Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the years we have completed the total synthesis of many natural products, including: spongistatin 1 (anti-mitotic agent); rapamycin (immunosuppressant); thapsigargin (SERCA pumps inhibitor); azadirachtin (insect antifeedant); and bengazole A (fungicide). In addition to our research on natural product synthesis, we also pioneered flow chemistry and machine assisted synthesis.

For more detailed research information and our publication list, please see our legacy group website.

Completed Natural Products

Publications

Regiospecific alkylation of β-ketothioesters and use in the synthesis of acyl-tetronic acids

PM Booth, CMJ Fox, SV Ley

Tetrahedron Letters

(1983)

5143

(doi: 10.1016/s0040-4039(00)94065-6)

STEREOCHEMISTRY OF A 5,5,10-TRIMETHYL-2-DECALONE BY PROTON NUCLEAR MAGNETIC-RESONANCE - A NEW APPLICATION OF INDOR DIFFERENCE SPECTROSCOPY

SV LEY, AJ WHITTLE, GE HAWKES

J CHEM RES-S

(1983)

210

Total synthesis of the structurally unique ionophore antibiotic X-14547 A

MP Edwards, SV Ley, SG Lister, BD Palmer

Chemical Communications

(1983)

630

(doi: 10.1039/C39830000630)

The X-ray structure and absolute configuration of insect antifeedant clerodane diterpenoids from Teucrium africanum

JR Hanson, DEA Rivett, SV Ley, DJ Williams

J CHEM SOC PERK T 1

(1982)

1005

(doi: 10.1039/p19820001005)

Synthesis of (cis-6-methyltetrahydropyran-2-yl)acetic acid involving the use of an organoselenium-mediated cyclization reaction

SV Ley, B Lygo, H Molines, JA Morton

Chemical Communications

(1982)

1251

(doi: 10.1039/c39820001251)

An unexpected rearrangement of 4-alkylaminoindoles

SV Ley, RA Porter

Journal of the Chemical Society Chemical Communications

(1982)

1356

(doi: 10.1039/c39820001356)

A short syntesis of (±)-hirsutene involving the use of an organoselenium-mediated cyclization reaction

SV Ley, PJ Murray

J. Chem. Soc., Chem. Commun.

(1982)

1252

(doi: 10.1039/C39820001252)

SYNTHESIS OF METHYL-1,6-DIOXASPIRO[4,5]DECANES USING ORGANOSELENIUM MEDIATED CYCLIZATION REACTIONS

SV Ley, B Lygo

Tetrahedron Letters

(1982)

4625

(doi: 10.1016/S0040-4039(00)85671-3)

A conformational study of elaiophylin by X-ray crystallography and difference 1H NMR methods; observation of a selective sign reversal of the nuclear overhauser effect

SV Ley, D Neuhaus, DJ Williams

Tetrahedron Letters

(1982)

1207

(doi: 10.1016/s0040-4039(00)87061-6)

Synthesis of polyoxygenated trans-decalins as potential insect antifeedants

SV Ley, D Neuhaus, NS Simpkins, AJ Whittle

Journal of the Chemical Society Perkin Transactions 1

(1982)

2157

(doi: 10.1039/p19820002157)

Professor Steve Ley CBE FRS FMedSci

Director of Research

Completed Natural Products

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