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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
SV LEY, D SANTAFIANOS, WM BLANEY, MSJ SIMMONDS
– Tetrahedron Letters
(1987)
28,
221
CORRECTION
SV LEY
– TETRAHEDRON LETT
(1987)
28,
1594
DEVELOPMENT OF A SYNTHETIC ROUTE TOWARDS MILBEMYCIN-BETA-1 - PREPARATION OF AN ADVANCED MODEL SYSTEM
NJ ANTHONY, P GRICE, SV LEY
– Tetrahedron Letters
(1987)
28,
5763
SYNTHESIS OF A NOVEL 3,4-DIHYDROMILBEMYCIN ANALOG
C GRECK, P GRICE, AB JONES, SV LEY
– Tetrahedron Letters
(1987)
28,
5759
An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
JN BILTON, HB BROUGHTON, PS JONES, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS
– Tetrahedron
(1987)
43,
2805
The use of β-ketothioesters for the exceptionally mild preparation of β-ketoamides
SV LEY, PR WOODWARD
– Tetrahedron Letters
(1987)
28,
3019
Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
PM BOOTH, CMJ FOX, SV LEY
– J CHEM SOC PERK T 1
(1987)
121
Application of ultrasound to the preparation of tricarbonyliron diene complexes
SV LEY, CMR LOW, AD WHITE
– Journal of Organometallic Chemistry
(1986)
302,
c13
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
PS JONES, SV LEY, NS SIMPKINS, AJ WHITTLE
– Tetrahedron
(1986)
42,
6519
X-Ray crystallographic structure determination of detigloyldihydroazadirachtin and reassignment of the structure of the limonoid insect antifeedant azadirachtin
HB BROUGHTON, SV LEY, AMZ SLAWIN, DJ WILLIAMS, ED MORGAN
– Chemical Communications
(1986)
1,
46
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk