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Department of Chemistry

 
Portrait of tpjk2

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Publications

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation
G Meisl, TP Knowles, D Klenerman
– Current Opinion in Neurobiology
(2020)
61,
58
The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils
FS Ruggeri, P Flagmeier, JR Kumita, G Meisl, DY Chirgadze, MN Bongiovanni, TPJ Knowles, CM Dobson
– ACS nano
(2020)
acsnano.9b09676
Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions.
Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GGL Bernandes, TPJ Knowles
– Soft matter
(2020)
16,
3082
Autoantibodies against the prion protein in individuals with PRNP mutations.
K Frontzek, M Carta, M Losa, M Epskamp, G Meisl, A Anane, J-P Brandel, U Camenisch, J Castilla, S Haïk, T Knowles, E Lindner, A Lutterotti, EV Minikel, I Roiter, JG Safar, R Sanchez-Valle, D Žáková, S Hornemann, A Aguzzi, THAUTAN-MC Study Group
– Neurology
(2020)
10.1212/wnl.0000000000009183
Lipid-Stabilized Double Emulsions Generated in Planar Microfluidic Devices.
L Kong, A Levin, Z Toprakcioglu, Y Xu, H Gang, R Ye, B-Z Mu, TPJ Knowles
– Langmuir
(2020)
36,
2349
Biocompatible Hybrid Organic/Inorganic Microhydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo.
L Schnaider, Z Toprakcioglu, A Ezra, X Liu, D Bychenko, A Levin, E Gazit, TPJ Knowles
– Nano Letters
(2020)
20,
1590
Microfluidic Diffusional Sizing for Studying Protein-Protein Interactions
MM Schneider, T Scheidt, CM Dobson, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
118,
512A
Investigation of Natural and Synthetic Aggregation Inhibitors using Microfluidic Applications
T Scheidt, J Carozza, JL Benesch, P Arosio, S Linse, TPJ Knowles
– BIOPHYSICAL JOURNAL
(2020)
118,
337A
Molecular Forces in the Liquid-Liquid Phase Separation of Biomolecules
TJ Welsh, G Krainer, TP Knowles
– BIOPHYSICAL JOURNAL
(2020)
118,
373A
Attolitre protein nanogels from droplet nanofluidics for intracellular delivery
Z Toprakcioglu, PK Challa, DB Morse, T Knowles
– Sci Adv
(2020)
6,
eaay7952
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Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk