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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

Single-molecule characterization of salivary protein aggregates from Parkinson’s disease patients: a pilot study
M Furlepa, YP Zhang, E Lobanova, L Kahanawita, G Vivacqua, CH Williams-Gray, D Klenerman
– Brain Commun
(2024)
6,
fcae178
(DOI: 10.1093/braincomms/fcae178)
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2024)
(DOI: 10.7554/elife.92350.2)
Single‐Molecule Characterization and Super‐Resolution Imaging of Alzheimer's Disease‐Relevant Tau Aggregates in Human Samples
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
– Angewandte Chemie International Edition
(2024)
136,
e202317756
(DOI: 10.1002/ange.202317756)
Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples.
D Böken, D Cox, M Burke, JYL Lam, T Katsinelos, JSH Danial, E Fertan, WA McEwan, JB Rowe, D Klenerman
– Angewandte Chemie - International Edition
(2024)
63,
e202317756
(DOI: 10.1002/anie.202317756)
High-density volumetric super-resolution microscopy.
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O'Holleran, SF Lee
– Nat Commun
(2024)
15,
1940
(DOI: 10.1038/s41467-024-45828-5)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
– Nature Communications
(2024)
15,
1940
(DOI: 10.1038/s41467-024-45828-5)
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, M Fellermeyer, J Clarke, S Sharma, S Moreira da Silva, B Akkaya, C Anzilotti, SH Morgan, CF Jessup, M Körbel, U Gileadi, J Leitner, R Knox, M Chirifu, J Huo, S Yu, N Ashman, Y Lui, I Wilkinson, KE Attfield, L Fugger, NJ Robertson, CJ Lynch, L Murray, P Steinberger, AM Santos, SF Lee, RJ Cornall, D Klenerman, SJ Davis
– Immunity
(2024)
57,
256
(DOI: 10.1016/j.immuni.2024.01.007)
Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– Nature Structural & Molecular Biology
(2023)
31,
390
(DOI: 10.1038/s41594-023-01179-1)
Cerebral organoids with chromosome 21 trisomy secrete Alzheimer's disease-related soluble aggregates detectable by single-molecule-fluorescence and super-resolution microscopy.
E Fertan, D Böken, A Murray, JSH Danial, JYL Lam, Y Wu, PA Goh, I Alić, MR Cheetham, E Lobanova, YP Zhang, D Nižetić, D Klenerman
– Molecular psychiatry
(2023)
29,
369
(DOI: 10.1038/s41380-023-02333-3)
Imaging Protein Aggregates in Parkinson's Disease Serum Using Aptamer-Assisted Single-Molecule Pull-Down.
YP Zhang, E Lobanova, D Emin, SV Lobanov, A Kouli, CH Williams-Gray, D Klenerman
– Analytical chemistry
(2023)
95,
15254
(DOI: 10.1021/acs.analchem.3c02515)
The delayed kinetics of Myddosome formation explains why Aβ aggregates trigger TLR4 less efficiently than LPS
B Li, P Suresh, J Brelstaff, S Kedia, C Bryant, D Klenerman
(2023)
(DOI: 10.1101/2023.09.28.559977)
Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD
S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue
– Nature structural & molecular biology
(2023)
30,
1628
(DOI: 10.1038/s41594-023-01095-4)
Author Correction: Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.
JSH Danial, JYL Lam, Y Wu, M Woolley, E Dimou, MR Cheetham, D Emin, D Klenerman
– Nature Protocols
(2023)
18,
3975
(DOI: 10.1038/s41596-023-00909-5)
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding.
E Dimou, T Katsinelos, G Meisl, BJ Tuck, S Keeling, AE Smith, E Hidari, JYL Lam, M Burke, S Lövestam, RT Ranasinghe, WA McEwan, D Klenerman
– Cell Reports
(2023)
42,
112725
(DOI: 10.1016/j.celrep.2023.112725)
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
A Miller, J Wei, S Meehan, CM Dobson, ME Welland, D Klenerman, M Vendruscolo, FS Ruggeri, TPJ Knowles
– Proc Natl Acad Sci U S A
(2023)
120,
e2216234120
(DOI: 10.1073/pnas.2216234120)
High-density volumetric super-resolution microscopy
S Daly, JF Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, J Beckwith, E Sanders, R Sims, D Klenerman, S Davis, K O’Holleran, S Lee
(2023)
(DOI: 10.1101/2023.05.02.539032)
Surfaces for Study of Receptor Dynamics on T Cells.
J McColl, D Klenerman
– Methods in Molecular Biology
(2023)
2654,
41
(DOI: 10.1007/978-1-0716-3135-5_3)
Antigen discrimination by T cells relies on size-constrained microvillar contact.
D Klenerman
– Nature Communications
(2023)
14,
1611
(DOI: 10.1038/s41467-023-36855-9)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, A Klymchenko, S Davis, E Paluch, D Klenerman, M Lew, K O’Holleran, S Lee
(2023)
(DOI: 10.1101/2023.02.07.527479)
Direct digital sensing of protein biomarkers in solution.
G Krainer, KL Saar, WE Arter, TJ Welsh, MA Czekalska, RPB Jacquat, Q Peter, WC Traberg, A Pujari, AK Jayaram, P Challa, CG Taylor, L-M van der Linden, T Franzmann, RM Owens, S Alberti, D Klenerman, TPJ Knowles
– Nat Commun
(2023)
14,
653
(DOI: 10.1038/s41467-023-35792-x)

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