Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
J. Chem. Soc., Chem. Commun.
(1985)
1805
(doi: 10.1039/C39850001805)
Structural reappraisal of the limonoid insect antifeedant azadirachtin
Journal of the Chemical Society Chemical Communications
(1985)
968
(doi: 10.1039/c39850000968)
Synthesis of the northern hemisphere of the milbemycins using a new strategy for the formation of the C15 to C16 bond.
Tetrahedron Letters
(1985)
26
5837
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
Tetrahedron
(1985)
41
5871
WITTIG AND HORNER-WITTIG COUPLING REACTIONS OF 2-SUBSTITUTED CYCLIC ETHERS AND THEIR APPLICATION TO SPIROKETAL SYNTHESIS
Tetrahedron
(1985)
41
3825
Preparation and reactions of 2-benzenesulphonyltetrahydropyran
Tetrahedron Letters
(1985)
26
535
Synthesis of the spiroacetal unit related to the avermectins and milbemycins
Journal of the Chemical Society Chemical Communications
(1984)
1381
(doi: 10.1039/c39840001381)
A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS
Tetrahedron Letters
(1984)
25
113
Synthesis of (±)- cis -6-methyltetrahydropyran-2-ylacetic acid, a natural product from Viverra civetta , using organoselenium-mediated cyclisation reactions
Journal of the Chemical Society Perkin Transactions 1
(1984)
2403
(doi: 10.1039/P19840002403)
THE USE OF "3-ACETOXY-1-TRIMETHYLSILYLBUTADIENE IN THE SYNTHESIS OF ANTHRACYCLINONE DERIVATIVES
J CHEM SOC PERK T 1
(1984)
1847
(doi: 10.1039/p19840001847)
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