Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Chemistry of insect antifeedants from azadirachta indica (part 6): Synthesis of an optically pure acetal intermediate for potential use in the synthesis of azadirachtin and novel antifeedants.
Tetrahedron Letters
(1990)
31
431
Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene
Tetrahedron
(1990)
46
4995
Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.
Tetrahedron Letters
(1990)
31
3437
Direct Substitution of 2-Benzenesulphonylpiperidines and -pyrrolidines by Carbon Nucleophiles: Synthesis of the Pyrrolidine Alkaloid Ruspolinone
Synlett
(1990)
1990
48
(doi: 10.1055/s-1990-20983)
Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a
Tetrahedron Letters
(1990)
31
3445
Enantioselective synthesis of the C3-C11 hydrocarbon fragment of the ionophore antibiotic tetronasin (ici 139603).
Tetrahedron Letters
(1990)
31
5521
Synthesis of the C12-C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)
Tetrahedron Letters
(1990)
31
5525
SYNTHESIS AND MODIFICATION OF AZADIRACHTIN AND RELATED ANTIFEEDANTS
RECENT ADVANCES IN THE CHEMISTRY OF INSECT CONTROL II
(1990)
79
90
SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS
CIBA FOUNDATION SYMPOSIA
(1990)
154
80
INSECT ANTIFEEDANTS
CHEMISTRY IN BRITAIN
(1990)
26
31
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