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Yusuf Hamied Department of Chemistry

 

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility. 

For more detailed research information, group members and our publication list please see the group website.

Publications

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives
JN BILTON, HB BROUGHTON, PS JONES, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS
– Tetrahedron
(1987)
43,
2805
Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene
SV LEY, F STERNFELD, S TAYLOR
– Tetrahedron Letters
(1987)
28,
225
PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES
SV LEY, PR WOODWARD
– Tetrahedron Letters
(1987)
28,
345
Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids
PM BOOTH, CMJ FOX, SV LEY
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1987)
121
A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques
GH BAKER, PJ BROWN, RJJ DORGAN, JR EVERETT, SV LEY, AMZ SLAWIN, DJ WILLIAMS
– Tetrahedron Letters
(1987)
28,
5565
Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant
SV LEY, D SANTAFIANOS, WM BLANEY, MSJ SIMMONDS
– Tetrahedron Letters
(1987)
28,
221
Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues
T CLARKE, SV LEY
– J CHEM SOC PERK T 1
(1987)
131
Application of ultrasound to the preparation of tricarbonyliron diene complexes
SV LEY, CMR LOW, AD WHITE
– Journal of Organometallic Chemistry
(1986)
302,
C13
Synthetic studies towards the acyltetronic acid iohophore M 139603
AM DOHERTY, SV LEY
– Tetrahedron Letters
(1986)
27,
105
Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes
PS JONES, SV LEY, NS SIMPKINS, AJ WHITTLE
– Tetrahedron
(1986)
42,
6519
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Research Group

Research Interest Groups

Telephone number

01223 336398

Email address

svl1000@cam.ac.uk