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Yusuf Hamied Department of Chemistry

 

Publications by Professor Sir Shankar Balasubramanian FMedSci FRS

Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36
MC Chen, R Tippana, NA Demeshkina, P Murat, S Balasubramanian, S Myong, AR Ferré-D'Amaré
– Nature
(2018)
558,
465
(DOI: 10.1038/s41586-018-0209-9)
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence.
AJ Parry, M Hoare, D Bihary, R Hänsel-Hertsch, S Smith, K Tomimatsu, E Mannion, A Smith, P D'Santos, IA Russell, S Balasubramanian, H Kimura, SA Samarajiwa, M Narita
– Nature communications
(2018)
9,
1840
(DOI: 10.1038/s41467-018-04283-9)
Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule.
C Marchetti, KG Zyner, SA Ohnmacht, M Robson, SM Haider, JP Morton, G Marsico, T Vo, S Laughlin-Toth, AA Ahmed, G Di Vita, I Pazitna, M Gunaratnam, RJ Besser, ACG Andrade, S Diocou, JA Pike, D Tannahill, RB Pedley, TRJ Evans, WD Wilson, S Balasubramanian, S Neidle
– Journal of Medicinal Chemistry
(2018)
61,
2500
(DOI: 10.1021/acs.jmedchem.7b01781)
Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing.
R Hänsel-Hertsch, J Spiegel, G Marsico, D Tannahill, S Balasubramanian
– Nature protocols
(2018)
13,
551
(DOI: 10.1038/nprot.2017.150)
Machine learning model for sequence-driven DNA G-quadruplex formation
AB Sahakyan, VS Chambers, G Marsico, T Santner, M Di Antonio, S Balasubramanian
– Scientific Reports
(2017)
7,
14535
(DOI: 10.1038/s41598-017-14017-4)
Synthesis and Multiple Incorporations of 2′‐O‐Methyl‐5‐hydroxymethylcytidine, 5‐Hydroxymethylcytidine and 5‐Formylcytidine Monomers into RNA Oligonucleotides
A Tanpure, S Balasubramanian
– ChemBioChem
(2017)
18,
2236
(DOI: 10.1002/cbic.201700492)
DNA sequencing at 40: Past, present and future
J Shendure, S Balasubramanian, GM Church, W Gilbert, J Rogers, JA Schloss, RH Waterston
– Nature
(2017)
550,
345
(DOI: 10.1038/nature24286)
Mapping and elucidating the function of modified bases in DNA
EA Raiber, Hardisty, van Delft, S Balasubramanian
– Nature Reviews Chemistry
(2017)
1,
0069
(DOI: 10.1038/s41570-017-0069)
THERAPEUTICS Click and discover
GS Vassiliou, S Balasubramanian
– Nature
(2017)
548,
162
(DOI: 10.1038/548162a)
Local epigenetic reprogramming induced by G-quadruplex ligands
S Balasubramanian
– Nature chemistry
(2017)
9,
1110
(DOI: 10.1038/nchem.2828)
The Profile and Dynamics of RNA Modifications in Animals
S Balasubramanian, P van Delft, A Akay, C Bueschl, K Rudolph, T Domenico, R Schuhmacher, E Miska
– Chembiochem
(2017)
18,
979
(DOI: 10.1002/cbic.201700093)
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition
AB Sahakyan, P Murat, C Mayer, S Balasubramanian
– Nature Structural & Molecular Biology
(2017)
24,
243
(DOI: 10.1038/nsmb.3367)
DNA G-quadruplexes in the human genome: Detection, functions and therapeutic potential
R Hänsel-Hertsch, M Di Antonio, S Balasubramanian
– Nature reviews. Molecular cell biology
(2017)
18,
279
(DOI: 10.1038/nrm.2017.3)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
H Xu, M Di Antonio, S McKinney, V Mathew, B Ho, NJ O'Neil, ND Santos, J Silvester, V Wei, J Garcia, F Kabeer, D Lai, P Soriano, J Banáth, DS Chiu, D Yap, DD Le, FB Ye, A Zhang, K Thu, J Soong, S-C Lin, AHC Tsai, T Osako, T Algara, DN Saunders, J Wong, J Xian, MB Bally, JD Brenton, GW Brown, SP Shah, D Cescon, TW Mak, C Caldas, PC Stirling, P Hieter, S Balasubramanian, S Aparicio
– Nature Communications
(2017)
8,
14432
(DOI: 10.1038/ncomms14432)
2'-$\textit{0}$-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA
SM Huber, P van Delft, A Tanpure, EA Miska, S Balasubramanian
– Journal of the American Chemical Society
(2017)
139,
1766
(DOI: 10.1021/jacs.6b12180)
Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming
I Milagre, TM Stubbs, MR King, J Spindel, F Santos, F Krueger, M Bachman, A Segonds-Pichon, S Balasubramanian, SR Andrews, W Dean, W Reik
– Cell Reports
(2017)
18,
1079
(DOI: 10.1016/j.celrep.2017.01.008)
Genome-wide mapping of 5-hydroxymethyluracil in the eukaryote parasite Leishmania.
F Kawasaki, D Beraldi, RE Hardisty, GR McInroy, P van Delft, S Balasubramanian
– Genome Biology
(2017)
18,
23
(DOI: 10.1186/s13059-017-1150-1)
Single genome retrieval of context-dependent variability in mutation rates for human germline
AB Sahakyan, S Balasubramanian
– BMC genomics
(2017)
18,
81
(DOI: 10.1186/s12864-016-3440-5)
Synthesis and biophysical analysis of modified thymine-containing DNA oligonucleotides
F Kawasaki, P Murat, Z Li, T Santner, S Balasubramanian
– Chem Commun (Camb)
(2017)
53,
1389
(DOI: 10.1039/c6cc08670e)
COMPARISON OF MATCHED GLIOBLASTOMA TUMOR AND MARGIN SAMPLES USING SINGLE BASE RESOLUTION MAPS REVEALS ACQUIRED, EARLY EPIGENETIC CHANGES THAT PREDISPOSE TO MUTATIONS DURING TUMOURIGENESIS
E-A Raiber, D Beraldi, SM Cuesta, G McInroy, Z Kingsbury, J Becq, T James, M Lopes, K Allinson, S Field, S Humphray, T Santarius, C Watts, D Bentley, S Balasubramanian
– NEURO-ONCOLOGY
(2017)
19,
102

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