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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir David Klenerman FMedSci FRS

Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling.
KY Chen, E Jenkins, M Körbel, A Ponjavic, AH Lippert, AM Santos, N Ashman, C O'Brien-Ball, J McBride, D Klenerman, SJ Davis
– Proceedings of the National Academy of Sciences
(2021)
118,
e2024250118
(DOI: 10.1073/pnas.2024250118)
Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase-Separated Microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
– Advanced Materials Interfaces
(2021)
8,
2101071
(DOI: 10.1002/admi.202101071)
Alpha Synuclein only Forms Fibrils In Vitro when Larger than its Critical Size of 70 Monomers.
SE Sanchez, DR Whiten, G Meisl, FS Ruggeri, E Hidari, D Klenerman
– ChemBioChem
(2021)
22,
2867
(DOI: 10.1002/cbic.202100285)
Imaging protein aggregates in the serum and cerebrospinal fluid in Parkinson’s disease
E Lobanova, D Whiten, FS Ruggeri, CG Taylor, A Kouli, Z Xia, D Emin, YP Zhang, JYL Lam, CH Williams-Gray, D Klenerman
– Brain
(2021)
145,
632
(DOI: 10.1093/brain/awab306)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (Adv. Mater. 33/2021)
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
– Advanced Materials
(2021)
33,
2170258
(DOI: 10.1002/adma.202170258)
Noncontact Nanoscale Imaging of Cells
D Klenerman, Y Korchev, P Novak, A Shevchuk
– Annual review of analytical chemistry (Palo Alto, Calif.)
(2021)
14,
347
(DOI: 10.1146/annurev-anchem-091420-120101)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
– Advanced materials (Deerfield Beach, Fla.)
(2021)
33,
2008670
(DOI: 10.1002/adma.202008670)
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease
DI Sideris, JSH Danial, D Emin, FS Ruggeri, Z Xia, YP Zhang, E Lobanova, H Dakin, S De, A Miller, JC Sang, TPJ Knowles, M Vendruscolo, G Fraser, D Crowther, D Klenerman
– Brain communications
(2021)
3,
fcab147
(DOI: 10.1093/braincomms/fcab147)
Mapping the binding site topology of amyloid protein aggregates using multivalent ligands.
E Sanna, M Rodrigues, SG Fagan, TS Chisholm, K Kulenkampff, D Klenerman, MG Spillantini, FI Aigbirhio, CA Hunter
– Chem Sci
(2021)
12,
8892
(DOI: 10.1039/d1sc01263k)
Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells.
JC Sang, E Hidari, G Meisl, RT Ranasinghe, MG Spillantini, D Klenerman
– Communications biology
(2021)
4,
613
(DOI: 10.1038/s42003-021-02126-w)
DeepSinse: deep learning-based detection of single molecules
JSH Danial, R Shalaby, K Cosentino, MM Mahmoud, F Medhat, D Klenerman, AJ Garcia Saez
– Bioinformatics (Oxford, England)
(2021)
37,
3998
(DOI: 10.1093/bioinformatics/btab352)
Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent inflammatory responses
D Klenerman, J Meng, Y Zhang, D Saman, S De, J Sang, K Jiang, J Humphrey, L Julian, E Hidari, A Floto, S Lee, C Bryant, J Benesch, Y Ye
(2021)
(DOI: 10.21203/rs.3.rs-374549/v1)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation.
A Vilalta, Y Zhou, J Sevalle, JK Griffin, K Satoh, DH Allendorf, S De, M Puigdellívol, A Bruzas, MA Burguillos, RB Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, PE Fraser, D Klenerman, SF Lee, P St George-Hyslop, GC Brown
– J Biol Chem
(2021)
296,
100631
(DOI: 10.1016/j.jbc.2021.100631)
CSPα reduces aggregates and rescues striatal dopamine release in α-synuclein transgenic mice
L Caló, E Hidari, M Wegrzynowicz, JW Dalley, BL Schneider, M Podgajna, O Anichtchik, E Carlson, D Klenerman, MG Spillantini
– Brain : a journal of neurology
(2021)
144,
1661
(DOI: 10.1093/brain/awab076)
Single molecule imaging of protein aggregation in Dementia: Methods, insights and prospects
JSH Danial, D Klenerman
– Neurobiology of disease
(2021)
153,
105327
(DOI: 10.1016/j.nbd.2021.105327)
Single-molecule light-sheet microscopy with local nanopipette de-livery.
B Li, A Ponjavic, W-H Chen, L Hopkins, C Hughes, Y Ye, C Bryant, D Klenerman
– Analytical Chemistry
(2021)
93,
4092
(DOI: 10.1021/acs.analchem.0c05296)
Direct Digital Sensing of Proteins in Solution through Single-Molecule Optofluidics
G Krainer, KL Saar, WE Arter, TPJ Knowles
– Biophysical Journal
(2021)
120,
114A
(DOI: 10.1016/j.bpj.2020.11.2269)
Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer’s R47H mutant does the opposite
A Vilalta, Y Zhou, J Sevalle, J Griffin, K Satoh, D Allendorf, S De, M Puigdellívol, A Bruzas, M Burguillos, R Dodd, F Chen, Y Zhang, P Flagmeier, L-M Needham, M Enomoto, S Qamar, J Henderson, J Walter, P Fraser, D Klenerman, S Lee, P St George-Hyslop, G Brown
(2020)
(DOI: 10.1101/2020.12.03.409995)
Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions
AH Lippert, IB Dimov, AK Winkel, J Humphrey, J McColl, KY Chen, AM Santos, E Jenkins, K Franze, SJ Davis, D Klenerman
– Biophysical Journal
(2020)
120,
35
(DOI: 10.1016/j.bpj.2020.11.021)
Amyloid precipitation in biofluids using a structure-specific chemical antibody
M Rodrigues, P Bhattacharjee, A Brinkmalm, D Do, C Pearson, S De, A Ponjavic, J Varela, F Ruggeri, I Baudrexel, J Lee, A Carr, K Kulenkampff, T Knowles, H Zetterberg, T Snaddon, S Gandhi, S Lee, D Klenerman
(2020)
(DOI: 10.21203/rs.3.rs-81521/v1)

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