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Yusuf Hamied Department of Chemistry

 

Publications by Professor Steve Ley CBE FRS FMedSci

A total synthesis of the ammonium ionophore, (−)-enniatin B
DX Hu, M Bielitza, P Koos, SV Ley
– Tetrahedron Letters
(2012)
53,
4077
(DOI: 10.1016/j.tetlet.2012.05.110)
On being green: Can flow chemistry help?
SV Ley
– Chemical Record
(2012)
12,
378
(DOI: 10.1002/tcr.201100041)
A "Catch-React-Release" Method for the Flow Synthesis of 2-Aminopyrimidines and Preparation of the Imatinib Base
RJ Ingham, E Riva, N Nikbin, IR Baxendale, SV Ley
– Organic Letters
(2012)
14,
3920
(DOI: 10.1021/ol301673q)
Continuous flow reaction monitoring using an on-line miniature mass spectrometer.
DL Browne, S Wright, BJ Deadman, S Dunnage, IR Baxendale, RM Turner, SV Ley
– Rapid Commun Mass Spectrom
(2012)
26,
1999
(DOI: 10.1002/rcm.6312)
Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds
J Zak, D Ron, E Riva, HP Harding, BCS Cross, IR Baxendale
– Chemistry
(2012)
18,
9901
(DOI: 10.1002/chem.201201039)
On being green: Can flow chemistry help?
SV Ley
– Chemical record (New York, N.Y.)
(2012)
12,
378
(DOI: 10.1002/tcr.201100041)
Asymmetric homogeneous hydrogenation in flow using a tube-in-tube reactor
S Newton, SV Ley, EC Arcé, DM Grainger
– Advanced Synthesis and Catalysis
(2012)
354,
1805
(DOI: 10.1002/adsc.201200073)
Rotamers or diastereomers? An overlooked NMR solution
DX Hu, P Grice, SV Ley
– The Journal of organic chemistry
(2012)
77,
5198
(DOI: 10.1021/jo300734r)
Continuous-Flow Processing of Gaseous Ammonia Using a Teflon AF-2400 Tube-in-Tube Reactor: Synthesis of Thioureas and In-Line Titrations
D Browne, M O'Brien, P Koos, PB Cranwell, A Polyzos, SV Ley
– Synlett
(2012)
23,
1402
(DOI: 10.1055/s-0031-1290963)
A flow-based synthesis of 2-aminoadamantane-2-carboxylic acid
C Battilocchio, IR Baxendale, M Biava, MO Kitching, SV Ley
– Organic Process Research & Development
(2012)
16,
798
(DOI: 10.1021/op300084z)
Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration
PB Cranwell, M O'Brien, DL Browne, P Koos, A Polyzos, M Peña-López, SV Ley
– Org Biomol Chem
(2012)
10,
5774
(DOI: 10.1039/c2ob25407g)
The Lab of the Future. the importance of remote monitoring and control
MD Hopkin, IR Baxendale, SV Ley
– Chimica Oggi Chemistry Today
(2012)
30,
24
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A-1
TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers
– Bioorganic and Medicinal Chemistry
(2012)
20,
1749
(DOI: 10.1016/j.bmc.2012.01.010)
The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
BCS Cross, PJ Bond, PG Sadowski, BK Jha, J Zak, JM Goodman, RH Silverman, TA Neubert, IR Baxendale, D Ron, HP Harding
– Proc Natl Acad Sci U S A
(2012)
109,
e869
(DOI: 10.1073/pnas.1115623109)
Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands
C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin
– Synthesis
(2012)
44,
635
(DOI: 10.1055/s-0031-1289676)
Scale-up of flow-assisted synthesis of C 2-symmetric chiral PyBox ligands
C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin
– Synthesis
(2012)
2012,
635
(DOI: 10.1055/s-0031-1289676)
Scale-Up of Flow-Assisted Synthesis of C 2-Symmetric Chiral PyBox Ligands
C Battilocchio, M Baumann, IR Baxendale, M Biava, MO Kitching, SV Ley, RE Martin, SA Ohnmacht, NDC Tappin
– Synthesis
(2012)
2012,
635
(DOI: 10.1055/s-0031-1289676)
A Total Synthesis of Millingtonine A
J Wegner, SV Ley, A Kirschning, A-L Hansen, JM Garcia, IR Baxendale
– Org Lett
(2012)
14,
696
(DOI: 10.1021/ol203158p)
A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles
TM Beale, DM Allwood, A Bender, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers, JW Shearman, J Temple, J Unger, CA Watts, J Xian
– ACS Medicinal Chemistry Letters
(2012)
3,
177
(DOI: 10.1021/ml200149g)
Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A–1
TM Beale, PJ Bond, JD Brenton, DS Charnock-Jones, SV Ley, RM Myers
– Bioorg Med Chem
(2012)
20,
1749
(DOI: 10.1016/j.bmc.2012.01.010)

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