Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
USE OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE FOR TETRAMIC ACID SYNTHESIS - TOTAL SYNTHESIS OF THE PLASMODIAL PIGMENT FULIGORUBIN-A
Tetrahedron Letters
(1988)
29
5829
Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (?)- and (+)-polygodial
Journal of chemical ecology
(1988)
14
1845
(doi: 10.1007/BF01013481)
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .3. REACTIONS ON THE C-22,23 ENOL ETHER DOUBLE-BOND OF AZADIRACHTIN AND CONVERSION TO 22,23-DIHYDRO-23-BETA-METHOXYAZADIRACHTIN
Tetrahedron Letters
(1988)
29
5433
1-BENZYLINDOLE
ORG SYNTH
(1988)
50-9
104
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
Tetrahedron Letters
(1988)
29
1853
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
ORG SYNTH
(1988)
66
108
Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols
Journal of the Chemical Society, Chemical Communications
(1987)
1625
(doi: 10.1039/C39870001625)
Use of S -t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
J CHEM SOC PERK T 1
(1987)
131
(doi: 10.1039/p19870000131)
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
Tetrahedron
(1987)
43
2805
DEVELOPMENT OF A SYNTHETIC ROUTE TOWARDS MILBEMYCIN-BETA-1 - PREPARATION OF AN ADVANCED MODEL SYSTEM
Tetrahedron Letters
(1987)
28
5763
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