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Yusuf Hamied Department of Chemistry

 

Publications by Professor Jason Chin FMedSci FRS

Automated orthogonal tRNA generation.
M Spinck, A Guppy, JW Chin
– Nature chemical biology
(2024)
21,
1
(DOI: 10.1038/s41589-024-01782-3)
Correction to: Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS (Nature Protocols, (2021), 16, 5, (2345-2380), 10.1038/s41596-020-00464-3)
WE Robertson, LFH Funke, D de la Torre, J Fredens, K Wang, JW Chin
– Nature protocols
(2024)
1
(DOI: 10.1038/s41596-024-01114-8)
Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming
DL Dunkelmann, JW Chin
– Chemical reviews
(2024)
124,
11008
(DOI: 10.1021/acs.chemrev.4c00243)
Capturing acyl-enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification.
J Luo, Y Yu, K Wang, S He, L Wang, F Liang, JW Chin, S Tang
– Nature Protocols
(2024)
19,
2967
(DOI: 10.1038/s41596-024-01006-x)
Establishing a synthetic orthogonal replication system enables accelerated evolution in E. coli
R Tian, FBH Rehm, D Czernecki, Y Gu, JF Zürcher, KC Liu, JW Chin
– Science (New York, N.Y.)
(2024)
383,
421
(DOI: 10.1126/science.adk1281)
Adding α,α-disubstituted and β-linked monomers to the genetic code of an organism
DL Dunkelmann, C Piedrafita, A Dickson, KC Liu, TS Elliott, M Fiedler, D Bellini, A Zhou, D Cervettini, JW Chin
– Nature
(2024)
625,
603
(DOI: 10.1038/s41586-023-06897-6)
Continuous synthesis of <i>E</i>. coli genome sections and Mb-scale human DNA assembly
JF Zürcher, AA Kleefeldt, LFH Funke, J Birnbaum, J Fredens, S Grazioli, KC Liu, M Spinck, G Petris, P Murat, FBH Rehm, JE Sale, JW Chin
– Nature
(2023)
619,
555
(DOI: 10.1038/s41586-023-06268-1)
Quintuply orthogonal pyrrolysyl-tRNA synthetase/tRNA<sup>Pyl</sup> pairs
AT Beattie, DL Dunkelmann, JW Chin
– Nat Chem
(2023)
15,
948
(DOI: 10.1038/s41557-023-01232-y)
Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles.
M Spinck, C Piedrafita, WE Robertson, TS Elliott, D Cervettini, D de la Torre, JW Chin
– Nature chemistry
(2022)
15,
61
(DOI: 10.1038/s41557-022-01082-0)
Refactored genetic codes enable bidirectional genetic isolation
JF Zürcher, WE Robertson, T Kappes, G Petris, TS Elliott, GPC Salmond, JW Chin
– Science (New York, N.Y.)
(2022)
378,
516
(DOI: 10.1126/science.add8943)
RBBP6 activates the pre-mRNA 3' end processing machinery in humans
V Boreikaite, TS Elliott, JW Chin, LA Passmore
– Genes &amp; Development
(2022)
36,
210
(DOI: 10.1101/gad.349223.121)
Mechanism-based traps enable protease and hydrolase substrate discovery.
S Tang, AT Beattie, L Kafkova, G Petris, N Huguenin-Dezot, M Fiedler, M Freeman, JW Chin
– Nature
(2022)
602,
701
(DOI: 10.1038/s41586-022-04414-9)
Cryptochrome proteins regulate the circadian intracellular behavior and localization of PER2 in mouse suprachiasmatic nucleus neurons.
NJ Smyllie, J Bagnall, AA Koch, D Niranjan, L Polidarova, JE Chesham, JW Chin, CL Partch, ASI Loudon, MH Hastings
– Proceedings of the National Academy of Sciences of the United States of America
(2022)
119,
e2113845119
(DOI: 10.1073/pnas.2113845119)
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites
F Bürmann, LFH Funke, JW Chin, J Löwe
– Mol Cell
(2021)
81,
4891
(DOI: 10.1016/j.molcel.2021.10.011)
A 68-codon genetic code to incorporate four distinct non-canonical amino acids enabled by automated orthogonal mRNA design.
DL Dunkelmann, SB Oehm, AT Beattie, JW Chin
– Nat Chem
(2021)
13,
1110
(DOI: 10.1038/s41557-021-00764-5)
Precise optical control of gene expression in <i>C elegans</i> using improved genetic code expansion and Cre recombinase
L Davis, I Radman, A Goutou, A Tynan, K Baxter, Z Xi, JM O'Shea, JW Chin, S Greiss
– Elife
(2021)
10,
e67075
(DOI: 10.7554/eLife.67075)
Sense codon reassignment enables viral resistance and encoded polymer synthesis.
WE Robertson, LFH Funke, D de la Torre, J Fredens, TS Elliott, M Spinck, Y Christova, D Cervettini, FL Böge, KC Liu, S Buse, S Maslen, GPC Salmond, JW Chin
– Science (New York, N.Y.)
(2021)
372,
1057
(DOI: 10.1126/science.abg3029)
Creating custom synthetic genomes in Escherichia coli with REXER and GENESIS
WE Robertson, LFH Funke, D de la Torre, J Fredens, K Wang, JW Chin
– Nature Protocols
(2021)
16,
2345
(DOI: 10.1038/s41596-020-00464-3)
Selective CRAF Inhibition Elicits Transactivation.
CW Morgan, IL Dale, AP Thomas, J Hunt, JW Chin
– Journal of the American Chemical Society
(2021)
143,
4600
(DOI: 10.1021/jacs.0c11958)
High-efficacy subcellular micropatterning of proteins using fibrinogen anchors.
JL Watson, S Aich, B Oller-Salvia, AA Drabek, SC Blacklow, J Chin, E Derivery
– Journal of Cell Biology
(2021)
220,
e202009063
(DOI: 10.1083/jcb.202009063)

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