chin, E Krause, D Fiedler
– Chemical science
(2018)
9,
5929
(DOI: 10.1039/c8sc01233d)
Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs
JCW Willis, JW Chin
– Nature chemistry
(2018)
10,
831
(DOI: 10.1038/s41557-018-0052-5)
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
C Dickson, AJ Fletcher, M Vaysburd, J-C Yang, DL Mallery, J Zeng, CM Johnson, SH McLaughlin, M Skehel, S Maslen, J Cruickshank, N Huguenin-Dezot, JW Chin, D Neuhaus, LC James
– eLife
(2018)
7,
e32660
(DOI: 10.7554/eLife.32660)
Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix
SG Burgess, M Mukherjee, S Sabir, N Joseph, C Gutiérrez-Caballero, MW Richards, N Huguenin-Dezot, JW Chin, EJ Kennedy, M Pfuhl, SJ Royle, F Gergely, R Bayliss
– EMBO Journal
(2018)
37,
e97902
(DOI: 10.15252/embj.201797902)
Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction
B Oller-Salvia, G Kym, JW Chin
– Angewandte Chemie International Edition
(2018)
57,
2831
(DOI: 10.1002/anie.201712370)

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