Yusuf Hamied Department of Chemistry

Publications by Professor Finian Leeper

BIOSYNTHESIS OF VITAMIN-B12 - STRUCTURE OF THE ESTER OF A NEW BIOSYNTHETIC INTERMEDIATE, PRECORRIN-6Y
D Thibaut, F Kiuchi, L Debussche, FJ Leeper, F Blanche, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1992)
(doi: 10.1039/C39920000139)
Biosynthesis of vitamin B12: structural studies on precorrin-8x, an octamethylated intermediate and the structure of its stable tautomer
D Thibaut, F Kiuchi, L Debussche, F Blanche, M Kodera, FJ Leeper, AR Battersby
Journal of the Chemical Society Chemical Communications
(1992)
(doi: 10.1039/C39920000982)
Biosynthesis of vitamin B 12 : the fate of 8-H as precorrin-2 is enzymically converted into cobyrinic acid
M Kodera, FJ Leeper, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1992)
(doi: 10.1039/c39920000835)
Biosynthesis of vitamin B12: Use of a single 13C label in the macrocycle to confirm C-11 methylation in precorrin-6x
F Blanche, M Kodera, M Couder, FJ Leeper, D Thibaut, AR Battersby
Journal of the Chemical Society Chemical Communications
(1992)
(doi: 10.1039/C39920000138)
BIOSYNTHESIS OF VITAMIN-B12 - STEREOCHEMISTRY OF TRANSFER OF A HYDRIDE EQUIVALENT FROM NADPH BY PRECORRIN-6X REDUCTASE
F Kiuchi, D Thibaut, L Debussche, FJ Leeper, F Blanche, AR Battersby
Chemical Communications
(1992)
(doi: 10.1039/C39920000306)
Modified substrates for tetrapyrrole biosynthesis: Analogues of porphobilinogen showing unusual inhibition of porphobilinogen deaminase
FJ Leeper, M Rock
Journal of the Chemical Society, Chemical Communications
(1992)
(doi: 10.1039/C39920000242)
Synthetic studies relevant to biosynthetic research on vitamin B12. Part 11. Modification of the east and west building blocks and study of different assembly methods for synthesis of isobacteriochlorins
AR Battersby, MH Block, FJ Leeper, SC Zimmerman
J CHEM SOC PERK T 1
(1992)
(doi: 10.1039/P19920002189)
Synthetic studies relevant to biosynthetic research on vitamin B12. Part 10. Construction of the east and west building blocks for synthesis of isobacteriochlorins
AR Battersby, MH Block, CJR Fookes, PJ Harrison, GB Henderson, FJ Leeper
J CHEM SOC PERK T 1
(1992)
(doi: 10.1039/p19920002175)
Biosynthesis of vitamin B12: The site of reduction of precorrin-6x
GW Weaver, FJ Leeper, AR Battersby, F Blanche, D Thibaut, L Debussche
Journal of the Chemical Society, Chemical Communications
(1991)
(doi: 10.1039/C39910000976)
Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: the stereochemical probe
MA Cassidy, N Crockett, FJ Leeper, AR Battersby
Chemical Communications
(1991)
(doi: 10.1039/c39910000384)
The synthesis of a fluorinated analogue of 5-aminolaevulinic acid, a potential inhibitor of porphyrin biosynthesis
FJ Leeper, M Rock
Journal of Fluorine Chemistry
(1991)
51
(doi: 10.1016/S0022-1139(00)80192-X)
The effect of strain on the catalytic reactions of bridged thiazolium salts as models of thiamin
FJ Leeper, DHC Smith
Journal of the Chemical Society, Chemical Communications
(1990)
(doi: 10.1039/c39900000961)
Biosynthesis of vitamin B12: Incorporation of (11S)-[11- 2H1-] and (11R)-[11-2H1] porphobilinogen into sirohydrochlorin and 2,7,20-trimethylisobacteriochlorin
GW Weaver, F Blanche, D Thibaut, L Debussche, FJ Leeper, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1990)
(doi: 10.1039/c39900001125)
Biosynthesis of vitamin B12: Structure of precorrin-6x octamethyl ester
D Thibaut, F Blanche, L Debussche, FJ Leeper, AR Battersby
Proc Natl Acad Sci U S A
(1990)
87
(doi: 10.1073/pnas.87.22.8800)
BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES .35. DISCOVERY OF A NOVEL DIPYRROLIC COFACTOR ESSENTIAL FOR THE CATALYTIC ACTION OF HYDROXYMETHYLBILANE SYNTHASE (PORPHOBILINOGEN DEAMINASE)
GJ Hart, AD Miller, U Beifuss, FJ Leeper, AR Battersby
Journal of the Chemical Society, Perkin Transactions 1
(1990)
(doi: 10.1039/p19900001979)
Synthetic studies relevant to biosynthetic research on vitamin B12. Part 9. Synthesis of 20-methyl and 20-cyano isobacteriochlorins
DM Arnott, PJ Harrison, GB Henderson, Z-C Sheng, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1989)
(doi: 10.1039/p19890000265)
SYNTHESES RELEVANT TO VITAMIN-B12 BIOSYNTHESIS - THE GLUTAMATE ROUTE TO (-)-RING-B IMIDE AND SYNTHESIS OF THE 2,7,12,20-TETRAMETHYLISOBACTERIOCHLORIN
B Müller, AN Collins, MK Ellis, WG Whittingham, FJ Leeper, AR Battersby
Chemical Communications
(1989)
(doi: 10.1039/c39890001119)
Biosynthesis of porphyrins and related macrocycles. Part 34. Synthesis and properties of S-pyrrolylmethylcysteinyl and ∈-N-pyrrolylmethyllysyl peptides
AD Miller, FJ Leeper, AR Battersby
J. Chem. Soc., Perkin Trans. 1
(1989)
(doi: 10.1039/p19890001943)
SYNTHESES RELEVANT TO VITAMIN-B12 BIOSYNTHESIS - THE MALATE ROUTE TO (-)-RING-B IMIDE AND SYNTHESIS OF THE 2,7,20-TRIMETHYLISOBACTERIOCHLORIN
WG Whittingham, MK Ellis, P Guerry, GB Henderson, B Müller, DA Taylor, FJ Leeper, AR Battersby
Journal of the Chemical Society Chemical Communications
(1989)
(doi: 10.1039/C39890001116)
The biosynthesis of porphyrins, chlorophylls, and vitamin B 12
FJ Leeper
Natural product reports
(1989)
6
(doi: 10.1039/NP9890600171)
Yusuf Hamied Department of Chemistry
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CB2 1EW
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enquiries@ch.cam.ac.uk
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