Professor Steve Ley CBE FRS FMedSci | Page 94 | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

An x-ray crystallographic, mass spectroscopic, and NMR study of the limonoid insect antifeedant azadirachtin and related derivatives

JN BILTON, HB BROUGHTON, PS JONES, SV LEY, Z LIDERT, ED MORGAN, HS RZEPA, RN SHEPPARD, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron

(1987)

43,

2805

(doi: 10.1016/s0040-4020(01)86886-1)

Microbial oxidation in synthesis: A six step perparation of (+)-pinitol from benzene

SV LEY, F STERNFELD, S TAYLOR

– Tetrahedron Letters

(1987)

28,

225

(doi: 10.1016/S0040-4039(00)95692-2)

PREPARATION OF TERT-BUTYL 4-DIETHYLPHOSPHONO-3-OXOBUTANETHIOATE AND USE IN THE SYNTHESIS OF (E)-4-ALKENYL-3-OXOESTERS AND MACROLIDES

SV LEY, PR WOODWARD

– Tetrahedron Letters

(1987)

28,

345

(doi: 10.1016/S0040-4039(00)95725-3)

Preparation of acyltetronic acids using t-butyl acetothioacetate: total synthesis of the fungal metabolites carolic, carlosic, and carlic acids

PM BOOTH, CMJ FOX, SV LEY

– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1

(1987)

121

(doi: 10.1039/p19870000121)

A conformational study of bafilomycin A1 by x-ray crystallography and nmr techniques

GH BAKER, PJ BROWN, RJJ DORGAN, JR EVERETT, SV LEY, AMZ SLAWIN, DJ WILLIAMS

– Tetrahedron Letters

(1987)

28,

5565

(doi: 10.1016/S0040-4039(00)96783-2)

Synthesis of a hydroxy dihydrofuran acetal related to azadirachtin: A potent insect antifeedant

SV LEY, D SANTAFIANOS, WM BLANEY, MSJ SIMMONDS

– Tetrahedron Letters

(1987)

28,

221

(doi: 10.1016/S0040-4039(00)95691-0)

Use of S-t-butyl acetothioacetate in the preparation of milbemycin seco-analogues

T CLARKE, SV LEY

– J CHEM SOC PERK T 1

(1987)

131

(doi: 10.1039/p19870000131)

Application of ultrasound to the preparation of tricarbonyliron diene complexes

SV LEY, CMR LOW, AD WHITE

– Journal of Organometallic Chemistry

(1986)

302,

C13

(doi: 10.1016/0022-328X(86)80072-9)

Synthetic studies towards the acyltetronic acid iohophore M 139603

AM DOHERTY, SV LEY

– Tetrahedron Letters

(1986)

27,

105

(doi: 10.1016/S0040-4039(00)83953-2)

Total synthesis of the insect antifeedant ajugarin I and degradation studies of related clerodane diterpenes

PS JONES, SV LEY, NS SIMPKINS, AJ WHITTLE

– Tetrahedron

(1986)

42,

6519

(doi: 10.1016/S0040-4020(01)88114-X)