Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.
For more detailed research information and our publication list, please see our legacy group website.
Completed Natural Products
Publications
Peterson olefination using phenylsulphonyltrimethylsilylmethane. A new preparation of vinylic sulphones
Chemical Communications
(1983)
1281
(doi: 10.1039/c39830001281)
Total synthesis of the structurally unique ionophore antibiotic X–14547 A
Chemical Communications
(1983)
630
(doi: 10.1039/c39830000630)
Synthesis of methyl-1,6-dioxaspiro[4,5]decanes using organoselenium mediated cyclization reactions
Tetrahedron Letters
(1982)
23
4625
A CONFORMATIONAL STUDY OF ELAIOPHYLIN BY X-RAY CRYSTALLOGRAPHY AND DIFFERENCE H-1-NMR METHODS - OBSERVATION OF A SELECTIVE SIGN REVERSAL OF THE NUCLEAR OVERHAUSER EFFECT
Tetrahedron Letters
(1982)
23
1207
The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum
J CHEM SOC PERK T 1
(1982)
1005
(doi: 10.1039/p19820001005)
Thermal rearrangement reactions of tricarbonyliron lactone complexes
J CHEM SOC PERK T 1
(1982)
1355
(doi: 10.1039/p19820001355)
Dehydrogenation of lactones using benzeneseleninic anhydride. X -Ray crystal structure of 3β-acetoxy-14α-hydroxy-17a-oxa- D -homo-5α-androst-15-en-17-one
J CHEM SOC PERK T 1
(1982)
1919
(doi: 10.1039/p19820001919)
A practical catalytic method for the preparation of steroidal 1,4-dien-3-ones by oxygen atom transfer from iodoxybenzene to diphenyl diselenide
J CHEM SOC PERK T 1
(1982)
1947
(doi: 10.1039/p19820001947)
Synthesis of polyoxygenated trans -decalins as potential insect antifeedants
J CHEM SOC PERK T 1
(1982)
2157
(doi: 10.1039/p19820002157)
Oxidation of benzylic hydrocarbons with benzeneseleninic anhydride and related reactions
Journal of the Chemical Society, Perkin Transactions 1
(1982)
2179
(doi: 10.1039/p19820002179)
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