Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
SYNTHESIS OF THE NORTHERN HEMISPHERE OF THE MILBEMYCINS USING A NEW STRATEGY FOR THE FORMATION OF THE C-15 TO C-16 BOND
Tetrahedron Letters
(1985)
26
5837
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
Tetrahedron
(1985)
41
4765
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
Tetrahedron
(1985)
41
5871
Structural reappraisal of the limonoid insect antifeedant azadirachtin
Journal of the Chemical Society Chemical Communications
(1985)
968
(doi: 10.1039/c39850000968)
USE OF PI-ALLYLTRICARBONYLIRON LACTAM COMPLEXES IN THE PREPARATION OF NOCARDICIN DERIVATIVES - SYNTHESIS OF (-)-3-OXO-1-[(PARA-BENZYLOXYPHENYL)-BENZYLOXYCARBONYLMETHYL]AZETIDIN-2-ONE
J. Chem. Soc., Perkin Trans. 1
(1985)
2375
(doi: 10.1039/P19850002375)
FE2(CO)9 IN TETRAHYDROFURAN OR UNDER SONOCHEMICAL CONDITIONS AS CONVENIENT PRACTICAL ROUTES TO PI-ALLYLTRICARBONYLIRON LACTONE COMPLEXES
Tetrahedron
(1984)
40
1737
Oxo complexes of ruthenium( VI ) and ( VII ) as organic oxidants
J CHEM SOC PERK T 1
(1984)
681
(doi: 10.1039/p19840000681)
Synthesis of spiroacetals using organoselenium-mediated cyclisation reactions. X-Ray molecular structure of (2S,8R)-8-methyl-2-phenyl-1,7-dioxaspiro[5.5]undecan-4(R)-ol
Journal of the Chemical Society, Perkin Transactions 1
(1984)
1371
(doi: 10.1039/p19840001371)
NOVEL REARRANGEMENT OF THE IONOPHORE ANTIBIOTIC X-14547A (INDANOMYCIN) AND RELATED DERIVATIVES INDUCED BY LITHIUM TETRAFLUOROBORATE
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1984)
1761
(doi: 10.1039/p19840001761)
A NEW ROUTE TO SPIRO-KETALS USING THE HORNER-WITTIG REACTION OF 2-DIPHENYLPHOSPHINOXY CYCLIC ETHERS
Tetrahedron Letters
(1984)
25
113
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