Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Dispiroketals in synthesis (part 10): Further reactions of dispoke protected lactate and glycolate enolates

GJ Boons, R Downham, KS Kim, SV Ley, M Woods

– Tetrahedron

(1994)

50,

7157

(doi: 10.1016/S0040-4020(01)85241-8)

Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates

R Downham, KS Kim, SV Ley, M Woods

– Tetrahedron Letters

(1994)

35,

769

(doi: 10.1016/S0040-4039(00)75813-8)

TETRAPROPYLAMMONIUM PERRUTHENATE, PR4N+RUO4-, TPAP - A CATALYTIC OXIDANT FOR ORGANIC-SYNTHESIS

SV LEY, J NORMAN, WP GRIFFITH, SP MARSDEN

– Synthesis

(1994)

1994,

639

(doi: 10.1055/s-1994-25538)

DISPIROKETALS IN SYNTHESIS .17. REGIOSELECTIVE PROTECTION OF D-GLUCOPYRANOSIDE, D-GALACTOPYRANOSIDE AND D-MANNOPYRANOSIDE SUBSTRATES

PJ EDWARDS, DA ENTWISTLE, C GENICOT, SV LEY, G VISENTIN

– Tetrahedron: Asymmetry

(1994)

5,

2609

(doi: 10.1016/s0957-4166(00)80404-8)

Diastereoselective addition reactions to carbonyl groups in the side-chain of π-allytricarbonyliron lactone complexes

SV LEY, G MEEK, KH METTEN, C PIQUE

– J. Chem. Soc., Chem. Commun.

(1994)

1931

(doi: 10.1039/c39940001931)

Dispiroketals in synthesis (Part 5): A new opportunity for oligosaccharide synthesis using differentially activated glycosyl donors and acceptors

GJ BOONS, P GRICE, R LESLIE, SV LEY, LL YEUNG

– Tetrahedron Letters

(1993)

34,

8523

(doi: 10.1016/S0040-4039(00)61375-8)

The chemistry of azadirachtin

SV LEY, AA DENHOLM, A WOOD

– Natural Product Reports

(1993)

10,

109

(doi: 10.1039/NP9931000109)

Selective Acylation and Alkylation Reactions of Diols Using Dibutyltin Dimethoxide

GJ BOONS, GH CASTLE, JA CLASE, P GRICE, SV LEY, C PINEL

– Synlett

(1993)

1993,

913

(doi: 10.1055/s-1993-22650)

Total synthesis of the spiroketal macrolide (+) milbemycin α₁

SV LEY, A MADIN, NJT MONCK

– Tetrahedron Letters

(1993)

34,

7479

(doi: 10.1016/S0040-4039(00)60158-2)

Synthesis of 4-substituted imidazoles via 4-metallo imidazole intermediates

RM TURNER, SV LEY, SD LINDELL

– Synlett

(1993)

1993,

748

(doi: 10.1055/s-1993-22594)