Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
Tetrahedron Letters
(1987)
28
1595
Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1987)
121
(doi: 10.1039/p19870000121)
Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
Journal of the Chemical Society, Perkin Transactions 1
(1987)
131
(doi: 10.1039/p19870000131)
CORRECTION
TETRAHEDRON LETTERS
(1987)
28
1594
Application of ultrasound to the preparation of tricarbonyliron diene complexes
Journal of Organometallic Chemistry
(1986)
302
C13
(doi: 10.1016/0022-328X(86)80072-9)
Synthetic studies towards the acyltetronic acid iohophore M 139603
Tetrahedron Letters
(1986)
27
105
X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
Chemical Communications
(1986)
1
46
(doi: 10.1039/c39860000046)
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
Tetrahedron
(1986)
42
3723
Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V
J. Chem. Soc., Chem. Commun.
(1986)
344
(doi: 10.1039/C39860000344)
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
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