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Yusuf Hamied Department of Chemistry

 
Portrait of tpjk2

Professor of Physical Chemistry and Biophysics

Our research

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Watch Professor Knowles discuss his research

Take a tour of the Sir Rodney Sweetnam laboratory

Publications

The pathological G51D mutation in alpha-synuclein oligomers confers distinct structural attributes and cellular toxicity
CK Xu, M Castellana-Cruz, SW Chen, Z Du, G Meisl, A Levin, B Mannini, LS Itzhaki, TPJ Knowles, CM Dobson, N Cremades, JR Kumita
– Molecules
(2022)
27,
1293
Hsc70 mediated disaggregation of α-synuclein fibrils
MM Schneider, S Gautam, TW Herling, G Krainer, E Andrzejewska, A Bracher, CM Dobson, U Hartl, TP Knowles
– Biophysical Journal
(2022)
121,
22
Mechanism of secondary nucleation from the direct observation of Aβ42 aggregation at the single fibril level
MR Zimmermann, SC Bera, G Meisl, S Dasadhikari, S Ghosh, S Linse, K Garai, TPJ Knowles
– Biophysical Journal
(2022)
121,
443a
Simultaneous fractionation and characterization of pre-fibrillar aggregates in solution with single-molecule microfluidics
EA Andrzejewska, G Krainer, CK Xu, R Jacquat, MM Schneider, W Arter, TPJ Knowles
– Biophysical Journal
(2022)
121,
353a
Universal lab-on-a-chip microfluidic spray deposition for bulk and single-molecule analytical methods on surfaces
AM Miller, SKR Chia, T Hakala, Z Toprakcioglu, M Vendruscolo, FS Ruggeri, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2022)
121,
351A
Using microscopy techniques to structurally characterise TDP-43 inclusions present in mammalian cell models
NS Matharu, CW Chung, JR Kumita, GS Kaminski, TP Knowles
– Biophysical Journal
(2022)
121,
268A
The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization
A Farzadfard, JN Pedersen, G Meisl, AK Somavarapu, P Alam, L Goksøyr, MA Nielsen, AF Sander, TPJ Knowles, JS Pedersen, DE Otzen
– Commun Biol
(2022)
5,
123
Multiphase condensates from a kinetically arrested phase transition
N Erkamp, T Sneideris, H Ausserwöger, D Qian, S Qamar, J Nixon-Abell, PS George-Hyslop, J Schmit, D Weitz, TPJ Knowles
(2022)
Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration
S Fiedler, S Devenish, A Morgunov, A Ilsley, F Ricci, M Emmenegger, V Kosmoliaptsis, E Theel, J Mills, A Sholukh, A Aguzzi, A Iwasaki, A Lynn, T Knowles
(2022)
Nanofluidic Traps by Two-Photon Fabrication for Extended Detection of Macromolecules and Colloids in Solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, PK Challa, Q Peter, Z Toprakcioglu, CK Xu, UF Keyser, JJ Baumberg, CF Kaminski, TPJ Knowles
– ACS Applied Nano Materials
(2022)
5,
1995
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Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk