Professor Steve Ley CBE FRS FMedSci | Page 94 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV Ley, D Santafianos, WM Blaney, MSJ Simmonds

– Tetrahedron Letters

(1987)

28,

1595

(doi: 10.1016/S0040-4039(00)95369-3)

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

JN BILTON, HB BROUGHTON, PS JONES, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron

(1987)

43,

2805

(doi: 10.1016/S0040-4020(01)86886-1)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV LEY, PR WOODWARD

– Tetrahedron Letters

(1987)

28,

345

(doi: 10.1016/s0040-4039(00)95725-3)

MICROBIAL OXIDATION IN SYNTHESIS - A 6 STEP PREPARATION OF (+/-)-PINITOL FROM BENZENE

SV LEY, F STERNFELD, S TAYLOR

– Tetrahedron Letters

(1987)

28,

225

(doi: 10.1016/S0040-4039(00)95692-2)

SYNTHESIS OF THE MONOCYCLIC NONAROMATIC C-1 TO C-10 FRAGMENTS OF THE MILBEMYCINS AND AVERMECTINS

NJ ANTHONY, T CLARKE, AB JONES, SV LEY

– Tetrahedron Letters

(1987)

28,

5755

(doi: 10.1016/s0040-4039(00)96833-3)

Synthesis of a novel 3, 4-dihydromilbemycin analogue.

C GRECK, P GRICE, AB JONES, SV LEY

– Tetrahedron Letters

(1987)

28,

5759

(doi: 10.1016/S0040-4039(00)96834-5)

CORRECTION

SV LEY

– TETRAHEDRON LETTERS

(1987)

28,

1594

(link to publication)

A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques

GH BAKER, PJ BROWN, RJJ DORGAN, JR EVERETT, SV LEY, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron Letters

(1987)

28,

5565

(doi: 10.1016/S0040-4039(00)96783-2)

Application of ultrasound to the preparation of tricarbonyliron diene complexes

SV LEY, CMR LOW, AD WHITE

– Journal of Organometallic Chemistry

(1986)

302,

c13

(doi: 10.1016/0022-328X(86)80072-9)

Synthestic approaches to the teleocidin-related tumour promoters: a total synthesis of (±)-indolactam V

SE DELASZLO, SV LEY, RA PORTER

– Chemical Communications

(1986)

344

(doi: 10.1039/C39860000344)