Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
SUBSTITUTION-REACTIONS OF 2-BENZENESULFONYL CYCLIC ETHERS WITH SILYL ENOL ETHERS PROMOTED BY ALUMINUM TRICHLORIDE
– Heterocycles
(1989)
28,
773
(doi: 10.3987/com-88-s145)
Microbial Oxidation in Synthesis: Preparation of (+)- and (−)-Pinitol from Benzene
– Tetrahedron
(1989)
45,
3463
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA INDICA .4. SYNTHESIS TOWARDS THE LIMONOID AZADIRACHTIN - PREPARATION OF A FUNCTIONALIZED DECALIN FRAGMENT
– Tetrahedron
(1989)
45,
2143
USE OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE FOR TETRAMIC ACID SYNTHESIS - TOTAL SYNTHESIS OF THE PLASMODIAL PIGMENT FULIGORUBIN-A
– Tetrahedron Letters
(1988)
29,
5829
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .1. CONVERSION FROM THE AZADIRACHTIN TO THE AZADIRACHTININ SKELETONS
– Tetrahedron Letters
(1988)
29,
1849
Preparation of cyclic ether acetals from 2-benzenesulphonylderivatives: a new mild glycosidation procedure
– Tetrahedron Letters
(1988)
29,
4873
Chemistry of insect antifeedants from azadirachta indica (part 2): Synthesis of a polyoxygenated decalin with limonoid structural homology.
– Tetrahedron Letters
(1988)
29,
1853
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE (IP3) AND RELATED DERIVATIVES
– Tetrahedron Letters
(1988)
29,
5305
PREPARATION OF TERT-BUTYL ACETOTHIOACETATE AND USE IN THE SYNTHESIS OF 3-ACETYL-4-HYDROXY-5,5-DIMETHYLFURAN-2(5H)-ONE
– ORG SYNTH
(1988)
66,
108
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