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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles
DS BROWN, M BRUNO, RJ DAVENPORT, SV LEY
– Tetrahedron
(1989)
45,
4293
(doi: 10.1016/S0040-4020(01)81323-5)
Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids
SV LEY, JC ANDERSON, WM BLANEY, PS JONES, Z LIDERT, ED MORGAN, NG ROBINSON, D SANTAFIANOS, MSJ SIMMONDS, PL TOOGOOD
– Tetrahedron
(1989)
45,
5175
(doi: 10.1016/S0040-4020(01)81095-4)
A highly convergent total synthesis of the spiroacetal macrolide (+)-milbemycinβ1
SV LEY, NJ ANTHONY, A ARMSTRONG, MG BRASCA, T CLARKE, D CULSHAW, C GRECK, P GRICE, AB JONES, B LYGO, A MADIN, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS
– Tetrahedron
(1989)
45,
7161
(doi: 10.1016/S0040-4020(01)89182-1)
Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene
SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD, A VIDAL
– Tetrahedron Letters
(1989)
30,
3557
(doi: 10.1016/s0040-4039(00)99439-5)
DIRECT SUBSTITUTION OF 2-BENZENESULFONYL CYCLIC ETHERS USING ORGANOZINC REAGENTS
DS BROWN, SV LEY
– Tetrahedron Letters
(1988)
29,
4869
(doi: 10.1016/S0040-4039(00)80630-9)
Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (-)- and (+)-polygodial
Y Asakawa, GW Dawson, DC Griffiths, JY Lallemand, SV Ley, K Mori, A Mudd, M Pezechk-Leclaire, JA Pickett, H Watanabe, CM Woodcock, Z Zhong-Ning
– Journal of chemical ecology
(1988)
14,
1845
(doi: 10.1007/BF01013481)
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE (IP3) AND RELATED DERIVATIVES
SV LEY, F STERNFELD
– Tetrahedron Letters
(1988)
29,
5305
(doi: 10.1016/S0040-4039(00)80744-3)
PREPARATION OF CYCLIC ETHER ACETALS FROM 2-BENZENESULFONYL DERIVATIVES - A NEW MILD GLYCOSIDATION PROCEDURE
DS BROWN, SV LEY, S VILE
– Tetrahedron Letters
(1988)
29,
4873
(doi: 10.1016/S0040-4039(00)80631-0)
1-BENZYLINDOLE
H HEANEY, SV LEY
– ORGANIC SYNTHESES
(1988)
50-9,
104
(link to publication)
Chemistry of insect antifeedants from azadirachta indica (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons
JN BILTON, PS JONES, SV LEY, NG ROBINSON, RN SHEPPARD
– Tetrahedron Letters
(1988)
29,
1849
(doi: 10.1016/s0040-4039(00)82061-4)
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Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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