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Department of Chemistry

Portrait of tpjk2

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.


Homage to Chris Dobson
J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia
– Frontiers in molecular biosciences
Scalable integration of nano-, and microfluidics with hybrid two-photon lithography
O Vanderpoorten, Q Peter, PK Challa, UF Keyser, J Baumberg, CF Kaminski, TPJ Knowles
– Microsyst Nanoeng
Trodusquemine enhances A beta(42) aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nature communications
Rapid two-dimensional characterisation of proteins in solution.
KL Saar, Q Peter, T Müller, PK Challa, TW Herling, TPJ Knowles
– Microsyst Nanoeng
Label-Free Analysis of Protein Aggregation and Phase Behavior
Z Toprakcioglu, P Challa, C Xu, TPJ Knowles
– ACS nano
Controllable coacervation of recombinantly produced spider silk protein using kosmotropic salts
P Mohammadi, C Jonkergouw, G Beaune, P Engelhardt, A Kamada, JVI Timonen, TPJ Knowles, M Penttila, MB Linder
– Journal of Colloid and Interface Science
Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation.
C Yuan, A Levin, W Chen, R Xing, Q Zou, TW Herling, PK Challa, TPJ Knowles, X Yan
– Angewandte Chemie International Edition
Modulating the Mechanical Performance of Macroscale Fibers through Shear-Induced Alignment and Assembly of Protein Nanofibrils.
A Kamada, A Levin, Z Toprakcioglu, Y Shen, V Lutz-Bueno, KN Baumann, P Mohammadi, MB Linder, R Mezzenga, TPJ Knowles
– Small (Weinheim an der Bergstrasse, Germany)
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.
R Frankel, M Törnquist, G Meisl, O Hansson, U Andreasson, H Zetterberg, K Blennow, B Frohm, T Cedervall, TPJ Knowles, T Leiding, S Linse
– Commun Biol
Autoantibodies against the prion protein in individuals with PRNP mutations
K Frontzek, MC Carta, M Losa, M Epskamp, G Meisl, A Anane, J-P Brandel, U Camenisch, J Castilla, S Haik, T Knowles, E Lindner, A Lutterotti, EV Minikel, I Roiter, J Safar, R Sanchez-Valle, D Zakova, S Hornemann, A Aguzzi
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01223 336344

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