Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

ASSESSMENT OF BUTENE-1,4-DIOLS AS STARTING MATERIALS FOR THE PREPARATION OF PI-ALLYLTRICARBONYLIRON COMPLEXES

RW BATES, D DIEZMARTIN, WJ KERR, JG KNIGHT, SV LEY, A SAKELLARIDIS

– Tetrahedron

(1990)

46,

4063

(doi: 10.1016/s0040-4020(01)90541-1)

PREPARATION OF O-METHYL 3-ACYL TETRONIC ACIDS BY THE DIRECT ACYLATION OF STANNYL TETRONATES

SV LEY, DJ WADSWORTH

– Tetrahedron Letters

(1989)

30,

1001

(doi: 10.1016/s0040-4039(00)95301-2)

PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE

PM BOOTH, HB BROUGHTON, MJ FORD, CMJ FOX, SV LEY, AMZ SLAWIN, DJ WILLIAMS, PR WOODWARD

– Tetrahedron

(1989)

45,

7565

(doi: 10.1016/s0040-4020(01)89218-8)

Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene

SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL

– Tetrahedron Letters

(1989)

30,

3557

(doi: 10.1016/S0040-4039(00)99439-5)

SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH SILYL ENOL ETHERS PROMOTED BY ALUMINUM TRICHLORIDE

DS BROWN, SV LEY, M BRUNO

– Heterocycles

(1989)

28,

773

(doi: 10.3987/com-88-s145)

INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .5. CHEMICAL MODIFICATION AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF AZADIRACHTIN AND SOME RELATED LIMONOIDS

SV LEY, JC ANDERSON, WM BLANEY, PS JONES, Z LIDERT, ED MORGAN, NG ROBINSON, D SANTAFIANOS, MSJ SIMMONDS, PL TOOGOOD

– Tetrahedron

(1989)

45,

5175

(doi: 10.1016/s0040-4020(01)81095-4)

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .4. SYNTHESIS TOWARDS THE LIMONOID AZADIRACHTIN - PREPARATION OF A FUNCTIONALIZED DECALIN FRAGMENT

SV LEY, AA SOMOVILLA, HB BROUGHTON, D CRAIG, AMZ SLAWIN, PL TOOGOOD, DJ WILLIAMS

– Tetrahedron

(1989)

45,

2143

(doi: 10.1016/s0040-4020(01)80075-2)

Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene

SV LEY, F STERNFELD

– Tetrahedron

(1989)

45,

3463

(doi: 10.1016/S0040-4020(01)81025-5)

The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B

JC ANDERSON, WM BLANEY, MD COLE, LL FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS

– Tetrahedron Letters

(1989)

30,

4737

(doi: 10.1016/s0040-4039(01)80789-9)

TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1

NJ ANTHONY, A ARMSTRONG, SV LEY, A MADIN

– Tetrahedron Letters

(1989)

30,

3209

(doi: 10.1016/s0040-4039(00)99203-7)

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