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Yusuf Hamied Department of Chemistry

 
Portrait of tpjk2
Professor of Physical Chemistry and Biophysics

Our research

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Watch Professor Knowles discuss his research

Take a tour of the Sir Rodney Sweetnam laboratory

Publications

Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates
TJ Welsh, G Krainer, JR Espinosa, JA Joseph, A Sridhar, M Jahnel, WE Arter, KL Saar, S Alberti, R Collepardo-Guevara, TPJ Knowles
– Nano letters
(2022)
acs.nanolett.1c03138
Biomembranes in bioelectronic sensing.
AK Jayaram, AM Pappa, S Ghosh, ZA Manzer, WC Traberg, TPJ Knowles, S Daniel, RM Owens
– Trends Biotechnol
(2022)
40,
107
Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic
R Limbocker, S Errico, D Barbut, TPJ Knowles, M Vendruscolo, F Chiti, M Zasloff
– Natural product reports
(2022)
Single-molecule sizing through nano-cavity confinement
R Jacquat, G Krainer, Q Peter, AN Babar, O Vanderpoorten, C Xu, C Kaminski, U Keyser, J Baumberg, T Knowles
(2021)
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
MM Schneider, M Emmenegger, CK Xu, I Condado Morales, G Meisl, P Turelli, C Zografou, MR Zimmermann, BM Frey, S Fiedler, V Denninger, RP Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, TP Knowles, A Aguzzi
– Life science alliance
(2021)
5,
e202101270
2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution
O Vanderpoorten, AN Babar, G Krainer, RPB Jacquat, P Challa, Q Peter, Z Toprakcioglu, C Xu, U Keyser, J Baumberg, C Kaminski, T Knowles
– ACS Applied Nano Materials
(2021)
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation.
DC Rodriguez Camargo, E Sileikis, S Chia, E Axell, K Bernfur, RL Cataldi, SIA Cohen, G Meisl, J Habchi, TPJ Knowles, M Vendruscolo, S Linse
– ACS Chem Neurosci
(2021)
12,
4406
Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates
DC Rodriguez Camargo, S Chia, J Menzies, B Mannini, G Meisl, M Lundqvist, C Pohl, K Bernfur, V Lattanzi, J Habchi, SI Cohen, TPJ Knowles, M Vendruscolo, S Linse
– Front Mol Biosci
(2021)
8,
757425
In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease.
G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman
– Science advances
(2021)
7,
eabh1448
Kinetic and Thermodynamic Driving Factors in the Assembly of Phenylalanine-Based Modules.
D Zaguri, MR Zimmermann, G Meisl, A Levin, S Rencus-Lazar, TPJ Knowles, E Gazit
– ACS Nano
(2021)
15,
18305
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Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk