Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding.
ACS omega
(2024)
9
42245
(doi: 10.1021/acsomega.4c04594)
Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis
ACS chemical biology
(2024)
19
2002
(doi: 10.1021/acschembio.4c00334)
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy-d-xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
RSC Med Chem
(2024)
15
1773
(doi: 10.1039/d4md00083h)
Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase.
Bioorganic & medicinal chemistry letters
(2023)
98
129571
(doi: 10.1016/j.bmcl.2023.129571)
Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes.
Org Biomol Chem
(2023)
21
6531
(doi: 10.1039/d3ob00884c)
Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation.
Bioorganic chemistry
(2023)
138
106602
(doi: 10.1016/j.bioorg.2023.106602)
Biosynthesis of Antifungal Solanimycin May Involve an Iterative Nonribosomal Peptide Synthetase Module
ACS chemical biology
(2023)
18
1148
(doi: 10.1021/acschembio.2c00947)
Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues.
ACS Med Chem Lett
(2023)
14
621
Preclinical PET Imaging of Tumor Cell Death following Therapy Using Gallium-68-Labeled C2Am
Cancers (Basel)
(2023)
15
1564
(doi: 10.3390/cancers15051564)
Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis
Organic and Biomolecular Chemistry
(2023)
21
1755
(doi: 10.1039/D2OB02272A)
Correction: Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity.
Rsc Medicinal Chemistry
(2023)
14
190
(doi: 10.17863/CAM.91768)
Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase
Organic and Biomolecular Chemistry
(2022)
20
8855
(doi: 10.1039/D2OB01819E)
Solanimycin: Biosynthesis and Distribution of a New Antifungal Antibiotic Regulated by Two Quorum-Sensing Systems
mBio
(2022)
13
e0247222
(doi: 10.1128/mbio.02472-22)
Enzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
Journal of the American Chemical Society
(2022)
144
14555
(doi: 10.1021/jacs.2c03313)
Metabolic Glycan Labeling of Cancer Cells Using Variably Acetylated Monosaccharides
Bioconjug Chem
(2022)
33
1467
Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
Rsc Medicinal Chemistry
(2022)
13
817
(doi: 10.1039/d2md00085g)
Prodrugs of Pyrophosphates and Bisphosphonates: Disguising Phosphorus Oxyanions
RSC Medicinal Chemistry
(2022)
13
375
(doi: 10.1039/d1md00297j)
Mechanistic Insights into Dideoxygenation in Gentamicin Biosynthesis
ACS Catalysis
(2021)
11
12274
(doi: 10.1021/acscatal.1c03508)
Revision in the first steps of the biosynthesis of the red antibiotic prodigiosin: use of a synthetic thioester to validate a new intermediate
RSC chemical biology
(2021)
2
551
(doi: 10.1039/d0cb00173b)
