Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of a C16-C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
Tetrahedron Letters
(1990)
31
3445
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .7. PREPARATION OF AN OPTICALLY PURE HYDROXYACETAL EPOXIDE RELATED TO AZADIRACHTIN
Tetrahedron Letters
(1990)
31
3437
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
Aldrichimica Acta
(1990)
23
13
Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene
Tetrahedron
(1990)
46
4995
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF 6-DEOXY CYCLITOL ANALOGS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE FROM BENZENE
Tetrahedron Letters
(1989)
30
3557
A HIGHLY CONVERGENT TOTAL SYNTHESIS OF THE SPIROACETAL MACROLIDE (+)-MILBEMYCIN BETA-1
Tetrahedron
(1989)
45
7161
PREPARATION OF BETA-KETOMACROLACTONES AND BETA-KETODIOLIDES USING S-TERT-BUTYL 3-OXOBUTANETHIOATE AND S-TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE
Tetrahedron
(1989)
45
7565
The structure of two new clerodane diterpenoid potent insect antifeedants from Scutellaria woronowii (Juz); jodrellin A & B
Tetrahedron Letters
(1989)
30
4737
TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1
Tetrahedron Letters
(1989)
30
3209
Preparation of O-methyl 3-acyl tetronic acids by the direct acylation of stannyl tetronates
Tetrahedron Letters
(1989)
30
1001
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