Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG
Tetrahedron Letters
(1987)
28
5759
SYNTHESIS OF THE MONOCYCLIC NONAROMATIC C-1 TO C-10 FRAGMENTS OF THE MILBEMYCINS AND AVERMECTINS
Tetrahedron Letters
(1987)
28
5755
A CONFORMATIONAL STUDY OF BAFILOMYCIN-A1 BY X-RAY CRYSTALLOGRAPHY AND NMR TECHNIQUES
Tetrahedron Letters
(1987)
28
5565
Application of ultrasound to the preparation of tricarbonyliron diene complexes
Journal of Organometallic Chemistry
(1986)
302
C13
(doi: 10.1016/0022-328X(86)80072-9)
X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
Chemical Communications
(1986)
1
46
(doi: 10.1039/c39860000046)
Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V
J. Chem. Soc., Chem. Commun.
(1986)
344
(doi: 10.1039/c39860000344)
Synthetic studies towards the acyltetronic acid iohophore M 139603
Tetrahedron Letters
(1986)
27
105
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1986)
303
(doi: 10.1039/p19860000303)
ALKYLATION REACTIONS OF ANIONS DERIVED FROM 2-BENZENESULFONYL TETRAHYDROPYRAN AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
Tetrahedron
(1986)
42
4333
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
Tetrahedron
(1986)
42
6519
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