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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
– Angewandte Chemie
(2018)
130,
4980
(DOI: 10.1002/ange.201710779)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
– ACS Chem Biol
(2018)
13,
636
(DOI: 10.1021/acschembio.7b01039)
Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates
F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman
– The FEBS journal
(2018)
285,
3604
(DOI: 10.1111/febs.14409)
Capturing resting T cells: the perils of PLL
AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee
– Nat Immunol
(2018)
19,
203
(DOI: 10.1038/s41590-018-0048-8)
Detecting RNA base methylations in single cells by in situ hybridization
RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman
– Nat Commun
(2018)
9,
655
(DOI: 10.1038/s41467-017-02714-7)
Activation of toll-like receptors nucleates assembly of the MyDDosome signaling hub
SL Latty, J Sakai, L Hopkins, B Verstak, T Paramo, NA Berglund, E Cammarota, P Cicuta, NJ Gay, PJ Bond, D Klenerman, CE Bryant
– eLife
(2018)
7,
e31377
(DOI: 10.7554/elife.31377)
Optical Structural Analysis of Individual α-Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
– Angew Chem Int Ed Engl
(2018)
57,
4886
(DOI: 10.1002/anie.201710779)
Inhibiting the Ca
A Drews, S De, P Flagmeier, DC Wirthensohn, W-H Chen, DR Whiten, M Rodrigues, C Vincke, S Muyldermans, RW Paterson, CF Slattery, NC Fox, JM Schott, H Zetterberg, CM Dobson, S Gandhi, D Klenerman
– Cell Reports
(2017)
21,
3310
(DOI: 10.1016/j.celrep.2017.11.057)
Single-Molecule Analysis of G Protein-Coupled Receptor Stoichiometry: Approaches and Limitations
JH Felce, SJ Davis, D Klenerman
– Trends in pharmacological sciences
(2017)
39,
96
(DOI: 10.1016/j.tips.2017.10.005)
Absolute Quantification of Amyloid Propagons by Digital Microfluidics
M Pfammatter, M Andreasen, G Meisl, CG Taylor, J Adamcik, S Bolisetty, A Sánchez-Ferrer, D Klenerman, CM Dobson, R Mezzenga, TPJ Knowles, A Aguzzi, S Hornemann
– Analytical chemistry
(2017)
89,
12306
(DOI: 10.1021/acs.analchem.7b03279)
Nanopore extended field-effect transistor for selective single-molecule biosensing
R Ren, Y Zhang, BP Nadappuram, B Akpinar, D Klenerman, AP Ivanov, JB Edel, Y Korchev
– Nature communications
(2017)
8,
586
(DOI: 10.1038/s41467-017-00549-w)
Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure
JH Felce, SL Latty, RG Knox, SR Mattick, Y Lui, SF Lee, D Klenerman, SJ Davis
– Cell Reports
(2017)
20,
2654
(DOI: 10.1016/j.celrep.2017.08.072)
Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
D Klenerman, M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, J-E Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E De Genst, D Klenerman
– BMC biology
(2017)
15,
57
(DOI: 10.1186/s12915-017-0390-6)
Ultrasensitive Measurement of Ca<sup>2+</sup> Influx into Lipid Vesicles Induced by Protein Aggregates.
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie International Edition
(2017)
56,
7750
(DOI: 10.1002/anie.201700966)
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TPJ Knowles, S Gandhi, CM Dobson, D Klenerman
– Angewandte Chemie
(2017)
129,
7858
(DOI: 10.1002/ange.201700966)
Three-Dimensional Super-Resolution in Eukaryotic Cells Using the Double-Helix Point Spread Function.
AR Carr, A Ponjavic, S Basu, J McColl, AM Santos, S Davis, ED Laue, D Klenerman, SF Lee
– Biophysical journal
(2017)
112,
1444
(DOI: 10.1016/j.bpj.2017.02.023)
3D structures of individual mammalian genomes studied by single-cell Hi-C.
TJ Stevens, D Lando, S Basu, LP Atkinson, Y Cao, SF Lee, M Leeb, KJ Wohlfahrt, W Boucher, A O’Shaughnessy-Kirwan, J Cramard, AJ Faure, M Ralser, E Blanco, L Morey, M Sanso, MGS Palayret, B Lehner, L Di Croce, A Wutz, B Hendrich, D Klenerman, ED Laue
– Nature
(2017)
544,
59
(DOI: 10.1038/nature21429)
Direct Modulation of the Mitochondrial Permeability Transition Pore by Oligomeric Alpha-Synuclein Causes Toxicity in PD
M Ludtmann, P Angelova, M-L Choi, M Horrocks, A Baev, D Little, M Devine, P Gissen, E Pavlov, D Klenerman, A Abramov, S Gandhi
– Biophysical Journal
(2017)
112,
440a
(DOI: 10.1016/j.bpj.2016.11.2351)
Imaging the early events of T-cell triggering
D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S108
Ultrasensitive measurement of Ca<SUP>2+</SUP> influx into lipid vesicles induced by protein aggregates
P Flagmeier, S De, DC Wirthensohn, SF Lee, C Vincke, S Muyldermans, TP Knowles, S Gandhi, CM Dobson, D Klenerman
– EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
46,
S237

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