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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

Lecanemab preferentially binds to smaller aggregates present at early Alzheimer's disease.
E Fertan, JYL Lam, G Albertini, M Dewilde, Y Wu, OES Akingbade, D Böken, EA English, B De Strooper, D Klenerman
– Alzheimer's and Dementia
(2025)
21,
e70086
(DOI: 10.1002/alz.70086)
Astrocytic RNA editing regulates the host immune response to alpha-synuclein.
K D’Sa, ML Choi, AZ Wagen, N Setó-Salvia, O Kopach, JR Evans, M Rodrigues, P Lopez-Garcia, J Lachica, BE Clarke, J Singh, A Ghareeb, J Bayne, M Grant-Peters, S Garcia-Ruiz, Z Chen, S Rodriques, D Athauda, EK Gustavsson, SA Gagliano Taliun, C Toomey, RH Reynolds, G Young, S Strohbuecker, T Warner, DA Rusakov, R Patani, C Bryant, DA Klenerman, S Gandhi, M Ryten
– Science Advances
(2025)
11,
eadp8504
(DOI: 10.1126/sciadv.adp8504)
Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease
D Cox, M Burke, S Milani, MA White, FM Waldron, D Böken, E Lobanova, J Sreedharan, JM Gregory, D Klenerman
(2025)
(DOI: 10.1101/2025.03.04.641150)
A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation
M Steindel, O Davis, K Neumann, L Pirvan, G Agsu, A Kranz, D Adhya, J Morf, S Yang, Z Zhang, J Fu, M Barile, A Wurmser, SE Strawbridge, I Mohorianu, P Madapura, B Huntly, B Göttgens, D Holcman, SA Samarajiwa, D Klenerman, K Anastassiadis, A Francis Stewart, S Basu
(2025)
(DOI: 10.1101/2025.02.21.639010)
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F K Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
– Cell chemical biology
(2025)
32,
338
(DOI: 10.1016/j.chembiol.2025.01.001)
Detecting the Undetectable: Advances in Methods for Identifying Small Tau Aggregates in Neurodegenerative Diseases
D Böken, Y Wu, Z Zhang, D Klenerman
– Chembiochem
(2025)
26,
e202400877
(DOI: 10.1002/cbic.202400877)
Ultrasensitive Protein Aggregate Quantification Assays for Neurodegenerative Diseases on the Simoa Platform.
D Böken, Z Xia, JYL Lam, E Fertan, Y Wu, EA English, J Konc, F Layburn, GJL Bernardes, H Zetterberg, MR Cheetham, D Klenerman
– Analytical Chemistry
(2024)
97,
290
(DOI: 10.1021/acs.analchem.4c04188)
Tau accumulation patterns in PSP constrain mechanisms and quantify cell-to-cell and cell-autonomous aggregation rates
S-H Huang, A Quaegebeur, T Pansuwan, T Rittman, R Wang, TPJ Knowles, J Rowe, D Klenerman, G Meisl
(2024)
(DOI: 10.1101/2024.12.14.24318991)
Clearance of beta-amyloid and tau aggregates is size dependent and altered by an inflammatory challenge.
E Fertan, C Hung, JSH Danial, JYL Lam, P Preman, G Albertini, EA English, D Böken, FJ Livesey, B De Strooper, R Patani, D Klenerman
– Brain Communications
(2024)
7,
fcae454
(DOI: 10.1093/braincomms/fcae454)
ASC specks as a single-molecule fluid biomarker of inflammation in neurodegenerative diseases.
D Klenerman
– Nature Communications
(2024)
15,
9690
(DOI: 10.1038/s41467-024-53547-0)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
D Klenerman, E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper
(2024)
(DOI: 10.21203/rs.3.rs-5290983/v1)
Single-molecule characterisation of soluble beta-amyloid aggregate binding by Aducanumab, Lecanemab, Gantenerumab, and Donanemab
E Fertan, J Lam, G Albertini, M Dewilde, Y Wu, O Akingbade, D Böken, E English, B De Strooper, D Klenerman
(2024)
(DOI: 10.1101/2024.10.11.617910)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
– Nature Methods
(2024)
21,
1873
(DOI: 10.1038/s41592-024-02382-8)
A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairment
AG Díaz, A Possenti, GA Urrutia, Y Bian, S Kedia, D Boeken, C Lim, D Licastro, B Mannini, D Klenerman, M Vendruscolo
(2024)
(DOI: 10.1101/2024.09.01.610673)
Aggregate-selective removal of pathological tau by clustering-activated degraders.
J Benn, S Cheng, S Keeling, AE Smith, MJ Vaysburd, D Böken, LVC Miller, T Katsinelos, C Franco, E Dupré, C Danis, I Landrieu, L Buée, D Klenerman, LC James, WA McEwan
– Science (New York, N.Y.)
(2024)
385,
1009
(DOI: 10.1126/science.adp5186)
SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy
S Kedia, E Fertan, Y Wu, YP Zhang, G Meisl, JYL Lam, F Wiseman, WA McEwan, A Quaegebeur, MG Spillantini, JSH Danial, D Klenerman
(2024)
(DOI: 10.1101/2024.08.24.609517)
Improved Imaging Surface for Quantitative Single-Molecule Microscopy.
YP Zhang, E Lobanova, A Dworkin, M Furlepa, WS Yang, M Burke, JX Meng, N Potter, RL Sala, L Kahanawita, F Layburn, OA Scherman, CH Williams-Gray, D Klenerman
– ACS Applied Materials and Interfaces
(2024)
16,
37255
(DOI: 10.1021/acsami.4c06512)
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
– eLife
(2024)
13,
(DOI: 10.7554/elife.92350.3)
The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide.
B Li, P Suresh, J Brelstaff, S Kedia, CE Bryant, D Klenerman
(2024)
(DOI: 10.7554/eLife.92350)
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease.
Z Xia, EE Prescott, A Urbanek, HE Wareing, MC King, A Olerinyova, H Dakin, T Leah, KA Barnes, MM Matuszyk, E Dimou, E Hidari, YP Zhang, JYL Lam, JSH Danial, MR Strickland, H Jiang, P Thornton, DC Crowther, S Ohtonen, M Gómez-Budia, SM Bell, L Ferraiuolo, H Mortiboys, A Higginbottom, SB Wharton, DM Holtzman, T Malm, RT Ranasinghe, D Klenerman, S De
– Nature communications
(2024)
15,
4695
(DOI: 10.1038/s41467-024-49028-z)

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