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Yusuf Hamied Department of Chemistry

 

Publications by Professor Finian Leeper

SYNTHETIC STUDIES RELEVANT TO BIOSYNTHETIC RESEARCH ON VITAMIN-B12 .10. CONSTRUCTION OF THE EAST AND WEST BUILDING-BLOCKS FOR SYNTHESIS OF ISOBACTERIOCHLORINS
AR BATTERSBY, MH BLOCK, CJR FOOKES, PJ HARRISON, GB HENDERSON, FJ LEEPER
– Journal of the Chemical Society Perkin Transactions 1
(1992)
2175
(DOI: 10.1039/p19920002175)
Biosynthesis of vitamin B 12 : structural studies on precorrin-8x, an octamethylated intermediate and the structure of its stable tautomer
D THIBAUT, F KIUCHI, L DEBUSSCHE, F BLANCHE, M KODERA, FJ LEEPER, AR BATTERSBY
– Journal of the Chemical Society, Chemical Communications
(1992)
982
(DOI: 10.1039/C39920000982)
BIOSYNTHESIS OF VITAMIN-B(12) - THE FATE OF 8-H AS PRECORRIN-2 IS ENZYMATICALLY CONVERTED INTO COBYRINIC ACID
M KODERA, FJ LEEPER, AR BATTERSBY
– Chemical Communications
(1992)
835
(DOI: 10.1039/c39920000835)
BIOSYNTHESIS OF VITAMIN-B12 - STEREOCHEMISTRY OF TRANSFER OF A HYDRIDE EQUIVALENT FROM NADPH BY PRECORRIN-6X REDUCTASE
F KIUCHI, D THIBAUT, L DEBUSSCHE, FJ LEEPER, F BLANCHE, AR BATTERSBY
– Chemical Communications
(1992)
306
(DOI: 10.1039/C39920000306)
Modified substrates for tetrapyrrole biosynthesis: Analogues of porphobilinogen showing unusual inhibition of porphobilinogen deaminase
FJ LEEPER, M ROCK
– Chemical Communications
(1992)
242
(DOI: 10.1039/c39920000242)
Biosynthesis of vitamin B<inf>12</inf>: Structure of the ester of a new biosynthetic intermediate, precorrin-6y
D THIBAUT, F KIUCHI, L DEBUSSCHE, FJ LEEPER, F BLANCHE, AR BATTERSBY
– Journal of the Chemical Society, Chemical Communications
(1992)
139
(DOI: 10.1039/C39920000139)
Biosynthesis of vitamin B12: use of a single 13C label in the macrocycle to confirm C-11 methylation in precorrin-6x
F BLANCHE, M KODERA, M COUDER, FJ LEEPER, D THIBAUT, AR BATTERSBY
– Chemical Communications
(1992)
138
(DOI: 10.1039/C39920000138)
Biosynthesis of vitamin B 12 : the site of reduction of precorrin-6x
GW WEAVER, FJ LEEPER, AR BATTERSBY, F BLANCHE, D THIBAUT, L DEBUSSCHE
– Chemical Communications
(1991)
976
(DOI: 10.1039/C39910000976)
Synthetic studies on the proposed spiro intermediate for biosynthesis of the natural porphyrins: the stereochemical probe
MA CASSIDY, N CROCKETT, FJ LEEPER, AR BATTERSBY
– Chemical Communications
(1991)
384
(DOI: 10.1039/C39910000384)
The synthesis of a fluorinated analogue of 5-aminolaevulinic acid, a potential inhibitor of porphyrin biosynthesis
FJ LEEPER, M ROCK
– Journal of Fluorine Chemistry
(1991)
51,
381
(DOI: 10.1016/s0022-1139(00)80192-x)
Biosynthesis of vitamin B<inf>12</inf>: Structure of precorrin-6x octamethyl ester
D Thibaut, F Blanche, L Debussche, FJ Leeper, AR Battersby
– Proc Natl Acad Sci U S A
(1990)
87,
8800
(DOI: 10.1073/pnas.87.22.8800)
Biosynthesis of vitamin B<inf>12</inf>: Incorporation of (11S)-[11- <sup>2</sup>H<inf>1</inf>-] and (11R)-[11-<sup>2</sup>H<inf>1</inf>] porphobilinogen into sirohydrochlorin and 2,7,20-trimethylisobacteriochlorin
GW WEAVER, F BLANCHE, D THIBAUT, L DEBUSSCHE, FJ LEEPER, AR BATTERSBY
– Journal of the Chemical Society, Chemical Communications
(1990)
1125
(DOI: 10.1039/c39900001125)
The effect of strain on the catalytic reactions of bridged thiazolium salts as models of thiamin
FJ LEEPER, DHC SMITH
– Chemical Communications
(1990)
961
(DOI: 10.1039/C39900000961)
Biosynthesis of porphyrins and related macrocycles. Part 35. Discovery of a novel dipyrrolic cofactor essential for the catalytic action of hydroxymethylbilane synthase (porphobilinogen deaminase)
GJ HART, AD MILLER, U BEIFUSS, FJ LEEPER, AR BATTERSBY
– J CHEM SOC PERK T 1
(1990)
1979
(DOI: 10.1039/p19900001979)
Synthetic studies relevant to biosynthetic research on vitamin B 12 . Part 9. Synthesis of 20-methyl and 20-cyano isobacteriochlorins
DM ARNOTT, PJ HARRISON, GB HENDERSON, ZC SHENG, FJ LEEPER, AR BATTERSBY
– J CHEM SOC PERK T 1
(1989)
265
(DOI: 10.1039/p19890000265)
Biosynthesis of porphyrins and related macrocycles. Part 34. Synthesis and properties of S -pyrrolylmethylcysteinyl and ε- N -pyrrolylmethyllysyl peptides
AD MILLER, FJ LEEPER, AR BATTERSBY
– Journal of the Chemical Society, Perkin Transactions 1
(1989)
1943
(DOI: 10.1039/p19890001943)
Stereospecific nucleophilic ring-opening of a deuteriated cyclopropylcarbinol
FJ LEEPER, P PADMANABHAN
– Tetrahedron Letters
(1989)
30,
5017
(DOI: 10.1016/S0040-4039(01)80570-0)
The biosynthesis of porphyrins, chlorophylls, and vitamin B12.
FJ Leeper
– Natural Product Reports
(1989)
6,
171
(DOI: 10.1039/np9890600171)
Biosynthesis of the pigments of life: Structure and mode of action of a novel enzymatic cofactor
PR ALEFOUNDER, GJ HART, AD MILLER, U BEIFUSS, C ABELL, FJ LEEPER, AR BATTERSBY
– Bioorganic Chemistry
(1989)
17,
121
(DOI: 10.1016/0045-2068(89)90013-8)
SYNTHESES RELEVANT TO VITAMIN-B12 BIOSYNTHESIS - THE MALATE ROUTE TO (-)-RING-B IMIDE AND SYNTHESIS OF THE 2,7,20-TRIMETHYLISOBACTERIOCHLORIN
WG WHITTINGHAM, MK ELLIS, P GUERRY, GB HENDERSON, B MULLER, DA TAYLOR, FJ LEEPER, AR BATTERSBY
– Chemical Communications
(1989)
1116
(DOI: 10.1039/c39890001116)

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