Publications | Page 5 | Yusuf Hamied Department of Chemistry

Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

PR Angelova, ML Choi, AV Berezhnov, MH Horrocks, CD Hughes, S De, M Rodrigues, R Yapom, D Little, KS Dolt, T Kunath, MJ Devine, P Gissen, MS Shchepinov, S Sylantyev, EV Pavlov, D Klenerman, AY Abramov, S Gandhi

– Cell Death Differ

(2020)

28,

1755

(DOI: 10.1038/s41418-020-00634-6)

Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses

GR Mallucci, D Klenerman, DC Rubinsztein

– ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 36, 2020

(2020)

36,

165

(DOI: 10.1146/annurev-cellbio-040320-120625)

Tumour necrosis factor induces increased production of extracellular amyloid-β- and α-synuclein-containing aggregates by human Alzheimer's disease neurons

DR Whiten, PW Brownjohn, S Moore, S De, A Strano, Y Zuo, M Haneklaus, D Klenerman, FJ Livesey

– Brain communication

(2020)

fcaa146

(DOI: 10.1093/braincomms/fcaa146)

Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation

P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, M Vendruscolo, S Linse, D Klenerman, TPJ Knowles, CM Dobson

– Nat Struct Mol Biol

(2020)

27,

886

(DOI: 10.1038/s41594-020-0471-z)

Direct detection of whole bacteria using a nonlinear acoustic resonator

S Khobragade, C Da Silva Granja, N Sandström, I Efimov, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh

– Sensors and Actuators, B: Chemical

(2020)

316,

128086

(DOI: 10.1016/j.snb.2020.128086)

Single-molecule visualisation of DNA G-quadruplex formation in live cells.

M Di Antonio, A Ponjavic, A Radzevičius, RT Ranasinghe, M Catalano, X Zhang, J Shen, L-M Needham, SF Lee, D Klenerman, S Balasubramanian

– Nature chemistry

(2020)

12,

832

(DOI: 10.1038/s41557-020-0506-4)

Direct digital sensing of protein biomarkers in solution

G Krainer, K Saar, W Arter, T Welsh, M Czekalska, RPB Jacquat, Q Peter, W Traberg, W Traberg, A Pujari, A Jayaram, P Challa, C Taylor, L-M van der Linden, T Franzmann, R Owens, S Alberti, D Klenerman, TPJ Knowles

– BIOPHYSICAL JOURNAL

(2020)

120,

2020.05.24.113498

(DOI: 10.1101/2020.05.24.113498)

Digital Sensing and Molecular Computation by an Enzyme-Free DNA Circuit

WE Arter, Y Yusim, Q Peter, CG Taylor, D Klenerman, UF Keyser, TPJ Knowles

– ACS nano

(2020)

14,

5763

(DOI: 10.1021/acsnano.0c00628)

Kinetic diversity of amyloid oligomers

AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, CM Dobson, TPJ Knowles

– Proc Natl Acad Sci U S A

(2020)

117,

12087

(DOI: 10.1073/pnas.1922267117)

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation (vol 45, pg 128, 2020)

– Cell Death & Differentiation

(2020)

27,

2747

(DOI: 10.1038/s41418-020-0552-x)

ThX-a next-generation probe for the early detection of amyloid aggregates

L-M Needham, J Weber, JA Varela, JWB Fyfe, DT Do, CK Xu, L Tutton, R Cliffe, B Keenlyside, D Klenerman, CM Dobson, CA Hunter, KH Müller, K O'Holleran, SE Bohndiek, TN Snaddon, SF Lee

– Chemical science

(2020)

11,

4578

(DOI: 10.1039/c9sc04730a)

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

N Esteras, F Kundel, GF Amodeo, EV Pavlov, D Klenerman, AY Abramov

– FEBS Journal

(2020)

288,

127

(DOI: 10.1111/febs.15340)

Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.

– Cell death and differentiation

(2020)

27,

2781

(DOI: 10.1038/s41418-020-0542-z)

A fluorescent molecular imaging probe with selectivity for soluble tau aggregated protein.

Y Zhao, O Tietz, W-L Kuan, AK Haji-Dheere, S Thompson, B Vallin, E Ronchi, G Tóth, D Klenerman, FI Aigbirhio

– Chemical science

(2020)

11,

4773

(DOI: 10.1039/c9sc05620c)

Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics

S Basu, O Shukron, D Hall, P Parutto, A Ponjavic, D Shah, W Boucher, D Lando, W Zhang, N Reynolds, LH Sober, A Jartseva, R Ragheb, X Ma, J Cramard, R Floyd, G Brown, J Balmer, TA Drury, AR Carr, L-M Needham, A Aubert, G Communie, K Gor, M Steindel, L Morey, E Blanco, T Bartke, L Di Croce, I Berger, C Schaffitzel, SF Lee, TJ Stevens, D Klenerman, BD Hendrich, D Holcman, ED Laue

– BioRxiv

(2020)

2020.04.03.003178

(DOI: 10.1101/2020.04.03.003178)

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

G Meisl, TP Knowles, D Klenerman

– Current Opinion in Neurobiology

(2020)

61,

(DOI: 10.1016/j.conb.2020.01.010)

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

C Hughes, ML Choi, J-H Yi, S-C Kim, A Drews, PS George-Hyslop, C Bryant, S Gandhi, K Cho, D Klenerman

– Communications Biology

(2020)

(DOI: 10.1038/s42003-020-0792-9)

Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies.

JB Sanderson, S De, H Jiang, M Rovere, M Jin, L Zaccagnini, A Hays Watson, L De Boni, VN Lagomarsino, TL Young-Pearse, X Liu, TC Pochapsky, BT Hyman, DW Dickson, D Klenerman, DJ Selkoe, T Bartels

– Brain Commun

(2020)

fcaa010

(DOI: 10.1093/braincomms/fcaa010)

A General <i>in Vitro</i> Assay for Studying Enzymatic Activities of the Ubiquitin System

Y Zuo, BK Chong, K Jiang, D Finley, D Klenerman, Y Ye

– Biochemistry

(2020)

59,

851

(DOI: 10.1021/acs.biochem.9b00602)

The Costs of Close Contacts: Visualizing the Energy Landscape of Cell Contacts at the Nanoscale.

K Kulenkampff, AH Lippert, J McColl, AM Santos, A Ponjavic, E Jenkins, J Humphrey, A Winkel, K Franze, SF Lee, SJ Davis, D Klenerman

– Biophysical Journal

(2020)

118,

1261

(DOI: 10.1016/j.bpj.2020.01.019)

Publications by Professor Sir David Klenerman FMedSci FRS

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