Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
PREPARATION OF O-METHYL 3-ACYL TETRONIC ACIDS BY THE DIRECT ACYLATION OF STANNYL TETRONATES
Tetrahedron Letters
(1989)
30
1001
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .4. SYNTHESIS TOWARDS THE LIMONOID AZADIRACHTIN - PREPARATION OF A FUNCTIONALIZED DECALIN FRAGMENT
Tetrahedron
(1989)
45
2143
Microbial Oxidation in Synthesis: Preparation of (+)- and (-)-Pinitol from Benzene
Tetrahedron
(1989)
45
3463
Substitution Reactions of 2-Benzensulphonyl Cyclic Ethers with Silyl Enol Ethers Promoted by Aluminium Trichloride
Heterocycles
(1989)
28
773
(doi: 10.3987/com-88-s145)
Insect antifeedants from azadirachta indica (part 5): Chemical modification and structure-activity relationships of azadirachtin and some related limonoids
Tetrahedron
(1989)
45
5175
ASSEMBLY OF THE T-CELL RECEPTOR CD3 COMPLEX
PROGRESS IN IMMUNOLOGY, VOL 7
(1989)
33
The antifeedant activity of clerodane diterpenoids from Teucrium
Phytochemistry
(1989)
28
1069
(doi: 10.1016/0031-9422(89)80184-0)
Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles
Tetrahedron
(1989)
45
4293
Organic synthesis with tricarbonyliron lactone complexes
Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences
(1988)
326
633
(doi: 10.1098/rsta.1988.0114)
Microbial oxidation in synthesis: Preparation from benzene of the cellular secondary messenger myo-inositol-1,4,5-trisphosphate (IP3) and related derivatives
Tetrahedron Letters
(1988)
29
5305
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