Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
ENANTIOSELECTIVE SYNTHESIS OF THE C3-C11 HYDROCARBON FRAGMENT OF THE IONOPHORE ANTIBIOTIC TETRONASIN (ICI 139603)
Tetrahedron Letters
(1990)
31
5521
Synthesis of the C12-C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)
Tetrahedron Letters
(1990)
31
5525
TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols
Aldrichimica Acta
(1990)
23
13
INSECT ANTIFEEDANTS
CHEMISTRY IN BRITAIN
(1990)
26
31
SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS
CIBA F SYMP
(1990)
154
80
Preparation of O-methyl 3-acyl tetronic acids by the direct acylation of stannyl tetronates
Tetrahedron Letters
(1989)
30
1001
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION OF 6-DEOXY CYCLITOL ANALOGS OF MYOINOSITOL 1,4,5-TRISPHOSPHATE FROM BENZENE
Tetrahedron Letters
(1989)
30
3557
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH CARBON NUCLEOPHILES
Tetrahedron
(1989)
45
4293
TOTAL SYNTHESIS OF (+) - MILBEMYCIN BETA-1
Tetrahedron Letters
(1989)
30
3209
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .4. SYNTHESIS TOWARDS THE LIMONOID AZADIRACHTIN - PREPARATION OF A FUNCTIONALIZED DECALIN FRAGMENT
Tetrahedron
(1989)
45
2143
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