Professor Steve Ley CBE FRS FMedSci | Yusuf Hamied Department of Chemistry

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Director of Research

In the Ley Group, we specialise in developing new synthesis methods and applying them to the construction of biologically important molecules. Over the last 10 years we have completed the total synthesis of 28 natural products including spongistatin 1 (anti-mitotic agent), rapamycin (immunosuppressant), thapsigargin (SERCA pumps inhibitor), azadirachtin (insect antifeedant) and bengazole A (fungicide), taking our group total to 150 completed total syntheses. In addition to our research on natural product synthesis, we also have a new state-of-the-art flow chemistry facility.

For more detailed research information, group members and our publication list please see the group website.

Publications

Dispiroketals in synthesis (part 7): Protection of D-glucopyranose substrates

AB HUGHES, SV LEY, HWM PRIEPKE, M WOODS

– Tetrahedron Letters

(1994)

35,

773

(doi: 10.1016/s0040-4039(00)75814-x)

Dispiroketals in synthesis (part 6): Highly stereoselective alkylation of dispiroketal protected lactate and glycolate enolates

R DOWNHAM, KS KIM, SV LEY, M WOODS

– Tetrahedron Letters

(1994)

35,

769

(doi: 10.1016/S0040-4039(00)75813-8)

TOWARDS THE SYNTHESIS OF THE C-37-C-42 FRAGMENT OF RAPAMYCIN - INTRAMOLECULAR REACTIONS OF ALLYL SILANES WITH OXONIUM IONS GENERATED FROM ALPHA-ALKOXY SULFONES

SV LEY, C KOUKLOVSKY

– Tetrahedron

(1994)

50,

835

(doi: 10.1016/s0040-4020(01)80798-5)

Two new routes to the C19C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603)

GJ BOONS, DS BROWN, JA CLASE, IC LENNON, SV LEY

– Tetrahedron Letters

(1994)

35,

319

(doi: 10.1016/s0040-4039(00)76542-7)

BIOSYNTHESIS OF TETRONASIN .1. INTRODUCTION AND INVESTIGATION OF THE DIKETIDE AND TRIKETIDE INTERMEDIATES BOUND TO THE POLYKETIDE SYNTHASE

HC HAILES, CM JACKSON, PF LEADLAY, SV LEY, J STAUNTON

– Tetrahedron Letters

(1994)

35,

307

(doi: 10.1016/s0040-4039(00)76539-7)

Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase

HC HAILES, S HANDA, PF LEADLAY, IC LENNON, SV LEY, J STAUNTON

– Tetrahedron Letters

(1994)

35,

311

(doi: 10.1016/s0040-4039(00)76540-3)

BIOSYNTHESIS OF TETRONASIN .3. PREPARATION OF DEUTERIUM-LABELED TRIKETIDES AND TETRAKETIDES AS PUTATIVE BIOSYNTHETIC PRECURSORS OF TETRONASIN

HC HAILES, S HANDA, PF LEADLAY, IC LENNON, SV LEY, J STAUNTON

– Tetrahedron Letters

(1994)

35,

315

(doi: 10.1016/S0040-4039(00)76541-5)

Novel polyene cyclisation routes to the acyl tetronic acid ionophore tetronasin (ICI M139603)

GJ BOONS, IC LENNON, SV LEY, ESE OWEN, J STAUNTON, DJ WADSWORTH

– Tetrahedron Letters

(1994)

35,

323

(doi: 10.1016/S0040-4039(00)76543-9)

Dispiroketals in synthesis (Part 17): Regioselective protection of D-glucopyranoside D-galactopyranoside and D-mannopyranoside substrates.

PJ EDWARDS, DA ENTWISTLE, C GENICOT, SV LEY, G VISENTIN

– Tetrahedron Asymmetry

(1994)

5,

2609

(doi: 10.1016/s0957-4166(00)80404-8)

DISPIROKETALS IN SYNTHESIS .9. RESOLUTION OF 1,2-DIOLS USING A C-2-SYMMETRICAL DIPHENYLTETRAHYDROBIPYRAN

PJ EDWARDS, DA ENTWISTLE, SV LEY, DR OWEN, EJ PERRY

– Tetrahedron Asymmetry

(1994)

5,

553

(doi: 10.1016/0957-4166(94)80016-2)