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Yusuf Hamied Department of Chemistry

 

Publications by Professor Finian Leeper

Stereochemical studies on the proposed spiro intermediate for the biosynthesis of the natural porphyrins: Determination by a novel X-ray method of the absolute configuration of the spirolactam which inhibits cosynthetase
AC SPIVEY, A CAPRETTA, CS FRAMPTON, FJ LEEPER, AR BATTERSBY
– Chemical Communications
(1995)
1789
(DOI: 10.1039/C39950001789)
Synthesis of bridged thiazolium salts as models for thiamin
FJ LEEPER, DHC SMITH
– J CHEM SOC PERK T 1
(1995)
861
(DOI: 10.1039/p19950000861)
Stereocontrolled syntheses of polyhydroxy indolizidines, including 8a-epi-, 6,8a-diepi- and 1,6-diepi-castanospermine, starting from malic acid
FJ LEEPER, S HOWARD
– Tetrahedron Letters
(1995)
36,
2335
(DOI: 10.1016/0040-4039(95)00249-C)
BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES .43. ISOLATION AND CHARACTERIZATION OF INTERMEDIATES OF COENZYME B-12 BIOSYNTHESIS, A COBYRINIC ACID TRIAMIDE, THE A,C-DIAMIDE AND THEIR CO-(5'-DEOXY-5'-ADENOSYL) DERIVATIVES, FROM PROPIONIBACTERIUM-SHERMANII
F Kiuchi, FJ Leeper, AR Battersby
– Chemistry and Biology
(1995)
2,
527
(DOI: 10.1016/1074-5521(95)90186-8)
Bridged thiazolium salts as models for thiamin: NMR, crystallographic and molecular mechanics studies
FJ LEEPER, DHC SMITH, MJ DOYLE, PR RAITHBY
– J CHEM SOC PERK T 2
(1995)
777
(DOI: 10.1039/p29950000777)
BIOSYNTHESIS OF VITAMIN-B-12 - MECHANISTIC STUDIES ON THE TRANSFER OF A METHYL-GROUP FROM C-11 TO C-12 AND INCORPORATION OF O-18
YF LI, AID ALANINE, RA VISHWAKARMA, S BALACHANDRAN, FJ LEEPER, AR BATTERSBY
– Journal of the Chemical Society, Chemical Communications
(1994)
2507
(DOI: 10.1039/c39940002507)
Design and synthesis of transition-state analogues for a cationic cyclisation
IM BELL, C ABELL, FJ LEEPER
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1994)
1997
(DOI: 10.1039/p19940001997)
BIOSYNTHESIS OF VITAMIN-B-12 - STUDIES OF THE OXIDATIVE AND LACTONE-FORMING STEPS BY O-18-LABELING
AID ALANINE, YF LI, NPJ STAMFORD, FJ LEEPER, F BLANCHE, L DEBUSSCHE, AR BATTERSBY
– Chemical Communications
(1994)
1649
(DOI: 10.1039/C39940001649)
BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES .42. PULSE LABELING EXPERIMENTS CONCERNING THE TIMING OF COBALT INSERTION DURING VITAMIN-B-12 BIOSYNTHESIS
S BALACHANDRAN, RA VISHWAKARMA, SM MONAGHAN, A PRELLE, NPJ STAMFORD, FJ LEEPER, AR BATTERSBY
– J CHEM SOC PERK T 1
(1994)
487
(DOI: 10.1039/p19940000487)
Biosynthesis of vitamin B12: use of specific 13C-labelling for structural studies on factor IV
AID ALANINE, K ICHINOSE, D THIBAUT, L DEBUSSCHE, NPJ STAMFORD, FJ LEEPER, F BLANCHE, AR BATTERSBY
– Chemical Communications
(1994)
193
(DOI: 10.1039/c39940000193)
Biosynthesis of the indolizidine alkaloid cyclizidine: Incorporation of singly and doubly labelled precursors
FJ LEEPER, SE SHAW, P SATISH
– Canadian Journal of Chemistry
(1994)
72,
131
(DOI: 10.1139/v94-021)
SYNTHESIS OF BETA-1-HOMONOJIRIMYCIN AND BETA-1-HOMOMANNOJIRIMYCIN USING THE ENZYME ALDOLASE
KE HOLT, FJ LEEPER, S HANDA
– J. Chem. Soc., Perkin Trans. 1
(1994)
231
(DOI: 10.1039/p19940000231)
Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: Inhibition of cosynthetase
WM STARK, CJ HAWKER, GJ HART, A PHILIPPIDES, PM PETERSEN, JD LEWIS, FJ LEEPER, AR BATTERSBY
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1993)
2875
(DOI: 10.1039/p19930002875)
Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups (13C18O2H) is enzymatically converted into cobyrinic acid
RA VISHWAKARMA, S BALACHANDRAN, AID ALANINE, NPJ STAMFORD, F KIUCHI, FJ LEEPER, AR BATTERSBY
– J.CHEM.SOC.PERKIN TRANS.1
(1993)
2893
(DOI: 10.1039/p19930002893)
Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: Inhibition of cosynthetase
WM Stark, CJ Hawker, GJ Hart, A Philippides, PM Petersen, JD Lewis, FJ Leeper, AR Battersby
– Journal of the Chemical Society, Perkin Transactions 1
(1993)
2875
Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups ( <sup>13</sup>C<sup>18</sup>O<inf>2</inf>H) is enzymatically converted into cobyrinic acid
RA Vishwakarma, S Balachandran, AID Alanine, NPJ Stamford, F Kiuchi, FJ Leeper, AR Battersby
– Journal of the Chemical Society, Perkin Transactions 1
(1993)
2893
PREPARATION OF [4R-H-3]NADH, [4R-H-3]NADPH AND THE CORRESPONDING 4S-ISOMERS ALL WITH SUBSTANTIAL SPECIFIC ACTIVITIES
K ICHINOSE, FJ LEEPER, AR BATTERSBY
– Journal of the Chemical Society, Perkin Transactions 1
(1993)
1213
(DOI: 10.1039/p19930001213)
Proof that the biosynthesis of vitamin B12 involves a reduction step in an anaerobic as well as an aerobic organism
K ICHINOSE, M KODERA, FJ LEEPER, AR BATTERSBY
– Journal of the Chemical Society, Chemical Communications
(1993)
515
(DOI: 10.1039/C39930000515)
A novel stereoselective synthesis of the macrocycle of haem d 1 that establishes its absolute configuration as 2 R ,7 R
J MICKLEFIELD, RL MACKMAN, CJ AUCKEN, M BECKMANN, MH BLOCK, FJ LEEPER, AR BATTERSBY
– Chemical Communications
(1993)
275
(DOI: 10.1039/c39930000275)
Synthetic studies relevant to biosynthetic research on vitamin B12. Part 11. Modification of the east and west building blocks and study of different assembly methods for synthesis of isobacteriochlorins
AR BATTERSBY, MH BLOCK, FJ LEEPER, SC ZIMMERMAN
– Journal of the Chemical Society, Perkin Transactions 1
(1992)
2189
(DOI: 10.1039/P19920002189)

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