Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Preparation of spiroketals by reaction of anions from 2-benzenesulphonyltetrahydropyrans with epoxides: synthesis of the c-11 to c-25 fragment of the milbemycins
Tetrahedron Letters
(1986)
27
5277
Synthetic studies towards the acyltetronic acid iohophore M 139603
Tetrahedron Letters
(1986)
27
105
Synthetic approaches to the teleocidin-related tumour promoters: A total synthesis of (±)-indolactam V
J. Chem. Soc., Chem. Commun.
(1986)
344
(doi: 10.1039/c39860000344)
X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
Journal of the Chemical Society Chemical Communications
(1986)
1
46
(doi: 10.1039/c39860000046)
Natural product synthesis using π-allyltricarbonyliron lactone complexes: Synthesis of parasorbic acid, the carpenter bee pheromone and malyngolide
Journal of Organometallic Chemistry
(1985)
285
C17
(doi: 10.1016/0022-328x(85)87394-0)
ORGANOSELENIUM-MEDIATED CYCLISATION REACTIONS IN ORGANIC SYNTHESIS.
Chemistry and Industry London
(1985)
101
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
Tetrahedron
(1985)
41
4765
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
CHEMISTRY & INDUSTRY
(1985)
101
Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1985)
1949
(doi: 10.1039/p19850001949)
Use of π-allyltricarbonyliron lactam complexes in the preparation of nocardicin derivatives: synthesis of (–)-3-oxo-1-[( p -benzyloxyphenyl)-benzyloxycarbonylmethyl]azetidin-2-one
J CHEM SOC PERK T 1
(1985)
2375
(doi: 10.1039/P19850002375)
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