Director of Research
In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.
For more detailed research information, group members and our publication list please see the group website.
Publications
Preparation and reactions of 2-benzenesulphonyltetrahydropyran
– Tetrahedron Letters
(1985)
26,
535
Wittig and horner-wittig coupling reactions of 2-substituted cyclic ethers and their application to spiroketal synthesis
– Tetrahedron
(1985)
41,
3825
Total synthesis of the sesquiterpene (±)-hirsutene using an organoselenium-mediated cyclization reaction
– Tetrahedron
(1985)
41,
4765
SYNTHETIC APPLICATIONS OF YNES, ENES AND ONES - ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS IN ORGANIC-SYNTHESIS
– CHEMISTRY & INDUSTRY
(1985)
101
Preparation of vinylic sulphones by Peterson olefination using phenyl trimethylsilylmethyl sulphone
– Journal of the Chemical Society, Perkin Transactions 1
(1985)
1949
(doi: 10.1039/p19850001949)
Synthesis of the β-lactam antibiotic (+)- thienamycin via an intermediate π-allyltricarbonyliron lactone complex
– Tetrahedron
(1985)
41,
5871
SYNTHESIS OF THE NORTHERN HEMISPHERE OF THE MILBEMYCINS USING A NEW STRATEGY FOR THE FORMATION OF THE C-15 TO C-16 BOND
– Tetrahedron Letters
(1985)
26,
5837
The use of t-butyl acetothioacetate as a route to bis-β-ketomacrolides
– Journal of the Chemical Society, Chemical Communications
(1985)
1805
(doi: 10.1039/C39850001805)
The use of 3-acetoxy-1-trimethylsilylbutadiene in the synthesis of anthracyclinone derivatives
– JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
(1984)
1847
(doi: 10.1039/p19840001847)
Synthesis of the spiroacetal unit related to the avermectins and milbemycins
– Chemical Communications
(1984)
1381
(doi: 10.1039/c39840001381)
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