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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

Measuring the prion-like character of tau by TIRF microscopy
F Kundel, B Falcon, L Hong, N Esteras, AJ Dear, AY Abramov, TPJ Knowles, M Goedert, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
Imaging the early events of T-cell triggering
D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S108
Non-perturbative single-molecule imaging of tau aggregates by genetic code expansion
F Kundel, MH Horrocks, Y Ye, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S240
DNA PAINTing amyloid aggregates
MH Horrocks, D Whiten, Y Zuo, L Calo, MG Spillantini, S Gandhi, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S236
Single α-synuclein oligomers are hydrophobically distinct from mature fibrils
J-E Lee, MN Bongiovanni, M Rodrigues, CM Dobson, SF Lee, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S348
Size dependent structure and effects of amyloid beta42
D Wirthensohn, F Kundel, S De, C Hughes, MH Horrocks, P Flagmeier, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S242
Monitoring Ca<sup>2+</sup> elevations in individual astrocytes upon local release of amyloid beta in acute brain slices.
O Tyurikova, K Zheng, A Rings, A Drews, D Klenerman, DA Rusakov
– Brain Research Bulletin
(2016)
136,
85
(DOI: 10.1016/j.brainresbull.2016.12.007)
pyFRET: A Python Library for Single Molecule Fluorescence Data Analysis
RR Murphy, SE Jackson, D Klenerman
– Proceedings of the 7th European Conference on Python in Science (EuroSciPy 2014)
(2016)
1412,
59
(DOI: 10.17863/CAM.7376)
Multi-dimensional super-resolution imaging enables surface hydrophobicity mapping.
MN Bongiovanni, J Godet, MH Horrocks, L Tosatto, AR Carr, DC Wirthensohn, RT Ranasinghe, JV Fritz, CM Dobson, D Klenerman, SF Lee
– Nature communications
(2016)
7,
13544
(DOI: 10.1038/ncomms13544)
Low Stress Ion Conductance Microscopy of Sub-Cellular Stiffness
RW Clarke, P Novak, A Zhukov, EJ Tyler, M Cano-Jaimez, A Drews, O Richards, K Volynski, C Bishop, D Klenerman
– Soft matter
(2016)
12,
7953
(DOI: 10.1039/c6sm01106c)
Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein.
M Iljina, L Tosatto, ML Choi, JC Sang, Y Ye, CD Hughes, CE Bryant, S Gandhi, D Klenerman
– Sci Rep
(2016)
6,
33928
(DOI: 10.1038/srep33928)
A microfluidic platform for trapping, releasing and super-resolution imaging of single cells
Y Zhou, S Basu, KJ Wohlfahrt, SF Lee, D Klenerman, ED Laue, AA Seshia
– Sensors and actuators. B, Chemical
(2016)
232,
680
(DOI: 10.1016/j.snb.2016.03.131)
Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells.
A Drews, J Flint, N Shivji, P Jönsson, D Wirthensohn, E De Genst, C Vincke, S Muyldermans, C Dobson, D Klenerman
– Sci Rep
(2016)
6,
31910
(DOI: 10.1038/srep31910)
The Nucleosome Remodeling and Deacetylase Complex NuRD is built from preformed catalytically active sub-modules
W Zhang, A Aubert, JM Gomez de Segura, M Karuppasamy, S Basu, A Murthy, A Diamante, TA Drury, J Balmer, J Cramard, AA Watson, D Lando, SF Lee, M Palayret, S Kloet, A Smits, M Deery, M Vermeulen, B Hendrich, D Klenerman, C Schaffitzel, I Berger, ED Laue
– J Mol Biol
(2016)
428,
2931
(DOI: 10.1016/j.jmb.2016.04.025)
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, CM Dobson, D Frenkel, TPJ Knowles, D Klenerman
– Sci Rep
(2016)
6,
28658
(DOI: 10.1038/srep28658)
Angular Approach Scanning Ion Conductance Microscopy
A Shevchuk, S Tokar, S Gopal, JL Sanchez-Alonso, AI Tarasov, AC Vélez-Ortega, C Chiappini, P Rorsman, MM Stevens, J Gorelik, GI Frolenkov, D Klenerman, YE Korchev
– Biophysical Journal
(2016)
110,
2252
(DOI: 10.1016/j.bpj.2016.04.017)
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions
P Jönsson, J Southcombe, AM Santos, J Huo, RA Fernandes, J McColl, M Lever, EJ Evans, A Hudson, VT Chang, T Hanke, A Godkin, PD Dunne, MH Horrocks, M Palayret, GR Screaton, J Petersen, J Rossjohn, L Fugger, O Dushek, X Xu, SJ Davis, D Klenerman
– Proc Natl Acad Sci U S A
(2016)
113,
5682
(DOI: 10.1073/pnas.1513918113)
Ca2+ is a key factor in α-synuclein-induced neurotoxicity.
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
– Development (Cambridge, England)
(2016)
143,
e1.1
(DOI: 10.1242/dev.139345)
PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits.
MJ Broadhead, MH Horrocks, F Zhu, L Muresan, R Benavides-Piccione, J DeFelipe, D Fricker, MV Kopanitsa, RR Duncan, D Klenerman, NH Komiyama, SF Lee, SGN Grant
– Sci Rep
(2016)
6,
24626
(DOI: 10.1038/srep24626)
Initiation of T cell signaling by CD45 segregation at 'close contacts'.
VT Chang, RA Fernandes, KA Ganzinger, SF Lee, C Siebold, J McColl, P Jönsson, M Palayret, K Harlos, CH Coles, EY Jones, Y Lui, E Huang, RJC Gilbert, D Klenerman, AR Aricescu, SJ Davis
– Nature immunology
(2016)
17,
574
(DOI: 10.1038/ni.3392)

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