Mechanism-based inhibition of 5-aminolaevulinic acid dehydratase from Bacillus subtilis by the 3-thia analogue of the substrate
D Appleton, FJ Leeper
Chemical Communications
(1996)
Stereochemical studies on the proposed spiro intermediate for the biosynthesis of the natural porphyrins: determination by a novel X-ray method of the absolute configuration of the spirolactam which inhibits cosynthetase
AC Spivey, A Capretta, CS Frampton, FJ Leeper, AR Battersby
Chemical Communications
(1995)
Stereocontrolled syntheses of polyhydroxy indolizidines, including 8a-epi-, 6,8a-diepi- and 1,6-diepi-castanospermine, starting from malic acid
FJ Leeper, S Howard
Tetrahedron Letters
(1995)
36
Bridged thiazolium salts as models for thiamin: NMR, crystallographic and molecular mechanics studies
FJ Leeper, DHC Smith, MJ Doyle, PR Raithby
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
(1995)
Biosynthesis of porphyrins and related macrocycles, part 43. Isolation and characterization of intermediates of coenzyme B12 biosynthesis, a cobyrinic acid triamide, the a,c-diamide and their Co-(5′-deoxy-5′-adenosyl) derivatives, from Propionibacterium shermanii
F Kiuchi, FJ Leeper, AR Battersby
Chemistry & Biology
(1995)
2
Synthesis of bridged thiazolium salts as models for thiamin
FJ Leeper, DHC Smith
Journal of the Chemical Society Perkin Transactions 1
(1995)
Biosynthesis of vitamin B12: use of specific 13C-labelling for structural studies on factor IV
AID Alanine, K Ichinose, D Thibaut, L Debussche, N Patrick, J Stamford, FJ Leeper, F Blanche, AR Battersby
Chemical Communications
(1994)
Biosynthesis of vitamin B12: Mechanistic studies on the transfer of a methyl group from C-11 to C-12 and incorporation of 18O
Y Li, AID Alanine, RA Vishwakarma, S Balachandran, FJ Leeper, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1994)
Biosynthesis of vitamin B 12 : studies of the oxidative and lactone-forming steps by 18 O-labelling
AID Alanine, Y Li, NPJ Stamford, FJ Leeper, F Blanche, L Debussche, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1994)
Design and synthesis of transition-state analogues for a cationic cyclisation
IM Bell, C Abell, FJ Leeper
Journal of the Chemical Society, Perkin Transactions 1
(1994)
Synthesis of β-1-homonojirimycin and β-1-homomannojirimycin using the enzyme aldolase
KE Holt, FJ Leeper, S Handa
J CHEM SOC PERK T 1
(1994)
Biosynthesis of the indolizidine alkaloid cyclizidine: Incorporation of singly and doubly labelled precursors
FJ Leeper, SE Shaw, P Satish
Canadian Journal of Chemistry
(1994)
72
Biosynthesis of porphyrins and related macrocycles. Part 42. Pulse labelling experiments concerning the timing of cobalt insertion during vitamin B 12 biosynthesis
S Balachandran, RA Vishwakarma, SM Monaghan, A Prelle, NPJ Stamford, FJ Leeper, AR Battersby
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1994)
Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups ( 13C18O2H) is enzymatically converted into cobyrinic acid
RA Vishwakarma, S Balachandran, AID Alanine, NPJ Stamford, F Kiuchi, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1993)
Proof that the biosynthesis of vitamin B12 involves a reduction step in an anaerobic as well as an aerobic organism
K Ichinose, M Kodera, FJ Leeper, AR Battersby
Journal of the Chemical Society Chemical Communications
(1993)
Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: Inhibition of cosynthetase
WM Stark, CJ Hawker, GJ Hart, A Philippides, PM Petersen, JD Lewis, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1993)
A novel stereoselective synthesis of the macrocycle of haem d1 that establishes its absolute configuration as 2R,7R
J Micklefield, RL Mackman, CJ Aucken, M Beckmann, MH Block, FJ Leeper, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1993)
PREPARATION OF [4R-H-3]NADH, [4R-H-3]NADPH AND THE CORRESPONDING 4S-ISOMERS ALL WITH SUBSTANTIAL SPECIFIC ACTIVITIES
K Ichinose, FJ Leeper, AR Battersby
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1993)
BIOSYNTHESIS OF PORPHYRINS AND RELATED MACROCYCLES .40. SYNTHESIS OF A SPIRO-LACTAM RELATED TO THE PROPOSED SPIRO-INTERMEDIATE FOR PORPHYRIN BIOSYNTHESIS - INHIBITION OF COSYNTHETASE
WM Stark, CJ Hawker, GJ Hart, A Philippides, PM Petersen, JD Lewis, FJ Leeper, AR Battersby
J CHEM SOC PERK T 1
(1993)
Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups ( 13 C 18 O 2 H) is enzymatically converted into cobyrinic acid
RA Vishwakarma, S Balachandran, AID Alanine, NPJ Stamford, F Kiuchi, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1993)