Professor Steve Ley CBE FRS FMedSci

Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .6. SYNTHESIS OF AN OPTICALLY PURE ACETAL INTERMEDIATE FOR POTENTIAL USE IN THE SYNTHESIS OF AZADIRACHTIN AND NOVEL ANTIFEEDANTS

JC ANDERSON, SV LEY

– Tetrahedron Letters

(1990)

31,

431

(doi: 10.1016/s0040-4039(00)94574-x)

Synthesis of the C12–C26 fragment of the acyltetronic acid lonophore antibiotic tetronasin (ici 139603)

SE DELASZLO, MJ FORD, SV LEY, GN MAW

– Tetrahedron Letters

(1990)

31,

5525

(doi: 10.1016/s0040-4039(00)97889-4)

Synthesis of a C16–C28 spiroacetal fragment of avermectin B1a and reassignment of some 1H and 13C resonances of avermectin B1a

D DIEZMARTIN, P GRICE, HC KOLB, SV LEY, A MADIN

– Tetrahedron Letters

(1990)

31,

3445

(doi: 10.1016/s0040-4039(00)97418-5)

TPAP: Tetra-n-propylammonium perruthenate, a mild and convenient oxidant for alcohols

WP Griffith, SV Ley

– Aldrichimica Acta

(1990)

23,

Chemistry of insect antifeedants from azadirachta indica (part 7): Preparation of an optically pure hydroxyacetal epoxide related to azadirachtin.

JC ANDERSON, SV LEY

– Tetrahedron Letters

(1990)

31,

3437

(doi: 10.1016/s0040-4039(00)97416-1)

Neo-clerodane insect antifeedants from Scutellaria galericulata

MD COLE, JC ANDERSON, WM BLANEY, LE FELLOWS, SV LEY, RN SHEPPARD, MSJ SIMMONDS

– Phytochemistry

(1990)

29,

1793

(doi: 10.1016/0031-9422(90)85018-B)

INSECT ANTIFEEDANTS

SV LEY, PL TOOGOOD

– CHEM BRIT

(1990)

26,

(link to publication)

SYNTHESIS OF ANTIFEEDANTS FOR INSECTS - NOVEL BEHAVIOR-MODIFYING CHEMICALS FROM PLANTS

SV LEY

– CIBA F SYMP

(1990)

154,

(link to publication)

Assessment of butene-1,4-diols as starting materials for the preparation of π-Allyltricarbonyliron complexes

RW BATES, D DIEZMARTIN, WJ KERR, JG KNIGHT, SV LEY, A SAKELLARIDIS

– Tetrahedron

(1990)

46,

4063

(doi: 10.1016/S0040-4020(01)90541-1)

Microbial oxidation in synthesis: preparation of myo-inositol phosphates and related cyclitol derivatives from benzene

SV LEY, M PARRA, AJ REDGRAVE, F STERNFELD

– Tetrahedron

(1990)

46,

4995

(doi: 10.1016/S0040-4020(01)85605-2)

Director of Research

Publications

Research Group

Research Interest Groups

Telephone number

Email address

College

About the Department

Departmental Services

Study at Cambridge

About the University

Research at Cambridge