Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Activity of drimane antifeedants and related compounds against aphids, and comparative biological effects and chemical reactivity of (?)- and (+)-polygodial

Y Asakawa, GW Dawson, DC Griffiths, JY Lallemand, SV Ley, K Mori, A Mudd, M Pezechk-Leclaire, JA Pickett, H Watanabe, CM Woodcock, Z Zhong-Ning

Journal of Chemical Ecology

(1988)

1845

(doi: 10.1007/bf01013481)

Direct substitution of 2-benzenesulphonyl cyclic ethers using organozinc reagents

DS Brown, SV Ley

Tetrahedron Letters

(1988)

4869

(doi: 10.1016/S0040-4039(00)80630-9)

MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE (IP3) AND RELATED DERIVATIVES

SV Ley, F Sternfeld

Tetrahedron Letters

(1988)

5305

(doi: 10.1016/S0040-4039(00)80744-3)

Chemistry of insect antifeedants from (part 1): Conversion from the azadirachtin to the azadirachtinin skeletons

JN Bilton, PS Jones, SV Ley, NG Robinson, RN Sheppard

Tetrahedron Letters

(1988)

1849

(doi: 10.1016/s0040-4039(00)82061-4)

Chemistry of insect antifeedants from (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.

MG Brasca, HB Broughton, D Craig, SV Ley, AA Somovilla, PL Toogood

Tetrahedron Letters

(1988)

1853

(doi: 10.1016/S0040-4039(00)82062-6)

Use of t-butyl 4-diethylphosphono-3-oxobutanethioate for tetramic acid synthesis: Total synthesis of the plasmodial pigment fuligorubin A

SV Ley, SC Smith, PR Woodward

Tetrahedron Letters

(1988)

5829

(doi: 10.1016/S0040-4039(00)82204-2)

Chemistry of insect antifeedants from azadirachta indica (part 3): reactions on the C-22,23 enol ether double bond of azadirachtin and conversion to 22,23-dihydro-23-β-methoxyazadirachtin.

SV Ley, JC Anderson, WM Blaney, Z Lidert, ED Morgan, NG Robinson, MSJ Simmonds

Tetrahedron Letters

(1988)

5433

(doi: 10.1016/S0040-4039(00)82888-9)

1-BENZYLINDOLE

H HEANEY, SV LEY

ORG SYNTH

(1988)

50-9

104

PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE

CMJ FOX, SV LEY

ORGANIC SYNTHESES

(1988)

108

Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols

WP Griffith, SV Ley, GP Whitcombe, AD White

Journal of the Chemical Society, Chemical Communications

(1987)

1625

(doi: 10.1039/C39870001625)

Professor Steve Ley CBE FRS FMedSci

Director of Research

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