Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

MICROBIAL OXIDATION IN SYNTHESIS - A 6 STEP PREPARATION OF (+/-)-PINITOL FROM BENZENE

SV Ley, F Sternfeld, S Taylor

Tetrahedron Letters

(1987)

28

225

(doi: 10.1016/S0040-4039(00)95692-2)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV Ley, D Santafianos, WM Blaney, MSJ Simmonds

Tetrahedron Letters

(1987)

28

221

(doi: 10.1016/s0040-4039(00)95691-0)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV Ley, D Santafianos, WM Blaney, MSJ Simmonds

Tetrahedron Letters

(1987)

28

1595

(doi: 10.1016/S0040-4039(00)95369-3)

The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

28

3019

(doi: 10.1016/S0040-4039(00)96273-7)

Preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides

SV Ley, PR Woodward

Tetrahedron Letters

(1987)

28

345

(doi: 10.1016/S0040-4039(00)95725-3)

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T Clarke, SV Ley

J CHEM SOC PERK T 1

(1987)

131

(doi: 10.1039/p19870000131)

Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids

PM Booth, CMJ Fox, SV Ley

Journal of the Chemical Society Perkin Transactions 1

(1987)

121

(doi: 10.1039/p19870000121)

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

JN Bilton, HB Broughton, PS Jones, SV Ley, HS Rzepa, RN Sheppard, AMZ Slawin, DJ Williams, Z Lidert, ED Morgan

Tetrahedron

(1987)

43

2805

(doi: 10.1016/s0040-4020(01)86886-1)

CORRECTION

SV LEY

TETRAHEDRON LETT

(1987)

28

1594

Development of a synthetic route towards milbemycin β1: Preparation of an advanced model system.

NJ Anthony, P Grice, SV Ley

Tetrahedron Letters

(1987)

28

5763

(doi: 10.1016/S0040-4039(00)96835-7)