Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
The champagne route to avermectins and milbemycins
– Strategies and Tactics in Organic Synthesis
(1991)
3,
237
SYNTHESIS OF INSECT ANTIFEEDANTS
– PESTICIDE CHEMISTRY : ADVANCES IN INTERNATIONAL RESEARCH, DEVELOPMENT, AND LEGISLATION
(1991)
97
TOTAL SYNTHESIS OF THE ANTHELMINTIC MACROLIDE AVERMECTIN B1A
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1991)
667
(doi: 10.1039/p19910000667)
Direct substitution of 2-phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by alkyl organometallic reagents in dichloromethane
– Synlett
(1990)
1990,
749
(doi: 10.1055/s-1990-21237)
DIRECT SUBSTITUTION OF 2-PHENYLSULPHONYLPYRROLIDINES, 2-PHENYLSULPHONYLPIPERIDINES, 2-PHENYLSULPHONYLTETRAHYDROFURANS AND 2-PHENYLSULPHONYLTETRAHYDROPYRANS BY ALKYL ORGANOMETALLIC REAGENTS IN DICHLOROMETHANE
– SYNLETT
(1990)
749
An efficient three-step synthesis of L-(-)-oleandrose from (S)-(-)-methyl lactate
– Synlett
(1990)
1990,
771
(doi: 10.1055/s-1990-21247)
A new ruthenium( VI ) oxidant: preparation, X -ray crystal structure, and properties of (Ph 4 P)[RuO 2 (OAc)Cl 2 ]
– Journal of the Chemical Society, Chemical Communications
(1990)
1219
(doi: 10.1039/C39900001219)
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
– ABSTR PAP AM CHEM S
(1990)
200,
55
SYNTHESIS OF BIOLOGICALLY-ACTIVE CYCLITOLS VIA MICROBIAL OXIDATION OF BENZENE
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1990)
200,
42
USE OF MICROBIAL OXIDANTS FOR THE PREPARATION OF INOSITOL DERIVATIVES AND RELATED CYCLITOLS
– ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(1990)
200,
123
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