Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
J CHEM SOC PERK T 1
(1987)
121
(doi: 10.1039/p19870000121)
A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES
Tetrahedron Letters
(1987)
28
5565
Synthesis of the monocyclic nonaromatic C-1 to C-10 fragments of the milbemycins and avermectins.
Tetrahedron Letters
(1987)
28
5755
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
Tetrahedron
(1987)
43
2805
Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene
Tetrahedron Letters
(1987)
28
225
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
Tetrahedron Letters
(1987)
28
221
Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
Journal of the Chemical Society, Perkin Transactions 1
(1987)
131
(doi: 10.1039/p19870000131)
CORRECTION
TETRAHEDRON LETTERS
(1987)
28
1594
The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides
Tetrahedron Letters
(1987)
28
3019
Development of a synthetic route towards milbemycin β1: Preparation of an advanced model system.
Tetrahedron Letters
(1987)
28
5763
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