Yusuf Hamied Department of Chemistry

Publications by Professor Finian Leeper

BIOSYNTHESIS OF VITAMIN-B-12 - STUDIES OF THE OXIDATIVE AND LACTONE-FORMING STEPS BY O-18-LABELING
AID Alanine, Y Li, NPJ Stamford, FJ Leeper, F Blanche, L Debussche, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1994)
(doi: 10.1039/c39940001649)
Biosynthesis of vitamin B12: Use of specific 13C-labelling for structural studies on factor IV
AID Alanine, K Ichinose, D Thibaut, L Debussche, N Patrick, J Stamford, FJ Leeper, F Blanche, AR Battersby
Chemical Communications
(1994)
(doi: 10.1039/C39940000193)
Biosynthesis of vitamin B12: mechanistic studies on the transfer of a methyl group from C-11 to C-12 and incorporation of 18O
Y Li, AID Alanine, RA Vishwakarma, S Balachandran, FJ Leeper, AR Battersby
Chemical Communications
(1994)
(doi: 10.1039/C39940002507)
Biosynthesis of the indolizidine alkaloid cyclizidine: Incorporation of singly and doubly labelled precursors
FJ Leeper, SE Shaw, P Satish
Canadian Journal of Chemistry
(1994)
72
(doi: 10.1139/v94-021)
Design and synthesis of transition-state analogues for a cationic cyclisation
IM Bell, C Abell, FJ Leeper
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1994)
(doi: 10.1039/p19940001997)
Biosynthesis of porphyrins and related macrocycles. Part 42. Pulse labelling experiments concerning the timing of cobalt insertion during vitamin B 12 biosynthesis
S Balachandran, RA Vishwakarma, SM Monaghan, A Prelle, NPJ Stamford, FJ Leeper, AR Battersby
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1994)
(doi: 10.1039/p19940000487)
Synthesis of β-1-homonojirimycin and β-1-homomannojirimycin using the enzyme aldolase
KE Holt, FJ Leeper, S Handa
Journal of the Chemical Society Perkin Transactions 1
(1994)
(doi: 10.1039/p19940000231)
PROOF THAT THE BIOSYNTHESIS OF VITAMIN-B12 INVOLVES A REDUCTION STEP IN AN ANAEROBIC AS WELL AS AN AEROBIC ORGANISM
K Ichinose, M Kodera, FJ Leeper, AR Battersby
Journal of the Chemical Society Chemical Communications
(1993)
(doi: 10.1039/C39930000515)
Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: Inhibition of cosynthetase
WM Stark, CJ Hawker, GJ Hart, A Philippides, PM Petersen, JD Lewis, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1993)
Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups ( 13C18O2H) is enzymatically converted into cobyrinic acid
RA Vishwakarma, S Balachandran, AID Alanine, NPJ Stamford, F Kiuchi, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1993)
A novel stereoselective synthesis of the macrocycle of haem d 1 that establishes its absolute configuration as 2 R ,7 R
J Micklefield, RL Mackman, CJ Aucken, M Beckmann, MH Block, FJ Leeper, AR Battersby
Chemical Communications
(1993)
(doi: 10.1039/c39930000275)
Biosynthesis of porphyrins and related macrocycles. Part 40. Synthesis of a spiro-lactam related to the proposed spiro-intermediate for porphyrin biosynthesis: Inhibition of cosynthetase
WM Stark, CJ Hawker, GJ Hart, A Philippides, PM Petersen, JD Lewis, FJ Leeper, AR Battersby
J CHEM SOC PERK T 1
(1993)
(doi: 10.1039/p19930002875)
Biosynthesis of porphyrins and related macrocycles. Part 41. Fate of oxygen atoms as precorrin-2 carrying eight labelled carboxyl groups ( 13 C 18 O 2 H) is enzymatically converted into cobyrinic acid
RA Vishwakarma, S Balachandran, AID Alanine, NPJ Stamford, F Kiuchi, FJ Leeper, AR Battersby
J Chem Soc Perkin Trans 1
(1993)
(doi: 10.1039/p19930002893)
Preparation of [4 R - 3 H]NADH, [4 R - 3 H]NADPH and the corresponding 4 S -isomers all with substantial specific activities
K Ichinose, FJ Leeper, AR Battersby
Journal of the Chemical Society Perkin Transactions 1
(1993)
(doi: 10.1039/p19930001213)
BIOSYNTHESIS OF VITAMIN-B12 - STRUCTURE OF THE ESTER OF A NEW BIOSYNTHETIC INTERMEDIATE, PRECORRIN-6Y
D Thibaut, F Kiuchi, L Debussche, FJ Leeper, F Blanche, AR Battersby
Journal of the Chemical Society Chemical Communications
(1992)
(doi: 10.1039/C39920000139)
Biosynthesis of vitamin B 12 : the fate of 8-H as precorrin-2 is enzymically converted into cobyrinic acid
M Kodera, FJ Leeper, AR Battersby
Chemical Communications
(1992)
(doi: 10.1039/c39920000835)
Modified substrates for tetrapyrrole biosynthesis: Analogues of porphobilinogen showing unusual inhibition of porphobilinogen deaminase
FJ Leeper, M Rock
Journal of the Chemical Society Chemical Communications
(1992)
(doi: 10.1039/c39920000242)
Biosynthesis of vitamin B12: Use of a single 13C label in the macrocycle to confirm C-11 methylation in precorrin-6x
F Blanche, M Kodera, M Couder, FJ Leeper, D Thibaut, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1992)
(doi: 10.1039/c39920000138)
Biosynthesis of vitamin B12: Structural studies on precorrin-8x, an octamethylated intermediate and the structure of its stable tautomer
D Thibaut, F Kiuchi, L Debussche, F Blanche, M Kodera, FJ Leeper, AR Battersby
Journal of the Chemical Society, Chemical Communications
(1992)
(doi: 10.1039/C39920000982)
BIOSYNTHESIS OF VITAMIN-B12 - STEREOCHEMISTRY OF TRANSFER OF A HYDRIDE EQUIVALENT FROM NADPH BY PRECORRIN-6X REDUCTASE
F Kiuchi, D Thibaut, L Debussche, FJ Leeper, F Blanche, AR Battersby
Chemical Communications
(1992)
(doi: 10.1039/C39920000306)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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