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Yusuf Hamied Department of Chemistry

 

Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Chemistry of insect antifeedants from azadirachta indica (part 8): Synthesis of hydroxydihydrofuran acetal fragments for biological evaluation and azadirachtin total synthesis studies.
JC ANDERSON, SV LEY, D SANTAFIANOS, RN SHEPPARD
– Tetrahedron
(1991)
47,
6813
(doi: 10.1016/S0040-4020(01)82332-2)
Synthesis of the β-lactone esterase inhibitor valilactone using π-allyltricarbonyliron lactone complexes.
RW BATES, R FERNANDEZMORO, SV LEY
– Tetrahedron Letters
(1991)
32,
2651
(doi: 10.1016/s0040-4039(00)78809-5)
Use of phenylsulphonylmethano ethers in synthesis: A new versatile route to substituted cyclic ethers
P CHARREAU, SV LEY, TM VETTIGER, S VILE
– Synlett
(1991)
1991,
415
(doi: 10.1055/s-1991-20747)
SUBSTITUTION-REACTIONS OF 2-PHENYLSULFONYL-PIPERIDINES AND 2-PHENYLSULFONYL-PYRROLIDINES WITH CARBON NUCLEOPHILES - SYNTHESIS OF THE PYRROLIDINE ALKALOIDS NORRUSPOLINE AND RUSPOLINONE
DS BROWN, P CHARREAU, T HANSSON, SV LEY
– Tetrahedron
(1991)
47,
1311
(doi: 10.1016/s0040-4020(01)86388-2)
USE OF 2-PHENYLSULFONYL CYCLIC ETHERS IN THE PREPARATION OF TETRAHYDROPYRAN AND TETRAHYDROFURAN ACETALS AND IN SOME GLYCOSIDATION REACTIONS
DS BROWN, SV LEY, S VILE, M THOMPSON
– Tetrahedron
(1991)
47,
1329
(doi: 10.1016/S0040-4020(01)86389-4)
The champagne route to avermectins and milbemycins
SV Ley, A Armstrong
– Strategies and Tactics in Organic Synthesis
(1991)
3,
237
(doi: 10.1016/b978-0-08-092430-4.50013-5)
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
SV LEY, AJ REDGRAVE, LL YEUNG
– ACS SYM SER
(1991)
463,
132
(link to publication)
SYNTHESIS OF TETRAHYDROPYRAN-CONTAINING NATURAL-PRODUCTS
SV LEY
– HETEROCYCLES IN BIO-ORGANIC CHEMISTRY
(1991)
1
(link to publication)
NOVEL ROUTES TO INOSITOL PHOSPHATES USING PSEUDOMONAS-PUTIDA OXIDATION OF ARENES
SV LEY, AJ REDGRAVE, LL YEUNG
– INOSITOL PHOSPHATES AND DERIVATIVES
(1991)
463,
132
(link to publication)
Microbial Oxidation in Synthesis: Preparation of Novel 3-Substitutedcis-Cyclohexa-3,5-diene-1,2-diol Derivatives from (1S,2S)-3-Bromocyclohexa-3,5-diene-1,2-diol
SV LEY, AJ REDGRAVE, SC TAYLOR, S AHMED, DW RIBBONS
– Synlett
(1991)
1991,
741
(doi: 10.1055/s-1991-34764)
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk

College

Trinity College

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