Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .2. SYNTHESIS OF A POLYOXYGENATED DECALIN WITH LIMONOID STRUCTURAL HOMOLOGY
– Tetrahedron Letters
(1988)
29,
1853
USE OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE FOR TETRAMIC ACID SYNTHESIS - TOTAL SYNTHESIS OF THE PLASMODIAL PIGMENT FULIGORUBIN-A
– Tetrahedron Letters
(1988)
29,
5829
MICROBIAL OXIDATION IN SYNTHESIS - PREPARATION FROM BENZENE OF THE CELLULAR SECONDARY MESSENGER MYO-INOSITOL-1,4,5-TRISPHOSPHATE (IP3) AND RELATED DERIVATIVES
– Tetrahedron Letters
(1988)
29,
5305
DIRECT SUBSTITUTION OF 2-BENZENESULFONYL CYCLIC ETHERS USING ORGANOZINC REAGENTS
– Tetrahedron Letters
(1988)
29,
4869
Preparation and use of tetra-n-butylammonium per-ruthenate (TBAP reagent) and tetra-n-propylammonium per-ruthenate (TPAP reagent) as new catalytic oxidants for alcohols
– Journal of the Chemical Society, Chemical Communications
(1987)
1625
(doi: 10.1039/C39870001625)
Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene
– Tetrahedron Letters
(1987)
28,
225
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
– Tetrahedron Letters
(1987)
28,
221
Preparation of acyltetronic acids using t-butyl acetothioacetate: Total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
– Journal of the Chemical Society Perkin Transactions 1
(1987)
121
(doi: 10.1039/p19870000121)
The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides
– Tetrahedron Letters
(1987)
28,
3019
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