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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

Ca2+ is a key factor in α-synuclein-induced neurotoxicity
PR Angelova, MHR Ludtmann, MH Horrocks, A Negoda, N Cremades, D Klenerman, CM Dobson, NW Wood, EV Pavlov, S Gandhi, AY Abramov
– Journal of cell science
(2016)
129,
1792
(DOI: 10.1242/jcs.180737)
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
M Iljina, GA Garcia, MH Horrocks, L Tosatto, ML Choi, KA Ganzinger, AY Abramov, S Gandhi, NW Wood, N Cremades, CM Dobson, TPJ Knowles, D Klenerman
– Proc Natl Acad Sci U S A
(2016)
113,
E1206
(DOI: 10.1073/pnas.1524128113)
Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids.
MH Horrocks, SF Lee, S Gandhi, NK Magdalinou, SW Chen, MJ Devine, L Tosatto, M Kjaergaard, JS Beckwith, H Zetterberg, M Iljina, N Cremades, CM Dobson, NW Wood, D Klenerman
– ACS chemical neuroscience
(2016)
7,
399
(DOI: 10.1021/acschemneuro.5b00324)
Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease
E Deas, N Cremades, PR Angelova, MHR Ludtmann, Z Yao, S Chen, MH Horrocks, B Banushi, D Little, MJ Devine, P Gissen, D Klenerman, CM Dobson, NW Wood, S Gandhi, AY Abramov
– Antioxid Redox Signal
(2016)
24,
376
(DOI: 10.1089/ars.2015.6343)
Spearhead Nanometric Field-Effect Transistor Sensors for Single-Cell Analysis
Y Zhang, J Clausmeyer, B Babakinejad, AL Córdoba, T Ali, A Shevchuk, Y Takahashi, P Novak, C Edwards, M Lab, S Gopal, C Chiappini, U Anand, L Magnani, RC Coombes, J Gorelik, T Matsue, W Schuhmann, D Klenerman, EV Sviderskaya, Y Korchev
– ACS Nano
(2016)
10,
3214
(DOI: 10.1021/acsnano.5b05211)
Combining Single-Molecule Techniques with Microfluidics for Protein Analysis
C Taylor, T Knowles, D Klenerman
– Biophysical Journal
(2016)
110,
195a
(DOI: 10.1016/j.bpj.2015.11.1086)
A single-molecule approach to deciphering the mechanism of T-cell receptor triggering.
KA Ganzinger, R Fernandes, S Lee, M Palayret, P Jonsson, J McColl, SJ Davis, D Klenerman
– MOLECULAR BIOLOGY OF THE CELL
(2016)
27,
A novel single molecule imaging approach to detect individual protein oligomers in CSF from patients with Parkinson's disease (PD)
S Gandhi, MH Horrocks, SF Lee, NW Wood, D Klenerman
– MOVEMENT DISORDERS
(2016)
31,
S281
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, N Cremades, CM Dobson, D Klenerman
– Scientific reports
(2015)
5,
16696
(DOI: 10.1038/srep16696)
Referenced Single-Molecule Measurements Differentiate between GPCR Oligomerization States.
SL Latty, JH Felce, L Weimann, SF Lee, SJ Davis, D Klenerman
– Biophysical Journal
(2015)
109,
1798
(DOI: 10.1016/j.bpj.2015.09.004)
The 2015 super-resolution microscopy roadmap
SW Hell, SJ Sahl, M Bates, X Zhuang, R Heintzmann, MJ Booth, J Bewersdorf, G Shtengel, H Hess, P Tinnefeld, A Honigmann, S Jakobs, I Testa, L Cognet, B Lounis, H Ewers, SJ Davis, C Eggeling, D Klenerman, KI Willig, G Vicidomini, M Castello, A Diaspro, T Cordes
– Journal of Physics D
(2015)
48,
443001
(DOI: 10.1088/0022-3727/48/44/443001)
Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α‑Synuclein Oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, M Dalla Serra, TPJ Knowles, CM Dobson, D Klenerman
– Analytical Chemistry
(2015)
87,
8818
(DOI: 10.1021/acs.analchem.5b01811)
Aggregated α-synuclein and complex I deficiency: Exploration of their relationship in differentiated neurons
AK Reeve, MHR Ludtmann, PR Angelova, EM Simcox, MH Horrocks, D Klenerman, S Gandhi, DM Turnbull, AY Abramov
– Cell Death & Disease
(2015)
6,
e1820
(DOI: 10.1038/cddis.2015.166)
Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus.
DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, BL Winters, D-H Kim, E Kim, P St George-Hyslop, D Klenerman, GL Collingridge, J Jo, K Cho
– Scientific Reports
(2015)
5,
10934
(DOI: 10.1038/srep10934)
A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.
SL Shammas, GA Garcia, S Kumar, M Kjaergaard, MH Horrocks, N Shivji, E Mandelkow, TPJ Knowles, E Mandelkow, D Klenerman
– Nature communications
(2015)
6,
7025
(DOI: 10.1038/ncomms8025)
Structural characterization of toxic oligomers that are kinetically trapped during alpha-synuclein fibril formation
SW Chen, S Drakulic, E Deas, MM Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, GE De, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
E1994
(DOI: 10.1073/pnas.1421204112.)
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, C Roodveldt, T Guilliams, EJ De-Genst, D Klenerman, NW Wood, TPJ Knowles, C Alfonso, G Rivas, AY Abramov, JM Valpuesta, CM Dobson, N Cremades
– Proceedings of the National Academy of Sciences
(2015)
112,
e1994
(DOI: 10.1073/pnas.1421204112)
On-demand delivery of single DNA molecules using nanopipets.
AP Ivanov, P Actis, P Jönsson, D Klenerman, Y Korchev, JB Edel
– ACS nano
(2015)
9,
3587
(DOI: 10.1021/acsnano.5b00911)
Lipid peroxidation is essential for α-synuclein-induced cell death
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
– Journal of Neurochemistry
(2015)
133,
582
(DOI: 10.1111/jnc.13024)
Lipid peroxidation is essential for α-synuclein-induced cell death.
PR Angelova, MH Horrocks, D Klenerman, S Gandhi, AY Abramov, MS Shchepinov
– J Neurochem
(2015)
133,
582
(DOI: 10.1111/jnc.13024)

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