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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
MC Moncrieffe, D Bollschweiler, B Li, PA Penczek, L Hopkins, CE Bryant, D Klenerman, NJ Gay
– Structure
(2020)
28,
281
(DOI: 10.1016/j.str.2020.01.003)
High-resolution label-free 3D mapping of extracellular pH of single living cells
Y Zhang, Y Takahashi, SP Hong, F Liu, J Bednarska, PS Goff, P Novak, A Shevchuk, S Gopal, I Barozzi, L Magnani, H Sakai, Y Suguru, T Fujii, A Erofeev, P Gorelkin, A Majouga, DJ Weiss, C Edwards, AP Ivanov, D Klenerman, EV Sviderskaya, JB Edel, Y Korchev
– Nature communications
(2019)
10,
5610
(DOI: 10.1038/s41467-019-13535-1)
α-Synuclein strains target distinct brain regions and cell types
A Lau, RWL So, HHC Lau, JC Sang, A Ruiz-Riquelme, SC Fleck, E Stuart, S Menon, NP Visanji, G Meisl, R Faidi, MM Marano, C Schmitt-Ulms, Z Wang, PE Fraser, A Tandon, BT Hyman, H Wille, M Ingelsson, D Klenerman, JC Watts
– Nat Neurosci
(2019)
23,
21
(DOI: 10.1038/s41593-019-0541-x)
N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme.
Y Ye, D Klenerman, D Finley
– Journal of Molecular Biology
(2019)
432,
585
(DOI: 10.1016/j.jmb.2019.08.021)
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, CG Taylor, FA Aprile, S Muyldermans, TPJ Knowles, M Vendruscolo, C Bryant, K Blennow, I Skoog, S Kern, H Zetterberg, D Klenerman
– Acta Neuropathologica Communications
(2019)
7,
120
(DOI: 10.1186/s40478-019-0777-4)
A cell-topography based mechanism for ligand discrimination by the T-cell receptor
RA Fernandes, KA Ganzinger, JC Tzou, P Jönsson, SF Lee, M Palayret, AM Santos, AR Carr, A Ponjavic, VT Chang, C Macleod, BC Lagerholm, AE Lindsay, O Dushek, A Tilevik, SJ Davis, D Klenerman
– Proceedings of the National Academy of Sciences
(2019)
116,
14002
(DOI: 10.1073/pnas.1817255116)
A general in vitro assay to study enzymatic activities of the ubiquitin system
Y Zuo, BK Chong, K Jiang, D Finley, D Klenerman, Y Ye
(2019)
660894
(DOI: 10.1101/660894)
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, SIA Cohen, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles, P Arosio
– Sci Adv
(2019)
5,
eaau3112
(DOI: 10.1126/sciadv.aau3112)
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, DR Whiten, D Emin, Z Xia, JA Varela, P Sormanni, F Kundel, TPJ Knowles, CM Dobson, C Bryant, M Vendruscolo, D Klenerman
– Nat Commun
(2019)
10,
1541
(DOI: 10.1038/s41467-019-09477-3)
Citrullination of HP1γ 1 chromodomain affects association to chromatin
M Wiese, AJ Bannister, S Basu, W Boucher, K Wohlfahrt, MA Christophorou, ML Nielsen, D Klenerman, ED Laue, T Kouzarides
– Epigenetics & chromatin
(2019)
12,
21
(DOI: 10.1186/s13072-019-0265-x)
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, J-E Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, TPJ Knowles, D Klenerman
– Chemical Science
(2019)
10,
4588
(DOI: 10.1039/c8sc05627g)
Spectrally-Resolved Photodynamics Of Individual Emitters In Large-Area Monolayers Of Hexagonal-Boron Nitride.
HL Stern, R Wang, Y Fan, R Mizuta, JC Stewart, L-M Needham, TD Roberts, R Wai, NS Ginsberg, D Klenerman, S Hofmann, SF Lee
– ACS Nano
(2019)
13,
4538
(DOI: 10.1021/acsnano.9b00274)
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42
T Weiffert, G Meisl, P Flagmeier, S De, CJR Dunning, B Frohm, H Zetterberg, K Blennow, E Portelius, D Klenerman, CM Dobson, TPJ Knowles, S Linse
– ACS Chemical Neuroscience
(2019)
10,
2374
(DOI: 10.1021/acschemneuro.8b00676)
Filamentous aggregates are fragmented by the proteasome holoenzyme
R Cliffe, JC Sang, F Kundel, D Finley, D Klenerman, Y Ye
– Cell Rep
(2019)
26,
2140
(DOI: 10.1016/j.celrep.2019.01.096)
Simple and ultrafast resonance frequency and dissipation shift measurements using a fixed frequency drive
A Guha, N Sandström, VP Ostanin, W van der Wijngaart, D Klenerman, SK Ghosh
– Sensors and Actuators B: Chemical
(2019)
281,
960
(DOI: 10.1016/j.snb.2018.11.052)
Picomolar concentrations of oligomeric alpha synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis
CD Hughes, ML Choi, M Ryten, L Hopkins, A Drews, JA Botía, M Iljina, M Rodrigues, SA Gagliano, S Gandhi, C Bryant, D Klenerman
– Acta Neuropathol
(2019)
137,
103
(DOI: 10.1007/s00401-018-1907-y)
Imaging rRNA Methylation in Bacteria by MR-FISH.
KA Ganzinger, MR Challand, J Spencer, D Klenerman, RT Ranasinghe
– Methods Mol Biol
(2019)
2038,
89
(DOI: 10.1007/978-1-4939-9674-2_7)
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease.
S De, D Klenerman
– BBA - Proteins and Proteomics
(2019)
1867,
870
(DOI: 10.1016/j.bbapap.2018.12.010)
Oligomer Diversity during the Aggregation of the Repeat Region of Tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, D Klenerman
– ACS Chemical Neuroscience
(2018)
9,
3060
(DOI: 10.1021/acschemneuro.8b00250)
Mapping Surface Hydrophobicity of α‑Synuclein Oligomers at the Nanoscale
J-E Lee, JC Sang, M Rodrigues, AR Carr, MH Horrocks, S De, MN Bongiovanni, P Flagmeier, CM Dobson, DJ Wales, SF Lee, D Klenerman
– Nano Lett
(2018)
18,
7494
(DOI: 10.1021/acs.nanolett.8b02916)

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