Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
Tetrahedron Letters
(1987)
28
1595
SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG
Tetrahedron Letters
(1987)
28
5759
Preparation of t-butyl 4-diethylphosphono-3-oxobutanethioate and use in the synthesis of (E)-4-alkenyl-3-oxoesters and macrolides
Tetrahedron Letters
(1987)
28
345
Application of ultrasound to the preparation of tricarbonyliron diene complexes
Journal of Organometallic Chemistry
(1986)
302
c13
(doi: 10.1016/0022-328X(86)80072-9)
Preparation of 2-substituted pyrroles and indoles by regioselective alkylation and deprotection of 1-(2-trimethylsilylethoxymethyl)pyrrole and 1-(2-trimethylsilylethoxymethyl) indole
Tetrahedron
(1986)
42
3723
The synthesis of trisubstituted tetrahydrofurans via the use of an organoselenium-mediated cyclisation reaction
Journal of the Chemical Society Perkin Transactions 1
(1986)
303
(doi: 10.1039/p19860000303)
Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V
J. Chem. Soc., Chem. Commun.
(1986)
344
(doi: 10.1039/c39860000344)
X-ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
Chemical Communications
(1986)
1
46
(doi: 10.1039/C39860000046)
PREPARATION OF SPIROKETALS BY REACTION OF ANIONS FROM 2-BENZENESULPHONYLTETRAHYDROPYRANS WITH EPOXIDES - SYNTHESIS OF THE C-11 TO C-25 FRAGMENT OF THE MILBEMYCINS
Tetrahedron Letters
(1986)
27
5277
Synthetic studies towards the acyltetronic acid iohophore M 139603
Tetrahedron Letters
(1986)
27
105
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