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Department of Chemistry

 
Portrait of tpjk2

We study the physical and chemical aspects of the behaviour of biopolymers and other soft systems. Much of our work has been focused on the physical aspects underlying the self-assembly of protein molecules. Self-organisation is the driving force generating complex matter in nature, and the process by which the machinery providing functionality in living systems is assembled. The goal of our research is to understand the physical and chemical factors which control the structures and dynamics of biomolecular assemblies, and the connections between the nanoscale characteristics of the component molecules and the physical properties of large-scale assemblies and their behaviour on a mesoscopic to macroscopic scale. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We work both with natural and synthetic polymers and our interests range from fundamental chemical physics to technological applications in material science and molecular medicine.

Publications

Lipid-stabilised double emulsions generated in planar microfluidic devices
L Kong, A Levin, Z Toprakcioglu, Y Xu, H Gang, R Ye, B-Z Mu, TPJ Knowles
– Langmuir
(2020)
acs.langmuir.9b03622
Biocompatible Hybrid Organic/Inorganic Micro-Hydrogels Promote Bacterial Adherence and Eradication in Vitro and in Vivo.
L Schnaider, Z Toprakcioglu, A Ezra, X Liu, D Bychenko, A Levin, E Gazit, TPJ Knowles
– Nano Letters
(2020)
acs.nanolett.9b04290
Coating and Stabilization of Liposomes by Clathrin-Inspired DNA Self-Assembly
KN Baumann, L Piantanida, J García-Nafría, D Sobota, K Voïtchovsky, TPJ Knowles, S Hernández-Ainsa
– ACS nano
(2020)
acsnano.9b09453
Transthyretin inhibits primary and secondary nucleation of amyloid-β peptide aggregation and reduces the toxicity of its oligomers.
SA Ghadami, S Chia, FS Ruggeri, G Meisl, F Bemporad, J Habchi, R Cascella, CM Dobson, M Vendruscolo, TPJ Knowles, F Chiti
– Biomacromolecules
(2020)
acs.biomac.9b01475
Attoliter protein nanogels from droplet nanofluidics for intracellular delivery
Z Toprakcioglu, PK Challa, DB Morse, T Knowles
– Science Advances
(2020)
6,
eaay7952
Chris Dobson (1949–2019)
TPJ Knowles, M Vendruscolo
– Nature chemical biology
(2020)
16,
105
The catalytic nature of protein aggregation.
AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles
– J Chem Phys
(2020)
152,
045101
Homage to Chris Dobson.
J Baum, F Chiti, A De Simone, TPJ Knowles, JR Kumita, SE Radford, CV Robinson, X Salvatella, K Valelli, M Vendruscolo, A Pastore, GG Tartaglia
– Front Mol Biosci
(2019)
6,
137
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, B Mannini, J Habchi, TCT Michaels, PK Challa, M Ahn, ST Casford, N Fernando, CK Xu, ND Kloss, SIA Cohen, JR Kumita, C Cecchi, M Zasloff, S Linse, TPJ Knowles, F Chiti, M Vendruscolo, CM Dobson
– Nat Commun
(2019)
10,
225
Label-Free Analysis of Protein Aggregation and Phase Behavior.
Z Toprakcioglu, P Challa, C Xu, TPJ Knowles
– ACS nano
(2019)
13,
13940
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Research Interest Groups

Telephone number

01223 336344

Email address

tpjk2@cam.ac.uk