Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
SYNTHESIS OF (+/-)-CIS-6-METHYLTETRAHYDROPYRAN-2-YLACETIC ACID, A NATURAL PRODUCT FROM VIVERRA-CIVETTA, USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS
J CHEM SOC PERK T 1
(1984)
2403
(doi: 10.1039/P19840002403)
The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives
J CHEM SOC PERK T 1
(1984)
1847
(doi: 10.1039/p19840001847)
Synthesis of the spiroacetal unit related to the avermectins and milbemycins
Chemical Communications
(1984)
1381
(doi: 10.1039/c39840001381)
π-allyltricarbonyliron lactone complexes in synthesis: Application to the synthesis of the β-lactam antibiotic (+)-thienamycin
Chemical Communications
(1984)
494
(doi: 10.1039/c39840000494)
Synthesis of β-lactams from π-allyltricarbonyliron (lactone) complexes
J. Chem. Soc., Perkin Trans. 1
(1983)
2851
(doi: 10.1039/p19830002851)
The Diels–Alder route to drimane related sesquiterpenes; synthesis of cinnamolide, polygodial, isodrimeninol, drimenin and warburganal
J CHEM SOC PERK T 1
(1983)
1579
(doi: 10.1039/p19830001579)
Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids
Tetrahedron Letters
(1983)
24
5143
Synthesis of the drimane-related sesquiterpenes euryfuran, confertifolin, and valdiviolide
J CHEM SOC PERK T 1
(1983)
1379
(doi: 10.1039/p19830001379)
STEREOCHEMISTRY OF A 5,5,10-TRIMETHYL-2-DECALONE BY PROTON NUCLEAR MAGNETIC-RESONANCE - A NEW APPLICATION OF INDOR DIFFERENCE SPECTROSCOPY
J CHEM RES-S
(1983)
210
The total synthesis of the clerodane diterpene insect antifeedant ajugarin I
Chemical Communications
(1983)
503
(doi: 10.1039/c39830000503)
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